Menée au Japon jusqu'en 2013 auprès de 89 283 personnes (âge : 45-74 ans), cette étude analyse l'effet du tabagisme sur l'association entre une consommation de fruits ou légumes et le risque de cancer colorectal (2 261 cas)

Vegetable and fruit intake and colorectal cancer risk by smoking status in adults: The Japan Public Health Center-based Prospective Study

Hori, Miyuki ; Sawada, Norie ; Kito, Kumiko ; Yamaji, Taiki ; Iwasaki, Motoki ; Inoue, Manami ; Tsugane, Shoichiro

Background: Cigarette smoke contains many oxidants and free radicals which may affect the association between vegetable and fruit intake and colorectal cancer (CRC) risk. However, this relationship remains unclear. Objective: This study aimed to investigate the associations between vegetable and fruit intake and CRC risk by smoking status. Methods: The Japan Public Health Center-based Prospective Study is a population-based prospective cohort study. Participants completed a self-administered [...]

Menée au Japon sur la période 1990-2013 par questionnaire auprès de 95 812 personnes, cette étude analyse l'association entre la consommation d'alcool et le risque de cancer du pancréas (598 cas), en fonction du statut tabagique

Association Between Alcohol Consumption and Risk of Pancreatic Cancer: The Japan Public Health Center-Based Prospective Study

Okita, Yuki ; Sobue, Tomotaka ; Zha, Ling ; Kitamura, Tetsuhisa ; Iwasaki, Motoki ; Inoue, Manami ; Yamaji, Taiki ; Tsugane, Shoichiro ; Sawada, Norie

Several studies have investigated the association between alcohol consumption and pancreatic cancer risk. However, these studies reported inconsistent results.This study included 95,812 participants from the Japan Public Health Center-Based Prospective Study, whose alcohol drinking habit was collected through the questionnaire of the baseline survey in 1990 to 1994 for Cohort I and in 1993 to 1995 for Cohort II, and followed-up until December 2013. The hazard ratios (HR) and 95% confidence [...]

Menée au Japon auprès de 74 455 personnes (âge : 45-74 ans ; durée de suivi : 16,7 ans), cette étude analyse l'association entre la consommation de boissons sucrées et le risque de cancer de l'estomac (2 141 cas)

Sugary drink consumption and the subsequent risk of gastric cancer: The Japan Public Health Center-based Prospective Study

Khairan, Paramita ; Sobue, Tomotaka ; Eshak, Ehab Salah ; Kitamura, Tetsuhisa ; Iwasaki, Motoki ; Inoue, Manami ; Yamaji, Taiki ; Iso, Hiroyasu ; Tsugane, Shoichiro ; Sawada, Norie

Background/objectives: Evidence on the association between sugary drink consumption and gastric cancer (GC) risk is limited, especially in Asian populations. This study aimed to investigate the association between consumption of sugary drinks (sugar-sweetened beverages and 100% fruit juices) and GC risk in a Japanese population. Subjects/methods: This study included 74,455 Japanese individuals aged 45–74 years (35,102 males and 39,353 females) who participated in a population-based cohort study [...]

Menée à partir de données 1961-2005 des registres des cancers en Finlande, Islande, Norvège et Suède portant sur 38 523 hommes et 1 998 femmes exerçant la profession d'officier de police, cette étude analyse le risque de cancer lié à la pollution de l'air, au travail de nuit et au rayonnement des radars

Incidence of cancer among Nordic police officers

Heikkinen, Sanna ; Demers, Paul A. ; Hansen, Johnni ; Jakobsen, Jarle ; Kjaerheim, Kristina ; Lynge, Elsebeth ; Martinsen, Jan Ivar ; Sivesind Mehlum, Ingrid ; Pitkäniemi, Janne ; Selander, Jenny ; Torfadóttir, Jóhanna ; Weiderpass, Elisabete ; Pukkala, Eero

Police work may expose officers to various circumstances that have potential for increasing their risk of cancer, including traffic-related air pollution, night shift work, and radiation from radars. In this study, we examined the incidence of cancer among Nordic male and female police officers. We utilize data from the Nordic Occupational Cancer (NOCCA) project, which linked census data on occupations from Finland, Iceland, Norway, and Sweden to national cancer registries for the period [...]

A partir d'une revue de la littérature publiée entre 2007 et 2021 (233 articles), cette étude fait le point sur les effets d'une exposition aux pesticides en Amérique Latine et aux Caraïbes

Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review

Liliana A. Zúñiga-Venegas ; Carly Hyland ; María Teresa Muñoz-Quezada ; Lesliam Quirós-Alcalá ; Mariana Butinof ; Rafael Buralli ; Andres Cardenas ; Ricardo A. Fernandez ; Claudia Foerster ; Nelson Gouveia ; Juan P. Gutiérrez Jara ; Boris A. Lucero ; María Pía Muñoz ; Muriel Ramírez-Santana ; Anna R. Smith ; Noemi Tirado ; Berna van Wendel de Joode ; Gloria M. Calaf ; Alexis J. Handal ; Agnes Soares da Silva ; Sandra Cortés ; Ana M. Mora

Background: Multiple epidemiological studies have shown that exposure to pesticides is associated with adverse health outcomes. However, the literature on pesticide-related health effects in the Latin American and the Caribbean (LAC) region, an area of intensive agricultural and residential pesticide use, is sparse. We conducted a scoping review to describe the current state of research on the health effects of pesticide exposure in LAC populations with the goal of identifying knowledge gaps [...]

Menée à partir de données du registre allemand des cancers pédiatriques portant sur tous les enfants atteints d'une leucémie diagnostiquée entre 2004 et 2019, cette étude analyse l'évolution de l'incidence de la maladie chez les enfants vivant à proximité d'une centrale nucléaire où au moins un réacteur a été arrêté en 2011

Incidence of childhood leukaemia before and after shut down of nuclear power plants in Germany in 2011: A population-based register study during 2004-2019

Russo, Antonello ; Blettner, Maria ; Merzenich, Hiltrud ; Wollschlaeger, Daniel ; Erdmann, Friederike ; Gianicolo, Emilio

The association between leukaemia and proximity to nuclear-power-plants (NPPs) has been assessed in several countries with inconsistent results. A case-control study from Germany had shown an increased risk for childhood leukaemia (diagnoses 1980-2003) near NPPs. Germany began shutting down nuclear reactors in 2011, following the Fukushima disaster. We tested whether the previously observed association between leukaemia and proximity to NPP persisted despite the shutdown. We used an ecological [...]

Menée en Ukraine à l'aide de données du registre des cancers et menée auprès d'une cohorte de 2 631 femmes qui allaitaient et/ou étaient enceintes entre avril et juin 1986, cette étude analyse l'incidence du cancer du sein (26 cas) liée aux retombées d'iode radioactif de Tchernobyl

Breast cancer risk in Ukrainian women exposed to Chornobyl fallout while pregnant or lactating: standardized incidence ratio analysis, 1998 to 2016

Vij, Vibha ; Shpak, Victor ; Zamotayeva, Galyna ; Lapikura, Oles ; Ryzhov, Anton ; Gorokh, Evgeniy ; Zhang, Rui ; Mabuchi, Kiyohiko ; Little, Mark P. ; Drozdovitch, Vladimir ; Chizhov, Konstantin ; Masuik, Sergii ; Preston, Dale ; Tronko, Mykola ; Cahoon, Elizabeth K.

The radiation-related risk of breast cancer among women following the Chornobyl accident remains uncertain. During pregnancy, there is rapid cell proliferation in the breast while radioactive iodine from fallout exposure can concentrate in lactating breast tissues. We conducted a standardized incidence ratio (SIR) analysis of breast cancer in a cohort of 2,631 women who were lactating and/or pregnant at any time during the 2-month period of radioiodine fallout (April 26, 1986–June 30, 1986). [...]

Menée à partir de données 2006-2010 de la "UK Biobank" portant sur 414 209 personnes (âge moyen : 56,3 ans ; 53 % de femmes), cette étude analyse l'association entre le variant I148M de la protéine PNPLA3 et le risque de carcinome hépatocellulaire, en fonction de la consommation d'alcool et de l'obésité

Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality

Kim, Hyun-seok ; Xiao, Xiangjun ; Byun, Jinyoung ; Jun, Goo ; DeSantis, Stacia M. ; Chen, Han ; Thrift, Aaron P. ; El-Serag, Hashem B. ; Kanwal, Fasiha ; Amos, Christopher I.

Alcohol drinking and obesity are associated with an increased risk of cirrhosis and hepatocellular carcinoma (HCC), but the risk is not uniform among people with these risk factors. Genetic variants, such as I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene, may play an important role in modulating cirrhosis and HCC risk.To investigate the joint associations of the PNPLA3 I148M variant, alcohol intake, and obesity with the risk of cirrhosis, HCC, and liver [...]

Menée en Chine sur la période 1996-2000 auprès de 72 807 femmes, cette étude analyse l'association entre des facteurs menstruels ou reproductifs et le risque de cancer primitif du foie (258 cas)

Menstrual Factors, Reproductive History and Liver Cancer Risk: Findings from a Prospective Cohort Study in Chinese Women

Tuo, Jia-Yi ; Li, Hong-Lan ; Wang, Jing ; Fang, Jie ; Tan, Yu-Ting ; Xiang, Yong-Bing

Many studies suggested that menstrual and reproductive factors affected the gender disparity in liver carcinogenesis, but the results were inconsistent. Moreover, there are few studies in Asian populations. Therefore, our study was to explore the association of menstrual and reproductive factors on liver cancer risk in Chinese women.72,807 women were recruited in 1996 to 2000 and followed until the end of 2016 in Shanghai, China. Cox regression models were used to estimate HRs and 95% [...]

Menée à l'aide de données 1987-2018 du registre suédois des patients hospitalisés portant sur 18 598 patients atteints d'un cancer hépatobiliaire (âge moyen au diagnostic : 69,9 ans), cette étude analyse l'association entre 13 comorbidités et le risque de développer un carcinome hépatocellulaire, un cancer de la vésicule biliaire, un cholangiocarcinome ou un cancer ampullaire

Personal Comorbidities and their Subsequent Risks for Liver, Gallbladder and Bile Duct Cancers

Hemminki, Kari ; Sundquist, Kristina ; Sundquist, Jan ; Försti, Asta ; Liska, Vaclav ; Hemminki, Akseli ; Li, Xinjun

Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included alcohol and non-alcohol related liver disease, chronic obstructive pulmonary disease, gallstone [...]

Menée à l'aide des données 1992-2015 d'un registre portant sur 26 199 patients adultes atteints de mucoviscidose, cette étude analyse l'association entre l'indice de masse corporelle, des facteurs aggravants et le risque de cancer (446 cas)

Body mass index and additional risk factors for cancer in adults with cystic fibrosis

Knotts, Rita M. ; Jin, Zhezhen ; Doyle, John B. ; Keating, Claire ; DiMango, Emily ; Abrams, Julian A.

Background: Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed to delineate associations between BMI and other factors with cancer risk in adults with CF. Methods: This was a retrospective cohort study using CF Foundation Patient Registry data from 1992 to 2015. [...]

Menée en Chine sur la période 2016-2019 auprès de 490 témoins et 490 patients atteints d'un cancer du poumon, cette étude analyse l'association entre les niveaux sériques de folates, de 5-méthyltétrahydrofolate (5-mTHF) ou de vitamine B12 et le risque de développer la maladie, en fonction du statut tabagique

Serum total folate, 5-methyltetrahydrofolate and vitamin B12 concentrations on incident risk of lung cancer

Wei, Yaping ; Xu, Benjamin ; He, Qiangqiang ; Chen, Ping ; Zhang, Qi ; Zhang, Xi ; Yuan, Hui ; Duan, Yong ; Wang, Zhuo ; Zhou, Ziyi ; Liu, Lishun ; Song, Yun ; Mao, Guangyun ; Qin, Xianhui ; Tang, Genfu ; Wang, Binyan ; Zhang, Hao ; Guo, Huiyuan ; Shi, Hanping

Tobacco smoking is a major known risk factor for lung cancer. While micronutrients, especially those involved in maintaining DNA integrity and regulating gene expression, may be protective, research on this association is limited. This report aimed to investigate associations of total folate, 5-methyltetrahydrofolate (5-mTHF) and vitamin B12 with incident risk of lung cancer, and whether the associations vary by smoking status. A nested case-control study with 490 incident lung cancer cases and [...]

Menée à partir des données de l'étude française "EPICAP" portant sur 819 patients atteints d'un cancer de la prostate et 879 témoins, cette étude analyse l'association entre des facteurs liés au sommeil (chronotype, insomnie, somnifères...) et le risque de développer la maladie

Sleep Patterns and Risk of Prostate Cancer: A Population-Based Case Control Study in France (EPICAP)

Cordina-Duverger, Emilie ; Cenée, Sylvie ; Tretarre, Brigitte ; Rebillard, Xavier ; Lamy, Pierre-Jean ; Wendeu-Foyet, Gaëlle ; Menegaux, Florence

Sleep disturbances have been singled out for their implication in the risk of several cancer sites. However, results for prostate cancer are still inconsistent.We used data from the EPICAP study, a French population-based case–control study including 819 incident prostate cancer cases and 879 controls frequency matched by age. Detailed information on sleep duration on work/free days, and sleep medication over lifetime was collected.Sleep duration and sleep deprivation were not associated with [...]

Menée en Finlande à l'aide de données portant sur des patientes ayant des antécédents familiaux de cancer du sein et auprès de 1 822 patientes atteintes d'un cancer du sein, cette étude analyse le niveau de risque associé à l'allèle ATM c.7570G>C

ATM c.7570G>C is a high-risk allele for breast cancer

Kankuri-Tammilehto, Minna ; Tervasmäki, Anna ; Kraatari-Tiri, Minna ; Rahikkala, Elisa ; Pylkas, Katri ; Kuismin, Outi

ATM is generally described as a moderate-risk breast cancer susceptibility gene. However, some of ATM variants might encounter higher risk. ATM c.7570G > C, p.Ala2524Pro, (rs769142993) is a pathogenic Finnish founder variant causative for recessively inherited ataxia-telangiectasia. At cellular level, it has been reported to have a dominant-negative effect. ATM c.7570G > C has recurrently been described in Finnish breast cancer families and unselected case cohorts collected from different parts [...]