Menée aux Etats-Unis, cette étude compare les symptômes déclarés par les patients pédiatriques atteints d'un cancer et recevant une chimiothérapie (âge : 7-18 ans) et ceux déclarés par leurs aidants familiaux ou proches

Profile Comparison of Patient-Reported and Proxy-Reported Symptoms in Pediatric Patients With Cancer Receiving Chemotherapy

Weaver, Meaghann S. ; Jacobs, Shana S. ; Withycombe, Janice S. ; Wang, Jichuan ; Greenzang, Katie A. ; Baker, Justin N. ; Hinds, Pamela S.

Importance : The variability in individual symptom and adverse event reporting between pediatric patient-reports and proxy-reports is widely reported. However, the question of whether symptom profiles based on reports from children with cancer and their caregivers are similar or disparate have not yet been studied. Objective : To compare proxy symptom reports with patient self-reports to assess alignment. Design, Setting, and Participants : A multicenter cohort study was conducted from October [...]

Menée en Italie auprès de 125 patients pédiatiques atteints d'une leucémie aiguë récemment diagnostiquée et de témoins sains, cette étude analyse leurs stratégies pour faire face à la douleur

Pain coping strategies in paediatric patients newly diagnosed with leukaemia compared with healthy peers

Tremolada, Marta ; Tasso, Giulia ; Bonichini, Sabrina ; Taverna, Livia ; Tumino, Manuela ; Putti, Maria Caterina ; Biffi, Alessandra ; Pillon, Marta

Objective : Children with leukaemia experience special difficulties adapting to stressful medical procedures and to the adverse effects of chemotherapy, though they can implement their coping strategies. The aims of the study were to assess whether the coping-with-pain strategies could be influenced by a child's personal and illness factors and to render possible comparisons between children with leukaemia and healthy peers. Another aim was to compare parents' and children's reports on coping [...]

Mené sur 62 adolescents et jeunes adultes atteints d'un cancer, cet essai randomisé évalue l'intérêt d'une intervention à base de musique jouée en direct par des musicothérapeutes professionnels pour améliorer leur bien-être physique et psychologique pendant une greffe de cellules souches hématopoïétiques

The efficacy of live music for adolescent and young adult patients during hematopoietic stem cell transplantation

Xie, Jianfei ; Wan, Ziyu ; Duan, Yinglong ; Wang, Miao ; Luo, Yating ; Xiao, Panpan ; Kang, Yue ; Zhou, Yi ; Luo, Xiaofei ; Sun, Qian ; Cheng, Andy S. K.

Background : Music therapy can improve mood in patients undergoing hematopoietic stem cell transplantation (HSCT). However, live music (LM) delivered by professional music therapists is not common in developing countries owing to the shortage of professional music therapists. Thus, in this study, we explored the effects of a multidisciplinary collaborative intervention based on LM on physical and psychological well-being of adolescent and young adult (AYA) patients undergoing HSCT with a [...]

Menée en Australie à partir de données portant sur des patientes ayant survécu à un cancer du sein, cette étude analyse l'association entre des facteurs liés au rythme circadien (chronotype, amplitude, stabilité) et des symptômes de fatigue, d'insomnie et de dépression

The association of circadian parameters and the clustering of fatigue, depression, and sleep problems in breast cancer survivors: a latent class analysis

de Rooij, Belle H. ; Ramsey, Imogen ; Clouth, Felix J. ; Corsini, Nadia ; Heyworth, Jane S. ; Lynch, Brigid M. ; Vallance, Jeff K. ; Boyle, Terry

Purpose : Circadian rhythms control a wide range of physiological processes and may be associated with fatigue, depression, and sleep problems. We aimed to identify subgroups of breast cancer survivors based on symptoms of fatigue, insomnia, and depression; and assess whether circadian parameters (i.e., chronotype, amplitude, and stability) were associated with these subgroups over time. Methods : Among breast cancer survivors, usual circadian parameters were assessed at 3–4 months after [...]

Menée au Canada par enquête auprès de 116 patients ayant survécu à un cancer de la tête et du cou, cette étude prospective analyse leur qualité de vie et leurs besoins et préférences vis à-vis des soins de suivi, 1, 2 et 3 ans après les traitements curatifs

Routine follow-up care for head and neck cancer after curative treatment: A 3-year experience of measuring patients' self-reported needs, preferences, quality of life and attitudes towards follow-up

Brennan, Kelly ; Hall, Stephen ; Yoo, John ; Rohland, Susan ; Theurer, Julie ; Peng, Paul

Objective : To evaluate and describe attitudes, quality of life (Qol), needs and preferences of patients with head and neck cancer after 3 years of follow-up care. Methods : This is an exploratory prospective study of recurrence-free patients. Survey results were compared between 1-, 2- and 3-year post-treatment and by disease characteristics. Results : A total of 116 patients were included with 46% oropharyngeal cancer, 66% early stage disease and 41% having had surgery. After 3 years, most [...]

Menée aux Etats-Unis, cette étude transversale analyse les difficultés d'accès aux soins en raison de problèmes de transport chez les patients ayant survécu à un cancer

Self-reported Transportation Barriers to Health Care Among US Cancer Survivors

Jiang, Changchuan ; Yabroff, K. Robin ; Deng, Lei ; Wang, Qian ; Perimbeti, Stuthi ; Shapiro, Charles L. ; Han, Xuesong

In 2019, there were 16.9 million cancer survivors in the US; prevalence is projected to reach 22.1 million by 2031.1 Cancer survivors have increased health care needs, given their elevated risk of comorbid illnesses and subsequent cancers,2 and timely access to care is critical to optimize health outcomes. Transportation barriers can impede timely access and treatment adherence.3 Nevertheless, little is known about delays in care due to transportation barriers affecting survivors. To inform [...]

Menée à partir des données des registres américains des cancers portant sur 187 487 patients atteints d'un mélanome cutané invasif diagnostiqué entre 2010 et 2018, cette étude analyse l'épaisseur du mélanome en fonction de l'origine ethnique, de facteurs socioéconomiques et du sexe

Differences in Thickness-Specific Incidence and Factors Associated With Cutaneous Melanoma in the US From 2010 to 2018

Chen, Michael L. ; de Vere Hunt, Isabella Joy ; John, Esther M. ; Weinstock, Martin A. ; Swetter, Susan M. ; Linos, Eleni

Importance : The recent incidence of cutaneous melanoma of different thicknesses in the US is not well described. Objective : To evaluate recent patterns in the incidence of melanoma by tumor thickness and examine associations of sex, race and ethnicity, and socioeconomic status with melanoma thickness-specific incidence. Design, Setting, and Participants : This population-based cohort study analyzed data for 187 487 patients with a new diagnosis of invasive cutaneous melanoma from the [...]

Menée en Australie, cette étude analyse les disparités géographiques dans l'incidence du mésothéliome et dans la survie

Geographic distribution of malignant mesothelioma incidence and survival in Australia

Cameron, Jessica K. ; Aitken, Joanne ; Reid, Alison ; Mengersen, Kerrie ; Cramb, Susanna ; Preston, Paige ; Armstrong, Bruce ; Baade, Peter

Objectives : To understand the geographic distribution of and area-level factors associated with malignant mesothelioma incidence and survival in Australia. Materials and Methods : Generalised linear models and Bayesian spatial models were fitted using populationregistry data. Area-level covariates were socioeconomic quintile, remoteness categoryand state or territory. The maximised excess events test was used to test for spatialheterogeneity. Results : There was strong evidence of spatial [...]

Menée aux Pays-Bas à partir de données portant sur des patients atteints d'un cancer du poumon non épidermoïde non à petites cellules de stade IV, cette étude de cohorte rétrospective analyse la présence de mutations au niveau du gène KRAS, notamment la mutation p.(G12C)

Prevalence of KRAS p.(G12C) in stage IV NSCLC patients in the Netherlands; A nation-wide retrospective cohort study

Cajiao Garcia, Betzabel N. ; van Kempen, Léon C. ; Kuijpers, Chantal C. H. J. ; Schuuring, Ed ; Willems, Stefan M. ; van der Wekken, Anthonie J.

Objectives : The recent accelerated FDA approval of sotorasib, a highly selective KRAS G12C inhibitor, offers new opportunities for the treatment of KRAS p.(G12C)-mutated non-squamous non-small cell lung cancer (NSCLC). The objective of the current study was to the determine the prevalence of KRAS mutations in stage IV non-squamous NSCLC in lung cancer in The Netherlands to reveal the potential impact of upcoming KRAS targeted therapy. Materials and methods : All patients diagnosed with stage [...]

Menée en Chine par enquête auprès de 17 hommes et 16 femmes atteints d'un cancer, cette étude analyse leur état psychologique et leur décision vis-à-vis du recours à des techniques de préservation de la fertilité

Psychological State and Decision Perceptions of Male and Female Cancer Patients on Fertility Preservation

Chen, Minxin ; Zhang, Yin ; Zhang, Feng ; Jiang, Feng ; Wang, Xiao

Objective : This study explored the emotional state and decision perceptions of fertility preservation (FP) decisions of male and female cancer patients undergoing FP. Setting : Obstetrics & Gynecology Hospital of Fudan University. Methods : All patients with a cancer diagnosis were referred by their physician to contact a fertility preservation specialist for FP plan discussion. After FP counseling, participants completed sociodemographic and basic information surveys and validated [...]

Menée en Australie par questionnaire auprès de 294 patients atteints d'un cancer de stade invasif, cette étude détermine les valeurs-seuil de différents systèmes de score pour identifier les patients présentant des symptômes cognitifs pendant la chimiothérapie

Screening for cognitive symptoms among cancer patients during chemotherapy: Sensitivity and specificity of a single item self-report cognitive change score

Fardell, Joanna E. ; Bray, Victoria ; Bell, Melanie L. ; Rabe, Brooke ; Dhillon, Haryana ; Vardy, Janette L.

Objectives : Cognitive symptoms are commonly reported among cancer patients and survivors, yet guidance on when self-reported cognitive symptoms warrant follow-up is lacking. We sought to establish cut-off scores for identifying patients with perceived low cognitive functioning on widely used self-report measures of cognition and a novel single item Cognitive Change Score. Methods : Adult patients diagnosed with invasive cancer who had completed at least one cycle of chemotherapy completed a [...]

A partir d'une revue de la littérature publiée jusqu'en février 2021 (28 études incluant un total de 22 407 690 patients), cette méta-analyse évalue le risque de décès par suicide des patients atteints d'un cancer

Suicide risk and mortality among patients with cancer

Heinrich, Michael ; Hofmann, Luisa ; Baurecht, Hansjörg ; Kreuzer, Peter M. ; Knüttel, Helge ; Leitzmann, Michael F. ; Seliger, Corinna

Despite substantial progress in cancer therapy in recent decades, patients with cancer remain at high suicide risk. Data from individual studies have not been comprehensively quantified and specific risk factors are ill-defined. We assessed suicide mortality risk according to cancer prognosis, stage, time since diagnosis, gender, ethnicity, marital status, year of recruitment and geographic region. We searched EMBASE, MEDLINE, PsycINFO, Web of Science, CINAHL and Google Scholar for relevant [...]

Mené sur 120 patients atteints d'un cancer et ayant subi une colostomie, cet essai randomisé évalue l'intéret et les mécanismes d'une intervention psychologique positive pour améliorer leur bien-être psychique

The efficacy and mechanism of positive psychological intervention on well-being for colostomy patients: a randomized controlled trial

Jin, Yanfei ; Wang, Yuqing ; Ma, Hongwen ; Tian, Xu ; Wang, Honghong

Aims : The positive psychology intervention (PPI) is an effective therapy designed to motivate individuals’ positive quality and power, to help them survive in an adverse situation, and to establish a high-quality personal and social life. This study aims to evaluate the efficacy and mechanism of PPI on the psychological capital, psychological distress, and life satisfaction among colostomy patients. Methods : Patients (n = 120) with permanent stomas were recruited and randomly assigned into [...]

Menée en France par enquête auprès de 1 153 patientes ayant survécu à un cancer de bon pronostic (âge moyen au diagnostic : 44 ans), cette étude analyse, 5 ans après le diagnostic de la maladie, les facteurs associés à leur peur de la récidive

Fear of cancer recurrence in young women 5 years after diagnosis with a good-prognosis cancer: the VICAN-5 national survey

Magnani, Clément ; Smith, Allan Ben ; Rey, Dominique ; Sarradon-Eck, Aline ; Préau, Marie ; Bendiane, Marc-Karim ; Bouhnik, Anne-Deborah ; Mancini, Julien

Purpose : Fear of cancer recurrence (FCR) is frequent in survivors, but less is known about FCR in long-term survivors with very low risk of relapse. Our aim was to estimate the prevalence and clinical and socio-behavioural factors associated with FCR in young women 5 years after diagnosis of a good-prognosis cancer. Methods : Using data from the VICAN-5 survey, conducted in 2015–2016 amongst a national representative French sample of cancer survivors, we included women with non-metastatic [...]

Menée aux Etats-Unis par enquête en ligne auprès de 211 femmes dont le test BRCA1/2 est positif, cette étude analyse l'association entre l'origine ethnique, le niveau de pauvreté et la présence de symptômes d'anxiété et de dépression

Anxiety and depression among racial/ethnic minorities and impoverished women testing positive for BRCA1/2 mutations in the United States

Dibble, Kate E. ; Connor, Avonne E.

Purpose : To outline the association between race/ethnicity and poverty status and perceived anxiety and depressive symptomologies among BRCA1/2-positive United States (US) women to identify high-risk groups of mutation carriers from medically underserved backgrounds. Methods : A total of 211 BRCA1/2-positive women from medically underserved backgrounds were recruited through national Facebook support groups and completed an online survey. Adjusted odds ratios (aOR) and 95% confidence intervals [...]

Menée auprès de 77 patients atteints d'un gliome malin récemment diagnostiqué et auprès de 61 aidants, cette étude prospective analyse les facteurs associés à leur détresse psychologique (symptômes d'anxiété et de dépression)

Factors associated with psychological distress in caregivers of patients with malignant gliomas

Forst, Deborah A. ; Podgurski, Alyx F. ; Quain, Kit M. ; Landay, Sophia L. ; Anand, Maya ; Kaslow-Zieve, Emilia ; Mesa, Michelle M. ; Jacobs, Jamie M. ; Dietrich, Jorg ; Parsons, Michael W. ; Horick, Nora ; Greer, Joseph A. ; Batchelor, Tracy T. ; Jackson, Vicki A. ; El-Jawahri, Areej ; Temel, Jennifer S.

Purpose : Caregivers of patients with malignant gliomas are at risk for psychological distress. However, factors associated with distress in this population have not been well described. We conducted a prospective study evaluating psychological distress in patients with malignant gliomas and their caregivers and exploring factors associated with caregiver distress. Methods : We enrolled patients with newly diagnosed malignant gliomas (N = 77) and their caregivers (N = 61). At baseline and 3, 6, [...]

Menée aux Etats-Unis à partir de données portant sur 2 022 patients atteints d'un cancer et sur 10 110 témoins, cette étude de cohorte analyse les coûts restant à charge des patients et l'évolution, dans les deux années suivant le diagnostic, de l'impact financier de la maladie

Cancer’s Lasting Financial Burden: Evidence from a Longitudinal Assessment

Shih, Ya-Chen Tina ; Owsley, Kelsey M ; Nicholas, Lauren Hersch ; Yabroff, K Robin ; Bradley, Cathy

BACKGROUND : To conduct a longitudinal analysis of out-of-pocket expenditure (OOPE) trajectories for the assessment of cancer’s lasting financial impact. METHODS : We identified newly diagnosed cancer patients and constructed matched non-cancer controls from the 2002-2018 Health and Retirement Study. Outcomes included monthly OOPE for prescription drugs (RX-OOPE_MONTHLY) and OOPE for medical services other than drugs in the past 2 years (non-RX-OOPE_2YR), consumer debt and new individual [...]

A partir d'une revue de la littérature (42 études), cette étude analyse les expériences de patients concernant leurs difficultés financières en lien avec les traitements anticancéreux dans des pays à faible ou moyen revenu

Cancer treatment-related financial toxicity experienced by patients in low- and middle-income countries: a scoping review

Udayakumar, Suji ; Solomon, Eden ; Isaranuwatchai, Wanrudee ; Rodin, Danielle L. ; Ko, Yoo-Joung ; Chan, Kelvin K. W. ; Parmar, Ambica

Purpose : In the past decade, literature has called attention to financial toxicities experienced by cancer patients. Though studies have addressed research questions in high-income countries, there remains a paucity of in-depth reviews regarding low- and middle-income countries (LMICs). Our scoping review provides an overview of treatment-related financial toxicities experienced by cancer patients in LMICs. Methods : A systematic search was conducted in MEDLINE, EMBASE and the Cochrane Central [...]

Menée à partir des données de la base Medicare et des registres américains des cancers portant sur 20 677 patientes âgées de plus de 65 ans et atteintes d'un cancer du sein HR+, cette étude analyse l'association entre une utilisation d'inhibiteurs de l'aromatase, leur remplacement par des médicaments génériques, une réduction des coûts restant à charge et une augmentation de l'adhésion au traitement

Hormonal Therapy Drug Switching, Out-of-Pocket Costs, and Adherence among Older Women with Breast Cancer

Qin, Xuanzi ; Huckfeldt, Peter ; Abraham, Jean ; Yee, Douglas ; Virnig, Beth A

Background : Adherence to aromatase inhibitors (AIs) and tamoxifen has significant survival benefits for postmenopausal women diagnosed with hormone receptor-positive (HR+) breast cancer. Reduced out-of-pocket (OOP) costs and treatment-related side effects could increase therapy adherence. Given that individuals’ side effect profiles could differ across AIs, generic AI entry could facilitate switching between AIs to manage side effects and improve adherence. Methods : From SEER-Medicare, we [...]

Menée au Japon à partir de données portant sur 103 patients atteints d'un cancer en phase terminale et recevant des soins palliatifs, cette étude rétrospective transversale analyse l'association entre la santé buccale et la possibilité d'une alimentation par voie orale

Association between oral health and advisability of oral feeding in advanced cancer patients receiving palliative care: a cross-sectional study

Furuya, Junichi ; Suzuki, Hiroyuki ; Hidaka, Rena ; Matsubara, Chiaki ; Motomatsu, Yuko ; Kabasawa, Yuji ; Tohara, Haruka ; Sato, Yuji ; Miyake, Satoshi ; Minakuchi, Shunsuke

Purpose : Maintenance of oral feeding is important in terms of maintaining and improving the quality of life in terminal cancer patients receiving palliative care. Although adequate oral health status is essential for oral feeding in hospitalized patients, the relationship between oral health and oral feeding in patients receiving palliative care remains unclear. This cross-sectional study aimed to examine how the general condition and oral health status of these patients relate to decisions [...]