Mené sur 92 patients atteints d'un cancer de stade avancé (âge moyen : 56 ans), cet essai randomisé évalue l'intérêt d'une musicothérapie pour prendre en charge la douleur

Music Therapy for Pain Management for People With Advanced Cancer: A Randomized Controlled Trial

Bradt, Joke ; Leader, Amy ; Worster, Brooke ; Myers-Coffman, Kate ; Bryl, Karolina ; Biondo, Jacelyn ; Schneible, Brigette ; Cottone, Carrie ; Selvan, Preethi ; Zhang, Fengqing

Objective: To improve mechanistic understanding, this randomized controlled trial examined anxiety, mood, emotional support, and pain-related self-efficacy as mediators of music therapy for pain management in people with advanced cancer. Methods: People with advanced cancer who had chronic pain were randomized (1:1) to 6 weekly individual music therapy or social attention control sessions. We measured mediators and pain outcomes (pain interference and pain intensity) using self-report measures [...]

Menée au Royaume-Uni par enquête auprès de 588 patients atteints d'un cancer de stade métastatique, cette étude identifie les facteurs associés à la pratique d'une activité physique

Factors associated with physical activity in individuals with metastatic cancer: a UK cross-sectional survey

Haider, Zainab Faatimah ; Smith, Samuel George ; Walwyn, Rebecca E. A. ; Lally, Phillippa ; Fisher, Abigail ; Beeken, Rebecca J.

Purpose: Physical activity is safe and feasible for individuals with metastatic cancer and may support symptom management. We investigated the extent to which individuals with metastatic cancer are meeting the World Health Organisation (WHO) moderate-vigorous physical activity (MVPA) guideline, factors associated with meeting the guideline, and perceptions about physical activity and receiving physical activity advice. Methods: Data were from UK adults with metastatic breast, prostate, or [...]

A partir d'une revue de la littérature (22 articles), cette étude analyse l'intérêt des programmes d'auto-déclaration des symptômes pour des patients atteints d'un cancer traité par immunothérapie

Patient-reported outcomes (PROs) programs for monitoring symptoms among patients treated with immunotherapy: A scoping review

Lambert, Sylvie D ; Soldera, Sara ; Kazdan, Jordana ; Frati, Francesca ; Slominska, Anita ; Boutin, Melina ; Samouëlian, Vanessa ; Letendre, Caroline ; Bilodeau, Karine ; Howell, Doris ; Breton, Karine Le ; Gratton, Michel-Olivier

Background: Monitoring toxicities among patients receiving immune checkpoint inhibitors (ICIs) using patient-reported outcome (PRO) measures (PROMs) is relatively recent. This scoping review aims to guide decision-making in the development of PROMs ICI programs. Methods: Four electronic databases were searched from inception to January 2024. Data on PROMs ICI programs (eg, PROMs used, frequency) were extracted. Two authors with established inter-rater reliability screened titles, abstracts, and [...]

A partir d'une revue de la littérature (14 études), cette étude analyse l'intérêt d'une thérapie par photobiomodulation pour prévenir une radiodermite aiguë chez des patients atteints d'un cancer

Photobiomodulation therapy for mitigating severity of radiodermatitis in cancer patients undergoing radiotherapy: a scoping review

Rao, Devika ; Dsouza, Cliva Neha ; Prabhu, Smitha S. ; Kumar, Praveen ; Prabhu, Vijendra

Purpose: Radiodermatitis (RD) is an adverse effect of radiation therapy. RD can negatively impact quality of life and can also hinder treatment in cancer patients. Photobiomodulation therapy (PBMT) has the potential to treat RD at the cellular level, and it is more promising compared to other therapy alternatives. This review aims to examine the effectiveness of PBMT for the treatment and management of RD in cancer patients undergoing radiation therapy. Methods: The methodology followed for the [...]

A partir d'une revue systématique de la littérature (16 essais, 3 115 patients), cette méta-analyse évalue l'efficacité de médicaments antiémétiques pour prévenir les nausées et vomissements induits par la chimiothérapie chez les enfants atteints d'un cancer

Antiemetic medications for preventing chemotherapy-induced nausea and vomiting in children: a systematic review and Bayesian network meta-analysis

Walker, R. ; Dias, S. ; Phillips, R. S.

Purpose: Children continue to experience chemotherapy-induced nausea and vomiting (CINV), despite effective antiemetic medications. Recommendations in clinical practice guidelines are underpinned by narrative syntheses and meta-analyses that compare only two treatments. This means not all antiemetics have been compared to one another, and estimates remain imprecise. We apply network meta-analysis (NMA) to overcome these limitations by comparing multiple treatments simultaneously. Methods: A [...]

A partir d'une revue systématique de la littérature (22 études, 1 524 patients), cette méta-analyse évalue l'effet, sur la détresse psychologique des patients atteints d'un cancer du poumon, d'interventions à base d'exercices physiques

The effectiveness of exercise interventions on psychological distress in patients with lung cancer: a systematic review and meta-analysis

Tadsuan, Jinsuta ; Lai, Yeur-Hur ; Lee, Yun-Hsiang ; Chen, Min-Ru

Purpose: To assess the effectiveness of exercise interventions on psychological distress in lung cancer patients and how this effectiveness varies by cancer stage, treatment, intervention type (exercise/with other interventions), exercise mode, duration, and sustained effects over time. Methods: Randomized controlled trials (RCTs) investigating exercise effects on psychological distress were included. Exclusion criteria were studies with less than 50% lung cancer patients, those on [...]

Mené sur 236 patientes atteintes d'un cancer du sein de stade métastatique, cet essai randomisé évalue l'intérêt d'une thérapie d'acceptation et d'engagement (ACT) dispensée par téléphone pour soulager leur fatigue

Randomized Controlled Trial of Acceptance and Commitment Therapy for Fatigue Interference With Functioning in Metastatic Breast Cancer

Catherine E. Mosher ; Shieun Lee ; Elizabeth L. Addington ; Seho Park ; Ashley B. Lewson ; Stella Snyder ; Adam T. Hirsh ; Jonathan B. Bricker ; Kathy D. Miller ; Tarah J. Ballinger ; Bryan P. Schneider ; Anna Maria Storniolo ; Erin V. Newton ; Victoria L. Champion ; Shelley A. Johns

PURPOSE: Fatigue is a highly prevalent and disabling symptom for patients with metastatic breast cancer (MBC). Evidence-based interventions for managing fatigue in advanced cancer populations are lacking. This phase II randomized controlled trial tested the effect of acceptance and commitment therapy (ACT) on fatigue interference with functioning in patients with MBC. METHODS: Eligible patients were women with stage IV breast cancer who had moderate to severe fatigue interference. Patients [...]

Menée à partir de données des registres canadiens des cancers portant sur 1 150 patientes atteintes d'un cancer traité par chimiothérapie pendant leur grossesse, cette étude de cohorte analyse les événements indésirables liés à la grossesse (morbidité et mortalité néonatale, troubles du développement neurologique et maladies chroniques chez l'enfant)

Cancer chemotherapy in pregnancy and adverse pediatric outcomes: a population-based cohort study

Metcalfe, Amy ; Cairncross, Zoe F ; McMorris, Carly A ; Friedenreich, Christine M ; Nelson, Gregg ; Bhatti, Parveen ; Fell, Deshayne B ; Lisonkova, Sarka ; Sikdar, Khokan C ; Shack, Lorraine ; Ray, Joel G

Background: Administration of chemotherapy during pregnancy is often delayed, while preterm delivery is common. If in utero exposure to chemotherapy is associated with adverse pediatric outcomes, it is unknown whether that relationship is directly attributable to the chemotherapy or is mediated by preterm birth. Methods: Cases were identified from Canadian cancer registries and administrative data in Alberta, British Columbia, and Ontario, 2003-2017, with follow-up until 2018. The primary [...]

Menée au Canada à partir de données 2006 et 2011 portant sur 47 105 patientes atteintes d'un cancer du sein, cette étude analyse les taux d'incidence et de mortalité en fonction de l'âge, du stade tumoral, du sous-type moléculaire et de l'origine ethnique

Breast cancer incidence and mortality, by age, stage and molecular subtypes, by race/ethnicity in Canada

Wilkinson, Anna N ; Ng, Carmina ; Ellison, Larry F ; Seely, Jean M

Background: Breast cancer (BC) characteristics and outcomes in Canada related to race/ethnicity are not currently documented. Methods: Age-specific and age-standardized BC incidence and mortality rates, age distribution of cases, proportions of stage, and molecular subtypes were calculated for women aged 20+, by race/ethnicity, using 2006 and 2011 Canadian Census Health and Environment Cohort databases of linked census, cancer, and death data. Results: In 47 105 BC cases, age-specific incidence [...]

Menée aux Etats-Unis à partir de données portant sur 357 patients atteints d'un cancer de la tête et du cou (âge médian : 59 ans), cette étude analyse l'association entre des troubles psychiques antérieurs au diagnostic de cancer, une consommation de substances psychoactives ou de tabac et le stade de la maladie au diagnostic

The association between the mental health disorders, substance abuse, and tobacco use with head & neck cancer stage at diagnosis

Woersching, Joanna ; Van Cleave, Janet H. ; Gonsky, Jason P. ; Ma, Chenjuan ; Haber, Judith ; Chyun, Deborah ; Egleston, Brian L.

Purpose: Mental health disorders, substance abuse, and tobacco use are prevalent in the US population. However, the association between these conditions and head and neck cancer (HNC) stage is poorly understood. This research aims to uncover the relationship between pre-existing mental health disorders, substance abuse, and tobacco use and HNC stage at diagnosis in patients receiving care in an integrated, public safety-net healthcare system. Methods: This study was a secondary data analysis of [...]

A partir d'une revue systématique de la littérature (8 études, 543 patients), cette méta-analyse évalue l'intérêt d'une thérapie par le rire pour soulager les symptômes psychologiques des patients atteints d'un cancer

The Efficacy of Laughter Therapy on Psychological Symptoms in People With Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Studies

Lin, Guijiao ; Yang, Liu ; Wang, Yajiao ; Lin, Rujia ; Huang, Bichun ; Sheng, Xia ; Wu, Xinlei ; Cao, Zhiyun

Objective: Cancer patients generally have high stress levels, which often leads to depression, anxiety and other psychological problems. Laughter therapy has been used to relieve stress, depression and anxiety in cancer patients, but its efficacy is uncertain. The study aims to summarize evidence on the efficacy of laughter therapy on psychological symptoms of people with cancer. Methods: A search was conducted in 10 electronic databases for randomized controlled trials (RCTs) reported before [...]

Menée aux Etats-Unis, cette étude analyse le rapport coût-efficacité d'un traitement néoadjuvant total en combinaison avec une prise en charge non opératoire sélective chez les patients atteints d'un cancer du rectum de stade localement avancé

Cost-Effectiveness of Total Neoadjuvant Therapy With Selective Nonoperative Management for Locally Advanced Rectal Cancer: Analysis of Data From the Organ Preservation for Rectal Adenocarcinoma Trial

Maria Widmar ; Mason McCain ; Akriti Mishra Meza ; Charles Ternent ; Andrew Briggs ; Julio Garcia-Aguilar

Purpose: The clinical efficacy of total neoadjuvant therapy (TNT) followed by selective nonoperative management (NOM) for locally advanced rectal cancer (LARC) was examined in the Organ Preservation for Rectal Adenocarcinoma (OPRA) trial. We investigated the cost and quality-of-life implications of adopting this treatment approach. Methods: We analyzed clinical, cost, and quality-of-life outcomes for TNT with selective NOM in comparison with chemoradiotherapy (CRT)-surgery-adjuvant chemotherapy [...]