Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" ou de la "FinnGen biobank" portant au total sur plus d'1 million de personnes, cette étude analyse l'association entre le niveau sérique d'apolipoprotéine B, la consommation de café et le risque de cancer gastrique, colorectal et oesophagien

Causal relationships between coffee intake, apolipoprotein B and gastric, colorectal, and esophageal cancers: univariable and multivariable Mendelian randomization

Liu, Xingwu ; Yu, Han ; Yan, Guanyu ; Xu, Boyang ; Sun, Mingjun ; Feng, Mingliang

Purpose: Coffee intake and apolipoprotein B levels have been linked to gastric, colorectal, and esophageal cancers in numerous recent studies. However, whether these associations are all causal remains unestablished. This study aimed to assess the potential causal associations of apolipoprotein B and coffee intake with the risk of gastric, colorectal, and esophageal cancers using Mendelian randomization analysis. Methods: In this study, we utilized a two-sample Mendelian randomization analysis [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2022 (5 études), cette méta-analyse évalue l'association entre une alimentation pro-inflammatoire, évaluée à l'aide d'un score, et le risque de cancer du foie

Association between pro-inflammatory diet and liver cancer risk: a systematic review and meta-analysis

Chen, Kaixia ; Gao, Xiaolian ; Qiao, Guiyuan ; Tao, Junxiu ; Xiao, Mingzhong ; Yang, Fen ; Zhang, Chunmei ; Zhu, Xinhong

Objective: This systematic review aimed to investigate the association between dietary inflammatory potential and liver cancer to provide evidence regarding scientific dietary health education. Design: Systematic review and meta-analysis. Setting: A comprehensive literature review was conducted to identify case–control or cohort studies that involved dietary inflammation index (DII)/empirical dietary inflammation pattern (EDIP) and liver cancer in PubMed, EMBASE, Cochrane, and Web of Science [...]

Menée à l'aide de données portant sur 296 505 vétérans du Viêtnam (durée moyenne de suivi : 51,1 ans), cette étude analyse l'association entre une exposition à l'agent orange et le risque de carcinome hépatocellulaire (2 654 cas)

Exposure to Agent Orange and Hepatocellular Carcinoma Among US Military Personnel

Benhammou, Jihane N. ; Leng, Mei ; Shah, Shailja C. ; Cholankeril, George ; Dong, Tien S. ; Patel, Arpan A. ; Tong, Myron J.

Hepatocellular carcinoma (HCC) and its mortality are on the rise. Viral hepatitis and alcohol are leading risk factors; however, other risk factors among veterans are less defined, including Agent Orange (AO), an herbicide linked to several cancers.To assess the association of AO exposure and HCC in a national cohort of Vietnam veterans.This retrospective cohort study included Vietnam veterans who served between 1966 and 1975, were male, were older than 18 years at the time of deployment, and [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études pangénomiques portant sur 18 169 témoins et 12 488 patients atteints d'un gliome, cette étude analyse l'association entre 12 infections virales et le risque de développer la maladie

Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis

Zhong, Sheng ; Yang, Wenzhuo ; Zhang, Zhiyun ; Xie, Yangyiran ; Pan, Lin ; Ren, Jiaxin ; Ren, Fei ; Li, Yifan ; Xie, Haoqun ; Chen, Hongyu ; Deng, Davy ; Lu, Jie ; Li, Hui ; Wu, Bo ; Chen, Youqi ; Peng, Fei ; Puduvalli, Vinay K. ; Sai, Ke ; Li, Yunqian ; Cheng, Ye ; Mou, Yonggao

Background: Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previous observational research has shown an association between viral infection and glioma risk. In this study, we used Mendelian randomization (MR) analysis to explore the direction and magnitude of the causal relationship between viral infection and glioma. Methods: We conducted a two-sample bidirectional MR analysis using genome-wide association study (GWAS) data. [...]

Menée à l'aide de données 1992-2013 des registres américains des cancers et de la base Medicare portant sur 200 000 témoins et 18 739 patients atteints d'un cancer des voies aérodigestives supérieures, cette étude analyse l'association entre des inflammations de la langue et le risque de cancer de la langue, de la cavité buccale ou de l'oropharynx chez les personnes âgées d'au moins 65 ans

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals

Joseph E. Tota ; Eric A. Engels ; Mark W. Lingen ; Nishant Agrawal ; Alexander R. Kerr ; Zachary S. Zumsteg ; Li C. Cheung ; Hormuzd A. Katki ; Christian C. Abnet ; Anil K. Chaturvedi

PURPOSE: The incidence of oral tongue cancers has increased since the 1980s among US men and women for unknown reasons. We investigated associations of inflammatory tongue conditions with risk of cancers of the oral tongue, other oral cavity, and oropharynx among the US elderly individuals (age 65 years or older). METHODS: We conducted a case-control study (2,534 oral tongue cancers, 6,832 other oral cavity cancers, 9,373 oropharyngeal cancers, and 200,000 controls) within the SEER-Medicare [...]

Menée en Chine à l'aide du génotypage de l'ADN de 572 témoins et 571 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre des polymorphismes à simple nucléotide du gène CYP4B1 et le risque de développer la maladie

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Yin, Yanhai ; Tong, Liangqian ; Wan, Zhenling ; Sui, Yanfang ; Li, Fen ; Huang, Qian ; Zhao, Xinhan

Background: Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene was abnormally expressed in BC and was associated with the prognosis of BC patients. This study aimed to explore the relationship between CYP4B1 single nucleotide polymorphisms (SNPs) and BC risk in Chinese women. Methods: A case-control study of 1,143 women (571 patients and 572 healthy individuals) was conducted. Rs2297813 G/T, rs12142787 G/A, and rs3766197 C/T [...]