A partir d'une revue systématique de la littérature publiée jusqu'en mai 2022, cette étude analyse l'association entre la quantité consommée de sucres, sucres ajoutés, fructose ou saccharose et la mortalité toutes causes confondues, par maladie cardiovasculaire et par cancer

Total sugar, added sugar, fructose, and sucrose intake and all-cause, cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies

Huang, Cuihong ; Liang, Zhiya ; Ma, Jianping ; Hu, Dongsheng ; Yao, Feifei ; Qin, Pei

Objective: This study performed a systematic review and dose–response meta-analysis to assess the associations of total sugars, added sugars, fructose, and sucrose with all-cause, cardiovascular disease (CVD), and cancer mortality. Methods: We searched PubMed, EMBASE, and Web of Science for prospective cohort studies up to 10 May 2022. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated by random-effect models, and the linear/nonlinear dose–response associations were [...]

Menée au Danemark à partir de données portant sur 1 126 témoins et 199 militaires atteints d'un mélanome cutané diagnostiqué sur la période 1990-2003, cette étude analyse l'association entre le travail à bord d'un avion et le risque de développer la maladie

Incident skin melanoma in Danish male military pilots: a nested case–control study

Pedersen, Julie Elbaek ; Hansen, Johnni

Objectives: A growing body of research has reported that pilots have an increased risk of skin melanoma, which may be caused by occupational exposure to cosmic and solar ultraviolet A radiation in aircraft cockpits. However, the existing literature cannot rule out confounding, for example, that pilots may spend more leisure time in the sun compared with the general population, which therefore leaves the current evidence inconclusive. The present study aimed to provide more knowledge regarding [...]

Menée à l'aide de données de la "UK Biobank" portant sur 234 363 femmes, cette étude analyse l'association entre des problèmes de santé bucco-dentaire et le risque de cancer du sein

The association between poor oral health and risk of breast cancer in the UK Biobank

Wu, Zeni ; Li, Fangyu ; Sang, Jian ; Gierach, Gretchen L. ; Vogtmann, Emily

Purpose: Specific oral health conditions may be risk factors for breast cancer. This study aimed to investigate the associations of oral health conditions with breast cancer risk. Methods: A total of 234,363 women from the UK Biobank prospective cohort were included in this study. We examined the association of self-reported painful/bleeding gums, loose teeth, mouth ulcers, toothache, and use of dentures with the risk of breast cancer. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) [...]

A partir d'une revue systématique de la littérature publiée entre 1986 et 2022 (162 études), cette méta-analyse évalue la prévalence conjointe de l'ADN du papillomavirus humain (HPV) et de la positivité à la protéine p16INK4a dans les néoplasies intra-épithéliales et le cancer de la vulve

Prevalence of human papillomavirus DNA and p16-INK4apositivity in vulvar cancer and vulvar intraepithelial neoplasia: a systematic review and meta-analysis

Li, Zhuang ; Liu, Penglin ; Wang, Ziying ; Zhang, Zhaoyang ; Chen, Zhongshao ; Chu, Ran ; Li, Guiju ; Han, Qiuyue ; Zhao, Yong ; Li, Li ; Miao, Jinwei ; Kong, Beihua ; Song, Kun

Background: Human papillomavirus (HPV) DNA and p16INK4a positivity have crucial roles in the pathogenesis of vulvar cancer and vulvar intraepithelial neoplasia. We aimed to examine the pooled prevalence of HPV DNA and p16INK4a positivity in vulvar cancer and vulvar intraepithelial neoplasia worldwide. Methods: In this systematic review and meta-analysis, we searched PubMed, Embase, and the Cochrane Library databases for studies published between Jan 1, 1986, and May 6, 2022, that reported the [...]

Menée aux Etats-Unis à partir de données de séquençage portant sur des cousins atteints d'un cancer du poumon non à petites cellules non épidermoïde à haut risque de récidive et menée à l'aide de données des registres américains des cancers puis validée à partir de données de la "UK Biobank", cette étude identifie un variant rare de FGF5 associé au risque de développer la maladie

A rare FGF5 candidate variant (rs112475347) for predisposition to non-squamous, non-small-cell lung cancer

Cannon-Albright, Lisa A ; Teerlink, Craig C ; Stevens, Jeff ; Facelli, Julio C ; Carr, Shamus R ; Allen-Brady, Kristina ; Puri, Sonam ; Bailey-Wilson, Joan E ; Musolf, Anthony M ; Genetic Epidemiology of Lung Cancer Consortium ; Akerley, Wallace

A unique approach with rare resources was used to identify candidate variants predisposing to familial non-squamous non-small-cell lung cancers (NSNSCLC). We analyzed sequence data from NSNSCLC-affected cousin pairs belonging to high-risk lung cancer pedigrees identified in a genealogy of Utah linked to statewide cancer records to identify rare, shared candidate predisposition variants. Variants were tested for association with lung cancer risk in UKBiobank. Evidence for linkage with lung [...]