Couplée aux données de la cohorte européenne EPIC portant sur 552 patients atteints d'un cancer du poumon et sur 552 témoins, puis validée sur 429 patients et 429 témoins inclus dans 3 autres études, cette étude évalue l'association entre des changements de niveaux de méthylation de l'ADN du sang périphérique avant et après le diagnostic, le statut tabagique et le risque de la maladie

DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk

Baglietto, Laura ; Ponzi, Erica ; Haycock, Philip ; Hodge, Allison ; Bianca Assumma, Manuela ; Jung, Chol-Hee ; Chung, Jessica ; Fasanelli, Francesca ; Guida, Florence ; Campanella, Gianluca ; Chadeau-Hyam, Marc ; Grankvist, Kjell ; Johansson, Mikael ; Ala, Ugo ; Provero, Paolo ; Wong, Ee Ming ; Joo, Jihoon ; English, Dallas R. ; Kazmi, Nabila ; Lund, Eiliv ; Faltus, Christian ; Kaaks, Rudolf ; Risch, Angela ; Barrdahl, Myrto ; Sandanger, Torkjel M. ; Southey, Melissa C. ; Giles, Graham G. ; Johansson, Mattias ; Vineis, Paolo ; Polidoro, Silvia ; Relton, Caroline L. ; Severi, Gianluca

DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether methylation in DNA from pre-diagnostic, peripheral blood samples is associated with lung cancer risk. We used a case-control study nested within the EPIC-Italy cohort and a study within the MCCS cohort as discovery sets (a total of 552 case-control pairs). We validated the top signals in 429 case-control pairs from another 3 studies. We identified six CpGs [...]

Menée en Corée à partir de données portant sur 239 615 patients masculins ayant survécu à un cancer entre 2003 et 2011, cette étude de cohorte évalue l'association entre une obésité avant le diagnostic du premier cancer et le risque de développer un second cancer primitif (4 799 cas de second cancer)

Prediagnosis Body Mass Index and Risk of Secondary Primary Cancer in Male Cancer Survivors: A Large Cohort Study

Park, Sang Min ; Yun, Young Ho ; Kim, Young Ae ; Jo, Minkyung ; Won, Young-Joo ; Back, Joung Hwan ; Lee, Eun-Sook

Purpose : Male cancer survivors have a higher risk of cancer than the general population, which might be caused by an increased prevalence of obesity or susceptibility to obesity-related carcinogenesis. We assessed the effects of obesity before the diagnosis of a first cancer on the development of secondary primary cancers (SPCs). Methods : The study population consisted of 239,615 Korean male cancer survivors between January 2003 and December 2010. Incident SPCs were assessed throughout [...]

Menée en Finlande à partir de données portant sur 11 370 jumeaux suivis entre 1981 et 2012, cette étude de cohorte prospective évalue l'association entre des troubles du sommeil et du rythme circadien aux alentours de la quarantaine, un travail posté et le risque de cancer de la prostate, puis analyse la mortalité spécifique

Sleep disruption, chronotype, shift work, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins

Dickerman, Barbra A. ; Markt, Sarah C. ; Koskenvuo, Markku ; Hublin, Christer ; Pukkala, Eero ; Mucci, Lorelei A. ; Kaprio, Jaakko

Purpose : Sleep disruption and shift work have been associated with cancer risk, but epidemiologic evidence for prostate cancer remains limited. We aimed to prospectively investigate the association between midlife sleep- and circadian-related parameters and later prostate cancer risk and mortality in a population-based cohort of Finnish twins. Methods : Data were drawn from the Older Finnish Twin Cohort and included 11,370 twins followed from 1981 to 2012. Over the study period, 602 incident [...]

Menée à Taïwan à partir de données portant sur 1 089 955 patients atteints d'une maladie pulmonaire obstructive chronique entre 2003 et 2010, cette étude évalue l'association entre une infection pulmonaire (tuberculose ou pneumonie), une utilisation de corticostéroïdes inhalés et le risque de cancer du poumon

Post-inhaled corticosteroid pulmonary tuberculosis and pneumonia increases lung cancer in patients with COPD

Wu, Ming-Fang ; Jian, Zhi-Hong ; Huang, Jing-Yang ; Jan, Cheng-Feng ; Nfor, Oswald Ndi ; Jhang, Kai-Ming ; Ku, Wen-Yuan ; Ho, Chien-Chang ; Lung, Chia-Chi ; Pan, Hui-Hsien ; Wu, Min-Chen ; Liaw, Yung-Po

Background : Inhaled corticosteroids (ICS) have been associated with decreased lung cancer risk. However, they have been associated with pulmonary infections (tuberculosis [TB] and pneumonia) in patients with chronic obstructive pulmonary disease (COPD). TB and pneumonia have increased lung cancer risk. The association between post-ICS pulmonary infections and lung cancer remains unclear. Methods : We conducted a retrospective cohort study from 2003 to 2010 using the Taiwan National Health [...]

A partir d'une revue systématique de la littérature (18 études cas-témoins, 4 études de cohorte), cette méta-analyse évalue l'association entre une utilisation de benzodiazépines et le risque de cancer

Use of benzodiazepine and risk of cancer: A meta-analysis of observational studies

Kim, Hong-Bae ; Myung, Seung-Kwon ; Park, Yon Chul ; Park, Byoungjin

Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publications in January 2016. Three evaluators independently reviewed and selected eligible studies based on predetermined selection criteria. Of 796 articles meeting our initial criteria, a [...]

A partir de données portant sur 32 familles présentant des cas de cancer de mélanome de l'uvée, cette étude met en évidence le rôle joué par des mutations constitutionnelles du gène BAP1 dans le développement de la maladie

Germline BAP1 Alterations in Familial Uveal Melanoma

Rai, Karan ; Pilarski, Robert ; Boru, Getachew ; Rehman, Muneeb ; Saqr, Ahmad H. ; Massengill, James B. ; Singh, Arun ; Marino, Meghan J. ; Davidorf, Frederick H. ; Cebulla, Colleen M. ; Abdel-Rahman, Mohamed

Uveal melanoma (UM) is the most commonly diagnosed primary intraocular tumor in adults. Familial UM (FUM), defined as two or more family members diagnosed with UM, is rare and estimated at less than 1% of all UM. Currently, BAP1 is the only gene known to contribute significant risk for UM. In this study we aimed to estimate the frequency of BAP1 mutation in FUM and to characterize the family and personal histories of other cancers in these families. We identified 32 families with FUM, including [...]

A partir des données de la cohorte "Nurses' Health Study II" incluant 86 972 participantes, cette étude prospective évalue l'association entre des antécédents de diabète gestationnel et le risque de cancer invasif du sein (durée de suivi : 22 ans, 5 188 femmes ayant eu un diabète gestationnel, 2 377 cas de cancer du sein)

History of gestational diabetes mellitus (GDM) and risk of incident invasive breast cancer among parous women in the Nurses' Health Study II prospective cohort

Powe, Camille ; Tobias, Deirdre K. ; Michels, Karin ; Chen, Wendy Y. ; Eliassen, A. Heather ; Manson, JoAnn E ; Rosner, Bernard ; Willett, Walter C. ; Hu, Frank B. ; Zhang, Cuilin ; Rich-Edwards, Janet W. ; Rexrode, Kathryn M.

Background: Type 2 diabetes is associated with breast cancer in epidemiologic studies. Pregnancy also modifies breast cancer risk. We hypothesized that women with a history of gestational diabetes mellitus (GDM), which shares pathogenesis and risk factors with type 2 diabetes, would have greater invasive breast cancer risk than parous women without a history of GDM. Methods: We conducted a prospective analysis among parous women in the Nurses' Health Study II, with mean age 35 years in 1989. [...]

Menée par une méthode de randomisation mendélienne à partir de données de 25 études portant sur 23 868 patients atteints d'un cancer de la prostate et sur 23 051 témoins, cette étude évalue l'association entre une consommation d'alcool, 68 polymorphismes à simple nucléotide de 8 gènes impliqués dans le métabolisme de l'alcool, le risque de la maladie et sa progression

Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study

Brunner, Clair ; Davies, Neil M. ; Martin, Richard M. ; Eeles, Rosalind ; Easton, Doug ; Kote-Jarai, Zsofia ; Al Olama, Ali Amin ; Benlloch, Sara ; Muir, Kenneth ; Giles, Graham ; Wiklund, Fredrik ; Gronberg, Henrik ; Haiman, Christopher A. ; Schleutker, Johanna ; Nordestgaard, Børge G. ; Travis, Ruth C. ; Neal, David ; Donovan, Jenny ; Hamdy, Freddie C. ; Pashayan, Nora ; Khaw, Kay-Tee ; Stanford, Janet L. ; Blot, William J. ; Thibodeau, Stephen ; Maier, Christiane ; Kibel, Adam S. ; Cybulski, Cezary ; Cannon-Albright, Lisa ; Brenner, Hermann ; Park, Jong ; Kaneva, Radka ; Batra, Jyotsna ; Teixeira, Manuel R. ; Pandha, Hardev ; The, Practical Consortium ; Zuccolo, Luisa

Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially due to methodological limitations of observational studies. In this study, we investigated the associations of genetic variants in alcohol-metabolising genes with prostate cancer incidence and survival. We analysed data from 23,868 men with prostate cancer and 23,051 [...]