Menée en Allemagne sur la période 2003-2020 par entretien auprès de 6 866 témoins et 6 264 patients atteints d'un cancer colorectal, cette étude analyse l'association entre une exposition au tabagisme et le risque de survenue précoce ou tardive de la maladie

Associations of smoking with early- and late-onset colorectal cancer

Li, Hengjing ; Chen, Xuechen ; Hoffmeister, Michael ; Brenner, Hermann

Incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Smoking is an established risk factor of CRC risk, but evidence on its impact on early-onset CRC (EOCRC) risk is limited. We aimed to evaluate the association of smoking exposure with EOCRC and compare it with late-onset CRC (LOCRC).Smoking history and other known or suspected CRC risk factors were ascertained in detail in personal interviews among 6,264 CRC patients and 6,866 controls (frequency matched for [...]

Menée à l'aide de données portant sur 450 105 participants de la cohorte "EPIC" (durée de suivi : 14,2 ans), cette étude analyse l'association entre des apports alimentaires en fer total, héminique ou non héminique et le risque de cancer colorectal (6 162 cas), en fonction du sexe

Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study

Aglago, Elom K. ; Cross, Amanda J. ; Riboli, Elio ; Fedirko, Veronika ; Hughes, David J. ; Fournier, Agnès ; Jakszyn, Paula ; Freisling, Heinz ; Gunter, Marc J. ; Dahm, Christina C. ; Overvad, Kim ; Tjønneland, Anne ; Kyrø, Cecilie ; Boutron-Ruault, Marie-Christine ; Rothwell, Joseph A. ; Severi, Gianluca ; Katzke, Verena ; Srour, Bernard ; Schulze, Matthias B. ; Wittenbecher, Clemens ; Palli, Domenico ; Sieri, Sabina ; Pasanisi, Fabrizio ; Tumino, Rosario ; Ricceri, Fulvio ; Bueno-de-Mesquita, Bas ; Derksen, Jeroen W. G. ; Skeie, Guri ; Jensen, Torill Enget ; Lukic, Marko ; Sánchez, María-José ; Amiano, Pilar ; Colorado-Yohar, Sandra ; Barricarte, Aurelio ; Ericson, Ulrika ; Van Guelpen, Bethany ; Papier, Keren ; Knuppel, Anika ; Casagrande, Corinne ; Huybrechts, Inge ; Heath, Alicia K. ; Tsilidis, Konstantinos K. ; Jenab, Mazda

Background: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive. Methods: We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) [...]

Menée à partir de données de registres australiens portant sur tous les patients atteints d'un mésothéliome diagnostiqué entre 2010 et 2021, cette étude analyse l'évolution de l'incidence et de la mortalité de la maladie, puis estime la part attribuable à une exposition professionnelle ou non à l'amiante

Incidence and mortality from malignant mesothelioma 1982–2020 and relationship with asbestos exposure: the Australian Mesothelioma Registry

Walker-Bone, Karen ; Benke, Geza ; MacFarlane, Ewan ; Klebe, S ; Takahashi, Ken ; Brims, Fraser ; Sim, Malcolm Ross ; Driscoll, Tim R

Objectives: Malignant mesothelioma is an uncommon cancer associated with asbestos exposure, predominantly occupational. Asbestos has been banned in Australia since 2003 but mesothelioma has a long latency and incident cases continue to present. The Australian Mesothelioma Registry was incepted to collect systematic data about incidence and mortality alongside asbestos exposure. Methods: Benefiting from the Australian national system of cancer notification, all incident cases of mesothelioma in [...]

Menée à l'aide de données 2004-2018 de registres danois portant sur des témoins et 176 176 patients atteints d'un cancer de la peau, cette étude analyse l'association entre une utilisation de méthotrexate et le risque de carcinome basocellulaire, de carcinome épidermoïde cutané et de mélanome malin cutané

Use of methotrexate and risk of skin cancer: a nationwide case–control study

Polesie, Sam ; Gillstedt, Martin ; Schmidt, Sigrun Alba Johannesdottir ; Egeberg, Alexander ; Pottegård, Anton ; Kristensen, Kasper

Background: Methotrexate (MTX) use has been suspected of increasing the risk of skin cancer. The aim of this investigation was to examine the association between the use of MTX and the risk of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC) and cutaneous malignant melanoma (CMM). Methods: In a nationwide Danish case–control study, we identified incident, histologically verified cases of BCC (n = 131,447), cSCC (n = 18,661) or CMM (26,068) from 2004 to 2018. We matched 10 [...]

Menée aux Pays-Bas auprès de 316 patients ayant survécu au moins 5 ans à un lymphome de Hodgkin (durée médiane de suivi : 26 ans ; 69,9 % d'hommes), cette étude multicentrique analyse l'association entre la dose de rayonnement reçue par le gros intestin et/ou la dose de procarbazine et le risque de cancer colorectal (78 cas)

Association of Radiation and Procarbazine Dose With Risk of Colorectal Cancer Among Survivors of Hodgkin Lymphoma

Geurts, Yvonne M. ; Shakir, Rebecca ; Ntentas, Georgios ; Roberti, Sander ; Aznar, Marianne C. ; John, Katinka M. ; Ramroth, Johanna ; Janus, Cécile P. M. ; Krol, Augustinus D. G. ; Roesink, Judith M. ; van der Maazen, Richard W. M. ; Zijlstra, Josée M. ; Darby, Sarah C. ; Aleman, Berthe M. P. ; van Leeuwen, Flora E. ; Cutter, David J. ; Schaapveld, Michael

Hodgkin lymphoma (HL) survivors have higher rates of colorectal cancer, which may be associated with subdiaphragmatic radiation therapy and/or alkylating chemotherapy. Although radiation dose-response associations with breast, lung, stomach, pancreatic, and esophageal cancer after HL have been demonstrated, the association of radiation therapy with colorectal cancer remains unclear.To quantify the rate of colorectal cancer according to radiation dose to the large bowel and procarbazine dose [...]