Menée à partir de données du "US Cancer Statistics" portant sur 248 749 patients pédiatriques atteints d'un cancer (âge : moins de 20 ans), cette étude analyse l'incidence et les tendances concernant les cancers pédiatriques sur la période 2003-2019

Counts, incidence rates, and trends of pediatric cancer in the United States, 2003-2019

Siegel, David A ; King, Jessica B ; Lupo, Philip J ; Durbin, Eric B ; Tai, Eric ; Mills, Kathi ; Van Dyne, Elizabeth ; Buchanan Lunsford, Natasha ; Henley, S Jane ; Wilson, Reda J

Cancer is a leading cause of death by disease among children and adolescents in the United States. This study updates cancer incidence rates and trends using the most recent and comprehensive US cancer registry data available.We used data from US Cancer Statistics to evaluate counts, age-adjusted incidence rates, and trends among children and adolescents aged <20 years diagnosed with malignant tumors during 2003-2019. We calculated average annual percent change and annual percent change [...]

Mené sur 2 146 patients fumeurs atteints d'un cancer et 246 professionnels de santé, cet essai randomisé évalue l'effet, sur l'engagement dans le sevrage tabagique, d'incitations apparaissant dans le dossier médical électronique des patients

Cluster Randomized Pragmatic Clinical Trial Testing Behavioral Economic Implementation Strategies to Improve Tobacco Treatment for Patients With Cancer Who Smoke

Brian P. Jenssen ; Robert Schnoll ; Rinad S. Beidas ; Justin Bekelman ; Anna-Marika Bauer ; Sarah Evers-Casey ; Tierney Fisher ; Callie Scott ; Jody Nicoloso ; Peter Gabriel ; David A. Asch ; Alison M. Buttenheim ; Jessica Chen ; Julissa Melo ; Dwayne Grant ; Michael Horst ; Randall Oyer ; Lawrence N. Shulman ; Alicia B.W. Clifton ; Adina Lieberman ; Tasnim Salam ; Katharine A. Rendle ; Krisda H. Chaiyachati ; Rachel C. Shelton ; Oluwadamilola Fayanju ; E. Paul Wileyto ; Sue Ware ; Daniel Blumenthal ; Daniel Ragusano ; Frank T. Leone

PURPOSE: Few cancer centers systematically engage patients with evidence-based tobacco treatment despite its positive effect on quality of life and survival. Implementation strategies directed at patients, clinicians, or both may increase tobacco use treatment (TUT) within oncology. METHODS: We conducted a four-arm cluster-randomized pragmatic trial across 11 clinical sites comparing the effect of strategies informed by behavioral economics on TUT engagement during oncology encounters with [...]

Menée à l'aide de données des registres américains des cancers portant sur 627 702 patients ayant survécu au moins 5 ans à un cancer du sein, de la prostate ou du côlon-rectum diagnostiqué sur la période 2003-2014 (âge moyen : 61,1 ans ; 69,3 % de femmes), cette étude évalue les taux de mortalité absolue et relative, spécifiques au cancer ou non et identifie des facteurs de risque associés

Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US

KC, Madhav ; Fan, Jane ; Hyslop, Terry ; Hassan, Sirad ; Cecchini, Michael ; Wang, Shi-Yi ; Silber, Andrea ; Leapman, Michael S. ; Leeds, Ira ; Wheeler, Stephanie B. ; Spees, Lisa P. ; Gross, Cary P. ; Lustberg, Maryam ; Greenup, Rachel A. ; Justice, Amy C. ; Oeffinger, Kevin C. ; Dinan, Michaela A.

Improvements in cancer outcomes have led to a need to better understand long-term oncologic and nononcologic outcomes and quantify cancer-specific vs noncancer-specific mortality risks among long-term survivors.To assess absolute and relative cancer-specific vs noncancer-specific mortality rates among long-term survivors of cancer, as well as associated risk factors.This cohort study included 627 702 patients in the Surveillance, Epidemiology, and End Results cancer registry with breast, [...]

Menée à l'aide de données de la "UK Biobank" portant sur 411 436 personnes (âge : 40-69 ans ; durée médiane de suivi : 12,7 ans), cette étude analyse l'association entre une carence et/ou une supplémentation en vitamine D et la mortalité par cancer (18 localisations)

Associations of 25-hydroxyvitamin D status and vitamin D supplementation use with mortality due to 18 frequent cancer types in the UK Biobank cohort

Sha, Sha ; Chen, Li-Ju ; Brenner, Hermann ; Schottker, Ben

Background: Although the associations of serum 25-hydroxyvitamin D (25(OH)D) levels and vitamin D supplementation with total cancer mortality are well-known, evidence regarding the association of 25(OH)D and cancer site-specific mortality is predominantly limited to common cancer types, and most studies on vitamin D supplementation use have limitations on sample size and adjustment of important confounding factors. Methods: We used cause-specific Cox regression models adjusted for 48 covariates [...]

Menée à l'aide de données de la "Mayo Clinic" portant sur 300 patients atteints d'un cancer colorectal, cette étude analyse le taux de néoplasies synchrones lors du diagnostic par coloscopie des patients ayant développé la maladie précocement ou après 50 ans

Synchronous Neoplasia Rates at Colonoscopic Diagnosis of Early-Onset vs Average-Onset Colorectal Cancer

Emiloju, Oluwadunni E. ; Saberzadeh-Ardestani, Bahar ; Sinicrope, Frank A.

The incidence of early-onset colorectal cancer (CRC) (age, <50 years) continues to increase globally within high-income countries.To examine and compare rates of synchronous neoplasia found in patients at colonoscopic diagnosis of early-onset CRC with rates found at diagnosis of average-onset CRC.In this multisite retrospective and cross-sectional study conducted at Mayo Clinic sites and in the Mayo Clinic Health System from January 1, 2012, to December 31, 2022, 150 randomly selected [...]

Menée à partir de données de registres suédois portant sur 5 493 patientes atteintes d'un cancer du sein et utilisant simultanément une hormonothérapie adjuvante et un traitement de réduction du risque d'événement cardiovasculaire (durée médiane de suivi : 7,2 ans ; âge : 40-74 ans), cette étude analyse le risque d'arrêt du traitement cardiovasculaire dans l'année précédant et suivant l'arrêt de l'hormonothérapie

Concomitant Discontinuation of Cardiovascular Therapy and Adjuvant Hormone Therapy Among Patients With Breast Cancer

He, Wei ; Zeng, Erwei ; Sjölander, Arvid ; Hübbert, Laila ; Hedayati, Elham ; Czene, Kamila

A large proportion of patients with breast cancer concomitantly use adjuvant hormone therapy and cardiovascular therapy.To examine the relative risk of discontinuing cardiovascular therapy during the periods before and after discontinuation of adjuvant hormone therapy.This population-based cohort study included all women aged 40 to 74 years in Stockholm, Sweden, who were diagnosed with breast cancer and concomitantly using adjuvant hormone therapy and cardiovascular therapy. Patients were [...]

Menée auprès de 286 patients atteints d'un carcinome épidermoïde de la cavité buccale diagnostiqué sur la période 2000-2020 (durée médiane de suivi : 10,2 ans), cette étude compare les caractéristiques cliniques, pathologiques et immunitaires d'un carcinome sporadique et d'un carcinome associé à un traitement par radiothérapie

Comparison of Clinical Outcomes, Pathologic Characteristics, and Immune-Related Features of Postradiation vs Sporadic Oral Cavity Squamous Cell Carcinoma

Chow, James C. H. ; Cheuk, Wah ; Cho, William C. S. ; Wong, Chi-Fai ; Au, Dennis W. Y. ; Tam, Anthony H. P. ; Wong, Rachel C. W. ; Chan, Jeffrey C. H. ; Law, Simon C. C. ; Ngan, Roger K. C. ; Wong, Kam-Hung ; Cheung, Ka-Man

Postradiation oral cavity squamous cell carcinoma (OCSCC) is a common secondary malignant neoplasm affecting survivors of head and neck cancer who underwent radiotherapy. The clinical, pathologic, and immune-related features of postradiation OCSCC are poorly characterized, and treatment options are limited because of surgical difficulty and high morbidity associated with reirradiation.To determine whether postradiation OCSCC has distinctive clinical, pathologic, and immune-related features [...]

Menée dans le secteur public américain, cette étude évalue le rapport coût-efficacité de sept nouveaux schémas thérapeutiques pour les patients atteints d'un cancer de la prostate métastatique hormonosensible

Cost-Effectiveness Analysis of seven treatments In Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): A Public-Payer Perspective

Yoo, Minkyoung ; Nelson, Richard E ; Haaland, Benjamin ; Dougherty, Maura ; Cutshall, Zachary ; Kohli, Rhea ; Beckstead, Rylee ; Kohli, Manish

Recently several new treatment regimens have been approved for treating metastatic hormone-sensitive prostate cancer (mHSPC), building on androgen deprivation therapy (ADT) alone. These include docetaxel-ADT (DA), Abiraterone Acetate-Prednisone-ADT (AAP), Apalutamide-ADT (AAT), Enzalutamide-ADT (ET), Darolutamide-Docetaxel-ADT (DAD) and Abiraterone- Prednisone-ADT-Docetaxel (AAD). There are no validated predictive biomarkers for choosing a specific regimen. The goal of this study was to conduct [...]

Cet article présente une mise à jour des recommandations 2020 de l'"American Society of Clinical Oncology" concernant la prise en charge d'une cachexie chez des patients atteints d'un cancer de stade avancé

Cancer Cachexia: ASCO Guideline Rapid Recommendation Update

Eric J. Roeland ; Kari Bohlke ; Vickie E. Baracos ; Thomas J. Smith ; Charles L. Loprinzi ; for the Cancer Cachexia Expert Panel

ASCO Rapid Recommendations Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual. The goal of these articles is to disseminate updated recommendations, in a timely manner, to better inform health practitioners and the public on the best available cancer care options. [...]

Menée à partir de données multicentriques de la "Société européenne des spécialistes du cancer du sein (EUSOMA)" portant sur 150 150 patientes atteintes d'un cancer du sein de stade précoce, cette étude analyse les tendances et différences concernant la prise en charge de la maladie en Europe

Trends and variation of treatment of early breast cancer in European certified breast centres: an EUSOMA based analysis

van Walle, Lien ; Verhoeven, Didier ; Marotti, Lorenza ; Ponti, Antonio ; Tomatis, Mariano ; Rubio, Isabel T.

Background: Practice indicators measure provided care making use of real-world data. This study describes trends and variations of adjuvant treatment of early breast cancer (EBC) using the European Society of Breast Cancer Specialists (EUSOMA) database. Methods: The analysis was conducted on anonymous cumulative data registered by 56 certified breast centres, which all entered at least 500 new diagnoses in the database in the ten-year period 2010-2019. Practice trends of radiotherapy, endocrine [...]