Menée en France par entretiens auprès de 17 patients atteints d'un cancer traité par thérapie ciblée avec ou sans chimiothérapie (âge médian : 63 ans), cette étude qualitative analyse leur niveau de tolérance des effets indésirables des traitements au cours d'un essai de phase I

Patients’ perceived tolerance of side effects in phase I cancer clinical trials: A qualitative study

Brédart, A. ; Bodson, S. ; Le Tourneau, C. ; Flahault, C. ; Bonnetain, F. ; Beaudeau, A. ; Coquan, E. ; Dolbeault, S. ; Paoletti, X.

This qualitative study aimed to explore cancer patients’ perceived tolerance of side effects in phase I drug trials. Patients with solid tumours receiving molecularly targeted agents with/without chemotherapy were eligible for inclusion. In-depth semi-structured interviews were carried out with 17 patients with a median [range] age of 63 [41–72] years. Treatment was discontinued in seven patients. Verbatim transcripts of the audio-taped interviews were analysed using a constructivist grounded [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2015 (30 études incluant au total 19 813 patientes), cette méta-analyse identifie les facteurs prédictifs associés à la survenue de douleurs persistantes après une intervention chirurgicale

Predictors of persistent pain after breast cancer surgery : a systematic review and meta-analysis of observational studies

Wang, Li ; Guyatt, Gordon H. ; Kennedy, Sean A. ; Romerosa, Beatriz ; Kwon, Henry Y. ; Kaushal, Alka ; Chang, Yaping ; Craigie, Samantha ; de Almeida, Carlos P.B. ; Couban, Rachel J. ; Parascandalo, Shawn R. ; Izhar, Zain ; Reid, Susan ; Khan, James S. ; McGillion, Michael ; Busse, Jason W.

Background : Persistent pain after breast cancer surgery affects up to 60% of patients. Early identification of those at higher risk could help inform optimal management. We conducted a systematic review and meta-analysis of observational studies to explore factors associated with persistent pain among women who have undergone surgery for breast cancer. Methods : We searched the MEDLINE, Embase, CINAHL and PsycINFO databases from inception to Mar. 12, 2015, to identify cohort or case–control [...]

A partir des données britanniques portant sur la période 1979-2014, cette étude présente des projections d'incidence de cancer et de mortalité spécifique pour la période 2015-2035

Cancer incidence and mortality projections in the UK until 2035

Smittenaar, C. R. ; Petersen, K. A. ; Stewart, K. ; Moitt, N.

Background: Cancer incidence and mortality projections are important for understanding the evolving landscape for cancer risk factors as well as anticipating future burden on the health service. Methods: We used an age–period–cohort model with natural cubic splines to estimate cancer cases and deaths from 2015 to 2035 based on 1979–2014 UK data. This was converted to rates using ONS population projections. Modified data sets were generated for breast and prostate cancers. Results: Cancer [...]

Menée aux Etats-Unis à partir de données portant sur 2 186 patients atteints d'un cancer du poumon non à petites cellules de stade I ayant subi une résection à visée curative, cette étude évalue l'association entre l'âge du patient, les morbidités, la mortalité spécifique ou liée à d'autres causes (1 532 patients âgés de plus de 65 ans dont 638 âgés de plus de 75 ans)

Impact of Increasing Age on Cause-Specific Mortality and Morbidity in Patients With Stage I Non–Small-Cell Lung Cancer: A Competing Risks Analysis

Eguchi, Takashi ; Bains, Sarina ; Lee, Ming-Ching ; Tan, Kay See ; Hristov, Boris ; Buitrago, Daniel H. ; Bains, Manjit S. ; Downey, Robert J. ; Huang, James ; Isbell, James M. ; Park, Bernard J. ; Rusch, Valerie W. ; Jones, David R. ; Adusumilli, Prasad S.

Purpose : To perform competing risks analysis and determine short- and long-term cancer- and noncancer-specific mortality and morbidity in patients who had undergone resection for stage I non–small-cell lung cancer (NSCLC). Patients and Methods : Of 5,371 consecutive patients who had undergone curative-intent resection of primary lung cancer at our institution (2000 to 2011), 2,186 with pathologic stage I NSCLC were included in the analysis. All preoperative clinical variables known to affect [...]

Menée en Irlande par questionnaires auprès de 3 348 patients ayant survécu à un cancer de la prostate, cette étude analyse les comorbidités et la prévalence d'effets indésirables sévères après les traitements anticancéreux (incontinence urinaire, dysfonctionnement érectile, perte de la libido, troubles intestinaux, bouffées de chaleur, fatigue, etc)

Factors associated with current and severe physical side-effects after prostate cancer treatment: What men report

Steentjes, L. ; Siesling, S. ; Drummond, F. J. ; van Manen, J. G. ; Sharp, L. ; Gavin, A.

We identified patient and disease characteristics associated with (1) “current” physical side-effects of any severity; and (2) “severe” physical side-effects “ever” experienced by 3,348 (54%) prostate cancer (PCa) survivors in Ireland diagnosed 2–18 years previously. Postal questionnaires collected symptoms at diagnosis, post-biopsy complications, comorbidities, primary treatments and physical side-effects post-treatment (urinary incontinence, erectile dysfunction, libido loss, bowel problems, [...]

Menée aux Pays-Bas, cette étude analyse, 2 à 6 ans après la fin des traitements anti-cancéreux, le recours au médecin généraliste par des patients ayant survécu à un cancer colorectal (nombre de consultations, prescriptions médicamenteuses)

Primary healthcare use during follow-up after curative treatment for colorectal cancer

Brandenbarg, D. ; Roorda, C. ; Groenhof, F. ; de Bock, G. H. ; Berger, M. Y. ; Berendsen, A. J.

The rising number of colorectal cancer (CRC) survivors is likely to impose a burden on healthcare systems. Effective resource allocation between primary and hospital care to ensure ongoing high-quality care is under discussion. Therefore, it is important to understand the current role of GPs during follow-up care of CRC. This study explores the primary healthcare use of patients 2–6 years after CRC treatment. Annual rates of face-to-face contacts, prescribed medication and referrals were [...]

A partir des données des registres suédois entre 1990 et 2010, cette étude de cohorte évalue le risque d'hospitalisation et de décès liés à des fractures osseuses chez des patientes ayant été atteintes d'un cancer du sein

Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study

Colzani, Edoardo ; Clements, Mark ; Johansson, Anna L. V. ; Liljegren, Annelie ; He, Wei ; Brand, Judith ; Adolfsson, Jan ; Fornander, Tommy ; Hall, Per ; Czene, Kamila

Background: Bone fractures may have an impact on prognosis of breast cancer. The long-term risks of bone fracture in breast cancer patients have not been thoroughly studied. Methods: Poisson regression was used to investigate the incidence of hospitalisation due to bone fracture comparing women with and without breast cancer based on Swedish National registers. Cox regression was used to investigate the risk of being hospitalised with bone fracture, and subsequent risk of death, in a regional [...]

Menée aux Etats-Unis auprès de 1 508 patientes atteintes d'un cancer du sein diagnostiqué entre 1996 et 1997, cette étude évalue l'association entre une exposition au tabagisme passif, la mortalité spécifique et toutes causes confondues (durée de suivi : supérieure à 18 ans, 597 décès dont 237 décès par cancer du sein)

Environmental Tobacco Smoke Exposure and Survival Following Breast Cancer

Parada, Humberto ; Bradshaw, Patrick T. ; Engel, Lawrence S. ; Conway, Kathleen ; Steck, Susan E. ; Teitelbaum, Susan L. ; Neugut, Alfred I. ; Santella, Regina M ; Gammon, Marilie D.

Background: Environmental tobacco smoke (ETS) exposure is hypothesized to influence survival after breast cancer, but few studies have examined this association. Methods: A population-based cohort of women (N=1,508) diagnosed with first primary invasive or in situ breast cancer in 1996-1997 was interviewed shortly after diagnosis and again approximately 5 years later to assess ETS exposure, and women were followed for over 18 years using the National Death Index; 597 deaths (237 associated with [...]

Menée aux Etats-Unis par questionnaire auprès de 580 patientes ayant survécu à un cancer de l'endomètre, cette étude de cohorte évalue l'association entre trois indicateurs mesurés après le diagnostic (indice de masse corporelle, activité physique, temps passé à regarder la télévision) et la mortalité

Body mass index, physical activity, and television time in relation to mortality risk among endometrial cancer survivors in the NIH-AARP Diet and Health Study cohort

Arem, Hannah ; Pfeiffer, Ruth M. ; Moore, Steven C. ; Brinton, Louise A. ; Matthews, Charles E.

Purpose : Endometrial cancer (EC) survivors are the second largest group of female cancer survivors in the USA, with high prevalence of obesity and physical inactivity. While higher pre-diagnosis body mass index (BMI) has been associated with higher all-cause and disease-specific mortality, pre-diagnosis physical activity has shown mixed evidence of an association with mortality. However, the association between BMI, physical activity, and TV viewing measured after diagnosis and mortality risk [...]

Menée aux Etats-Unis auprès de 765 patients atteints de divers cancers traités par chimiothérapie, cette étude analyse l'association entre les symptômes, des caractéristiques psychologiques et leur participation dans la prise de décision thérapeutique

Factors associated with oncology patients' involvement in shared decision making during chemotherapy

Colley, Alexis ; Halpern, Jodi ; Paul, Steven ; Micco, Guy ; Lahiff, Maureen ; Wright, Fay ; Levine, Jon D. ; Mastick, Judy ; Hammer, Marilyn J. ; Miaskowski, Christine ; Dunn, Laura B.

Objective: Oncology patients are increasingly encouraged to play an active role in treatment decision making. While previous studies have evaluated relationships between demographic characteristics and decision-making roles, less is known about the association of symptoms and psychological adjustment characteristics (eg, coping styles and personality traits) and decision-making roles. Methods: As part of a larger study of symptom clusters, patients (n = 765) receiving chemotherapy for breast, [...]

A partir d'une revue systématique de la littérature (102 études), cette méta-synthèse fait le point sur les peurs liées au cancer en population générale

What do people fear about cancer? A systematic review and meta-synthesis of cancer fears in the general population

Vrinten, Charlotte ; McGregor, Lesley M. ; Heinrich, Małgorzata ; von Wagner, Christian ; Waller, Jo ; Wardle, Jane ; Black, Georgia B.

Background: Cancer has long inspired fear, but the effect of fear is not well understood; it seems both to facilitate and to deter early diagnosis behaviours. To elucidate fear's behavioural effects, we systematically reviewed and synthesised qualitative literature to explore what people fear about cancer. Methods: We searched Medline, Embase, PsycInfo, Web of Science, AnthroSource, and Anthrobase for studies on cancer fear in breast, cervical, and colorectal cancer screening and analysed 102 [...]

Mené sur 164 patients atteints d'un mélanome et à haut risque de développer un second mélanome primitif, cet essai randomisé évalue l'efficacité d'une intervention psychologique et pédagogique destinée à diminuer leur peur de la récidive de la maladie

Psychoeducational Intervention to Reduce Fear of Cancer Recurrence in People at High Risk of Developing Another Primary Melanoma: Results of a Randomized Controlled Trial

Dieng, Mbathio ; Butow, Phyllis N. ; Costa, Daniel S.J. ; Morton, Rachael L. ; Menzies, Scott W. ; Mireskandari, Shab ; Tesson, Stephanie ; Mann, Graham J. ; Cust, Anne E. ; Kasparian, Nadine A.

Purpose : People with a history of melanoma commonly report a fear of cancer recurrence (FCR), yet psychologic support is not routinely offered as part of ongoing melanoma care. This randomized controlled trial examined the efficacy of a psychoeducational intervention to reduce FCR and improve psychologic adjustment in this patient group compared with usual care. Methods : The intervention comprised a newly developed psychoeducational resource and three telephone-based psychotherapeutic [...]

Menée en Australie par enquête auprès de 30 hommes et 118 femmes âgés de 40 à 70 ans, cette étude analyse les facteurs psychologiques, notamment le sentiment de dégoût, empêchant leur participation au dépistage du cancer colorectal

An investigation of the emotion of disgust as an affective barrier to intention to screen for colorectal cancer

Davis, M. ; Oaten, M. ; Occhipinti, S. ; Chambers, S. K. ; Stevenson, R. J.

Colorectal cancer (CRC) screening participation remains unacceptably low. This study investigated the emotion of disgust as a potential deterrent to intention to screen for CRC. The study utilised a convenience sample of individuals' 40–70 years of age to complete an online survey. Participants included 30 men and 118 women recruited between December 1, 2013 and March 31, 2014. Data on socio-demographics, health status, screening intentions and emotional barriers to bowel screening were [...]

A partir d'une revue systématique de la littérature (24 études qualitatives), cette étude analyse les difficultés et les besoins de nature psychosociale de patientes atteintes d'un cancer du sein

The psychosocial experiences of women with breast cancer across the lifespan: a systematic review

Campbell-Enns, Heather J. ; Woodgate, Roberta L.

Objective: To summarize the psychosocial experience of women with breast cancer from a lifespan perspective by examining the findings of qualitative studies. Methods: A meta-aggregate review of 24 qualitative studies was undertaken. To be included, studies must include women with a breast cancer diagnosis and focus on younger or older women (as defined by the study), or compare a psychosocial issue across the lifespan. Eight databases were searched systematically. Results: Study participants [...]

Menée aux Etats-Unis par enquête auprès de 80 patientes atteintes d'un cancer du sein métastatique, cette étude analyse l'association entre leurs symptômes et leur participation à une thérapie de nature cognitivo-comportementale, dite "thérapie d'acceptation et d'engagement"

Symptom experiences in metastatic breast cancer patients: relationships to activity engagement, value-based living, and psychological inflexibility

Mosher, Catherine E. ; Tometich, Danielle B. ; Hirsh, Adam ; Rand, Kevin L. ; Johns, Shelley A. ; Matthias, Marianne S. ; Outcalt, Samantha D. ; Bricker, Jonathan ; Schneider, Bryan ; Mina, Lida ; Storniolo, Anna Maria ; Newton, Erin ; Miller, Kathy

Objective: This study examined symptom-based subgroups of metastatic breast cancer (MBC) patients and the extent to which they differed across key constructs of acceptance and commitment therapy (ACT). Methods: Eighty women with MBC completed self-report surveys assessing 10 common symptoms and several ACT variables (ie, activity engagement, psychological inflexibility, value obstruction, and value progress) during a single time point. Results: A cluster analysis yielded 3 patient subgroups: [...]

A partir d'une revue systématique de la littérature (35 études), cette méta-synthèse fait le point sur les relations entre les médecins généralistes et les professionnels de santé spécialistes en oncologie dans la prise en charge et le suivi des patients atteints de cancer

The primary care provider (PCP)-cancer specialist relationship: A systematic review and mixed-methods meta-synthesis

Dossett, Lesly A. ; Hudson, Janella N. ; Morris, Arden M. ; Lee, M. Catherine ; Roetzheim, Richard G. ; Fetters, Michael D. ; Quinn, Gwendolyn P.

Although they are critical to models of coordinated care, the relationship and communication between primary care providers (PCPs) and cancer specialists throughout the cancer continuum are poorly understood. By using predefined search terms, the authors conducted a systematic review of the literature in 3 databases to examine the relationship and communication between PCPs and cancer specialists. Among 301 articles identified, 35 met all inclusion criteria and were reviewed in-depth. Findings [...]

Menée en Australie, cette étude évalue le rapport coût-efficacité d'une surveillance régulière des lésions cutanées dans un établissement spécialisé pour les personnes à risque élevé de mélanome

Cost-Effectiveness of Skin Surveillance Through a Specialized Clinic for Patients at High Risk of Melanoma

Watts, Caroline G. ; Cust, Anne E. ; Menzies, Scott W. ; Mann, Graham J. ; Morton, Rachael L.

Purpose : Clinical guidelines recommend that people at high risk of melanoma receive regular surveillance to improve survival through early detection. A specialized High Risk Clinic in Sydney, Australia was found to be effective for this purpose; however, wider implementation of this clinical service requires evidence of cost-effectiveness and data addressing potential overtreatment of suspicious skin lesions. Patients and Methods : A decision-analytic model was built to compare the costs and [...]