Menée auprès de 6 919 témoins et 1 990 patients atteints d'un carcinome papillaire de la thyroïde (75,5 % de femmes), cette étude analyse l'association entre une exposition aux particules fines (PM2.5) et le risque de développer la maladie, puis identifie les caractéristiques des patients à risque

Socioeconomic disparity in the association between fine particulate matter exposure and papillary thyroid cancer

Crepeau, Philip ; Zhang, Zhenyu ; Udyavar, Rhea ; Morris-Wiseman, Lilah ; Biswal, Shyam ; Ramanathan, Murugappan ; Mathur, Aarti

Background: Limited data exists suggesting that cumulative exposure to air pollution in the form of fine particulate matter (aerodynamic diameter ≤ 2.5 

Menée en France auprès de 75 606 femmes ménopausées de la cohorte "E3N" (durée moyenne de suivi : 15,3 ans), cette étude analyse l'association entre le type de traitement hormonal substitutif utilisé et le risque de cancer de l'ovaire (416 cas)

Use of menopausal hormone therapy and ovarian cancer risk in a French cohort study

Fournier, Agnès ; Cairat, Manon ; Severi, Gianluca ; Gunter, Marc J ; Rinaldi, Sabina ; Dossus, Laure

Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations between different MHT types and the risk of ovarian cancer in a prospective cohort.The study population included 75,606 postmenopausal women from the E3N cohort. Exposure to MHT was identified from self-reports in biennial questionnaires between 1992 and 2004 [...]

Menée à partir de données de 7 registres nationaux danois portant sur 2 222 797 enfants nés entre 1978 et 2015 (durée moyenne de suivi : 12 ans), cette étude analyse l'association entre une infection maternelle pendant la grossesse et le risque de leucémie chez l'enfant (1 307 cas)

Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark

He, Jian-Rong ; Yu, Yongfu ; Fang, Fang ; Gissler, Mika ; Magnus, Per ; László, Krisztina D. ; Ward, Mary H. ; Paltiel, Ora ; Tikellis, Gabriella ; Maule, Milena Maria ; Qiu, Xiu ; Du, Jiangbo ; Valdimarsdóttir, Unnur Anna ; Rahimi, Kazem ; Wiemels, Joseph L. ; Linet, Martha S. ; Hirst, Jane E. ; Li, Jiong ; Dwyer, Terence

Maternal infection is common during pregnancy and is an important potential cause of fetal genetic and immunological abnormalities. Maternal infection has been reported to be associated with childhood leukemia in previous case-control or small cohort studies.To evaluate the association of maternal infection during pregnancy with childhood leukemia among offspring in a large study.This population-based cohort study used data from 7 Danish national registries (including the Danish Medical Birth [...]

Menée à partir de données 2002-2019 de l'Assurance maladie coréenne portant sur 217 777 patients atteints d'un cancer de la thyroïde (âge moyen : 47,2 ans ; durée médiane de suivi : 7,7 ans), cette étude analyse l'association entre la dose d'iode radioactif reçue et le risque de second cancer primitif

Linear Association between Radioactive Iodine Dose and Second Primary Malignancy Risk in Thyroid Cancer

Kim, Kyeong Jin ; Kim, Kyoung Jin ; Choi, Jimi ; Kim, Nam Hoon ; Kim, Sin Gon

We aimed to investigate whether the risk of second primary malignancy (SPM) in TC patients receiving RAI therapy increases in a cumulative dose-dependent manner compared to those without.Using the Korean National Health Insurance Service-National Health Information Database (NHIS-NHID, 2002–2019), we investigated hazard ratios (HRs) of SPM associated with RAI in TC. SPM was defined as a second primary malignancy diagnosed at least 1 year after TC diagnosis.Of 217,777 TC patients (177,385 women [...]

Menée en Chine à l'aide du génotypage ADN de 505 témoins et de 509 patients atteints d'un cancer de l'estomac (âge moyen : 61 ans), cette étude identifie, en fonction du sexe et de l'âge, des polymorphismes à simple nucléotide des gènes TFF1 et PALB2 associés au risque de développer la maladie

Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population

Zou, Wenjing ; Zhang, Qian ; Sun, Ruifang ; Li, Xu ; He, Shuixiang

Objective: Gastric carcinoma (GC) has received extensive attention due to its complex pathogenesis. Studies have shown that the expression of Trefoil factor 1 (TFF1) and Partner and localiser of BRCA2 (PALB2) genes promotes the occurrence of GC. Therefore, we investigated whether TFF1 and PALB2 gene polymorphisms are associated with GC risk in the Chinese Han population. Methods: A total of 509 GC cases and 505 controls were recruited, and single nucleotide polymorphisms (SNPs) of TFF1 and [...]

A partir d'une revue systématique de la littérature (16 méta-analyses), cette étude évalue l'association entre l'indice de masse corporelle et le risque de cancer

Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies

Chen, Junhao ; Ke, Kaimin ; Liu, Zhenghuan ; Yang, Luchen ; Wang, Linchun ; Zhou, Jing ; Dong, Qiang

Increasing evidence indicates that obesity is a risk factor for various tumors. We aimed to clarify the evidence for an association between body mass index (BMI) and cancer risk based on existing systematic reviews and meta-analyses. Eighteen studies were included in this umbrella review after searching PubMed, Embase and Web of science. The results revealed that underweight was inversely associated with the incidence of brain tumors and positively related to the risk of esophageal and lung [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de 2 études d'association sur le génome entier portant au total sur 207 703 Européens, cette étude analyse l'association entre des variants génétiques liés à la signalisation de l'interleukine IL-6 et le risque de cancer du sein

Mendelian Randomization Study on Causal Association of IL-6With Breast Cancer

Zhang, Min ; Ma, Ning ; Wang, Renxi

Background: Previous studies have shown an important role of interleukin 6 (IL-6) in the progression and metastasis of breast cancer. The present 2-sample Mendelian randomization (MR) study aimed to identify the genetic causal link between IL-6 and breast cancer. Material and Methods: IL-6-signaling and its negative regulator soluble IL-6 receptor (sIL-6R) genetic instruments were chosen from 2 large-scale genome-wide association studies (GWAS) of 204,402 and 3,301 European individuals, [...]