Menée à partir de données portant sur 474 patients atteints d'un cancer traité par chimiothérapie à base d'anthracycline entre 2009 et 2014 (192 cas de cancer du sein, 184 cas de lymphome, 98 cas de sarcome ; age médian : 61 ans), cette étude rétrospective analyse l'association entre un indice mesurant la masse musculaire des pectoraux et la survenue d'événements cardiaques indésirables induits par les traitements anticancéreux ainsi que la survie

Impact of pectoralis muscle loss on cardiac outcome and survival in Cancer patients who received anthracycline based chemotherapy: retrospective study

Toama, Wael ; Wiederin, Jason ; Shanley, Ryan ; Jewett, Patricia ; Gu, Christina ; Shenoy, Chetan ; Nijjar, Prabhjot S. ; Blaes, Anne H.

Introduction : The impact of pectoralis muscle mass index (PMI) on cardiac events is not well studied in cancer patients, especially in those who have received chemotherapy with high potential cardiac toxicity such as anthracyclines. Methods : Individuals aged ≥18 years with a diagnosis of breast cancer, sarcoma, or lymphoma who received anthracycline-based chemotherapy at the University of Minnesota MHealth Fairview between 2009 and 2014. Eligible patients had to have two CT scans: a baseline [...]

Menée en Guadeloupe à partir de données 2008-2017 du registre des cancers, cette étude analyse l'évolution des disparités géographiques dans l'incidence des cancers

Geographical variations of cancer incidence in Guadeloupe, French West Indies

Bhakkan-Mambir, Bernard ; Deloumeaux, Jacqueline ; Luce, Danièle

Background : Geographical disparities in cancer incidence are observed at different scales and may highlight areas of high risk that need special attention to improve health policies. In Guadeloupe, a French archipelago in the Caribbean, environmental and socioeconomic factors are potential factors associated with cancer incidence. Our objective was to describe geographical variations of cancer incidence in Guadeloupe at a small-area level, in order to identify potential clusters. Methods : We [...]

Menée à partir des données 1990-2017 du registre finlandais des cancers, cette étude analyse l'évolution de l'incidence des tumeurs du système nerveux central chez les enfants (âge : 0-14 ans)

Incidence trends of childhood central nervous system tumors in Finland 1990–2017

Abuhamed, Jad ; Nikkilä, Atte ; Raitanen, Jani ; Alimam, Wafa ; Lohi, Olli ; Pitkäniemi, Janne ; Haapasalo, Hannu ; Auvinen, Anssi

Introduction : Central nervous system (CNS) tumors are a leading cause of cancer-related morbidity and mortality in children. Our aim is to characterize incidence trends of pediatric CNS tumors in Finland over the last three decades. Methods : Data on all benign and malignant incident CNS tumors diagnosed in children aged 0–14 years in 1990–2017 were extracted from the Finnish Cancer Registry and classified according to the 2016 WHO classification of CNS tumors. We analyzed age-standardized [...]

Cet article analyse la prise en charge de l'épilepsie chez les patients atteints d'une tumeur cérébrale

Management of epilepsy in brain tumor patients

Van der Meer, Pim B. ; Taphoorn, Martin J.B. ; Koekkoek, Johan A.F.

Isocitrate dehydrogenase mutation and its active metabolite d-2-hydroxyglutarate seem important contributing factors to epileptogenesis. Antiepileptic drug (AED) levetiracetam seems the preferred choice in brain tumor-related epilepsy. In case of inadequate seizure control on AED monotherapy, potential add-on AEDs include lacosamide, perampanel, and valproic acid. In the end-of-life phase when oral intake of medication is hampered, benzodiazepines via nonoral administration routes are potential [...]

Mené sur 192 patients atteints d'un cancer de la prostate de stade avancé, cet essai randomisé évalue l'intérêt, pour réduire les symptômes et améliorer la qualité de vie, d'une intervention collective de gestion du stress dispensée sur tablette

Who benefits from an eHealth-based stress management intervention in advanced prostate cancer? Results from a randomized controlled trial

Benzo, Roberto M. ; Moreno, Patricia I. ; Noriega-Esquives, Blanca ; Otto, Amy K. ; Penedo, Frank J.

Objective : Conduct a secondary analysis to examine the effects of a tablet-delivered, group-based cognitive-behavioral stress management (CBSM) intervention for reducing symptom burden among men with advanced prostate cancer (APC) and elevated baseline levels of symptom burden Methods : A total of 192 men with APC were randomized to either a CBSM or a health promotion condition and followed for one year. Six analytical samples were included in our study, each including participants who [...]

Menée à partir de données portant sur des patientes ayant survécu à un cancer du sein, cette étude de cohorte rétrospective analyse l'association entre une neuropathie périphérique induite par la chimiothérapie et le risque de dépression et d'anxiété

Chemotherapy-induced peripheral neuropathy onset is associated with early risk of depression and anxiety in breast cancer survivors

McNeish, Brendan L. ; Richardson, James K. ; Whitney, Daniel G.

Objective : The objective was to assess for an association between chemotherapy-induced peripheral neuropathy (CIPN) onset and development of depression and anxiety in breast cancer (BrCa) survivors. Methods : A retrospective observational cohort was used and identified from Optum's De-identified Clinformatics® Data Mart Database years 2012–2015. Three groups of women were derived based on BrCa and CIPN status: BrCa+/CIPN+ (n = 244), BrCa+/CIPN− (n = 8870), and BrCa−/CIPN− (n = 1,125,711). The [...]

A partir d'une revue systématique de la littérature publiée entre 1994 et 2022 (7 études), cette méta-analyse évalue l'effet de soins concernant l'apparence physique sur la santé psychosociale de patientes attteintes d'un cancer du sein (estime de soi, anxieté, dépression, sexualité)

Effects of the appearance care on psychosocial outcomes for breast cancer: a systematic review and meta-analysis

Zhu, Mengyao ; Sun, Shihao ; Zhang, Yiheng ; Chen, Lili ; He, Haiyan ; Chen, Juanjuan ; Zhang, Ni ; Zhang, Meifen

Purpose : To synthesize the evidence for the immediate and short-term effects of appearance care on psychosocial outcomes in breast cancer patients in order to inform the design of future research and clinical practice. Methods : A search of four databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science). The JBI Critical Appraisal Checklists were used by two reviewers to assess methodology quality. Subgroup analysis was conducted for the different time [...]

Menée aux Etats-Unis auprès de 53 parents atteints d'un cancer, cette étude analyse l'intérêt d'une intervention psychosociale en ligne pour les aider à parler de la maladie avec leurs enfants

Families Addressing Cancer Together (FACT): feasibility and acceptability of a web-based psychosocial intervention for parents with cancer

Park, Eliza M. ; Deal, Allison M. ; Heiling, Hillary M. ; Jung, Ahrang ; Yopp, Justin M. ; Bowers, Savannah M. ; Hanson, Laura C. ; Song, Mi-Kyung ; Valle, Carmina G. ; Yi, Brian ; Cassidy, Anna ; Won, Hannah ; Rosenstein, Donald L.

Purpose : Although parents with cancer report that talking with their children about cancer and dying is distressing, accessible support is rare. We assessed the feasibility, acceptability, and preliminary effects of Families Addressing Cancer Together (FACT), a web-based, tailored psychosocial intervention to help parents talk about their cancer with their children. Methods : This pilot study used a pre-posttest design. Eligible participants were parents with new or metastatic solid tumors who [...]

A partir d'une revue de la littérature (25 essais randomisés incluant un total de 5 160 patients), cette méta-analyse évalue l'effet des soins palliatifs sur la qualité de vie des patients adultes atteints d'un cancer de stade avancé

Impact of palliative care on quality of life in advanced cancer: A meta-analysis of randomised controlled trials

Hoomani Majdabadi, Fatemeh ; Ashktorab, Tahereh ; Ilkhani, Mahnaz

Introduction : This study aimed to examine the impact of palliative care on the life quality of adults with advanced cancer. Methods : After a comprehensive and regular search using [MeSH] keywords in some important databases, 25 published randomised controlled trials (RCTs) involving 5160 adults with advanced cancer were selected and examined through meta-analysis. Results : Analysis of 36 reports in 1–3 months follow-up, and 19 reports in 4–7 months follow-up, showed that compared to usual [...]

A partir d'une revue sytématique de la littérature (57 études), cette étude analyse les différents outils permettant d'évaluer et de prendre en charge la fatigue liée à la maladie chez des patients atteints d'un cancer et recevant des soins palliatifs

Cancer-related fatigue measures in palliative care: A psychometric systematic review

Montagut-Martínez, Pedro ; Pérez-Cruzado, David ; Gutiérrez-Sánchez, Daniel

Introduction : In palliative care, the prevention and relief of fatigue are regarded as crucial goals in patients with cancer. Methods : A systematic review was carried out according to the COnsensus-based Standards for the selection of health status Measurement INstruments methodology. Searches were conducted in Medline (through PubMed), Web of Science, Open Gray, Scielo, Cochrane, CINAHL and EMBASE. All instruments found in each study were assessed using the COnsensus-based Standards for the [...]

Cet article identifie les problèmes éthiques liés à l'utilisation des technologies de l'intelligence artificielle en cancérologie et propose une feuille de route pour le déploiement de ces technologies

A Process Framework for Ethically Deploying Artificial Intelligence in Oncology

Hantel, Andrew ; Clancy, Dillon D. ; Kehl, Kenneth L. ; Marron, Jonathan M. ; Van Allen, Eliezer M. ; Abel, Gregory A.

Artificial Intelligence (AI) is an emerging technology that uses complex algorithms to arrive at an outcome over a range of circumstances, leveraging the ability of computer systems to perform tasks that would usually require human levels of intelligence.1-3 The use of AI in cancer care is rapidly expanding: a May 2022 PubMed search of the term cross-referenced with cancer revealed approximately 26,000 citations, with more than 60% published in the past five years. Ethical considerations for AI [...]

Menée en Allemagne, cette étude analyse les informations concernant les médecines complémentaires et alternatives communiquées par les médecins généralistes à leurs patients atteints d'un cancer

General practitioners' communication on complementary and integrative medicine for cancer patients: Findings from an analysis of consultations with standardised patients

Engler, Jennifer ; Güthlin, Corina ; Bertram, Laura ; Tesky, Valentina ; Schall, Arthur ; Joos, Stefanie ; Valentini, Jan

Objective : Our aim was to explore whether general practitioners (GPs) communicate with cancer patients on complementary and integrative medicine (CIM) in a patient-centred and case-specific manner. Methods : We designed two cases of standardised breast cancer patients and allocated 29 GPs to hold a consultation either with Case 1 or Case 2. Case 1 presented with fears of possible physical side effects of hormone treatment. Case 2 feared a loss in social functioning because of nausea and emesis [...]