Menée aux Etats-Unis par enquête auprès de 1 324 jeunes et 2 904 adultes, cette étude évalue leur compréhension de la liste des composants nocifs et potentiellement nocifs présents dans la fumée de cigarette puis analyse leur perception des effets du tabagisme sur la santé

Youth and adult understanding of public displays of information about harmful constituents in cigarette smoke

Venrick, Samantha J. ; Margolis, Katherine A. ; Bernat, Jennifer K. ; Pepper, Jessica K. ; Nonnemaker, James M. ; Eggers, Matthew E.

The U.S. FDA is required by law to publicly display a list of harmful and potentially harmful constituents (HPHCs) “by brand and by quantity in each brand and subbrand” in a format that is “understandable and not misleading to a lay person.” An online experiment examined youth and adult understanding of which HPHCs are present in cigarette smoke, understanding of health effects of smoking cigarettes, and endorsement of misleading information after viewing HPHC information displayed in one of [...]

Menée aux Etats-Unis auprès de 21 089 femmes ménopausées (durée moyenne de suivi : 7,4 ans), cette étude analyse l'association entre une activité physique quotidienne mesurée par accéléromètre et le risque de cancer du sein (640 cas)

Accelerometer-measured physical activity and postmenopausal breast cancer incidence in the Women's Health Accelerometry Collaboration

Hyde, Eric T. ; LaCroix, Andrea Z. ; Evenson, Kelly R. ; Howard, Annie Green ; Anuskiewicz, Blake ; Di, Chongzhi ; Bellettiere, John ; LaMonte, Michael J. ; Manson, JoAnn E. ; Buring, Julie E. ; Shiroma, Eric J. ; Lee, I-Min ; Parada Jr., Humberto

Background: Few studies have examined accelerometer-measured physical activity and incident breast cancer (BC). Thus, this study examined associations between accelerometer-measured vector magnitude counts per 15 seconds (VM/15s) and average daily minutes of light physical activity (LPA), moderate-to-vigorous PA (MVPA), and total PA (TPA) and BC risk among women in the Women's Health Accelerometry Collaboration (WHAC). Methods: The WHAC comprised 21,089 postmenopausal women (15,375 from the [...]

Menée à l'aide de données 2000-2015 des registres américains des cancers, cette étude analyse l'association entre le niveau d'accès à une alimentation saine, évalué à l'aide d'un indicateur, et le risque de cancer de l'estomac

Food Environment Index is Inversely Associated with Gastric Cancer Incidence in the United States

Wu, Shenghui ; Liu, Yanning ; Thompson, Martie ; Hege, Adam

The first epidemiologic study was conducted to prospectively examine the association between Food Environment Index (FEI) and gastric cancer (GC) risk in the US. Surveillance, Epidemiology, and End Results provided information on GC incident cases diagnosed between 2000 and 2015 from 16 population-based cancer registries across the US. The county-level food environment was assessed using the FEI, an indicator of access to healthy foods (0 is worst, 10 is best). Poisson regression was used to [...]

Menée à partir de données 2002-2019 de la base "United States Cancer Statistics", cette étude analyse l'effet de la politique de vaccination contre le papillomavirus humain (HPV) sur l'incidence des cancers liés au HPV, par tranche d'âge et en fonction du sexe

Incidence of HPV-related cancers among males and females 15-34 years old in the US

Guo, Fangjian ; Adekanmbi, Victor ; Hsu, Christine D ; Berenson, Abbey B

Post-market surveillance of the incidence of Human papillomavirus (HPV)-related cancers is essential to monitor the effectiveness of HPV vaccines. We directly compared HPV-related cancer incidences during the pre- and post- vaccine era to assess the effects of HPV vaccination among vaccine-eligible age groups in the US using data from United States Cancer Statistics (USCS) database. The 5–year average annual incidence rates for HPV-related cancers decreased in 2015–2019 compared to 2002–2006 [...]

Mené en Suisse entre 2017 et 2020 sur 255 fumeurs, cet essai randomisé évalue l'intérêt, du point de vue du taux d'abstinence tabagique et de la prise de poids, du dulaglutide (un analogue du GLP-1) pendant le sevrage tabagique

Effect of dulaglutide in promoting abstinence during smoking-cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial

Lengsfeld, Sophia ; Burkard, Thilo ; Meienberg, Andrea ; Jeanloz, Nica ; Vukajlovic, Tanja ; Bologna, Katja ; Steinmetz, Michelle ; Bathelt, Cemile ; Sailer, Clara O. ; Vogt, Deborah R. ; Hemkens, Lars G. ; Speich, Benjamin ; Urwyler, Sandrine A. ; Kühne, Jill ; Baur, Fabienne ; Lutz, Linda N. ; Erlanger, Tobias E. ; Christ-Crain, Mirjam ; Winzeler, Bettina

Background: Quitting smoking is difficult due to barriers such as craving for cigarettes and post-cessation weight gain. Recent experimental data suggest a role of glucagon-like peptide-1 (GLP-1) in the pathophysiology of addiction in addition to appetite regulation and weight control. We hypothesized that a pharmacological intervention with the GLP-1 analogue dulaglutide during smoking cessation may improve abstinence rates and reduce post-cessation weight gain. Methods: This is a [...]

Menée aux Etats-Unis à partir de données 2011-2017, cette étude analyse l'association entre l'indice de masse corporelle, le niveau de rayonnement UV et le risque de mélanome

Is obesity a risk factor for melanoma?

Arbel, Yuval ; Arbel, Yifat ; Kerner, Amichai ; Kerner, Miryam

Objectives: Are twofold: 1) to estimate the relationship between obesity (BMI ≥30) and the prevalence of melanoma in different US states and 2) to examine the possibility of defining a new risk group. This might enhance the possibility of detection, which in turn, might increase the survival rates of patients. Study design: A cohort Study, based on data at the US statewide level in 2011–2017, where the dependent variable (the annual new melanoma cases per 100,000 persons) is adjusted for age. [...]

Menée aux Pays-Bas auprès de 2 557 femmes asymptomatiques porteuses d'un variant pathogène de BRCA1/2 et ayant subi une salpingo-ovariectomie prophylactique sur la période 1995-2018, cette étude identifie des facteurs cliniques associés au risque de carcinome séreux de haut grade de l'ovaire

High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants: Prevalence and Clinical Factors

Iris A.S. Stroot ; Jan Brouwer ; Joost Bart ; Harry Hollema ; Denise J. Stommel-Jenner ; Marise M. Wagner ; Helena C. van Doorn ; Joanne A. de Hullu ; Katja N. Gaarenstroom ; Marc Beurden ; Luc R.C.W. van Lonkhuijzen ; Brigitte F.M. Slangen ; Ronald P. Zweemer ; Encarna B. Gómez Garcia ; Margreet G.E.M. Ausems ; Ingrid A. Boere ; Klaartje van Engelen ; Christi J. van Asperen ; Marjanka K. Schmidt ; Marijke R. Wevers ; Geertruida H. de Bock ; Marian J.E. Mourits ; on behalf of the HEBON Investigators

PURPOSE: To investigate the prevalence of and clinical factors associated with high-grade serous carcinoma (HGSC) at risk-reducing salpingo-oophorectomy (RRSO) in asymptomatic BRCA1/2-pathogenic variant (PV) carriers. PATIENTS AND METHODS: We included BRCA1/2-PV carriers who underwent RRSO between 1995 and 2018 from the Hereditary Breast and Ovarian cancer in the Netherlands study. All pathology reports were screened, and histopathology reviews were performed for RRSO specimens with epithelial [...]