Menée à partir de données de "the Ovarian Cancer Association Consortium" portant sur 558 témoins et 570 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre un apport en folates et le risque de cancer de l'ovaire chez les femmes atteintes d'endométriose

Folate intake and ovarian cancer risk among women with endometriosis: a case-control study from the Ovarian Cancer Association Consortium

Gersekowski, Kate ; Ibiebele, Torukiri I. ; Doherty, Jennifer A. ; Harris, Holly R. ; Goodman, Marc T. ; Terry, Kathryn L. ; Wu, Anna H. ; Bandera, Elisa V. ; Qin, Bo ; Ong, Jue-Sheng ; Tyrer, Jonathan P. ; Dixon-Suen, Suzanne C. ; Modugno, Francesmary ; Risch, Harvey A. ; Webb, Penelope M.

Background: While folate intake has not been associated with an increased risk of ovarian cancer overall, studies of other cancer types have suggested that high folate intake may promote carcinogenesis in pre-cancerous lesions. Women with endometriosis (a potential pre-cancerous lesion) have an increased risk of developing ovarian cancer; however, whether high folate intake increases risk in this group is unknown. Methods: We conducted a pooled analysis of six case-control studies from the [...]

Menée auprès de 146 027 personnes, cette étude analyse l'association entre l'indice de masse corporelle, une activité physique d'aérobie d'intensité modérée à vigoureuse, le temps de loisir passé en position assise et le risque de cancer de la vessie, en fonction du sexe et du statut tabagique

Physical activity, obesity, and bladder cancer incidence

Chantaprasopsuk, Sicha ; Rees-Punia, Erika ; Patel, Alpa V.

Purpose: Cigarette smoking is an established risk factor for bladder cancer (BC), but evidence for physical inactivity and obesity is limited. Methods: This analysis included 146,027 participants from the Cancer Prevention Study-II (CPS-II) Nutrition Cohort, a large prospective cohort of cancer incidence established in 1992. Multivariable-adjusted Cox proportional hazards models were used to examine associations between body mass index (BMI), moderate-to-vigorous intensity aerobic physical [...]

Menée à Montréal sur la période 2005-2012 auprès de 1 994 témoins et 1 931 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre le taux de privation matérielle et sociale du voisinage et le risque de développer la maladie

Neighbourhood social deprivation and risk of prostate cancer

Salmon, Charlotte ; Quesnel-Vallée, Amélie ; Barnett, Tracie A. ; Benedetti, Andrea ; Cloutier, Marie-Soleil ; Datta, Geetanjali D. ; Kestens, Yan ; Nicolau, Belinda ; Parent, Marie-Élise

Background: Striking geographic variations in prostate cancer incidence suggest an aetiological role for spatially-distributed factors. We assessed whether neighbourhood social deprivation, which can reflect limited social contacts, unfavourable lifestyle and environmental exposures, is associated with prostate cancer risk. Methods: In 2005–2012, we recruited 1931 incident prostate cancer cases and 1994 controls in a case–control study in Montreal, Canada. Lifetime residential addresses were [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2023 (61 études), cette méta-analyse identifie 15 facteurs environnementaux ou génétiques associés au risque de survenue précoce d'un cancer colorectal sporadique et/ou d'un adénome colorectal avancé

Field synopsis of environmental and genetic risk factors of sporadic early-onset colorectal cancer and advanced adenoma

Zhang, Rongqi ; Boakye, Daniel ; Yang, Nan ; Zhou, Xuan ; Zhou, Yajing ; Jiang, Fangyuan ; Yu, Lili ; Wang, Lijuan ; Sun, Jing ; Yuan, Shuai ; Chen, Jie ; Hamilton, Ashleigh C. ; Coleman, Helen G. ; Larsson, Susanna C. ; Little, Julian ; Dunlop, Malcolm G. ; Giovannucci, Edward L. ; Theodoratou, Evropi ; Li, Xue

Background: To systematically appraise and synthesize available epidemiological evidence on the associations of environmental and genetic factors with the risk of sporadic early-onset colorectal cancer (EOCRC) and early-onset advanced colorectal adenoma (EOCRA). Methods: Multiple databases were comprehensively searched to identify eligible observational studies. Genotype data from UK Biobank were incorporated to examine their associations with EOCRC in a nested case-control design. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2022 (14 études), cette méta-analyse évalue l'association entre le niveau de cadmium mesuré dans le sang et les cheveux et le risque de cancer du foie

Elevated serum and hair levels of cadmium as a risk factor for liver carcinoma: a meta-analysis

Zhang, Liang ; Wang, Yan ; Li, Tian ; Zhuo, Wenlei ; Zhu, Yi

Background: Cadmium (Cd) exposure might confer cancer risk. Published studies on the association between Cd levels and liver cancer risk have generated conflicting results. We aimed to conduct a meta-analysis to address the controversy. Methods: Relevant literature was searched from the popular bio-databases up to Nov 2022. Essential information was extracted and data were pooled to assess the association between Cd levels and liver cancer risk. Subgroup analysis on sample types and [...]

Menée en Suède sur la période 1980-2016 auprès de 5 millions de personnes et à l'aide de données du registre suédois des cancers, cette étude analyse l'association entre une ablation des amygdales et/ou des végétations et le risque de cancer

Cancer risk following surgical removal of tonsils and adenoids — a population-based, sibling-controlled cohort study in Sweden

Liang, Jinfeng ; Huang, Yi ; Yin, Li ; Sadeghi, Fatemeh ; Yang, Yanping ; Xiao, Xue ; Adami, Hans-Olov ; Ye, Weimin ; Zhang, Zhe ; Fang, Fang

Background: Removal of tonsils and adenoids is among the most common surgical procedures worldwide. Evidence of increased risk of cancer following such surgery is, however, inconclusive. Methods: We conducted a population-based, sibling-controlled cohort study of 4,953,583 individuals in Sweden with a follow-up during 1980–2016. History of tonsillectomy, adenotonsillectomy, and adenoidectomy was identified from the Swedish Patient Register whereas incident cases of cancer during follow-up were [...]

A partir d'une revue systématique de la littérature (38 études), cette méta-analyse évalue l'association entre des coups de soleil (fréquence, intensité) et le risque de carcinome basocellulaire

A meta-analysis of sunburn and basal cell carcinoma risk

Lashway, Stephanie G. ; Worthen, Aimee D. M. ; Abuasbeh, Jumanah N. ; Harris, Robin B. ; Farland, Leslie V. ; O’Rourke, Mary Kay ; Dennis, Leslie K.

Basal cell carcinoma (BCC) is the most common cancer in the United States. Sunburn is a modifiable risk factor for BCC. The objective of this project was to synthesize research on BCC and sunburn to quantify the impact and severity of sunburn at different life stages on BCC risk in the general population. A systematic literature search of four electronic databases was conducted and data were extracted by two independent reviewers using standardized forms. Data from 38 studies were pooled using [...]

Menée en France auprès de 17 104 enfants atteints d'une coronaropathie diagnostiquée ou traitée par cathétérisme cardiaque sur la période 2000-2013 (âge : moins de 16 ans), cette étude analyse le risque de tumeur maligne lympho-hématopoïétique associé au rayonnement ionisant à faible dose lors d'un cathétérisme cardiaque

Lympho-hematopoietic malignancies risk after exposure to low dose ionizing radiation during cardiac catheterization in childhood

Abalo, Kossi D. ; Malekzadeh-Milani, Sophie ; Hascoët, Sébastien ; Dreuil, Serge ; Feuillet, Tiphaine ; Damon, Cecilia ; Bouvaist, Hélène ; Bouzguenda, Ivan ; Cohen, Sarah ; Dauphin, Claire ; Di Filippo, Sylvie ; Douchin, Stéphanie ; Godart, François ; Guérin, Patrice ; Helms, Pauline ; Karsenty, Clément ; Lefort, Bruno ; Mauran, Pierre ; Ovaert, Caroline ; Piéchaud, Jean-François ; Thambo, Jean-Benoît ; Lee, Choonsik ; Little, Mark P. ; Bonnet, Damien ; Bernier, Marie-Odile ; Rage, Estelle

Pediatric patients with congenital heart disease (CHD) often undergo low dose ionizing radiation (LDIR) from cardiac catheterization (CC) for the diagnosis and/or treatment of their disease. Although radiation doses from a single CC are usually low, less is known about the long-term radiation associated cancer risks. We aimed to assess the risk of lympho-hematopoietic malignancies in pediatric CHD patients diagnosed or treated with CC. A French cohort of 17,104 children free of cancer who had [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2023 (29 études), cette méta-analyse évalue l'association entre les niveaux circulants d'hormones sexuelles et le risque de cancer de l'appareil digestif (oesophage, estomac, foie, pancréas, côlon-rectum)

Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies

Liu, Zhiqiang ; Zhang, Yingfan ; Lagergren, Jesper ; Li, Shanshan ; Li, Jingru ; Zhou, Zhixian ; Hu, Zhijian ; Xie, Shao-Hua

Sex hormones may influence the development of gastrointestinal cancer, but evidence is inconsistent.We systematically searched MEDLINE and Embase databases to identify prospective studies examining associations between prediagnostic circulating levels of sex hormones and risk of five gastrointestinal cancers: esophageal, gastric, liver, pancreatic, and colorectal cancer. Pooled ORs and 95% confidence intervals (95% CI) were calculated using random-effects models.Among 16,879 identified studies, [...]

Menée au Japon auprès de 55 242 personnes (durée médiane de suivi : 9,3 ans ; âge médian : 57 ans ; 55 % de femmes), cette étude analyse l'association entre le débit de filtration glomérulaire et l'incidence du cancer (4 278 cas) ainsi que la mortalité

Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi-Institutional Collaborative Cohort Study

Kurasawa, Shimon ; Imaizumi, Takahiro ; Maruyama, Shoichi ; Tanaka, Keitaro ; Kubo, Yoko ; Nagayoshi, Mako ; Ikezaki, Hiroaki ; Suzuki, Sadao ; Koyama, Teruhide ; Koriyama, Chihaya ; Kadota, Aya ; Katsuura-Kamano, Sakurako ; Kuriki, Kiyonori ; Wakai, Kenji ; Matsuo, Keitaro

The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55?242 participants (median age, 57?years; 55% women) from the Japan Multi-Institutional Collaborative Cohort Study. We also investigated [...]

Menée à l'aide de données 2006-2016 de la "UK Biobank" portant sur 393 114 personnes, cette étude analyse l'association entre des habitudes de sommeil (chronotype, durée, sieste diurne, somnolence diurne, ronflement, insomnie) et le risque d'adénocarcinome (294 cas) ou de carcinome épidermoïde (95 cas) de l'oesophage

Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer

Wang, Xiaoyan ; Tian, Ruiyi ; Zong, Xiaoyu ; Jeon, Myung Sik ; Luo, Jingqin ; Colditz, Graham A. ; Wang, Jean S. ; Tsilidis, Konstantinos K. ; Ju, Yo-El S. ; Govindan, Ramaswamy ; Puri, Varun ; Cao, Yin

Background: Risk factors contributing to more than tenfold increase in esophageal cancer in the last 50 years remain underexplored. We aim to examine the associations of sleep behaviors with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). Methods: We prospectively assessed the associations between sleep behaviors (chronotype, duration, daytime napping, daytime sleepiness, snoring, and insomnia) and EAC and ESCC risk in 393,114 participants in the UK Biobank (2006-2016). [...]

Menée à partir de données d'un registre portant sur 4 562 participants ayant effectué des tests génétiques, cette étude analyse le risque d'adénocarcinome canalaire du pancréas chez les parents au premier degré de patients atteints de la maladie et porteurs de variants constitutionnels pathogènes ou probablement pathogènes de gènes associés au risque de cancer (234 cas ; ATM, BRCA1, BRCA2, PALB2, MLH1, MSH2, MSH6, PMS2, CDKN2A)

Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants

Chen, Xuan ; Meyer, Margaret A. ; Kemppainen, Jennifer L. ; Horibe, Masayasu ; Chandra, Shruti ; Majumder, Shounak ; Petersen, Gloria M. ; Rabe, Kari G.

Increased cancer risk in first-degree relatives of probands with pancreatic ductal adenocarcinoma (PDAC probands) who carry pathogenic or likely pathogenic germline variants (PGVs) in cancer syndrome–associated genes encourages cascade genetic testing. To date, unbiased risk estimates for the development of cancers on a gene-specific basis have not been assessed.To quantify the risk of development of PDAC and extra-PDAC among first-degree relatives of PDAC probands who carry a PGV in 1 of 9 [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 142 995 hommes, 61 106 témoins et 79 148 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre la pression artérielle systolique, des inhibiteurs des canaux calciques et le risque de développer la maladie

Blood pressure, calcium channel blockers, and the risk of prostate cancer: a Mendelian randomization study

Kazmi, Nabila ; Valeeva, Elena V. ; Khasanova, Gulshat R. ; Lewis, Sarah J. ; Plotnikov, Denis ; Practical consortium

Background: Observational studies have found some evidence of an association between elevated blood pressure and prostate cancer risk; however, the results are inconclusive. We tested whether systolic blood pressure (SBP) influences prostate cancer risk and evaluated the effect of calcium channel blockers (CCB) on the disease using Mendelian randomization (MR) approach. Methods: We used 278 genetic variants associated with SBP and 16 genetic variants in CCB genes as instrumental variables. [...]