A partir d'une revue de la littérature, cette étude présente les recommandations d'un groupe d'experts concernant la détection du risque de malnutrition après un diagnostic de cancer, pendant et après les traitements anticancéreux

The Pathways to Prevention (P2P) Program: Nutrition as Prevention for Improved Cancer Outcomes

Clayton, Margaret F ; Collins, Karen K ; Gold, Heather T ; Laiyemo, Adeyinka O ; Truesdale, Kimberly Parker ; Ritzwoller, Debra P ; Hiatt, Robert A

Adequate nutrition is central to well-being and health and can enhance recovery during illness. Although it is well known that malnutrition, both undernutrition and overnutrition, poses an added challenge for patients with cancer diagnoses, it remains unclear when and how to intervene and if such nutritional interventions improve clinical outcomes. In July 2022, the National Institutes of Health convened a workshop to examine key questions, identify related knowledge gaps, and provide [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2020 (219 articles), cette étude analyse l'impact, sur la survenue d'évenéments indésirables, la durée des hospitalisations et la qualité de vie, d'interventions comportant des conseils nutritionnels et dispensées avant et pendant les traitements anticancéreux

Nutrition as Prevention for Improved Cancer Health Outcomes: A Systematic Literature Review

Parsons, Helen M ; Forte, Mary L ; Abdi, Hamdi I ; Brandt, Sallee ; Claussen, Amy M ; Wilt, Timothy ; Klein, Mark ; Ester, Elizabeth ; Landsteiner, Adrienne ; Shaukut, Aasma ; Sibley, Shalamar S ; Slavin, Joanne ; Sowerby, Catherine ; Ng, Weiwen ; Butler, Mary

Background: Among adults with cancer, malnutrition is associated with decreased treatment completion, more treatment harms and use of healthcare, and worse short-term survival. To inform the National Institutes of Health Pathways to Prevention (P2P) workshop, Nutrition as Prevention for Improved Cancer Health Outcomes, this systematic review examined the evidence for the effectiveness of providing nutritional interventions before or during cancer therapy to improve outcomes of cancer treatment. [...]

A partir d'une revue systématique de la littérature (11 études), cette étude analyse l'effet, sur la santé psychique et physique des patientes atteintes d'un cancer gynécologique, des interventions à base d'exercices physiques pendant et après les traitements anticancéreux

Efficacy of exercise interventions for women during and after gynaecological cancer treatment – a systematic scoping review

Rose, Grace Laura ; Stewart, Elizabeth Mary ; Clifford, Briana Kristine ; Bailey, Tom George ; Rush, Alexandra Jane ; Abbott, Claudia Rose ; Hayes, Sandra Christine ; Obermair, Andreas ; McCarthy, Alexandra Leigh

Purpose: To systematically synthesise evidence of exercise intervention efficacy for physical/psychosocial outcomes that matter to women during/following treatment for gynaecological cancer. Methods: Five databases were searched (PubMed, EMBASE, CINAHL, PsychInfo, Scopus). Exercise-only intervention studies that included women during/ following treatment for any gynaecological cancer, with/ without control comparison, on any physical or psychosocial outcome(s), were included and qualitatively [...]

Menée aux Pays-Bas à partir de données portant sur 249 patients ayant survécu plus de 10 ans à un cancer pédiatrique, cette étude analyse leur santé buccale et dentaire

Self-reported outcomes on oral health and oral health-related quality of life in long-term childhood cancer survivors—A DCCSS-LATER 2 Study

Stolze, Juliette ; Raber-Durlacher, Judith E. ; Loonen, Jacqueline J. ; Teepen, Jop C. ; Ronckers, Cecile M. ; Tissing, Wim J. E. ; de Vries, Andrica C. H. ; Neggers, Sebastian J. C. M. M. ; Dulmen-den Broeder, Eline ; Heuvel-Eibrink, Marry M. ; van der Pal, Helena J. H. ; Versluys, A. Birgitta ; Heiden-van der Loo, Margriet ; Louwerens, Marloes ; Kremer, Leontien C. M. ; Bresters, Dorine ; Brand, Henk S. ; Grootenhuis, Martha ; van Leeuwen, Flora ; van der Steeg, Lideke ; Janssens, Geert ; van Santen, Hanneke ; Veening, Margreet ; den Hartoghg, Jaap ; Pluijm, Saskia ; Batenburg, Lilian ; de Ridder, Hanneke ; Hollema, Nynke ; Teunissen, Lennart ; Schellekens, Anke ; and on behalf of the, Dccss-Later Study Group

Purpose: The present study aimed to determine the prevalence of self-reported oral problems and the oral health–related quality of life (OHRQoL) in childhood cancer survivors (CCS). Methods: Patient and treatment characteristics of CCS have been collected in a cross-sectional study, part of the multidisciplinary DCCSS-LATER 2 Study. To assess self-reported oral health problems and dental problems, CCS filled out the ‘Toegepast-Natuurwetenschappelijk Onderzoek’ (TNO) oral health questionnaire. [...]

Menée aux Pays-Bas par enquête auprès de 3 752 patients ayant survécu à un cancer, cette étude analyse leurs expériences concernant une neuropathie périphérique induite par la chimiothérapie, l'implication des professionnels de santé et le soutien social

Experiences of cancer survivors with chemotherapy-induced peripheral neuropathy in the Netherlands: symptoms, daily limitations, involvement of healthcare professionals, and social support

van de Graaf, Daniëlle L. ; Engelen, Vivian ; de Boer, Aize ; Vreugdenhil, Gerard ; Smeets, Tom ; van der Lee, Marije L. ; Trompetter, Hester R. ; Mols, Floortje

Purpose: A significant proportion of cancer patients suffer from chemotherapy-induced peripheral neuropathy (CIPN). This descriptive study aimed to examine patients’ experience of CIPN symptoms, daily limitations, involvement of healthcare professionals, and social support. Methods: Cross-sectional data have been collected in the Netherlands via a national online questionnaire comprising closed items only (February 2021). Results: Out of 3752 respondents, 1975 received chemotherapy only (i.e., [...]

Menée au Canada dans un contexte de vie réelle à partir de données portant sur 7 126 patients atteints d'un cancer traité par inhibiteurs de points de contrôle immunitaire, cette étude de cohorte rétrospective analyse les facteurs associés à la mortalité prématurée (dans les 60 jours suivant le début du traitement)

Early mortality in patients with cancer treated with immune checkpoint inhibitors in routine practice

Raphael, Jacques ; Richard, Lucie ; Lam, Melody ; Blanchette, Phillip ; Leighl, Natasha B ; Rodrigues, George ; Trudeau, Maureen ; Krzyzanowska, Monika K

Background: We sought to estimate the proportion of patients with cancer treated with immune checkpoint inhibitors (ICI) who die soon after starting ICI in the real world and to examine factors associated with early mortality (EM). Methods: We conducted a retrospective cohort study using linked health administrative data from Ontario, Canada. EM was defined as death from any cause within 60 days of ICI initiation. Patients with melanoma, lung, bladder, head and neck or kidney cancer treated [...]

Menée au Royaume-Uni à partir de données portant sur 23 000 patients atteints d'un diabète de type 1 traité par insuline, cette étude de cohorte analyse le risque de cancer et la mortalité

Cancer incidence and mortality in 23 000 patients with type 1 diabetes in the UK: Long-term follow-up

Swerdlow, Anthony J. ; Jones, Michael E. ; Slater, Stefan D. ; Burden, Andrew C. F. ; Botha, Johannes L. ; Waugh, Norman R. ; Morris, Andrew D. ; Gatling, Wendy ; Gillespie, Kathleen M. ; Patterson, Christopher C. ; Schoemaker, Minouk J.

Type 2 diabetes is associated with raised risk of several cancers, but for type 1 diabetes risk data are fewer and inconsistent We assembled a cohort of 23 473 UK patients with insulin-treated diabetes diagnosed at ages <30, almost all of whom will have had type 1 diabetes, and for comparison 5058 diagnosed at ages 30 to 49, of whom we estimate two-thirds will have had type 2, and followed them for an average of 30 years for cancer incidence and mortality compared with general population rates. [...]

Menée en Suède à partir de données 1993-2019 portant sur 27 854 patients atteints d'un adénocarcinome de l'oesophage, du cardia ou de l'estomac, cette étude de cohorte analyse l'évolution de l'incidence et de la survie selon l'âge au diagnostic (survenue précoce de la maladie : 20-54 ans, survenue tardive de la maladie : 55-99 ans)

Incidence Trends and Survival in Early-Onset Esophagogastric Adenocarcinoma: A Swedish Population-Based Cohort Study

Radkiewicz, Cecilia ; Asplund, Johannes ; Lagergren, Jesper

Early-onset adenocarcinomas of different sites are increasing in high-income countries, data on esophagogastric adenocarcinoma are sparse.We performed a Swedish population-based cohort study over 1993 to 2019 to delineate differences in incidence and survival in early-onset (age 20–54 years) compared with later-onset (55–99 years) esophageal, cardia, and noncardia gastric adenocarcinoma. Temporal incidence trends were quantified as annual percentage changes (APC) and survival differences as [...]

Menée aux Etats-Unis à partir de données 2015-2019 portant sur 15 407 patients atteints d'un carcinome à cellules rénales de stade métastatique et bénéficiant de la couverture Medicare, cette étude analyse les disparités dans l'utilisation des immunothérapies

Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma

Chow, Ryan D ; Long, Jessica B ; Hassan, Sirad ; Wheeler, Stephanie B ; Spees, Lisa P ; Leapman, Michael S ; Hurwitz, Michael E ; McManus, Hannah D ; Gross, Cary P ; Dinan, Michaela A

Disparities in metastatic renal cell carcinoma (mRCC) outcomes persist in the era of oral anticancer agents (OAAs) and immunotherapies (IOs). We examined variation in the utilization of mRCC systemic therapies among US Medicare beneficiaries from 2015-2019. Logistic regression models evaluated the association between therapy receipt and demographic covariates including patient race, ethnicity and sex. In total, 15,407 patients met study criteria. After multivariable adjustment, non-Hispanic [...]

Menée à partir de données portant sur 3 388 patients atteints d'un cancer de la vessie sans envahissement musculaire (âge moyen : 69,8 ans) et sur 3 079 témoins (âge moyen : 70 ans), cette étude analyse l'association entre une injection du vaccin du BCG, le risque de démence et de maladie d'Alzheimer ainsi que le risque de décès

Association of BCG Vaccine Treatment With Death and Dementia in Patients With Non–Muscle-Invasive Bladder Cancer

Weinberg, Marc S. ; Zafar, Affan ; Magdamo, Colin ; Chung, Sun Young ; Chou, Wesley H. ; Nayan, Madhur ; Deodhar, Mayuresh ; Frendl, Daniel M. ; Feldman, Adam S. ; Faustman, Denise L. ; Arnold, Steven E. ; Vakulenko-Lagun, Bella ; Das, Sudeshna

Importance : The BCG vaccine—used worldwide to prevent tuberculosis—confers multiple nonspecific beneficial effects, and intravesical BCG vaccine is currently the recommended treatment for non–muscle-invasive bladder cancer (NMIBC). Moreover, BCG vaccine has been hypothesized to reduce the risk of Alzheimer disease and related dementias (ADRD), but previous studies have been limited by sample size, study design, or analyses. Objective : To evaluate whether intravesical BCG vaccine exposure is [...]

Menée auprès de 61 patients atteints d'une tumeur cérébrale, cette étude analyse l'intérêt d'un outil pour détecter des symptômes de dépression

Depression in brain tumor patients—early detection and screening

Finze, Alida ; Deleanu, Laura ; Weiss, Christel ; Ratliff, Miriam ; Seiz-Rosenhagen, Marcel

Background: Depres sion is reported in up to 90% of cancer patients but to this date, a standardized screening tool for depression specifically modified for patients diagnosed with brain tumors is lacking. Thus, this study aims to develop an adapted screening tool and identify a suitable time slot for screening. Methods: Sixty-one patients with brain lesions were interviewed prior to neurosurgical resection. For screening purposes, established depression scores were used. A study-specific [...]

Menée à partir de données portant sur 837 adultes ayant survécu à un neuroblastome (âge médian : 25 ans) et sur 728 témoins (âge médian : 32 ans), cette étude analyse leurs déficiences neurocognitives en lien avec les traitements anticancéreux

Neurocognitive outcomes in adult survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study

Hesko, Caroline ; Liu, Wei ; Srivastava, Deo K. ; Brinkman, Tara M. ; Diller, Lisa ; Gibson, Todd M. ; Oeffinger, Kevin C. ; Leisenring, Wendy M. ; Howell, Rebecca ; Armstrong, Gregory T. ; Krull, Kevin R. ; Henderson, Tara O.

Background: Despite survival improvements, there is a paucity of data on neurocognitive outcomes in neuroblastoma survivors. This study addresses this literature gap. Methods: Neurocognitive impairments in survivors were compared to sibling controls from the Childhood Cancer Survivor Study (CCSS) using the CCSS Neurocognitive Questionnaire. Impaired emotional regulation, organization, task efficiency, and memory defined as scores ≥90th percentile of sibling norms. Modified Poisson regression [...]

Menée aux Etats-Unis à partir de données 2001-2019 portant sur des patients atteints d'un cancer (âge : 20-64 ans), cette étude compare, avant et après l'extension de la couverture médicale Medicaid (2014), l'incidence des cancers et la mortalité spécifique

Changes in Cancer Mortality after Medicaid Expansion and the Role of Stage at Diagnosis

Barnes, Justin M ; Johnson, Kimberly J ; Osazuwa-Peters, Nosayaba ; Robin Yabroff, K ; Chino, Fumiko

Background: Medicaid expansion is associated with improved survival following cancer diagnosis. However, little research has assessed how changes in cancer stage may mediate improved cancer mortality or how expansion may have decreased population-level cancer mortality rates. Methods: Nationwide state-level cancer data from 2001-2019 for individuals ages 20-64 years were obtained from the combined Surveillance, Epidemiology, and End Results/National Program of Cancer Registries (incidence) and [...]

Cet article plaide pour le développement d'actions visant à réduire les inégalités, entre les personnes incarcérées et le grand public, en matière de lutte contre le cancer

Cancer equity for those impacted by mass incarceration

Ramaswamy, Megha ; Manz, Christopher ; Kouyoumdjian, Fiona ; Vest, Noel ; Puglisi, Lisa ; Wang, Emily ; Salyer, Chelsea ; Osei, Beverly ; Zaller, Nick ; Rebbeck, Timothy R

The cancer disparities between people with incarceration histories compared to those who do not have those histories are vast. Opportunities for bolstering cancer equity among those impacted by mass incarceration exist in criminal legal system policy, carceral, community, and public health linkages, better cancer prevention, screening, and treatment services in carceral settings, expansion of health insurance, education of professionals, and use of carceral sites for health promotion and [...]