Cet article passe en revue les données concernant le risque de lésions gonadiques associées aux traitements chez les patients ayant développé une tumeur de Wilms pendant l'enfance puis présente les options de préservation de la fertilité ainsi que des recommandations

White paper: Oncofertility in pediatric patients with Wilms tumor

van der Perk, M. E. Madeleine ; Cost, Nicholas G. ; Bos, Annelies M. E. ; Brannigan, Robert ; Chowdhury, Tanzina ; Davidoff, Andrew M. ; Daw, Najat C. ; Dome, Jeffrey S. ; Ehrlich, Peter ; Graf, Norbert ; Geller, James ; Kalapurakal, John ; Kieran, Kathleen ; Malek, Marcus ; McAleer, Mary F. ; Mullen, Elizabeth ; Pater, Luke ; Polanco, Angela ; Romao, Rodrigo ; Saltzman, Amanda F. ; Walz, Amy L. ; Woods, Andrew D. ; van den Heuvel-Eibrink, Marry M. ; Fernandez, Conrad V.

The survival of childhood Wilms tumor is currently around 90%, with many survivors reaching reproductive age. Chemotherapy and radiotherapy are established risk factors for gonadal damage and are used in both COG and SIOP Wilms tumor treatment protocols. The risk of infertility in Wilms tumor patients is low but increases with intensification of treatment including the use of alkylating agents, whole abdominal radiation or radiotherapy to the pelvis. Both COG and SIOP protocols aim to limit the [...]

Menée à l'aide de données de registres des cancers et du VIH dans 12 régions des États-Unis, cette étude analyse l'évolution, sur la période 2001-2015, de l'incidence du carcinome épidermoïde anal chez les personnes infectées par le VIH

Impact of HIV on Anal Squamous Cell Carcinoma Rates in the United States, 2001-2015

Zhang, Elizabeth R ; Pfeiffer, Ruth M ; Austin, April ; Clarke, Megan A ; Hayes, Jennifer ; Horner, Marie-Josephe ; Monterosso, Analise ; Pawlish, Karen S ; Engels, Eric A ; Shiels, Meredith S

Incidence of anal squamous cell carcinoma (SCC) has increased in the U.S. Persons living with HIV (PLWH) have an elevated risk of anal SCC, and changes in the number of anal SCCs among PLWH may have influenced general population trends.Data were obtained from a linkage of HIV and cancer registries in 12 U.S. regions. The proportion of anal SCCs occurring among PLWH was estimated by sex, age group and race and ethnicity. To assess the impact of anal SCCs among PLWH on general population trends, [...]

Menée à partir des données des registres américains des cancers portant sur 60 146 patients atteints d'un cancer du foie diagnostiqué entre 2004 et 2018, cette étude analyse les disparités ethniques dans le stade de la maladie au diagnostic et dans la mortalité spécifique

Disparities in risk of advanced stage liver cancer and mortality by race and ethnicity

Li, Delfino Y ; VoPham, Trang ; Tang, Mei-Tzu C ; Li, Christopher I

Background : In the United States liver cancer is the 5th and 7th most common cause of cancer related-death among men and women, respectively. Compared to other racial/ethnic groups in the U.S. Asian and Pacific Islander populations experience the highest incidence rates of liver cancer, but little is known about disparities in risk of advanced stage disease or risk of liver cancer mortality across these heterogenous populations. All statistical tests were 2-sided. Methods : In a [...]

Menée aux Etats-Unis auprès de 1 768 patients ayant survécu à un cancer du sein, de la prostate ou du côlon-rectum, cette étude multicentrique identifie les facteurs associés à l'utilisation des soins de santé et au retard dans les soins médicaux

Healthcare utilization in cancer survivors: six-month longitudinal cohort data

Gonzalez, Nicole ; Mead, K. Holly ; Pratt-Chapman, Mandi L. ; Arem, Hannah

Purpose: To describe healthcare utilization and reasons for delaying medical care and to identify factors that influence high healthcare utilization and care delay among cancer survivors. Methods: Baseline (n = 991) and 6 month follow-up data (n = 777) were collected among breast, prostate, and colorectal cancer survivors from 32 US cancer centers. Participants completed surveys on healthcare utilization (e.g., number of visits to specific providers) and delay of medical care. We categorized [...]

Menée en Angleterre à partir de données portant sur des patients décédés d'un cancer entre 2010 et 2017, cette étude rétrospective analyse l'utilisation des soins de santé, leur intensité et les coûts associés, durant les 12 derniers mois de vie

Intensity of care in cancer patients in the last year of life: a retrospective data linkage study

Luta, Xhyljeta ; Diernberger, Katharina ; Bowden, Joanna ; Droney, Joanne ; Hall, Peter ; Marti, Joachim

Background : Delivering high-quality palliative and end-of-life care for cancer patients poses major challenges for health services. We examine the intensity of cancer care in England in the last year of life. Methods : We included cancer decedents aged 65+ who died between January 1, 2010 and December 31, 2017. We analysed healthcare utilisation and costs in the last 12 months of life including hospital-based activities and primary care. Results : Healthcare utilisation and costs increased [...]

Menée à partir de données 1980-2009 des registres américains des cancers portant sur 4 288 adolescents ou jeunes adultes ayant survécu au moins 5 ans à une leucémie (durée médiane de suivi : 12,3-12,7 ans), cette étude analyse les facteurs associés à la survie à long terme

Long-Term Outcomes among Adolescent and Young Adult Survivors of Acute Leukemia: A Surveillance, Epidemiology, and End Results Analysis

Berkman, Amy M. ; Andersen, Clark R. ; Cuglievan, Branko ; McCall, David C. ; Lupo, Philip J. ; Parsons, Susan K. ; DiNardo, Courtney D. ; Short, Nicholas J. ; Jain, Nitin ; Kadia, Tapan M. ; Livingston, J.A. ; Roth, Michael E.

There is a growing population of adolescent and young adult (AYA, age 15–39 years) acute leukemia survivors in whom long-term mortality outcomes are largely unknown.The current study utilized the Surveillance, Epidemiology, and End Results (SEER) registry to assess long-term outcomes of AYA acute leukemia 5-year survivors. The impact of diagnosis age, sex, race/ethnicity, socioeconomic status, and decade of diagnosis on long-term survival were assessed utilizing an accelerated failure time [...]

Menée à partir de données portant sur 9 702 patientes atteintes d'un cancer du sein localisé et incluses dans des essais du "National Cancer Institute", cette étude analyse la survie sans récidive à distance en fonction de l'origine ethnique

Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials

Kim, Gina ; Pastoriza, Jessica M. ; Qin, Jiyue ; Lin, Juan ; Karagiannis, George S. ; Condeelis, John S. ; Yothers, Greg ; Anderson, Stewart ; Julian, Thomas ; Entenberg, David ; Rohan, Thomas E. ; Xue, Xiaonan ; Sparano, Joseph A. ; Oktay, Maja H.

Background: Black race is associated with worse outcome in patients with breast cancer. The distant relapse-free survival (DRFS) between Black and White women with localized breast cancer who participated in National Cancer Institute–sponsored clinical trial was evaluated. Methods: Pooled data were analyzed from 8 National Surgical Adjuvant Breast and Bowel Project (NSABP) trials including 9702 women with localized breast cancer treated with adjuvant chemotherapy (AC, n = 7485) or neoadjuvant [...]

Menée à partir de données 1997-2009 du registre des cancers de l'Utah portant sur 6 641 patientes ayant survécu au moins 10 ans à un cancer du sein et auprès de 36 612 témoins de la population générale, cette étude analyse l'incidence des maladies cardiovasculaires et les facteurs de risque associés

Cardiovascular disease risk in long-term breast cancer survivors: A population-based cohort study

Koric, Alzina ; Chang, Chun-Pin ; Mark, Bayarmaa ; Rowe, Kerry ; Snyder, John ; Dodson, Mark ; Deshmukh, Vikrant G. ; Newman, Michael G. ; Fraser, Alison M. ; Smith, Ken R. ; Date, Ankita P. ; Gren, Lisa H. ; Porucznik, Christina A. ; Haaland, Benjamin A. ; Henry, N. Lynn ; Hashibe, Mia

Background: Breast cancer survival is increasing, making late effects such as cardiovascular disease (CVD) more relevant. The purpose of this study was to evaluate incident CVD following breast cancer diagnosis among long-term survivors and to investigate possible risk factors for CVD. Methods: A population-based cohort of 6641 breast cancer survivors diagnosed between 1997 and 2009 who survived at least 10 years was identified within the Utah Cancer Registry. In addition, 36,612 cancer-free [...]

Menée aux Etats-Unis auprès de 455 patients ayant survécu à un cancer du testicule (âge médian : 31 ans ; durée médiane de suivi : 26 mois), cette étude analyse l'association entre la répartition de la graisse corporelle après une chimiothérapie à base de cisplatine et le risque cardiométabolique

Associations of Body Fat Distribution and Cardiometabolic Risk of Testicular Cancer Survivors after Cisplatin-Based Chemotherapy

Wibmer, Andreas G ; Dinh, Paul C, Jr ; Travis, Lois B ; Chen, Carol ; Bromberg, Maria ; Zheng, Junting ; Capanu, Marinela ; Sesso, Howard D ; Feldman, Darren R ; Vargas, Hebert Alberto

It is unknown how body fat distribution modulates the cardiometabolic risk of testicular cancer survivors (TCSs) after cisplatin-based chemotherapy.For 455 patients enrolled in The Platinum Study at Memorial Sloan Kettering Cancer Center, visceral (VAT) and subcutaneous (SAT) adipose tissue was quantified on pre-chemotherapy CT. VAT/SAT ratio was calculated as a quantitative measure of central adiposity. Endpoints were incidence of new post-chemotherapy cardiometabolic disease (new [...]

Menée en Corée par enquête auprès de 1 033 patients adultes ayant survécu à un cancer, cette étude transversale analyse la présence de pensées suicidaires, 5 ans ou plus après le diagnostic

Suicidal ideation in long-term adult cancer survivors: Findings of a nationwide cross-sectional study

Hwang, In Cheol ; Ahn, Hong Yup ; Suh, Heuy Sun

Background: Cancer survivors suffer substantial psychological distress, but little is known about their vulnerabilities to suicidal ideation more than 5 years after diagnosis. Methods: We compared suicidal ideation among 1,033 adult cancer survivors, who had received a diagnosis of cancer more than 5 years previously, with that among individuals without a cancer history using nationwide survey data. Logistic regression models were used to evaluate suicidal ideation in cancer survivors. Results: [...]

Menée aux Pays-Bas auprès de 61 patientes atteintes d'un cancer du sein, cette étude prospective analyse l'association entre des symptômes d'anxiété et de dépression présents avant le début d'une chimiothérapie à base de taxane et le risque de neuropathie périphérique

Symptoms of anxiety but not depression before start of taxane-based chemotherapy are associated with peripheral neuropathy: a multicenter study in women with breast cancer

Verhoeff-Jahja, Rita ; ter Kuile, Moniek M. ; Weijl, Nir I. ; Oosterkamp, Rianne ; Cloos, Marissa ; Portielje, Johanneke E. A. ; Kroep, Judith R. ; Hinnen, Chris

Background : Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy, especially after taxane-based therapy. This study aimed to examine the relationship between symptoms of anxiety and depression before the start of taxane-based chemotherapy and the development of CIPN in women with breast cancer. Methods : In this prospective study, women with breast cancer receiving taxane-based (neo)adjuvant chemotherapy were recruited from four hospitals in the [...]