Menée à l'aide des données de 6 études américaines portant sur 544 016 personnes (durée de suivi : 20-37 ans), cette étude analyse l'association entre l'indice de masse corporelle chez l'adulte jeune (18-21 ans), l'indice de masse corporelle chez l'adulte, le tour de taille, la masse grasse et le risque de myélome multiple (2 756 cas)

Anthropometric traits and risk of multiple myeloma: a pooled prospective analysis

Bertrand, Kimberly A. ; Teras, Lauren R. ; Deubler, Emily L. ; Chao, Chun R. ; Rosner, Bernard A. ; Wang, Ke ; Zhong, Charlie ; Wang, Sophia S. ; Birmann, Brenda M.

Background: Obesity is a risk factor for multiple myeloma (MM), yet results of prior studies have been mixed regarding the importance of early and/or later adult obesity; other measures of body composition have been less well studied. Methods: We evaluated associations of early adult (ages 18–21) and usual adult body mass index (BMI), waist circumference, and predicted fat mass with MM by pooling data from six U.S. prospective cohort studies comprising 544,016 individuals and 2756 incident [...]

Menée à partir de données de la cohorte européenne EPIC portant sur 327 790 personnes (durée médiane de suivi : 15 ans), cette étude analyse l'association entre 92 aliments ou nutriments et le risque de cancer du poumon (2 420 cas)

Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Heath, Alicia K. ; Muller, David C. ; van den Brandt, Piet A. ; Critselis, Elena ; Gunter, Marc ; Vineis, Paolo ; Weiderpass, Elisabete ; Boeing, Heiner ; Ferrari, Pietro ; Merritt, Melissa A. ; Rostgaard-Hansen, Agnetha L. ; Tjønneland, Anne ; Overvad, Kim ; Katzke, Verena ; Srour, Bernard ; Masala, Giovanna ; Sacerdote, Carlotta ; Ricceri, Fulvio ; Pasanisi, Fabrizio ; Bueno-de-Mesquita, Bas ; Downward, George S. ; Skeie, Guri ; Sandanger, Torkjel M. ; Crous-Bou, Marta ; Rodriguez-Barranco, Miguel ; Amiano, Pilar ; Huerta, José María ; Ardanaz, Eva ; Drake, Isabel ; Johansson, Mikael ; Johansson, Ingegerd ; Key, Tim ; Papadimitriou, Nikos ; Riboli, Elio ; Tzoulaki, Ioanna ; Tsilidis, Konstantinos K.

It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327,790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per standard deviation (SD) higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the [...]

Menée à l'aide d'échantillons sanguins collectés auprès de 2 718 femmes ménopausées, cette étude analyse l'association entre le niveau plasmatique de 38 acides gras phospholipidiques et le risque de cancer du sein (905 cas)

Circulating plasma phospholipid fatty acid levels and breast cancer risk in the Cancer Prevention Study-II Nutrition Cohort

Matta, Michèle ; Deubler, Emily ; Chajès, Veronique ; Vozar, Beatrice ; Gunter, Marc J. ; Murphy, Neil ; Gaudet, Mia M.

Prospective studies that objectively measure circulating levels of fatty acids are needed to clarify their role in the aetiology of breast cancer. Thirty-eight phospholipid fatty acids were measured using gas chromatograph in the plasma fraction of blood samples collected prospectively from 2,718 postmenopausal women (905 breast cancer cases) enrolled in the Cancer Prevention Study II Nutrition Cohort. Associations of 28 fatty acids that passed quality control metrics (modelled as per [...]

Menée à partir de données du registre suédois des cancers portant sur les individus de moins de 20 ans nés entre 1960 et 2014, cette étude analyse l'association entre une exposition maternelle ou paternelle aux solvants hydrocarbonés et aux gaz d'échappement des moteurs essence ou diesel et le risque de cancer chez l'enfant

Risk of Cancer in Children of Parents Occupationally Exposed to Hydrocarbon Solvents and Engine Exhaust Fumes: A Register-Based Nested Case-Control Study from Sweden (1960-2015)

Marios Rossides ; Christina-Evmorfia Kampitsi ; Mats Talbäck ; Hanna Mogensen ; Pernilla Wiebert ; Maria Feychting ; Giorgio Tettamanti

Background: It remains unclear whether parental occupational exposure to hydrocarbon solvents (HCS) or engine exhaust fumes (EEF) is associated with higher risks of cancer in the offspring. Objectives: Our aim was to estimate relative risks of childhood cancers associated with maternal or paternal exposure to aliphatic/alicyclic, aromatic, or chlorinated HCS or gasoline/diesel EEF. Methods: We conducted a case–control study in which individuals <20y old, born 1960–2014, were identified from the [...]

Menée auprès de 451 945 personnes (âge : 50-71 ans ; durée moyenne de suivi : 12,2 ans), cette étude analyse l'association entre la lumière nocturne extérieure et le risque de cancer du foie (897 cas)

Outdoor light at night and risk of liver cancer in the NIH-AARP diet and health study

Park, Yikyung ; Ramirez, Yesenia ; Xiao, Qian ; Liao, Linda M. ; Jones, Gieira S. ; McGlynn, Katherine A.

Purpose: Accumulating evidence suggests that light at night (LAN) disrupts circadian rhythms and may increase risk of liver cancer. However, there is no population-based study that examined LAN and liver cancer risk. Therefore, we aimed to investigate the association between outdoor LAN and liver cancer risk in a prospective cohort. Methods: Residential outdoor LAN level was measured from satellite imagery in the NIH-AARP Diet and Health Study, a prospective cohort of 451,945 men and women, [...]

Menée à partir des données d'une étude japonaise portant sur des échantillons sanguins prélevés sur 7 849 personnes, cette étude analyse l'association entre la concentration plasmatique de fer, ferritine ou hepcidine et le risque de cancer

Association of plasma iron status with subsequent risk of total and site-specific cancer: A large case-cohort study within JPHC Study

Miyamoto, Yoshihisa ; Nakano, Shiori ; Ihira, Hikaru ; Yamaji, Taiki ; Katagiri, Ryoko ; Sawada, Norie ; Inoue, Manami ; Tsugane, Shoichiro ; Iwasaki, Motoki

It is unclear whether prediagnostic iron-related biomarkers in circulation are associated with cancer risk. We constructed a case-cohort of participants who had plasma samples available from the Japan Public Health Center-based Prospective Study and determined the incidence of cancer in these participants. We measured plasma concentrations of iron, ferritin, and hepcidin and assessed the association between each biomarker and cancer incidence using a weighted Cox regression model. There were [...]

Menée à l'aide d'une méthode de randomisation mendélienne et des données de deux études d'association à l'échelle du génome portant sur 372 617 personnes, cette étude analyse l'association entre la protéine C-réactive, les régulateurs inflammatoires sériques et le risque de myélome multiple

Causal Relationships Between Inflammatory Factors and Multiple Myeloma: A Bidirectional Mendelian Randomization Study

Wang, Qiangsheng ; Shi, Qiqin ; Lu, Jiawen ; Wang, Zhenqian ; Hou, Jian

Changes in serum inflammatory factors occur throughout the onset and multiple myeloma (MM) progression, the feedback loops make it harder to distinguish between causes and effects. In the present study, we performed a bidirectional summary-level Mendelian randomization (MR) analysis to elucidate the causal relationships of C-reactive protein (CRP) and inflammatory regulators with MM. Summary-level data of genetic variants associated with inflammation were extracted from two genome-wide [...]