Menée aux Etats-Unis à l'aide de données 2019-2020 portant sur 2 240 jeunes (âge moyen : 18,6-19,4 ans), cette étude analyse l'effet du stress sur l'utilisation de la cigarette électronique

Perceived stress and E-cigarette use during emerging adulthood: A longitudinal examination of initiation, progression, and continuation

Mantey, Dale S. ; Clendennen, Stephanie I. ; Sumbe, Aslesha ; Wilkinson, Anna V. ; Harrell, Melissa B.

E-cigarettes are the most commonly used tobacco product among youth and young adults in the US. Limited research has examined how stress impacts e-cigarette use among young people. We examine the longitudinal associations between perceived stress scale (PSS) score and e-cigarette use behaviors among a diverse cohort of emerging adults. We analyzed two waves of data collected in Fall 2019 (baseline) and Spring 2020 (6-month follow-up) of the Texas Adolescent Tobacco and Marketing Surveillance [...]

Menée aux Etats-Unis à l'aide de données d'enquêtes réalisées entre 2013 et 2017 auprès de 10 086 adolescents (âge : 12-17 ans), cette étude identifie les facteurs associés aux différentes trajectoires d'utilisation de la cigarette électronique et de la cigarette classique

Predictors of e-cigarette and cigarette use trajectory classes from early adolescence to emerging adulthood across four years (2013-2017) of the PATH Study

Stanton, Cassandra A ; Tang, Zhiqun ; Sharma, Eva ; Seaman, Elizabeth ; Gardner, Lisa D ; Silveira, Marushka L ; Hatsukami, Dorothy ; Day, Hannah R ; Cummings, K Michael ; Goniewicz, Maciej L ; Limpert, Jean ; Everard, Colm ; Bansal-Travers, Maansi ; Ambrose, Bridget ; Kimmel, Heather L ; Borek, Nicolette ; Compton, Wilson M ; Hyland, Andrew J ; Pearson, Jennifer L

This study examines predictors of trajectories of cigarette and e-cigarette use among a cohort of U.S. adolescents transitioning into young adulthood. Comparing trajectories of each tobacco product is important to determine if different intervention targets are needed to prevent progression to daily use.Latent trajectory class analyses identified cigarette and e-cigarette use (never, ever excluding past 12-month, past 12-month (excluding past 30-day (P30D)), P30D 1-5 days, P30D 6+ days) [...]

Menée aux Etats-Unis à partir de données 2018-2019 portant sur 8 072 fumeurs (âge moyen : 44,7 ans ; 53,2 % d'hommes), cette étude analyse l'effet, sur les comportements tabagiques, d'un programme de conseils d'anciens fumeurs (Tips), en fonction de l'orientation sexuelle

Intentions and Attempts to Quit Smoking Among Sexual Minoritized Adult Smokers After Exposure to the Tips From Former Smokers Campaign

Wang, Yu ; Duan, Zongshuan ; Emery, Sherry L. ; Weaver, Scott R. ; Self-Brown, Shannon R. ; Ashley, David L. ; Huang, Jidong

Significant disparities exist in smoking behaviors by sexual minority status in the US.To examine potential differences in the associations between exposure to the Tips From Former Smokers (Tips) campaign and intentions and attempts to quit smoking by sexual minority status.This cross-sectional study used data from the wave 5 survey of the Population Assessment of Tobacco and Health study. Data from 8072 adults who were currently established cigarette smokers were collected from December 2018 [...]

A partir d'une revue systématique de la littérature (24 articles, 37 280 patients atteints d'un cancer colorectal), cette étude analyse l'association entre l'apport alimentaire en folate et le risque de développer la maladie

Folate intake and risk of colorectal cancer: a systematic review and up-to-date meta-analysis of prospective studies

Fu, Hongjuan ; He, Jianbo ; Li, Cancan ; Deng, Zhihui ; Chang, Hui

Purpose: Colorectal cancer is one of the most commonly diagnosed and deadly cancers worldwide. Epidemiological studies on the relationship between folate intake and the risk of colorectal cancer have reported inconsistent findings since folate fortification in the USA. For this situation, we conducted a large number of data analyses to study the relationship between folate intake and colorectal cancer risk. Methods: PubMed and EMBASE databases were used to search the literature systematically. [...]

Menée auprès de 603 patientes atteintes d'un cancer du sein traité par chirurgie, cette étude analyse l'association entre la capacité antioxydante totale de l'alimentation et le risque de récidive de la maladie

Association of Dietary Total Antioxidant Capacity with Cancer Recurrence and Mortality among Breast Cancer Survivors: A Prospective Cohort Study

Han, Doyeon ; Chung, Minsung ; Park, Yongsoon

Antioxidants decrease the risk of breast cancer by reducing oxidative stress, but the association between dietary total antioxidant capacity (DTAC) and cancer recurrence has not yet been investigated. The present study aimed to test the hypothesis that DTAC is inversely associated with cancer recurrence and mortality in breast cancer patients. Breast cancer patients (n?=?603) who underwent breast cancer surgery and a dietary survey within 5?years after surgery were recruited. This study [...]

Menée sur la période 2016-2018 auprès de 372 finlandaises de 25 ans, cette étude compare l'immunogénicité, du point de vue des taux d'anticorps spécifiques induits par la vaccination (17 types de HPV), des vaccins contre le papillomavirus humain (HPV) bivalent et nonavalent

Head-to-head comparison of bi- and nonavalent human papillomavirus vaccine-induced antibody responses

Mühr, Laila Sara Arroyo ; Eklund, Carina ; Lagheden, Camilla ; Eriksson, Tiina ; Pimenoff, Ville N. ; Gray, Penelope ; Lehtinen, Matti ; Dillner, Joakim

For head-to-head comparison of Human Papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old naïve women were given either the bivalent (n=188) or the nonavalent HPV vaccine (n=184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured.Antibodies against HPV16/18 were higher after bivalent HPV vaccination (Mean International Units (IU) 1140.1 and 170.5 for HPV 16 [...]

Menée par enquête en ligne auprès de 1 501 adolescents, cette étude identifie dans les publicités les éléments marquants pour la prévention du vapotage

Perceived effectiveness of objective elements of vaping prevention messages among adolescents

Boynton, Marcella H ; Sanzo, Nora ; Brothers, Whitney ; Kresovich, Alex ; Sutfin, Erin L ; Sheeran, Paschal ; Noar, Seth M

Introduction: In recent years, vaping prevention campaigns have proliferated in response to a surge of e-cigarette use among adolescents in the USA. To date, the research literature has provided minimal guidance as to what vaping prevention message elements have the greatest potential for discouraging vaping, are ineffective or have unintended negative effects. The purpose of the current study was to identify and test a large set of vaping prevention ads used by federal, state, local and [...]

Menée à l'aide de modèles murins modifiés génétiquement et de xénogreffes de naevi cutanés géants d'origine humaine, cette étude met en évidence l'intérêt, pour induire la régression du naevus ou prévenir le risque de mélanome, d'un traitement topique comportant un inhibiteur de MEK et un inhibiteur de PI3K en combinaison avec un inhibiteur de c-KIT ou l'ester de dibutyle de l'acide squarique

Topical therapy for regression and melanoma prevention of congenital giant nevi

Choi, Yeon Sook ; Erlich, Tal H. ; von Franque, Max ; Rachmin, Inbal ; Flesher, Jessica L. ; Schiferle, Erik B. ; Zhang, Yi ; Pereira da Silva, Marcello ; Jiang, Alva ; Dobry, Allison S. ; Su, Mack ; Germana, Sharon ; Lacher, Sebastian ; Freund, Orly ; Feder, Ezra ; Cortez, Jose L. ; Ryu, Suyeon ; Babila Propp, Tamar ; Samuels, Yedidyah Leo ; Zakka, Labib R. ; Azin, Marjan ; Burd, Christin E. ; Sharpless, Norman E. ; Liu, X. Shirley ; Meyer, Clifford ; Austen, William Gerald, Jr. ; Bojovic, Branko ; Cetrulo, Curtis L., Jr. ; Mihm, Martin C. ; Hoon, Dave S. ; Demehri, Shadmehr ; Hawryluk, Elena B. ; Fisher, David E.

Giant congenital melanocytic nevi are NRAS-driven proliferations that may cover up to 80% of the body surface. Their most dangerous consequence is progression to melanoma. This risk often triggers preemptive extensive surgical excisions in childhood, producing severe lifelong challenges. We have presented preclinical models, including multiple genetically engineered mice and xenografted human lesions, which enabled testing locally applied pharmacologic agents to avoid surgery. The murine models [...]