Menée aux Etats-Unis à partir de données portant sur 3 085 adultes ayant survécu à un cancer diagnostiqué pendant l'enfance, cette étude transversale analyse l'association entre différentes catégories de symptômes déclarés par les patients, leurs capacités physiques et neurocognitives et leur qualité de vie

Associations of Symptom Clusters and Health Outcomes in Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

Shin, Hyewon ; Dudley, William N. ; Bhakta, Nickhill ; Horan, Madeline R. ; Wang, Zhaoming ; Bartlett, T. Robin ; Srivastava, Deokumar ; Yasui, Yutaka ; Baker, Justin N. ; Robison, Leslie L. ; Ness, Kirsten K. ; Kevin, Krull R. ; Hudson, Melissa M. ; Huang, I. Chan

PURPOSE : To identify symptom clusters among adult survivors of childhood cancers and test associations with health-related quality of life (HRQOL) and physical and neurocognitive performance. METHODS : This cross-sectional study included 3,085 survivors (mean age at evaluation 31.9 ± 8.3 years; mean years from diagnosis 28.1 ± 9.1) participating in the St Jude Lifetime Cohort Study. Survivors self-reported the presence of 37 symptoms capturing 10 domains (cardiac, pulmonary, sensory, [...]

Menée en Allemagne à partir de données portant sur 70 patients atteints d'un myélome multiple (âge médian : 62 ans), cette étude prospective observationnelle analyse l'impact, sur leur qualité de vie, de facteurs individuels (âge, sexe, symptômes d'anxiété, etc.) et liés aux traitements

The influence of baseline characteristics, treatment and depression on health-related quality of life in patients with multiple myeloma: a prospective observational study

Fischer, Julia ; Knop, Stefan ; Danhof, Sophia ; Einsele, Hermann ; Keller, Daniela ; Löffler, Claudia

Background : Multiple myeloma (MM) is the third most common hematologic malignancy with increasing importance due to improving treatment strategies and long-term outcomes in an aging population. This study aims to analyse influencing factors on health-related quality of life (HRQoL), such as treatment strategies, participation in a clinical trial and patient characteristics like anxiety, depression, gender, and age. A better understanding of the individual factors in context with HRQoL could [...]

Menée en Allemagne auprès de 30 patients atteints d'un myélome multiple, cette étude de cohorte analyse la faisabilité et l'intérêt d'un programme d'exercices physiques ainsi que l'adhésion des patients

Clinical exercise therapy program with multiple myeloma patients: Impacts on feasibility, adherence and efficacy

Wefelnberg, Michael Mendes ; Niels, Timo ; Holtick, Udo ; Jundt, Franziska ; Scheid, Christoph ; Baumann, Freerk T.

Purpose : Multiple myeloma (MM) is a severe hemato-oncological disease with high mortality and increasing incidence rate. Since evidence on exercise therapy in MM patients remains limited, this study examines feasibility, adherence, and efficacy based on real-life data from an oncologic care structure. Methods : A data evaluation of MM patients who participated in the oncologic exercise and movement therapy (OTT) at the Cologne University Hospital between 2012 and 2019 was conducted. The [...]

Cette étude analyse l'évolution du taux de sevrage tabagique des adultes aux Etats-Unis entre 2013 et 2019

National longitudinal tobacco product cessation rates among US adults from the PATH Study: 2013–2019 (waves 1–5)

Kasza, Karin A ; Tang, Zhiqun ; Xiao, Haijun ; Marshall, Daniela ; Stanton, Cassandra A ; Gross, Amy L ; Jackson, Kathy M ; Kelley, Dannielle ; Schroeder, Megan J ; Vivar, Juan C ; Hyland, Andrew

Objective: To report on longitudinal tobacco product cessation rates, by product type, among adults (ages 18+ years) in the USA between 2013 and 2019. Methods: The Population Assessment of Tobacco and Health Study, a nationally representative, longitudinal cohort study was used to report on annual and biennial rates of the following three cessation behaviours across 2013–2019: (1) discontinuing tobacco product use (ie, transition from past 30-day use to no past 30-day use), (2) attempting to [...]

Menée à partir de données 1989-2020 du registre néerlandais des cancers portant sur 318 002 patientes atteintes d'un cancer du sein et 12 370 patientes atteintes d'un cancer de la thyroïde, cette étude analyse l'incidence synchrone ou métachrone de ces 2 maladies

The co-occurrence of both breast- and differentiated thyroid cancer: incidence, association and clinical implications for daily practice

Piek, Marceline W. ; De Boer, Jan Paul ; van Duijnhoven, Frederieke ; van der Wal, Jacqueline E. ; Vriens, Menno ; van Leeuwaarde, Rachel S. ; van der Ploeg, Iris M. C.

Background: Breast cancer (BC) and differentiated thyroid cancer (TC) are two common cancer types with the highest incidence in women. BC and TC can develop synchronous or metachronous and the occurrence of both is higher than expected by chance. This study aimed to examine the association between BC and TC in the Netherlands. Methods: This is a retrospective cohort study during the period of 1989–2020 retrieved from the Netherlands Cancer Registry (NCR). Patients diagnosed with BC-TC and BC [...]

Menée aux Etats-Unis à l'échelle du comté (727 comtés étudiés) et à partir des données des registres américains des cancers portant sur des patients de type caucasien non hispanique atteints d'un mélanome diagnostiqué entre 2012 et 2016, cette étude analyse l'association entre une exposition à des rayonnements ultraviolets de sources différentes, des critères liés à l'accès aux examens diagnostiques (revenus du foyer, offre de soins primaires, présence de dermatologues) et le risque de développer la maladie

Association of UV Radiation Exposure, Diagnostic Scrutiny, and Melanoma Incidence in US Counties

Adamson, Adewole S. ; Welch, Heather ; Welch, H. Gilbert

Although UV radiation exposure is the conventionally reported risk factor for cutaneous melanoma, an alternative exposure is diagnostic scrutiny: the more physicians look for and biopsy moles, the more melanoma they find.To assess the association of proxies for UV radiation exposure and diagnostic scrutiny with geographical patterns of melanoma incidence.This was a cross-sectional ecological analysis of the 727 continental US counties reporting to the Surveillance, Epidemiology, and End Results [...]

Menée aux Etats-Unis, cette étude présente, pour l'année 2022, les données d'incidence du cancer du sein, de la mortalité et de la survie associées

Breast Cancer Statistics, 2022

Giaquinto, Angela N. ; Sung, Hyuna ; Miller, Kimberly D. ; Kramer, Joan L. ; Newman, Lisa A. ; Minihan, Adair ; Jemal, Ahmedin ; Siegel, Rebecca L.

This article is the American Cancer Society’s update on female breast cancer statistics in the United States, including population-based data on incidence, mortality, survival, and mammography screening. Breast cancer incidence rates have risen in most of the past four decades; during the most recent data years (2010–2019), the rate increased by 0.5% annually, largely driven by localized-stage and hormone receptor-positive disease. In contrast, breast cancer mortality rates have declined [...]

Menée à partir de données multicentriques 2008-2016 portant sur 20 624 patientes atteintes d'un cancer du sein métastatique (durée médiane de suivi : 50,5 mois), cette étude analyse la survie globale chez les patientes porteuses d'une mutation constitutionnelle de BRCA1/2

Survival outcomes of metastatic breast cancer patients by germline BRCA1/2 status in a large multicenter real-world database

Mailliez, Audrey ; D’Hondt, Veronique ; Lusque, Amélie ; Caron, Olivier ; Cabel, Luc ; Gonçalves, Anthony ; Debled, Marc ; Gladieff, Laurence ; Ferrero, Jean-Marc ; Petit, Thierry ; Mouret-Reynier, Marie Ange ; Eymard, Jean-Christophe ; Levy, Christelle ; Uwer, Lionel ; Leheurteur, Marianne ; Desmoulins, Isabelle ; Bachelot, Thomas ; Frenel, ean-Sebastien ; de la Motte rouge, Thibault ; Simon, Gaëtane ; Jacot, William ; Delaloge, Suzette

The outcomes and best treatment strategies for germline BRCA1/2 mutation (gBRCAm) carriers with metastatic breast cancer (MBC) remain uncertain. We compared the overall survival and the first line progression free survival (PFS1) of patients with a gBRCAm identified at initiation of first-line treatment with those of BRCA wild-type (WT) and not-tested (NT) individuals in the ESME real-world database of MBC patients between 2008 and 2016 (NCT03275311). Among the 20624 eligible patients, 325 had [...]

Menée aux Etats-Unis à partir de données portant sur 8 962 patients atteints d'un cholangiocarcinome intra-hépatique diagnostiqué entre 2000 et 2018, cette étude analyse les causes de décès (7 335 décès ; âge moyen lors du décès : 67,9 ans)

Survival and Causes of Death among Patients with Intrahepatic Cholangiocarcinoma in the United States from 2000 to 2018

Elgenidy, Anas ; Afifi, Ahmed M. ; Jalal, Prasun K.

Background: Intrahepatic cholangiocarcinoma (iCCA) has shown a substantial increase in mortality globally. On the contrary, perihilar cholangiocarcinoma and distal cholangiocarcinoma have been decreasing. We aim to evaluate the causes of death after iCCA diagnosis. Methods: We studied 8,962 patients with iCCA diagnosed between 2000 and 2018 in the United States. The standardized mortality ratio for each cause of death was calculated. We used R software version 3.5 to perform Kaplan–Meier [...]

Menée à partir des données 2020 de la base GLOBOCAN, cette étude estime, à une échelle internationale, l'incidence du cancer de l'oropharynx et la mortalité spécifique

The Current Burden of Oropharyngeal Cancer: A Global Assessment Based on GLOBOCAN 2020

Lorenzoni, Valentina ; Chaturvedi, Anil K. ; Vignat, Jérôme ; Laversanne, Mathieu ; Bray, Freddie ; Vaccarella, Salvatore

Oropharyngeal cancer (OPC) is a complex disease whose etiologies, either related to risk factors such as smoking or alcohol, or linked to HPV infection, are believed to be responsible for wide gender and geographical variability. This study depicts the current burden of OPC worldwide.Estimated OPC new cases, deaths, age-standardized rates (ASR) for both incidence and mortality in 2020 were obtained from the GLOBOCAN database for each country and across 20 UN-defined world regions by sex. The [...]

Menée à partir de données portant sur 11 223 patients atteints d'une tumeur neuroendocrine et sur 11 223 témoins atteints d'un cancer du côlon, cette étude de cohorte rétrospective analyse, pour ces deux populations, le risque de développer une maladie psychiatrique après le diagnostic de cancer

Incidence of psychiatric illness in patients with neuroendocrine tumors: a comparative population-based analysis

Hallet, Julie ; Isenberg-Grzeda, Elie ; Law, Calvin H. L. ; Barabash, Victoria ; Zuckerman, Jesse ; Singh, Simron ; Myrehaug, Sten D. ; Assal, Angela ; Chan, Wing C. ; Coburn, Natalie G. ; Mahar, Alyson L.

Purpose : Diversion of tryptophan to tumoral hormonal production has been suggested to result in psychiatric illnesses in neuroendocrine tumors (NET). We measured the occurrence of psychiatric illness after NET diagnosis and compare it to colon cancer (CC). Methods : We conducted a population-based retrospective cohort study. Adults with NET were matched 1:1 to CC (2000–2019). Psychiatric illness was defined by mental health diagnoses and mental health care use after a cancer diagnosis, [...]

Menée à Hong Kong à partir de données portant sur 226 patients atteints d'un cancer du poumon de stade avancé et inclus dans un essai clinique prospectif, cette étude transversale identifie les facteurs associés à la perception de leurs déficiences cognitives

Factors associated with perceived cognitive impairment in patients with advanced lung cancer: a cross-sectional analysis

Takemura, Naomi ; Ho, Mu-Hsing ; Cheung, Denise Shuk Ting ; Lin, Chia-Chin

Purpose : Perceived cognitive impairment refers to cognitive dysfunction that particularly involves impairment in working or short-term memory, and inattention. This study aimed to identify factors associated with perceived cognitive impairment in patients with advanced lung cancer. Methods : This cross-sectional analysis used pooled data from a prospective, ongoing randomized controlled trial examining the effectiveness of exercise in patients with advanced lung cancer (Trial Registration: [...]

Menée à partir de données portant sur 329 témoins et 400 patientes âgées de plus de 60 ans et ayant survécu à un cancer du sein (âge moyen : 67,7 ans), cette étude longitudinale analyse l'association entre une inflammation chronique, mesurée par le niveau de protéine C-réactive, et des troubles cognitifs

Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study

Judith E. Carroll ; Zev M. Nakamura ; Brent J. Small ; Xingtao Zhou ; Harvey J. Cohen ; Tim A. Ahles ; Jaeil Ahn ; Traci N. Bethea ; Martine Extermann ; Deena Graham ; Claudine Isaacs ; Heather S.L. Jim ; Paul B. Jacobsen ; Brenna C. McDonald ; Sunita K. Patel ; Kelly Rentscher ; James Root ; Andrew J. Saykin ; Danielle B. Tometich ; Kathleen Van Dyk ; Wanting Zhai ; Elizabeth C. Breen ; Jeanne S. Mandelblatt

PURPOSE : To examine longitudinal relationships between levels of C-reactive protein (CRP) and cognition in older breast cancer survivors and noncancer controls. METHODS : English-speaking women age ≥ 60 years, newly diagnosed with primary breast cancer (stage 0-III), and frequency-matched controls were enrolled from September 2010 to March 2020; women with dementia, neurologic disorders, and other cancers were excluded. Assessments occurred presystemic therapy/enrollment and at annual visits [...]

Menée par entretien auprès de 12 patientes ayant survécu à un cancer du sein, cette étude évalue la validité et la pertinence de l'échelle d'évaluation des troubles de l'image corporelle en oncologie (BIS)

Exploring the validity of the body image scale with survivors of breast cancer: A cognitive interview approach

Effa, Corrie ; Al Onazi, Mona M. ; Spencer, Nancy ; Pritchard, Lesley ; Fletcher, Ian ; McNeely, Margaret L.

Objective: The aim of this study is to explore the construct validity of the Body Image Scale for Cancer Questionnaire (BIS) using cognitive interviews. Methods: Twelve breast cancer survivors participated in a cognitive interview while completing the BIS. Each participant was asked to think-out-loud while answering items, and an interviewer asked probing questions relating to the participants' comprehension, example retrieval, certainty of answer and other decision-making factors. Interviews [...]

Menée aux Etats-Unis à partir de données portant sur 956 témoins et 3 555 patients ayant survécu plus de 5 ans à un cancer pédiatrique, cette étude analyse les facteurs associés à la présence de difficultés financières après la mise en place de la loi sur la protection des patients et les soins abordables ("Obamacare")

Financial Hardship in Adult Survivors of Childhood Cancer in the Era After Implementation of the Affordable Care Act: A Report From the Childhood Cancer Survivor Study

Paul C. Nathan ; I-Chan Huang ; Yan Chen ; Tara O. Henderson ; Elyse R. Park ; Anne C. Kirchhoff ; Leslie L. Robison ; Kevin Krull ; Wendy Leisenring ; Gregory T. Armstrong ; Rena M. Conti ; Yutaka Yasui ; K. Robin Yabroff

PURPOSE : To estimate the prevalence of financial hardship among adult survivors of childhood cancer compared with siblings and identify sociodemographic, cancer diagnosis, and treatment correlates of hardship among survivors in the era after implementation of the Affordable Care Act. METHODS : A total of 3,555 long-term (≥ 5 years) survivors of childhood cancer and 956 siblings who completed a survey administered in 2017-2019 were identified from the Childhood Cancer Survivor Study. Financial [...]

Cette étude fait le point sur la recherche et les développements, notamment sur les inhibiteurs de la tyrosine kinase, qui pourraient influencer les stratégies de première ligne pour le traitement de la leucémie myéloïde chronique

The influence of drug prices, new availability of inexpensive generic imatinib, new approvals, and post-marketing research on the treatment of chronic myeloid leukaemia in the USA

Kantarjian, Hagop ; Paul, Shilpa ; Thakkar, Jigar ; Jabbour, Elias

Several research and market developments in the past 5 years could influence front-line and subsequent-line strategies in chronic myeloid leukaemia. These developments include the increased availability of effective and safe generic imatinib at affordable prices, studies showing that doses of tyrosine kinase inhibitors (TKIs) lower than the approved dose are effective and less toxic, studies showing that dose-adjusted ponatinib therapy at a reduced dose is effective and substantially safer than [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2021 (9 articles), cette étude analyse les facteurs associés aux capacités des patients atteints d'un cancer à chercher et à comprendre l'information sur la santé disponible en ligne

Factors influencing the e-health literacy in cancer patients: a systematic review

Zhang, Yan ; Xu, Peirong ; Sun, Qiannan ; Baral, Shantanu ; Xi, Lijuan ; Wang, Daorong

Purpose : As Internet technology evolves, electronic health (e-health) literacy gradually becomes a key factor in healthy behaviors and health-related decision-making. However, little is known about the influencing factors of e-health literacy among cancer survivors. Thus, the objective of this study was to systematically review the status quo, assessment tools, and influencing factors of e-health literacy in cancer patients. Methods : We conducted a comprehensive search in several databases, [...]

Menée en Australie sur la période 2018-2021 par entretien auprès de 15 proches aidants de patients décédés d'un cancer thoracique et inclus dans un essai randomisé (âge médian : 63 ans), cette étude analyse l'effet, sur leur prise de conscience de la maladie et leur relation avec leur proche malade, d'une orientation précoce vers les soins palliatifs

Palliative care facilitates the preparedness of caregivers for thoracic cancer patients

Zomerdijk, Nienke ; Panozzo, Stacey ; Mileshkin, Linda ; Yoong, Jaclyn ; Nowak, Anna K. ; Stockler, Martin R. ; Philip, Jennifer

Objective: Palliative care improves outcomes for patients with thoracic cancer; however, limited evidence exists for the benefits of this approach for caregivers. This study aimed to advance understanding of the experiences of palliative care described by bereaved caregivers. Methods: Fifteen adult caregivers completed semi-structured interviews following prior participation in a randomised controlled trial of early referral to palliative care versus discretionary referral to palliative care. [...]