Menée à partir des données 2002-2016 du projet "TRACTOR" portant sur l'ensemble de la main-d'oeuvre agricole française, cette étude analyse l'association entre 26 activités agricoles et le risque de tumeur du système nerveux central (1 017 cas)

Agricultural activities and risk of central nervous system tumors among French farm managers: results from the TRACTOR project

Petit, Pascal ; Gandon, Gérald ; Chabardès, Stéphan ; Bonneterre, Vincent

The etiology of central nervous system (CNS) tumors is complex and involves many suspected risk factors. Scientific evidence is still insufficient, in particular in the agricultural field. The goal of this study was to investigate associations between agricultural activities and CNS tumors in the entire French farm manager workforce using data from the TRACTOR project. The TRACTOR project hold a large administrative health database covering the entire French agricultural workforce, over the [...]

Menée en Asie auprès de 538 835 personnes, cette étude internationale analyse l'association entre l'indice de masse corporelle et le risque de cancer gastrique (8 997 cas)

Association between body mass index and risk of gastric cancer by anatomical and histological subtypes in over 500,000 East and Southeast Asian cohort participants

Jang, Jieun ; Lee, Sangjun ; Ko, Kwang-Pil ; Abe, Sarah K. ; Rahman, Md Shafiur ; Saito, Eiko ; Islam, Md Rashedul ; Sawada, Norie ; Shu, Xiao-Ou ; Koh, Woon-Puay ; Sadakane, Atsuko ; Tsuji, Ichiro ; Kim, Jeongseon ; Oze, Isao ; Nagata, Chisato ; Tsugane, Shoichiro ; Cai, Hui ; Yuan, Jian-Min ; Gao, Yu-Tang ; Ozasa, Kotaro ; Matsuyama, Sanae ; Kanemura, Seiki ; Shin, Aesun ; Ito, Hidemi ; Wada, Keiko ; Sugawara, Yumi ; Chen, Yu ; Ahsan, Habibul ; Boffetta, Paolo ; Chia, Kee Seng. ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Park, Sue K.

Background: This study was performed to investigate the association between body mass index (BMI) and gastric cancer (GC) in East and Southeast Asia where most of GC is non-cardia GC. Methods: Based on 8,997 GC cases among the Asia Cohort Consortium participants from China, Japan, Korea, and Singapore (N=538,835), we assessed GC risk according to BMI by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) using the Cox proportional hazard regression model. Results: A U-shaped [...]

Menée auprès de 1 215 personnes incluses dans l'essai européen "Selenium Trial" puis validée auprès de 1 491 participants à une étude autrichienne, cette étude d'association à l'échelle du génome entier identifie les variants génétiques associés au risque d'adénome colorectal métachrone

Genome-Wide Association Study of Metachronous Colorectal Adenoma Risk among Participants in the Selenium Trial

Trejo, Mario Jesus ; Batai, Ken ; Chen, Yuliang ; Brezina, Stefanie ; Chow, H. H. Sherry ; Ellis, Nathan ; Lance, Peter ; Hsu, Chiu-Hsieh ; Pogreba-Brown, Kristen ; Bishop, Maria ; Gsur, Andrea ; Jacobs, Elizabeth T.

Genetic variants related to colorectal adenoma may help identify those who are at highest risk of colorectal cancer development or illuminate potential chemopreventive strategies. The purpose of this genome-wide association study was to identify genetic variants that are associated with risk of developing a metachronous colorectal adenoma among 1,215 study participants of European descent from the Selenium Trial. Associations of variants were assessed with logistic regression analyses and [...]