A partir d'une revue systématique de la littérature (17 études incluant 799 patients), cette méta-analyse évalue l'intérêt d'intégrer, dans des programmes de réadaption, des interventions utilisant la réalité virtuelle pour améliorer la santé physique, cognitive et psychologique de patients atteints d'un cancer

Effects of virtual reality on physical, cognitive, and psychological outcomes in cancer rehabilitation: a systematic review and meta-analysis

Hao, Jie ; Li, Yanfei ; Swanson, Rebecca ; Chen, Zhen ; Siu, Ka-Chun

Purpose: To systematically examine and summarize the current evidence regarding the effects of virtual reality (VR) on physical, cognitive, and psychological outcomes in cancer rehabilitation. Methods: Six bioscience and engineering databases were searched. Two independent reviewers screened the titles and abstracts of 2397 records and retrieved 25 full-text articles. Inclusion criteria included patients with a current or previous diagnosis of cancer; VR was used as an intervention for [...]

A partir d'une revue systématique de la littérature (28 études incluant 10 245 patients), cette étude analyse l'impact de différentes stratégies thérapeutiques sur la qualité de vie des patients atteints d'un myélome multiple réfractaire ou récidivant

The impact of current therapeutic options on the health-related quality of life of patients with relapse/refractory multiple myeloma: a systematic review of clinical studies

Ojo, Ademola S. ; Araoye, Mojisola O. ; Ali, Ahmed ; Sarma, Ravi

Purpose : Patients with relapse and/or refractory multiple myeloma (RRMM) have a high disease burden with poor health-related quality of life (HRQoL) which worsens with each additional relapse. We aimed to review the impact of triplet, doublet, monotherapies, and salvage autologous stem cell transplantation on the HRQoL of RRMM patients. Methods : We performed a comprehensive literature search of Medline/PubMed, Wiley Cochrane Library, EMBASE, Scopus, CINAHL, and Clinicaltrials.gov to identify [...]

Menée auprès de 44 patients atteints d'un cancer bronchique traité par cisplatine et auprès de 44 témoins, cette étude analyse l'association entre la perte de goût et d'odorat pendant la chimiothérapie et le changement d'habitudes alimentaires

Loss of smell in lung cancer patients undergoing chemotherapy: prevalence and relationship with food habit changes

Drareni, K. ; Dougkas, A. ; Giboreau, A. ; Laville, M. ; Souquet, P. J. ; Nazare, J. A. ; Fournel, P. ; Bensafi, M.

Background and Objectives: Cancer patients undergoing cytotoxic chemotherapies exhibit a series of adverse side effects including smell and taste alterations, which can have a significant impact on their food behavior and quality of life. Particularly, olfactory alterations are often underestimated, although declared as frequent by cancer patients. In the present study, we set out to examine loss of smell in lung cancer patients undergoing chemotherapy and its relationship to food habits. [...]

A partir d'une revue de la littérature publiée entre 2015 et 2021 (14 études), cette étude analyse les caractéristiques des interventions de santé développées sur mobile pour le suivi de patients ayant survécu à un cancer de la prostate

Mobile health (mHealth) interventions in prostate cancer survivorship: a scoping review

Ogunsanya, Motolani E. ; Sifat, Munjireen ; Bamidele, Olufikayo O. ; Ezenwankwo, Elochukwu F. ; Clifton, Shari ; Ton, Chelsea ; Knight, Jennifer M. ; Odedina, Folakemi T. ; Greer, Joseph A. ; Dwyer, Kathleen ; Kendzor, Darla E.

Purpose: This scoping review explores the application of mHealth technology in prostate cancer (CaP) management along the survivorship continuum. Methods: The scoping review was conducted using the five-step framework developed by Arksey and O'Malley. Using predefined criteria, we screened citations from Embase, EBSCOHost, Cochrane Library, PubMed, ProQuest, SCOPUS, and Web of Science for primary studies published before December 2021. We selected studies that explored the application of [...]

Menée en France à partir de données portant sur 3 079 patientes atteintes d'un cancer du sein de stade précoce, cette étude de cohorte analyse l'association entre la qualité de vie initiale, des réductions de doses de chimiothérapie et les toxicités après une chimiothérapie

Baseline quality of life and chemotherapy toxicities in patients with early breast cancer

Licaj, Idlir ; Coquan, Elodie ; Dabakuyo-Yonli, Tienhan Sandrine ; Dauchy, Sarah ; VAZ LUIS, Ines ; Charles, Cécile ; Lemogne, Cédric ; Tredan, Olivier ; Vanlemmens, Laurence ; Jouannaud, Christelle ; Levy, Christelle ; Rigal, Olivier ; Fournier, Marion ; Petit, Thierry ; Dalenc, Florence ; Rouanet, Philippe ; Lemonnier, Jérôme ; Everhard, Sibille ; Cottu, Paul ; Joly, Florence

Background: The authors used the French breast cancer Cancer and Toxicities (CANTO) cohort to study the associations between baseline quality of life and chemotherapy dose-reductions (CDRs) or postchemotherapy-toxicities (PCTs). Methods: In total, 3079 patients with breast cancer who received chemotherapy were included in this analysis. The associations between baseline physical functioning (PF) and fatigue measured using the European Organization for Research and Treatment of Cancer [...]

Menée aux Etats-Unis à partir de données portant sur des patientes atteintes d'un cancer du sein, cette étude de cohorte rétrospective analyse les facteurs associés à leur décision d'utiliser un dispositif de refroidissement du cuir chevelu pour prévenir une alopécie induite par la chimiothérapie

Retrospective cohort study of scalp cooling in breast cancer patients

Rose, Lucy ; Schnell, Patrick M. ; Radcliff, Lindsey ; Lustberg, Maryam ; Dulmage, Brittany

For patients with cancer, alopecia is a common side effect that negatively impacts personal identity, body image, self-esteem, quality of life, and medical decision-making. Scalp cooling is a technique used to prevent alopecia in patients undergoing chemotherapy in which patients wear a cooled cap during chemotherapy infusions, causing localized vasoconstriction of blood vessels on the scalp. Because of the recent emergence of scalp cooling, there is a need to explore further the reasons why [...]

Menée par questionnaire auprès de 243 patients ayant survécu à un cancer du testicule, cette étude analyse leurs déficiences fonctionnelles auto-déclarées induites par une perte d'audition et par la présence d'acouphènes liées à une chimiothérapie par cisplatine

Patient-Reported Functional Impairment Due to Hearing Loss and Tinnitus After Cisplatin-Based Chemotherapy

Victoria A. Sanchez ; Megan M. Shuey ; Paul C. Dinh Jr ; Patrick O. Monahan ; Sophie D. Fossa ; Howard D. Sesso ; M. Eileen Dolan ; Lawrence H. Einhorn ; David J. Vaughn ; Neil E. Martin ; Darren R. Feldman ; Kurt Kroenke ; Chunkit Fung ; Robert D. Frisina ; Lois B. Travis

PURPOSE: Cisplatin is widely used and highly ototoxic, but patient-reported functional impairment because of cisplatin-related hearing loss (HL) and tinnitus has not been comprehensively evaluated. PATIENTS AND METHODS: Testicular cancer survivors (TCS) given first-line cisplatin-based chemotherapy completed validated questionnaires, including the Hearing Handicap Inventory for Adults (HHIA) and Tinnitus Primary Function Questionnaire (TPFQ), each of which quantifies toxicity-specific [...]

Menée aux Etats-Unis à partir de données 2007-2019 portant sur 318 549 patients âgés de plus de 65 ans et atteints d'un cancer de mauvais pronostic, cette étude analyse les disparités ethniques dans l'accès aux opioïdes

Racial and Ethnic Disparities in Opioid Access and Urine Drug Screening Among Older Patients With Poor-Prognosis Cancer Near the End of Life

Andrea C. Enzinger ; Kaushik Ghosh ; Nancy L. Keating ; David M. Cutler ; Cheryl R. Clark ; Narjust Florez ; Mary Beth Landrum ; Alexi A. Wright

PURPOSE: To characterize racial and ethnic disparities and trends in opioid access and urine drug screening (UDS) among patients dying of cancer, and to explore potential mechanisms. METHODS: Among 318,549 non-Hispanic White (White), Black, and Hispanic Medicare decedents older than 65 years with poor-prognosis cancers, we examined 2007-2019 trends in opioid prescription fills and potency (morphine milligram equivalents [MMEs] per day [MMEDs]) near the end of life (EOL), defined as 30 days [...]

Menée à partir de données portant sur 151 enfants (âge moyen : 9,3 ans), cette étude de cohorte multicentrique analyse leur développement cognitif et comportemental en lien avec une exposition aux traitements anticancéreux reçus par leur mère pendant la grossesse

Cognitive and Behavioral Development of 9-Year-Old Children After Maternal Cancer During Pregnancy: A Prospective Multicenter Cohort Study

Indra A. Van Assche ; Evangeline A. Huis in 't Veld ; Kristel Van Calsteren ; Mathilde van Gerwen ; Jeroen Blommaert ; Elyce Cardonick ; Michael J. Halaska ; Robert Fruscio ; Monica Fumagalli ; Jurgen Lemiere ; Elisabeth M. van Dijk-Lokkart ; Camilla Fontana ; Harm van Tinteren ; Jessie De Ridder ; Martine van Grotel ; Marry M. van den Heuvel-Eibrink ; Lieven Lagae ; Frederic Amant

This multicenter cohort study reports on the long-term effects of prenatal exposure to maternal cancer and its treatment on cognitive and behavioral outcomes in 9-year-old children. In total, 151 children (mean age, 9.3 years; range, 7.8-10.6 years) were assessed using a neurocognitive test battery and parent-report behavioral questionnaires. During pregnancy, 109 children (72.2%) were exposed to chemotherapy (only or in combination with other treatment modalities), 18 (11.9%) to surgery only, [...]

Menée par enquête auprès de 9 664 jeunes adultes ayant survécu à un cancer pédiatrique (âge médian au diagnostic : 10,5 ans) et de 2 221 témoins (durée médiane de suivi : 6,6 ans), cette étude analyse la présence d'un sentiment de solitude et son impact sur leur détresse émotionnelle, leurs comportements de santé et leur état de santé

Emotional, behavioral, and physical health consequences of loneliness in young adult survivors of childhood cancer: Results from the Childhood Cancer Survivor Study

Papini, Chiara ; Fayad, Ameera A. ; Wang, Mingjuan ; Schulte, Fiona S. M. ; Huang, I-Chan ; Chang, Yu-Ping ; Howell, Rebecca M. ; Srivastava, Deokumar ; Leisenring, Wendy M. ; Armstrong, Gregory T. ; Gibson, Todd M. ; Robison, Leslie L. ; Oeffinger, Kevin C. ; Krull, Kevin R. ; Brinkman, Tara M.

Background : Young adults in the general population are at risk of experiencing loneliness, which has been associated with physical and mental health morbidities. The prevalence and consequences of loneliness in young adult survivors of childhood cancer remain unknown. Methods : A total of 9664 young adult survivors of childhood cancer (median age at diagnosis 10.5 years [interquartile range (IQR), 5–15], 27.1 years at baseline [IQR, 23–32]) and 2221 siblings enrolled in the Childhood Cancer [...]

A partir d'une revue systématique de la littérature publiée entre 1960 et 2020 (47 études incluant un total de 1  019  908 patients), cette méta-analyse analyse, chez des patients afro-américains et chez des patients de type caucasien tous atteints d'un cancer de la prostate, l'association entre des déterminants sociaux de santé et la mortalité spécifique ainsi que la survie globale

Evaluation of Social Determinants of Health and Prostate Cancer Outcomes Among Black and White Patients: A Systematic Review and Meta-analysis

Vince, Randy A., Jr ; Jiang, Ralph ; Bank, Merrick ; Quarles, Jake ; Patel, Milan ; Sun, Yilun ; Hartman, Holly ; Zaorsky, Nicholas G. ; Jia, Angela ; Shoag, Jonathan ; Dess, Robert T. ; Mahal, Brandon A. ; Stensland, Kristian ; Eyrich, Nicholas W. ; Seymore, Mariana ; Takele, Rebecca ; Morgan, Todd M. ; Schipper, Matthew ; Spratt, Daniel E.

Importance : As the field of medicine strives for equity in care, research showing the association of social determinants of health (SDOH) with poorer health care outcomes is needed to better inform quality improvement strategies. Objective : To evaluate the association of SDOH with prostate cancer–specific mortality (PCSM) and overall survival (OS) among Black and White patients with prostate cancer. Data Sources : A MEDLINE search was performed of prostate cancer comparative effectiveness [...]

Menée auprès de 1 326 patients ayant survécu à un cancer colorectal, cette étude analyse les raisons de leur non participation à des essais évaluant l'intérêt d'interventions de psychothérapie pour soulager la détresse psychique

Reasons for Non-Participation in a Psychological Intervention Trial for Distress in Colorectal Cancer Survivors

Custers, J.A.E. ; Döking, S. ; van der Hoeven, Y. C. W. ; Thewes, B. ; Dekker, J. ; Braamse, A.M.J. ; Prins, J.B.

Objective : High psychological distress is reported by one third of colorectal cancer survivors (CRCS). However, intervention studies for CRCS have reported low participation rates. In this study, reasons for non-participation and low uptake in a psychological intervention trial were investigated. Methods : CRCS were recruited for a randomized clinical trial on the efficacy of blended cognitive behavior therapy for psychological distress via databases, follow-up consultations, advertisements [...]

Mené sur 72 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt d'une psychothérapie dispensée sur internet pour réduire la peur de la récidive de la maladie ainsi que les symptômes de dépression et d'anxiété

Internet-delivered cognitive behavioural therapy for depression and anxiety in breast cancer survivors: Results from a randomised controlled trial

Akkol-Solakoglu, Selin ; Hevey, David

Objective: Depression and anxiety symptoms are common among breast cancer survivors. Access to evidence-based psychological therapy remains a major challenge. Despite the proven effectiveness of internet-delivered cognitive behavioural therapy (iCBT) in reducing depression and anxiety, the research with cancer survivors is still limited. This study evaluated the effectiveness of an iCBT intervention on depression and anxiety, quality of life, fear of recurrence, active and avoidant coping, and [...]

Menée auprès de 117 patientes ayant survécu à un cancer du sein et souffrant de troubles cognitifs, cette étude analyse l'intérêt d'une intervention basée sur le concept de la pleine conscience pour réduire leurs déficiences cognitives liées à la maladie

The impact of mindfulness on cancer-related cognitive impairment in breast cancer survivors with cognitive complaints

Melis, Michelle ; Schroyen, Gwen ; Leenaerts, Nicolas ; Smeets, Ann ; Sunaert, Stefan ; Van der Gucht, Katleen ; Deprez, Sabine

Background: Interventions that target cancer-related cognitive impairment (CRCI) to improve the quality of life of cancer survivors are needed. In this study, the potential of a mindfulness-based intervention to reduce CRCI in breast cancer survivors, compared with physical training and a wait list control group, was investigated. Methods: Breast cancer survivors with cognitive complaints (N = 117) were randomly allocated to a mindfulness (n = 43), physical training (n = 36), or wait list [...]

Mené sur 20 506 patients atteints d'un cancer (âge moyen : 60 ans), cet essai randomisé évalue l'impact, sur la qualité de vie du patient et les soins de fin de vie, d'incitations comportementales destinées au médecin pour qu'il engage des conversations sur les maladies graves avec ses patients présentant un risque élevé de décès

Long-term Effect of Machine Learning–Triggered Behavioral Nudges on Serious Illness Conversations and End-of-Life Outcomes Among Patients With Cancer: A Randomized Clinical Trial

Manz, Christopher R. ; Zhang, Yichen ; Chen, Kan ; Long, Qi ; Small, Dylan S. ; Evans, Chalanda N. ; Chivers, Corey ; Regli, Susan H. ; Hanson, C. William ; Bekelman, Justin E. ; Braun, Jennifer ; Rareshide, Charles A. L. ; O’Connor, Nina ; Kumar, Pallavi ; Schuchter, Lynn M. ; Shulman, Lawrence N. ; Patel, Mitesh S. ; Parikh, Ravi B.

Importance : Serious illness conversations (SICs) between oncology clinicians and patients are associated with improved quality of life and may reduce aggressive end-of-life care. However, most patients with cancer die without a documented SIC. Objective : To test the impact of behavioral nudges to clinicians to prompt SICs on the SIC rate and end-of-life outcomes among patients at high risk of death within 180 days (high-risk patients) as identified by a machine learning algorithm. Design, [...]