Mené sur 74 patients atteints d'une leucémie myéloïde aiguë et ayant reçu une greffe allogénique de cellules souches hématopoïétiques, cet essai randomisé de phase II évalue l'intérêt, du point de vue de la réduction du taux d'infections à 4 mois, d'une transplantation de microbiote fécal

Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML

Armin Rashidi ; Maryam Ebadi ; Tauseef Ur Rehman ; Heba Elhusseini ; David Kazadi ; Hossam Halaweish ; Mohammad H. Khan ; Andrea Hoeschen ; Qing Cao ; Xianghua Luo ; Amanda J. Kabage ; Sharon Lopez ; Shernan G. Holtan ; Daniel J. Weisdorf ; Alexander Khoruts ; Christopher Staley

PURPOSE: Gut microbiota injury in allogeneic hematopoietic cell transplantation (HCT) recipients and patients with AML has been associated with adverse clinical outcomes. Previous studies in these patients have shown improvements in various microbiome indices after fecal microbiota transplantation (FMT). However, whether microbiome improvements translate into improved clinical outcomes remains unclear. We examined this question in a randomized, double-blind, placebo-controlled phase II trial. [...]

A partir d'une revue systématique de la littérature (33 études incluant un total de 303 patients atteints d'une tumeur cérébrale et 368 aidants), cette étude analyse les besoins en soins de support des patients et de leurs aidants puis examine leurs perceptions vis-à-vis de l'utilité de ces soins

What are the experiences of supportive care in people affected by brain cancer and their informal caregivers: A qualitative systematic review

Paterson, C. ; Roberts, C. ; Li, J. ; Chapman, M. ; Strickland, K. ; Johnston, N. ; Law, E. ; Bacon, R. ; Turner, M. ; Mohanty, I. ; Pranavan, G. ; Toohey, K.

Purpose: To critically synthesise qualitative research to understand experiences of supportive care in people affected by brain cancer and their informal caregivers. Methods : A qualitative systematic review was conducted according to the Joanna Briggs methodology and has been reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines. Electronic databases were searched by an expert systematic review librarian for all qualitative studies [...]

A partir d'une revue systématique de la littérature (13 études incluant au total 14 946 patients), cette méta-analyse évalue l'impact du délai entre le diagnostic et la prise en charge thérapeutique sur la survie des patients atteints d'une leucémie myéloïde aiguë

Systematic review and meta-analysis: Prognostic impact of time from diagnosis to treatment in patients with acute myeloid leukemia

Franco, Stephanie ; Geng, Xue ; Korostyshevskiy, Valeriy ; Karp, Judith E. ; Lai, Catherine

Background : Acute myeloid leukemia (AML) has been considered an oncologic emergency that requires initiation of chemotherapy immediately after diagnosis. With the introduction of novel targeted therapies, there is a potential benefit associated with delaying definitive treatment for identification of actionable therapeutic targets. Unfortunately, cytogenetic/molecular testing can take >7 days to return, and there is not a consensus regarding the prognostic impact of time from diagnosis to [...]

Menée aux Etats-Unis à partir de données portant sur 45 915 patients atteints d'un cancer du pancréas et bénéficiant de la couverture Medicare, cette étude de cohorte rétrospective analyse l'association entre le lieu d'habitation (zone urbaine ou rurale), le statut socioéconomique, l'origine ethnique et l'accès aux traitements chirurgicaux ou la survie

Association of rurality, socioeconomic status, and race with pancreatic cancer surgical treatment and survival

Brooks, Gabriel A ; Tomaino, Marisa R ; Ramkumar, Niveditta ; Wang, Qianfei ; Kapadia, Nirav S ; O’Malley, A James ; Wong, Sandra L ; Loehrer, Andrew P ; Tosteson, Anna N A

Background: Pancreatectomy is a necessary component of curative intent therapy for pancreatic cancer, and patients living in non-metropolitan areas may face barriers to accessing timely surgical care. We evaluated the intersecting associations of rurality, socioeconomic status (SES), and race on treatment and outcomes of Medicare beneficiaries with pancreatic cancer. Methods: We conducted a retrospective cohort study, using fee-for-service Medicare claims of beneficiaries with incident [...]

Menée aux Etats-Unis à partir de données portant sur 6 813 patients atteints d'un cancer du poumon diagnostiqué entre 2010 et 2019, cette étude identifie les facteurs démographiques, cliniques et socioéconomiques associés à la survie en fonction du statut tabagique

Smoking status and the association between patient-level factors and survival among lung cancer patients

Carroll, Nikki M ; Burnett-Hartman, Andrea N ; Rendle, Katharine A ; Neslund-Dudas, Christine M ; Greenlee, Robert T ; Honda, Stacey A ; Vachani, Anil ; Ritzwoller, Debra P

BACKGROUND: Declines in the prevalence of cigarette smoking, advances in targeted therapies, and implementation of lung cancer screening have changed the clinical landscape for lung cancer. An increasing proportion of lung cancer deaths are in those who have never smoked cigarettes. To better understand contemporary patterns in survival among patients with lung cancer, a comprehensive evaluation of factors associated with survival, including differential associations by smoking status, is [...]

Menée aux Etats-Unis à partir de données portant sur 995 patients atteints d'un glioblastome, cette étude de cohorte rétrospective analyse la survie en fonction de l'origine ethnique et du niveau socioéconomique

Racial and socioeconomic disparities in glioblastoma outcomes: A single-center, retrospective cohort study

Estevez-Ordonez, Dagoberto ; Abdelrashid, Moaaz ; Coffee, Elizabeth ; Laskay, Nicholas M. B. ; Atchley, Travis J. ; Chkheidze, Rati ; Fiveash, John B. ; Markert, James M. ; Lobbous, Mina ; Maveal, Brandon M. ; Burt Nabors, Louis

Background : Glioblastoma (GBM) is the most common malignant primary brain tumor. Emerging reports have suggested that racial and socioeconomic disparities influence the outcomes of patients with GBM. No studies to date have investigated these disparities controlling for isocitrate dehydrogenase (IDH) mutation and O-6-methylguanine-DNA methyltransferase (MGMT) status. Methods : Adult patients with GBM were retrospectively reviewed at a single institution from 2008 to 2019. Univariable and [...]

Menée à partir de données portant sur 2 375 adultes ayant survécu à un cancer pédiatrique (âge moyen : 31,8 ans) et sur 232 témoins, cette étude de cohorte identifie les facteurs associés au risque de déficiences neurocognitives à long terme

Late-onset Cognitive Impairment and Modifiable Risk Factors in Adult Childhood Cancer Survivors

Phillips, Nicholas S. ; Stratton, Kayla L. ; Williams, AnnaLynn M. ; Ahles, Tim ; Ness, Kirsten K. ; Cohen, Harvey Jay ; Edelstein, Kim ; Yasui, Yutaka ; Oeffinger, Kevin ; Chow, Eric J. ; Howell, Rebecca M. ; Robison, Leslie L. ; Armstrong, Gregory T. ; Leisenring, Wendy M. ; Krull, Kevin R.

Importance : Long-term survivors of childhood cancer may be at elevated risk for new neurocognitive impairment and decline as they age into adulthood. Objective : To determine whether aging adult childhood cancer survivors report more new-onset neurocognitive impairments compared with their siblings and to identify risk factors associated with such impairments. Design, Setting, and Participants : Participants of this cohort study included adult survivors of childhood cancer from the Childhood [...]

Menée aux Etats-Unis à partir de données portant sur 375 parents d'un enfant atteint d'une leucémie lymphoblastique aiguë (âge : 1-17 ans) et inclus dans un essai multicentrique, cette étude identifie les facteurs associés à une détresse psychologique sévère

Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia

Umaretiya, Puja J ; Koch, Victoria B ; Flamand, Yael ; Aziz-Bose, Rahela ; Ilcisin, Lenka ; Valenzuela, Ariana ; Cole, Peter D ; Gennarini, Lisa M ; Kahn, Justine M ; Kelly, Kara M ; Tran, Thai Hoa ; Michon, Bruno ; Welch, Jennifer J G ; Wolfe, Joanne ; Silverman, Lewis B ; Bona, Kira

Background : Parent psychological distress during childhood cancer treatment has short-and long-term implications for parent, child, and family well-being. Identifying targetable predictors of parental distress is essential to inform interventions. We investigated the association between household material hardship (HMH), a modifiable poverty-exposure defined as housing, food, or utility insecurity, and severe psychological distress among parents of children ages 1-17 years with acute [...]

Mené sur 359 patients traités par chirurgie pour un cancer du tractus gastro-intestinal supérieur (âge moyen : 64,6 ans), cet essai randomisé évalue l'intérêt, du point de vue de la qualité de vie peropératoire, d'une équipe constituée de chirurgiens et de spécialistes des soins palliatifs

Effect of Perioperative Palliative Care on Health-Related Quality of Life Among Patients Undergoing Surgery for Cancer: A Randomized Clinical Trial

Aslakson, Rebecca A. ; Rickerson, Elizabeth ; Fahy, Bridget ; Waterman, Brittany ; Siden, Rachel ; Colborn, Kathryn ; Smith, Shelby ; Verano, Mae ; Lira, Isaac ; Hollahan, Caroline ; Siddiqi, Amn ; Johnson, Kemba ; Chandrashekaran, Shivani ; Harris, Elizabeth ; Nudotor, Richard ; Baker, Joshua ; Heidari, Shireen N. ; Poultsides, George ; Conca-Cheng, Alison M. ; Cook Chapman, Allyson ; Lessios, Anna Sophia ; Holdsworth, Laura M. ; Gustin, Jillian ; Ejaz, Aslam ; Pawlik, Timothy ; Miller, Judi ; Morris, Arden M. ; Tulsky, James A. ; Lorenz, Karl ; Temel, Jennifer S. ; Smith, Thomas J. ; Johnston, Fabian

Importance : Involvement of palliative care specialists in the care of medical oncology patients has been repeatedly observed to improve patient-reported outcomes, but there is no analogous research in surgical oncology populations. Objective : To determine whether surgeon–palliative care team comanagement, compared with surgeon team alone management, improves patient-reported perioperative outcomes among patients pursuing curative-intent surgery for high morbidity and mortality upper [...]