Menée auprès de 100 témoins et 268 agriculteurs utilisant du glyphosate, cette étude analyse le potentiel cancérogène de cet herbicide à travers l'association entre la concentration urinaire de glyphosate et le niveau des biomarqueurs de stress oxydatif

Glyphosate Exposure and Urinary Oxidative Stress Biomarkers in the Agricultural Health Study

Chang, Vicky C ; Andreotti, Gabriella ; Ospina, Maria ; Parks, Christine G ; Liu, Danping ; Shearer, Joseph J ; Rothman, Nathaniel ; Silverman, Debra T ; Sandler, Dale P ; Calafat, Antonia M ; Beane Freeman, Laura E ; Hofmann, Jonathan N

Glyphosate is the most widely applied herbicide worldwide, and its use has been associated with increased risks of certain hematopoietic cancers in epidemiologic studies. Animal and in vitro experiments suggest that glyphosate may induce oxidative stress, a key characteristic of carcinogens; however, evidence in human populations remains scarce. We investigated associations between glyphosate exposure and urinary oxidative stress biomarkers in the Biomarkers of Exposure and Effect in [...]

Menée notamment à l'aide de données de l'"U.S. Environmental Protection Agency’s Toxics Release Inventory" (durée médiane de suivi : 16,6 ans), cette étude analyse l'association entre une exposition environnementale résidentielle à l'oxyde d'éthylène et le risque de cancer du sein (12 222 cas) ou de lymphone non hodgkinien (6 484 cas)

Ethylene oxide emissions and incident breast cancer and non-Hodgkin lymphoma in a U.S. cohort

Jones, Rena R ; Fisher, Jared A ; Medgyesi, Danielle N ; Buller, Ian D ; Liao, Linda M ; Gierach, Gretchen ; Ward, Mary H ; Silverman, Debra T

Ethylene oxide (EtO) is a carcinogenic gas used in chemical production and to sterilize medical equipment that has been linked to risk of breast and lymphohematopoietic cancers in a small number of occupational studies. We investigated the relationship between environmental EtO exposure and risk of these cancers.Using the U.S. Environmental Protection Agency’s Toxics Release Inventory, we estimated historical exposures for NIH-AARP Diet and Health Study participants enrolled in 1995-1996. We [...]

Cette étude fait le point sur le risque de cancer du sein et de l'ovaire associé aux traitement hormonaux utilisés lors d'une transition de genre

Assessing Breast and Ovarian Cancer Risk Prior to Gender-Affirming Surgery

Cortina, Chandler S.

A growing number of adult individuals in the US identify as transgender or nonbinary, and many are seeking gender-affirming therapies, including gender-affirming operations and gender-affirming hormone therapy. Examples of gender-affirming operations for transmasculine persons include chest masculinization surgery, colloquially called top surgery, in which the majority of breast tissue is removed, and bottom surgery, which includes metoidioplasty, phalloplasty, and scrotoplasty and may also [...]

Menée à partir de données européennes portant sur 797 193 personnes (âge moyen : 42,8 ans), cette étude analyse l'association entre l'indice de masse corporelle et le risque de cancers liés à l'obésité (23 630 cas), en fonction de la présence de troubles métaboliques

Metabolically (un)healthy obesity and risk of obesity-related cancers: a pooled study

Sun, Ming ; Fritz, Josef ; Häggström, Christel ; Bjørge, Tone ; Nagel, Gabriele ; Manjer, Jonas ; Engeland, Anders ; Zitt, Emanuel ; Van Guelpen, Bethany ; Stattin, Pär ; Ulmer, Hanno ; Stocks, Tanja

Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce.We investigated body mass index (BMI, normal weight/overweight/obesity) jointly and in interaction with metabolic health status in relation to obesity-related cancer risk (n = 23,630) among 797,193 European individuals. A metabolic score comprising mid-blood pressure, plasma glucose and triglycerides was used to define metabolically healthy [...]

Menée à l'aide d'échantillons plasmatiques prélevés sur 1 983 témoins et 1 695 patientes atteintes d'un cancer du sein, cette étude identifie de nouveaux métabolites associés au risque de cancer du sein

A prospective case-cohort analysis of plasma metabolites and breast cancer risk

Stevens, V. L. ; Carter, B. D. ; Jacobs, E. J. ; McCullough, M. L. ; Teras, L. R. ; Wang, Y.

BACKGROUND: Breast cancer incidence rates have not declined despite an improvement in risk prediction and the identification of modifiable risk factors, suggesting the need to identify novel risk factors and etiological pathways involved in this cancer. Metabolomics has emerged as a promising tool to find circulating metabolites associated with breast cancer risk. METHODS: Untargeted metabolomic analysis was done on prediagnostic plasma samples from a case-cohort study of 1695 incident breast [...]