Menée à l'aide des données de 10 études portant sur 4 349 patients atteints d'un cancer gastrique et 8 441 témoins, cette étude analyse l'effet de facteurs liés au mode de vie (tabagisme, consommation d'alcool, consommation de fruits et légumes, consommation de viande transformée et consommation de sel) sur l'association entre le niveau d'éducation et le risque de développer la maladie

The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project

Alicandro, Gianfranco ; Bertuccio, Paola ; Collatuzzo, Giulia ; Pelucchi, Claudio ; Bonzi, Rossella ; Liao, Linda M. ; Rabkin, Charles S. ; Sinha, Rashmi ; Negri, Eva ; Dalmartello, Michela ; Zaridze, David ; Maximovich, Dmitry ; Vioque, Jesús ; Garcia de la Hera, Manoli ; Tsugane, Shoichiro ; Hidaka, Akihisa ; Hamada, Gerson Shigueaki ; López-Carrillo, Lizbeth ; Hernández-Ramírez, Raúl Ulises ; Malekzadeh, Reza ; Pourfarzi, Farhad ; Zhang, Zuo-Feng ; Kurtz, Robert C. ; Camargo, M. Constanza ; Curado, Maria Paula ; Lunet, Nuno ; Boffetta, Paolo ; La Vecchia, Carlo

Background: The causal pathway between high education and reduced risk of gastric cancer (GC) has not been explained. The study aimed at evaluating the mediating role of lifestyle factors on the relationship between education and GC Methods: Ten studies with complete data on education and five lifestyle factors (smoking, alcohol drinking, fruit and vegetable intake, processed meat intake and salt consumption) were selected from a consortium of studies on GC including 4349 GC cases and 8441 [...]

Menée à l'aide de données 2009-2018 de la "UK Biobank" portant sur 171 616 personnes (âge moyen : 55,6 ans ; durée médiane de suivi : 7 ans), cette étude analyse l'association entre une consommation de café sucré, édulcoré ou sans sucre et la mortalité toutes causes confondues ou par cancer (1 725 décès)

Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality

Background: Previous observational studies have suggested an association between coffee intake and reduced risk for death, but these studies did not distinguish between coffee consumed with sugar or artificial sweeteners and coffee consumed without. Objective: To evaluate the associations of consumption of sugar-sweetened, artificially sweetened, and unsweetened coffee with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: Data were extracted from the UK [...]

A partir d'une revue systématique de la littérature publiée entre 2014 et 2021 (14 méta-analyses), cette méta-analyse évalue l'association entre un comportement sédentaire et le risque de cancer (17 localisations)

Sedentary behavior and cancer–an umbrella review and meta-analysis

Hermelink, Rafael ; Leitzmann, Michael F. ; Markozannes, Georgios ; Tsilidis, Kostas ; Pukrop, Tobias ; Berger, Felix ; Baurecht, Hansjörg ; Jochem, Carmen

Several systematic reviews and meta-analyses have summarized the association between sedentary behavior (SB) and cancer. However, the level of evidence and the potential for risk of bias remains unclear. This umbrella review summarized the current data on SB in relation to cancer incidence and mortality, with a particular emphasis on assessing the risk of bias. We searched PubMed, Web of Science and Cochrane Database for systematic reviews and meta-analyses on the association between SB and [...]

Menée à l'aide de données portant sur 57 873 mineurs ayant extrait de l'uranium à partir de 1960 au Canada, en République tchèque, en France, en Allemagne et aux États-Unis, cette étude analyse l'association entre une exposition au radon et la mortalité par cancer du poumon (1 217 cas)

Lung Cancer and Radon: Pooled Analysis of Uranium Miners Hired in 1960 or Later

David B. Richardson ; Estelle Rage ; Paul A. Demers ; Minh T. Do ; Nora Fenske ; Veronika Deffner ; Michaela Kreuzer ; Jonathan Samet ; Stephen J. Bertke ; Kaitlin Kelly-Reif ; Mary K. Schubauer-Berigan ; Ladislav Tomasek ; Lydia B. Zablotska ; Charles Wiggins ; Dominique Laurier

Background: Despite reductions in exposure for workers and the general public, radon remains a leading cause of lung cancer. Prior studies of underground miners depended heavily upon information on deaths among miners employed in the early years of mine operations when exposures were high and tended to be poorly estimated. Objectives: To strengthen the basis for radiation protection, we report on the follow-up of workers employed in the later periods of mine operations for whom we have more [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2021, cette étude analyse le rôle de différents agents pathogènes ou inflammatoires dans la carcinogenèse prostatique

Multiple pathogens and prostate cancer

Lawson, James S. ; Glenn, Wendy K.

Background: The aim of this review is to consider whether multiple pathogens have roles in prostate cancer. Methods: We have reviewed case control studies in which infectious pathogens in prostate cancer were compared to normal and benign prostate tissues. We also reviewed additional evidence from relevant published articles. Results: We confirmed that high risk human papilloma viruses are a probable cause of prostate cancer. We judged Escherichia coli, Cutibacterium acnes, Neisseria [...]

Menée en Australie entre 2006 et 2013 auprès de 107 706 hommes, cette étude analyse l'association entre des facteurs sociodémographiques, comportementaux ou médicaux et le risque de cancer de la prostate (4 257 cas)

Family history, obesity, urological factors and diabetic medications and their associations with risk of prostate cancer diagnosis in a large prospective study

Nair-Shalliker, Visalini ; Bang, Albert ; Egger, Sam ; Yu, Xue Qin ; Chiam, Karen ; Steinberg, Julia ; Patel, Manish I. ; Banks, Emily ; O’Connell, Dianne L. ; Armstrong, Bruce K. ; Smith, David P.

Background: Prostate cancer (PC) aetiology is unclear. PC risk was examined in relation to several factors in a large population-based prospective study. Methods: Male participants were from Sax Institute’s 45 and Up Study (Australia) recruited between 2006 and 2009. Questionnaire and linked administrative health data from the Centre for Health Record Linkage and Services Australia were used to identify incident PC, healthcare utilisations, Prostate Specific Antigen (PSA) testing reimbursements [...]

A partir d'une revue de la littérature publiée jusqu'en mars 2022 (15 études, 30 323 patients), cette méta-analyse évalue l'association entre l'âge des parents et le risque de tumeur solide pédiatrique

Parental age and childhood lymphoma and solid tumor risk: A literature review and meta-analysis

Domingues, Allison ; Moore, Kristin J ; Sample, Jeannette ; Kharoud, Harmeet ; Marcotte, Erin L ; Spector, Logan G

Though advanced parental age has been definitively linked to pediatric acute lymphoblastic leukemia (ALL), studies of parental age and pediatric solid tumors have not reached firm conclusions. This analysis aimed to elucidate the relationship between parental age and pediatric solid tumors through meta-analysis of existing studies based in population registries.We searched Medline (PubMed) and Embase for registry-based studies of parental age and solid tumors through March 2022. We performed [...]

Menée à partir des données de 6 cohortes japonaises portant sur 271 694 personnes, cette étude analyse l'association entre la durée du sommeil et l'incidence des cancers (40 751 cas) ou la mortalité spécifique (18 323 décès), en fonction du sexe

Sleep duration and risk of cancer incidence and mortality: a pooled analysis of six population-based cohorts in Japan

Wilunda, Calistus ; Abe, Sarah Krull ; Svensson, Thomas ; Sawada, Norie ; Tsugane, Shoichiro ; Wada, Keiko ; Nagata, Chisato ; Kimura, Takashi ; Tamakoshi, Akiko ; Sugawara, Yumi ; Tsuji, Ichiro ; Ito, Hidemi ; Kitamura, Tetsuhisa ; Sakata, Ritsu ; Mizoue, Tetsuya ; Matsuo, Keitaro ; Tanaka, Keitaro ; Lin, Yingsong ; Inoue, Manami ; for the Research Group for the Development ; Evaluation of Cancer Prevention Strategies in Japan

Sleep duration is emerging as an important modifiable risk factor for morbidity and mortality. We assessed the association between sleep duration and cancer incidence and mortality among Japanese adults using data from six population-based cohorts with 271 694 participants. During a total follow-up period of about 5.9 million person-years, we identified 40 751 incident cancer cases and 18 323 cancer deaths. We computed study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) using [...]