A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2020 (34 études), cette méta-analyse évalue, en fonction du polymorphisme de l'aldéhyde déshydrogénase ALDH2, le risque de cancer attribuable à la consommation d'alcool en Asie de l'Est

ALDH2 polymorphism, alcohol intake and the attributable burden of cancer in East Asia: systematic review, meta-analysis, and modelling study

Ng, Carmen S. ; Ong, Xin Jiong ; Au, Minnie ; Lau, Yan Ho ; Kwok, Harley H. Y. ; Quan, Jianchao

Background: East Asian populations, where alcohol consumption is rising, has a high prevalence of the inactivated aldehyde dehydrogenase-2 (ALDH2) enzyme involved in alcohol metabolism. This study estimates the burden of alcohol-attributable cancer accounting for genotype-specific cancer risk and alcohol exposure. Methods: We conducted a systematic review and meta-analysis of eight databases on cancer risk to derive alcohol dose-response curves by ALDH2 genotype. A simulation-based approach [...]

Menée aux Etats-Unis auprès de 79 034 femmes ménopausées (durée moyenne de suivi : 15,8 ans), cette étude multicentrique analyse l'association entre plusieurs mesures anthropométriques, des trajectoires de l'indice de masse corporelle entre 18 et 50 ans et le risque de cancer colorectal (1 514 cas)

Body size over the adult life course and the risk of colorectal cancer among postmenopausal women

Su, L. ; Hendryx, M. ; Li, M. ; Shadyab, A. H. ; Saquib, N. ; Stefanick, M. L. ; Luo, J.

OBJECTIVE: To assess the associations among several anthropometric measures, as well as BMI trajectories and colorectal cancer (CRC) risk in older women. DESIGN: Prospective cohort study. SETTING: Forty clinical centres in the USA. PARTICIPANTS: Totally, 79 034 postmenopausal women in the Women's Health Initiative Observational Study. RESULTS: During an average of 15·8 years of follow-up, 1514 CRC cases were ascertained. Five BMI trajectories over 18-50 years of age were identified using growth [...]

Menée en France sur la période 2015-2018 auprès de 670 témoins et 454 patients atteints d'une tumeur germinale du testicule, cette étude multicentrique analyse l'association entre la profession exercée, le secteur d'activité (industrie) et le risque de développer la maladie

Testicular germ cell tumour risk by occupation and industry: a French case–control study – TESTIS

Objective: Testicular germ cell tumours (TGCT) are the most common cancer in men of working age and its incidence has increased notably over the past 40 years. Several occupations have been identified as potentially associated with TGCT risk. The aim of this study was to further explore the relationship between occupations, industries and TGCT risk in men aged 18–45 years. Methods: The TESTIS study is a multicenter case–control study conducted between January 2015 and April 2018 in 20 of 23 [...]

Menée en Italie auprès de 726 témoins et 182 patients pédiatriques atteints d'une leucémie diagnostiquée sur la période 1998-2019, cette étude analyse l'association entre la proximité d'une station-service, la quantité de carburant délivrée et le risque de développer la maladie

Residential proximity to petrol stations and risk of childhood leukemia

Malavolti, Marcella ; Malagoli, Carlotta ; Filippini, Tommaso ; Wise, Lauren A. ; Bellelli, Alessio ; Palazzi, Giovanni ; Cellini, Monica ; Costanzini, Sofia ; Teggi, Sergio ; Vinceti, Marco

Petrol stations emit benzene and other contaminants that have been associated with an increased risk of childhood leukemia. We carried out a population-based case-control study in two provinces in Northern Italy. We enrolled 182 cases of childhood leukemia diagnosed during 1998–2019 and 726 age- and sex-matched population controls. We geocoded the addresses of child residences and 790 petrol stations located in the study area. We estimated leukemia risk according to distance from petrol [...]

Menée à partir de données 1978-2016 de registres nationaux danois portant sur 103 526 témoins et 4 125 enfants atteints d'un cancer (âge : 0-19 ans), cette étude analyse l'association entre une infection post-natale et le risque de déveloper un cancer infantile

Association between medically diagnosed postnatal infection and childhood cancers: A matched case-control study in Denmark, 1978 to 2016

Sirirungreung, Anupong ; Hansen, Johnni ; Ritz, Beate ; Heck, Julia E.

Although the association between infection and childhood cancer has been long investigated, there is limited information on rarer cancers. This article aimed to explore the association between postnatal infection and childhood cancers in the Danish population. A matched case-control study was conducted using Danish nationwide registries from 1978 to 2016. Each childhood cancer case was matched 1:25 with controls by birth date within a week and sex. Postnatal infections were identified from the [...]

Menée à l'aide de données internationales portant sur 228 témoins et 228 patients atteints d'un cancer des os et menée auprès de 69 460 personnes ayant survécu au moins 5 ans à un cancer développé pendant l'enfance, cette étude analyse l'association entre les doses de rayonnements ionisants reçues par le tissu osseux, une exposition aux agents alkylants et le risque de cancer des os

Risk Factors for Primary Bone Cancer After Childhood Cancer: A PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies Nested Case-Control Study

Raoul C. Reulen ; David L. Winter ; Ibrahim Diallo ; Cristina Veres ; Damien Llanas ; Rodrigue S. Allodji ; Francesca Bagnasco ; Edit Bardi ; Elizabeth A.M. Feijen ; Daniela Alessi ; Miranda M. Fidler-Benaoudia ; Stine Høgsholt ; Jop C. Teepen ; Helena Linge ; Nadia Haddy ; Julianne Byrne ; Ghazi Debiche ; Desiree Grabow ; Thorgerdur Gudmundsdottir ; Romain Fauchery ; Wael Zrafi ; Gisela Michel ; Hilde Øfstaas ; Peter Kaatsch ; Giao Vu-Bezin ; Helen Jenkinson ; Melanie Kaiser ; Roderick Skinner ; Trevor Cole ; Nicolas Waespe ; Grit Sommer ; Susanne Nordenfelt ; Momcilo Jankovic ; Tuomas Lähteenmäki Taalas ; Milena M. Maule ; Helena J.H. van der Pal ; Cécile M. Ronckers ; Flora E. van Leeuwen ; Judith L. Kok ; Monica Terenziani ; Maria Winther Gunnes ; Thomas Wiebe ; Carlotta Sacerdote ; Zsuzsanna Jakab ; Riccardo Haupt ; Päivi M. Lähteenmäki ; Lorna Zadravec Zaletel ; Claudia E. Kuehni ; Jeanette Falck Winther ; Leontien C.M. Kremer ; Lars Hjorth ; Florent de Vathaire ; Michael M. Hawkins

PURPOSE: Radiation to the bone and exposure to alkylating agents increases the risk of bone cancer among survivors of childhood cancer, but there is uncertainty regarding the risks of bone tissue radiation doses below 10 Gy and the dose-response relationship for specific types of chemotherapy. METHODS: Twelve European countries contributed 228 cases and 228 matched controls to a nested case-control study within a cohort of 69,460 5-year survivors of childhood cancer. Odds ratios (ORs) of [...]

Menée à l'aide de données des cohortes "the Nurses’ Health Studies" et de la "UK Biobank" portant au total sur 639 747 personnes, cette étude analyse l'association entre une utilisation d'inhibiteurs de la pompe à protons et le risque de cancer des voies biliaires (375 cas)

Confounded association between proton pump inhibitor use and risk of biliary tract cancer: Result from three cohorts

He, Qiangsheng ; Huang, Chongfei ; Qin, Xiwen ; Yu, Yuanyuan ; Tang, Di ; Huang, Junjie ; Kuo, Zi Chong ; Ling, Yuyao ; Mao, Deli ; Xia, Bin ; Li, Wenjing ; Lu, Kuiqing ; Yang, Man ; He, Yulong ; Meng, Wenbo ; Yuan, Jinqiu ; Pan, Yihang

Recent epidemiological studies suggested that proton pump inhibitor (PPI) use was associated with an increased risk of biliary tract cancer (BTC), however, confounders were not adequately controlled. Our study aimed to evaluate PPI use and subsequent risk of BTC and its subtypes in three well-established cohorts. We conducted a pooled analysis of the subjects free of cancers in UK Biobank (n = 463 643), Nurses' Health Study (NHS, n = 80 235) and NHS II (n = 95 869). Propensity score weighted [...]