A partir d'une revue systématique de la littérature publiée entre 2000 et 2020 (22 études), cette étude analyse, chez des patients ayant reçu une greffe de cellules souches hématopoïétiques, la prévalence et la sévérité d'une xérostomie ainsi que la détresse psychique associée

The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress

Bulthuis, Marjolein S. ; van Gennip, Lucky L. A. ; Bronkhorst, Ewald M. ; Blijlevens, Nicole M. A. ; Huysmans, Marie-Charlotte D. N. J. M. ; van Leeuwen, Stephanie J. M. ; Thomas, Renske Z.

Objective: The aim of the present systematic review is to assess the prevalence and severity of and distress caused by xerostomia over time in adult hematopoietic stem cell transplantation (HSCT) recipients. Methods: PubMed, Embase, and the Cochrane Library were searched for papers published between January 2000 and May 2022. Clinical studies were included if patient-reported subjective oral dryness was reported in adult autologous or allogeneic HSCT recipients. Risk of bias was assessed [...]

Menée aux Etats-Unis par entretiens auprès d'aidants de patients atteints d'un cancer du sang, cette étude analyse leurs expériences et leurs besoins en soins de support lors d'un nouvelle ligne de traitement ou à la fin des traitements

Survivorship transitions in blood cancer: Identifying experiences and supportive care needs for caregivers

Mullis, M. Devyn ; Fisher, Carla L. ; Kastrinos, Amanda L. ; Sae-Hau, Maria ; Weiss, Elisa S. ; Rajotte, Michelle ; Bylund, Carma L.

Purpose: Survivorship care often refers to continued healthcare after cancer treatment. Jacobsen and colleagues advocated to expand this to include patients on extended treatments and maintenance/prophylactic therapies, recognizing the care continuum as more complex. Transitions of care for individuals diagnosed with a blood cancer can be complicated. We sought to better understand blood cancer caregivers’ experiences as their diagnosed family member encountered “survivorship transitions” [...]

Mené sur 266 patientes ayant survécu à un cancer du sein et en situation d'obésité ou de surpoids, cet essai randomisé évalue l'intérêt, pour développer leur adhésion à une alimentation saine et/ou promouvoir une activité physique, d'une intervention à base de conseils individualisés dispensés par un diététicien, un psychologue et un kinésithérapeute

Physical activity and/or dietary intervention in overweight or obese breast cancer survivors: results of the InForma randomized trial

Gnagnarella, Patrizia ; Dragà, Daniele ; Raja, Silvia ; Baggi, Federica ; Simoncini, Maria Claudia ; Sabbatini, Annarita ; Mazzocco, Ketti ; Masiero, Marianna ; Bassi, Fabio Domenico ; Peradze, Nickolas ; Zorzino, Laura ; Latella, Marialetizia ; Pravettoni, Gabriella ; Maisonneuve, Patrick

Purpose: This study aimed to test the efficacy of a 6-month intervention on weight loss in a group of overweight or obese breast cancer (BC) survivors. We promoted adherence to a healthy diet or/and to increase physical activity, making use of a step counter device. Here we present results regarding the change in anthropometric measures and blood parameters. Methods: 266 women treated for BC with a BMI ≥ 25 kg/m2 were randomized to a 6-month intervention into four arms: Dietary Intervention [...]

Menée par questionnaire auprès de 100 témoins et 55 patients ayant survécu à une tumeur germinale non séminomateuse du testicule (âge médian : 32 ans), cette étude analyse leur qualité de vie

Quality of life assessment in testicular non-seminomatous germ cell tumour survivors

Pathak, Neha ; Raj, Abhishek ; Santhosh, Akhil P. ; Kumar, Sudhir ; Haresh, K. P. ; Singh, Prabhjot ; Nayak, Brusabhanu ; Shamim, Shamim Ahmed ; Seth, Amlesh ; Ray, Mukurdipi ; Kaushal, Seema ; Sahoo, Ranjit Kumar ; Batra, Atul

Purpose: Patients with Germ cell tumours (GCT) are at risk of long-term toxicities due to multimodality therapy. It is debatable whether there is an impact on the quality of life(QoL) of GCT survivors. Methods: A case–control study was conducted at a tertiary care centre in India, using the EORTC QLQ C30 questionnaire, to compare the QoL between GCT survivors(disease free > 2 years) and healthy matched controls. A multivariate regression model was used to identify factors affecting QoL. [...]

Menée par enquête auprès de 4 507 patients ayant survécu à un cancer et appartenant à des minorités sexuelles ou de genre, cette étude cas-témoins analyse leurs comportements de santé et leur état de santé physique et psychique

Cancer survivors’ health behaviors and outcomes: A population-based study of sexual and gender minorities

Boehmer, Ulrike ; Chang, Shine ; Sanchez, Nelson F ; Jesdale, Bill M ; Schabath, Matthew B

Background: Most case-control studies compare cancer survivors to general population controls without considering sexual orientation or gender identity. This case-control analysis compared health risk behaviors and health outcomes among sexual and gender minority (SGM) cancer survivors to those of matched SGM non-cancer controls. Methods: Using data from the 2014-2021 Behavioral Risk Factor Surveillance System, a population-based sample of 4,507 cancer survivors who self-identified as [...]

Menée à partir de données portant sur 172 963 patients atteints d'un cancer et sur des témoins (durée médiane de suivi : 6,5 ans), cette étude analyse le risque de fracture associé à la maladie

Fracture risk among patients with cancer compared to individuals without cancer: a population-based study

Gong, Inna Y. ; Chan, Kelvin K. W. ; Lipscombe, Lorraine L. ; Cheung, Matthew C. ; Mozessohn, Lee

Background: Patients with cancer may be at increased risk of osteoporosis and fracture; however, gaps exist in the existing literature and the association between cancer and fracture requires further examination. Methods: We conducted a population-based cohort study of Ontario patients with cancer (breast, prostate, lung, gastrointestinal, haematologic) diagnosed between January 2007 to December 2018 and 1:1 matched non-cancer controls. The primary outcome was incident fracture (end of [...]

Menée au Royaume-Uni dans un contexte de vie réelle à partir de données portant sur 1 037 patients atteints d'un cancer (âge médian : 63 ans), cette étude de cohorte rétrospective analyse le risque de lésion rénale aiguë liée ou non à une utilisation d'inhibiteurs de points de contrôle immunitaire

Acute Kidney Injury in Patients receiving Immune Checkpoint Inhibitors: a Retrospective Real-world Study

Lumlertgul, Nuttha ; Vassallo, Pietro ; Tydeman, Florence ; Lewis, Natasha ; Hobill, Abigail ; Weerapolchai, Kittisak ; Nordin, Nurul Zaynah ; Seylanova, Nina ; Martin, Luke ; Cennamo, Armando ; Wang, Yanzhong ; Rigg, Anne ; Shaunak, Nisha ; Ostermann, Marlies

Background: Immune checkpoint inhibitors (ICPi) can cause immune-related adverse events (irAEs) including acute kidney injury (AKI). We investigated the incidence of ICPi-associated AKI (ICPi-AKI) and AKI from other causes (non-ICPi-AKI) in cancer patients treated with ICPi. Methods: This was a single-centre retrospective cohort study of patients receiving ICPi therapy between December 2011 and August 2020. AKI was defined and staged by the Kidney Disease Improving Global Outcomes (KDIGO) [...]

Menée à partir de données portant sur 106 enfants atteints d'une leucémie lymphoblastique aiguë traitée par chimiothérapie, cette étude identifie des facteurs associés au risque d'infection du sang

Gastrointestinal barrier integrity and mucosal inflammation as risk factors of blood stream infections in children treated for acute lymphoblastic leukaemia

De Pietri, Silvia ; Weischendorff, Sarah ; Rathe, Mathias ; Frandsen, Thomas Leth ; Hasle, Henrik ; Nersting, Jacob ; Nielsen, Claus H. ; Moser, Claus ; Müller, Klaus

Chemotherapy-induced mucositis increases the risk of blood stream infections (BSI) due to translocation of bacteria across the intestinal epithelium. Our study investigated if quantitative measures of intestinal mucositis severity, including plasma citrulline (a marker of functional enterocytes) and CCL20 (an intestinal immune homeostatic chemokine), could identify patients at risk of BSI. A total of 106 children with ALL undergoing induction treatment (NOPHO ALL 2008) were included and [...]

Menée à partir de données des registres américains des cancers portant sur 21 098 patients atteints d'un cancer du poumon non à petites cellules de stade IV, cette étude analyse les disparités ethniques dans l'utilisation des immunothérapies et dans la survie globale

Unequal Racial Distribution of Immunotherapy for Late-Stage Non-Small Cell Lung Cancer

Chang, Annie ; Flores, Raja M ; Taioli, Emanuela

Immunotherapy has increased survival for non-small cell lung cancer (NSCLC), especially for those diagnosed with late-stage disease. However, it is not known if its use is equally distributed across races. We assessed immunotherapy use in 21,098 pathologically confirmed stage IV NSCLC according to race in the Surveillance Epidemiology, and End Results (SEER)-Medicare linked dataset. Multivariable models were conducted to evaluate the independent association of receipt of immunotherapy with [...]

Mené sur 82 patients atteints d'une tumeur cérébrale primitive et sur 36 aidants, cet essai randomisé évalue l'intérêt d'une intervention par visioconférence pour améliorer leur santé psychique et leur qualité de vie

Evaluation of the telehealth making sense of brain tumor psychological support intervention for people with primary brain tumor and their caregivers: A randomized controlled trial

Ownsworth, Tamara ; Chambers, Suzanne ; Jones, Stephanie ; Parker, Giverny ; Aitken, Joanne F. ; Foote, Matthew ; Gordon, Louisa G. ; Shum, David H. K. ; Robertson, Julia ; Conlon, Elizabeth ; Pinkham, Mark B.

Objective: This pragmatic randomized control trial aimed to evaluate clinical efficacy of the Making Sense of Brain Tumour program delivered via videoconferencing (Tele-MAST) for improving mental health and quality of life (QoL) relative to standard care in individuals with primary brain tumor (PBT). Method: Adults with PBT experiencing at least mild distress (Distress Thermometer ≥4) and caregivers were randomly allocated to the 10-session Tele-MAST program or standard care. Mental health and [...]

Cet article analyse les disparités concernant l'accès au dépistage et aux soins des patientes atteintes d'un cancer du sein et en situation de handicap

Disparities in Breast Cancer Patients with Disabilities: Care Gaps, Accessibility, and Best Practices

Keegan, Grace ; Rizzo, John-Ross ; Joseph, Kathie-Ann

Significant disparities exist in detecting and treating breast cancer in women with disabilities, leading to cancer detection at advanced stages. This paper provides an overview of disparities for women with disabilities related to breast cancer screening and care, primarily focusing on significant mobility disabilities. Current care gaps include screening barriers related to accessibility and inequitable treatment options, with race/ethnicity, socioeconomic status, geographic location, and [...]

Menée en Allemagne par enquête auprès de 210 patients atteints d'un cancer, cette étude transversale analyse leurs connaissances concernant les soins palliatifs et leur souhait d'y avoir recours selon la nature de la maladie (tumeur solide ou cancer hématologique)

Knowledge, feelings, and willingness to use palliative care in cancer patients with hematologic malignancies and solid tumors: a prospective, cross-sectional study in a comprehensive cancer center in Germany

Gebel, Cordula ; Basten, Judith ; Kruschel, Isabel ; Ernst, Thomas ; Wedding, Ulrich

Purpose: Patients with hematologic malignancies (HM) receive palliative care (PC) less often and later than patients with solid tumors (ST). Patients’ lack of knowledge about PC and negative feelings about PC are barriers to their willingness to use PC. Is there a difference between patients with HM and ST in their knowledge and willingness to use PC? Methods: Two hundred ten patients (85 HM, 125 ST) from an oncology day clinic at a university hospital participated in this cross-sectional, [...]

A partir d'une revue de la littérature (23 études), cette étude analyse les interventions de e-santé en soins palliatifs pour des patients atteints d'un cancer de stade avancé

Telehealth palliative care interventions for patients with advanced cancer: a scoping review

Mathews, Jean Jacob ; Chow, Ronald ; Wennberg, Erica ; Lau, Jenny ; Hannon, Breffni ; Zimmermann, Camilla

Purpose: Telehealth allows patients to maintain contact with healthcare providers without necessitating travel, and is becoming increasingly utilized. The purpose of this study is to describe the components of telehealth palliative care interventions for patients with advanced cancer before the COVID-19 pandemic; identify any intervention components associated with improvements in outcomes; and evaluate reporting of interventions. Methods: This scoping review was registered on the Open Science [...]

Cet article analyse, à l'échelle nationale et mondiale, le pouvoir des forces politiques du secteur de la santé pour promouvoir l'équité dans la lutte contre le cancer et dans l'accès aux soins

Leveraging national and global political determinants of health to promote equity in cancer care

Dee, Edward Christopher ; Eala, Michelle Ann B ; Robredo, Janine Patricia G ; Ramiah, Duvern ; Hubbard, Anne ; Ho, Frances Dominique V ; Sullivan, Richard ; Aggarwal, Ajay ; Booth, Christopher ; Legaspi, Gerardo D ; Nguyen, Paul L ; Pramesh, C S ; Grover, Surbhi

Health and politics are deeply intertwined. In the context of national and global cancer care delivery, political forces –the political determinants of health—influence every level of the cancer care continuum. We explore the “three-i” framework—which structures the upstream political forces that impact policy choices in the context of actors’ interests, ideas, and institutions—to examine how political determinants of health underlie cancer disparities.Interests are “the agendas of societal [...]

Cet article décrit la création d'une enquête permettant de recueillir les expériences relatives à la survenue d'événements indésirables liés aux traitements de patients inclus dans des essais de phase I

A tailored phase I-specific patient-reported outcome (PRO) survey to capture the patient experience of symptomatic adverse events

Janse van Rensburg, Helena J. ; Liu, Zhihui ; Watson, Geoffrey A. ; Veitch, Zachary W. ; Shepshelovich, Daniel ; Spreafico, Anna ; Abdul Razak, Albiruni R. ; Bedard, Philippe L. ; Siu, Lillian L. ; Minasian, Lori ; Hansen, Aaron R.

Background: Patient perspectives are fundamental to defining tolerability of investigational anti-neoplastic therapies in clinical trials. Phase I trials present a unique challenge in designing tools for efficiently collecting patient-reported outcomes (PROs) given the difficulty of anticipating adverse events of relevance. However, phase I trials also offer an opportunity for investigators to optimize drug dosing based on tolerability for future larger-scale trials and in eventual clinical [...]

Cet article analyse les facteurs entravant la prise de décision partagée en oncologie et propose des axes d'amélioration

The Decision Aid is the Easy Part: Workflow Challenges of Shared Decision-Making in Cancer Care

Salwei, Megan E ; Ancker, Jessica S ; Weinger, Matthew B

Delivering high-quality, patient-centered cancer care remains a challenge. Both the National Academy of Medicine and the American Society of Clinical Oncology recommend shared decision-making to improve patient-centered care. However, widespread adoption of shared decision-making into clinical care has been limited. Shared decision-making is a process in which a patient and the patient’s health care professional weigh the risks and benefits of different options and come to a joint decision on [...]