A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2021 (9 études, 3 494 patients atteints d'un cancer gastrique), cette méta-analyse évalue l'association entre la vitamine B12 et le risque de développer la maladie

Association between Vitamin B12 and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Epidemiological Studies

He, Jianbo ; Fu, Hongjuan ; Li, Cancan ; Deng, Zhihui ; Chang, Hui

Epidemiological studies focusing on the association between vitamin B12 and gastric cancer risk reported inconsistent findings. We conducted a systematic review and meta-analysis to assess the relationship. PubMed (Medline), Web of science and EMBASE databases were systematically searched. A total of nine studies involving 3,494 cases of with gastric cancer and 611,638 participants were included. The result showed that there is no significant association between vitamin B12 intake and the risk [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2021 (17 études, 4 953 patients atteints d'un carcinome hépatocellulaire), cette méta-analyse évalue l'association entre une consommation de viandes (viande rouge, viande blanche, poisson, viande transformée et viande totale) et le risque de développer la maladie

Meat Intake and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies

Yu, Jinchuan ; Liu, Zhengxiang ; Liang, Di ; Li, Jiujiu ; Ma, Shaodi ; Wang, Guangjun ; Chen, Wenjun

The association between meat intake and hepatocellular carcinoma (HCC) risk is still unclear. We conducted a meta-analysis with observational studies to clarify this relationship. A total of 17 studies involving 2,915,680 participants and 4,953 cases of HCC were included in the meta-analysis. Ten studies reported red meat intake, nine reported white meat intake, nine reported fish intake, seven reported processed meat intake, and five reported total meat intake. The results showed that the [...]

Menée à l'aide de données 2002-2018 de l'Assurance maladie coréenne et à partir de données 1999-2017 de registres des cancers, cette étude analyse le risque de cancer dans une zone résidentielle exposée aux incinérateurs de déchets industriels

Cancer risk in the residents of a town near three industrial waste incinerators in Korea: a retrospective cohort study

Choi, Kyung-Hwa ; Lim, Hyungryul ; Bae, Sanghyuk ; Ha, Mina ; Kwon, Ho-Jang ; Yoon, Mira ; Hong, Seonmi ; Eom, Sang-Yong ; Kim, Yong-Dae ; Kim, Heon

Background: Three industrial waste incinerators (IWIs) were built in 1999, 2001, and 2010, within a 3 km radius of a town with a population of around 5000 in Korea. This study evaluated whether residents near these three IWIs had increased cancer incidence than those from other areas in Korea using regional health data. Methods: Standardized incidence ratios (SIR) were calculated using the frequency of cancer cases in the National Cancer Registry of the exposed area (Buki-myeon), [...]

Menée à partir de données de l'Assurance maladie coréenne portant sur 685 436 témoins et 90 944 patients atteints d'une hépatite B chronique diagnostiquée entre 2012 et 2014 (durée médiane de suivi : 47,4 mois), cette étude analyse l'association entre un traitement par analogues nucléotidiques ou nucléosidiques et le risque de développer une tumeur extrahépatique (30 413 cas)

Association of Chronic Hepatitis B Infection and Antiviral Treatment With the Development of the Extrahepatic Malignancies: A Nationwide Cohort Study

Dong Hyeon Lee ; Sung Won Chung ; Jeong-Hoon Lee ; Hwi Young Kim ; Goh Eun Chung ; Mi-Sook Kim ; Bo Ram Yang ; Joon Yeul Nam ; Yun Bin Lee ; Yoon Jun Kim ; Jung-Hwan Yoon

PURPOSE: Epidemiologic studies suggest that chronic hepatitis B (CHB) is a risk factor for various primary extrahepatic malignancies. Our aim was to evaluate the associations of CHB and nucleos(t)ide analog (NA) treatment with the risk of the development of extrahepatic malignancies. PATIENTS AND METHODS: We conducted an 18-month landmark analysis using nationwide claims data from the National Health Insurance Service of South Korea. Patients newly diagnosed with CHB in 2012-2014 (n = 90,944) [...]

Menée à l'aide de données de l'Assurance maladie coréenne portant sur des témoins et sur 5 177 patients ayant reçu une greffe de cellules souches hématopoïétiques allogéniques entre 2002 et 2018 (durée médiane de suivi : 2 374 jours), cette étude analyse le risque de cancer secondaire non hématologique

Risk of Secondary Non-hematologic Malignancies after Allogeneic Stem Cell Transplantation: A Nationwide Case-Control Cohort Study

Park, Sung-Soo ; Park, Si-Hyun ; Han, Seunghoon

This study investigated the incidence of secondary non-hematologic malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT) and explored its risk compared with the general population. A population-based case cohorts with adult patients who received allo-SCT between January 2002 and December 2018 and a control cohort with matched general population were extracted from the Korean National Health Insurance Service database. Each case and control cohort [...]

Menée aux Pays-Bas à l'aide de données portant sur 98 630 participants, cette étude analyse l'association entre un débit expiratoire limité et le risque de cancer du poumon, en fonction du statut tabagique

Airflow limitation increases lung cancer risk in smokers: the Lifelines cohort study

Du, Yihui ; Sidorenkov, Grigory ; Groen, Harry JM. ; Heuvelmans, Marjolein A. ; Vliegenthart, Rozemarijn ; Dorrius, Monique D. ; Timens, Wim ; de Bock, Geertruida H.

Background: The relationship between smoking, airflow limitation and lung cancer occurrence is unclear. This study aims to evaluate the relationship between airflow limitation and lung cancer, and the effect modification by smoking status. Methods: We included participants with spirometry data from Lifelines, a population-based cohort study from the Northern Netherlands. Airflow limitation was defined as FEV1/FVC ratio < 0.7. The presence of pathology-confirmed primary lung cancer during [...]

Menée en Chine à l'aide du génotypage de 304 témoins et 304 patients atteints d'un cancer du poumon à petites cellules, cette étude analyse le rôle des variants des gènes des TLR dans la carcinogenèse pulmonaire

TLR4 regulatory region variants reduce the susceptibility of small-cell lung cancer in Chinese population

Zhang, Hongmei ; Gao, Hui ; Li, Ang ; Wu, Hongjiao ; Xie, Yuning ; Zhang, Zhi ; Zhang, Xuemei

Objectives: Toll-like receptors (TLRs) participate in the induction and regulation of immune responses and are closely related to the occurrence and development of small-cell lung cancer (SCLC). This study aimed to investigate the impact of polymorphisms in the regulatory regions of TLRs on the susceptibility of SCLC. Methods: The case–control study included 304 SCLC patients and 304 healthy controls. TLRs gene polymorphisms were genotyped by PCR-restrictive fragment length polymorphism [...]

Menée à l'aide de données d'études de randomisation mendélienne notamment, cette étude analyse l'association entre la testostérone libre et le risque de cancer agressif de la prostate

Circulating free testosterone and risk of aggressive prostate cancer: prospective and Mendelian randomization analyses in international consortia

Watts, Eleanor L. ; Perez-Cornago, Aurora ; Fensom, Georgina K. ; Smith-Byrne, Karl ; Noor, Urwah ; Andrews, Colm D. ; Gunter, Marc J. ; Holmes, Michael V. ; Martin, Richard M. ; Tsilidis, Konstantinos K. ; Albanes, Demetrius ; Barricarte, Aurelio ; Bueno-de-Mesquita, H. Bas ; Chen, Chu ; Cohn, Barbara A. ; Dimou, Niki L. ; Ferrucci, Luigi ; Flicker, Leon ; Freedman, Neal D. ; Giles, Graham G. ; Giovannucci, Edward L. ; Goodman, Gary E. ; Haiman, Christopher A. ; Hankey, Graeme J. ; Huang, Jiaqi ; Huang, Wen-Yi ; Hurwitz, Lauren M. ; Kaaks, Rudolf ; Knekt, Paul ; Kubo, Tatsuhiko ; Langseth, Hilde ; Laughlin, Gail ; Le Marchand, Loic ; Luostarinen, Tapio ; MacInnis, Robert J. ; Mäenpää, Hanna O. ; Mannisto, Satu ; Metter, E. Jeffrey ; Mikami, Kazuya ; Mucci, Lorelei A. ; Olsen, Anja W. ; Ozasa, Kotaro ; Palli, Domenico ; Penney, Kathryn L. ; Platz, Elizabeth A. ; Rissanen, Harri ; Sawada, Norie ; Schenk, Jeannette M. ; Stattin, Pär ; Tamakoshi, Akiko ; Thysell, Elin ; Tsai, Chiaojung Jillian ; Tsugane, Shoichiro ; Vatten, Lars ; Weiderpass, Elisabete ; Weinstein, Stephanie J. ; Wilkens, Lynne R. ; Yeap, Bu B. ; The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS ; Allen, Naomi E. ; Key, Timothy J. ; Travis, Ruth C.

Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate cancer. In blood-based analyses, odds ratios (OR) and 95% confidence intervals (CI) for prostate [...]