Menée à partir de données portant sur 237 adultes ayant survécu à un cancer pédiatrique traité par sels de platine et radiothérapie de la tête et du cou (âge moyen lors de l'étude : 37 ans ; durée moyenne depuis le diagnostic : 29,1 ans), cette étude analyse l'association entre la prévalence d'une perte d'audition liée aux traitements, le handicap auditif auto-perçu et des difficultés psychosociales

Association of hearing loss with patient-reported functional outcomes in adult survivors of childhood cancer

Bass, Johnnie K ; Wang, Fang ; Thaxton, Mackenzie E ; Warren, Sarah E ; Srivastava, Deo Kumar ; Hudson, Melissa M ; Ness, Kirsten K ; Brinkman, Tara M

Background: Hearing loss (HL) is prevalent following ototoxic therapy for childhood cancer. Associations between HL, self-perceived hearing handicap, and functional outcomes have not been examined in survivors. Methods: Adult survivors treated with platinum or head/neck radiotherapy with HL were recruited. Two hundred thirty-seven survivors (median[range] age at survey 37.0[30.0-45.0] years, 29.1[22.4-35.0] years since diagnosis, 4.0[2.9-7.7] years from last audiogram to survey) completed the [...]

A partir d'une revue systématique de la littérature (11 études, 777 patients), cette méta-analyse évalue l'intérêt des exercices de yoga (hata yoga et lyengar yoga) pour soulager les symptômes de fatigue et de dépression et améliorer la qualité de vie des patients atteints d'un cancer

No effects were found in favor of Hatha or Iyengar yoga exercises for improving cancer-related fatigue, depression symptoms, or quality of life: a systematic review with meta-analysis and metaregression

García-Muñoz, Cristina ; Villar-Alises, Olga ; Rodríguez-Sánchez-Laulhé, Pablo ; Matias-Soto, Javier ; Martinez-Calderon, Javier

Objective: To summarize the evidence on the effectiveness of Hatha or Iyengar yoga exercises on cancer-related fatigue, depression symptoms, and the overall quality of life in adults with cancer. Methods: A systematic review with meta-analysis was conducted. The CINAHL (via EBSCOhost), Embase, PubMed, and SPORTDiscus (via EBSCOhost) databases were searched from inception to 7th November 2022. Clinical trials evaluating cancer-related fatigue, depression symptoms, and the overall quality of life [...]

Mené sur 420 dyades constituées d'un aidant et d'un patient pédiatrique atteint d'un cancer ou ayant reçu une greffe de cellules souches hématopoïétiques, cet essai randomisé compare l'intérêt de 3 outils permettant de déclarer les symptômes du patients pendant les traitements (un outil renseigné par la dyade, un outil renseigné par l'aidant, un outil renseigné par le patient)

Randomized trial of dyadic-report vs. proxy-report/self-report symptom assessment for pediatric patients receiving cancer treatments

Tomlinson, Deborah ; Tardif-Theriault, Cassandra ; Schechter, Tal ; Dupuis, L Lee ; Sung, Lillian

Background: We validated different approaches to symptom assessment for pediatric cancer patients based on Symptom Screening in Pediatrics Tool (SSPedi) for self-report (SSPedi and mini-SSPedi), proxy-report (proxy-SSPedi) and a structured dyadic-report (co-SSPedi). Objective was to compare co-SSPedi scores vs proxy-report (proxy-SSPedi) and self-report (SSPedi/mini-SSPedi) scores for pediatric patients receiving cancer treatments. Methods: This was a single center, randomized cross-over study [...]

A partir d'une revue de la littérature publiée entre 1995 et 2022 (92 articles), cette étude analyse les donnés portant sur la prise en charge de l'après-cancer chez des patients ayant survécu à un lymphome hodgkinien ou non-hodgkinien

Survivorship care for patients curatively treated for Hodgkin’s and non-Hodgkin’s lymphoma: a scoping review

Powis, Melanie ; Hack, Saidah ; Fazelzad, Rouhi ; Hodgson, David ; Kukreti, Vishal

Purpose: We undertook a scoping review of the literature to synthesize what is known about lymphoma survivorship and develop a comprehensive set of lymphoma-specific survivorship recommendations. Methods: We searched the peer-reviewed literature from January 1995 to April 2022, focused on topics relevant to survivorship care in patients ≥ 18 years of age, treated curatively for non-Hodgkin’s and Hodgkin’s lymphoma, and in remission for at least 2 years. Results: We retained 92 articles; themes [...]

Menée au Danemark à partir de données portant sur 457 334 patients ayant survécu à un cancer diagnostiqué entre 1997 et 2014 (âge médian au diagnostic : 68,3 ans ; durée médiane de suivi : 3,6 ans), cette étude de cohorte rétrospective analyse l'incidence de second cancer primitif et les facteurs de risque associés

Cumulative incidence of second primary cancers in a large nationwide cohort of Danish cancer survivors: a population-based retrospective cohort study

Kjaer, Trille Kristina ; Andersen, Elisabeth Anne Wreford ; Ursin, Giske ; Larsen, Signe Benzon ; Bidstrup, Pernille Envold ; Winther, Jeanette Falck ; Borre, Michael ; Johansen, Christoffer ; Dalton, Susanne Oksbjerg

Background: A new primary cancer is a serious late effect of a pre-existing cancer diagnosis, and can be attributed to hereditary cancer syndromes, immune or hormonal factors, cancer treatment, or modifiable lifestyle or environmental factors. We investigated the absolute and relative incidence of second primary cancers in a large cohort of Danish cancer survivors. Furthermore, we examined the association between alcohol-related, smoking-related, virus-related, and hormone-related first and [...]

Menée aux Etats-Unis à partir de données portant sur 748 patients atteints d'un cancer de la prostate de stade avancé de novo (âge médian : 75 ans), cette étude de cohorte analyse, en fonction de l'origine ethnique, l'utilisation d'une hormonothérapie (abiratérone, enzalutamide, apalutamide ou darolutamide)

Racial and Ethnic Disparities in Use of Novel Hormonal Therapy Agents in Patients With Prostate Cancer

Ma, Ting Martin ; Agarwal, Neeraj ; Mahal, Brandon ; Barragan-Carrillo, Regina ; Spratt, Daniel ; Rettig, Matthew B. ; Valle, Luca F. ; Steinberg, Michael L. ; Garraway, Isla ; Vapiwala, Neha ; Xiang, Michael ; Kishan, Amar U.

Importance : Novel hormonal therapy (NHT) agents have been shown to prolong overall survival in numerous randomized clinical trials for patients with advanced prostate cancer (PCa). There is a paucity of data regarding the pattern of use of these agents in patients from different racial and ethnic groups. Objective : To assess racial and ethnic disparities in the use of NHT in patients with advanced PCa. Design, Setting, and Participants : This cohort study comprised all men diagnosed with de [...]

Menée en Autriche à partir de données portant sur 296 170 patients asymptômatiques et ayant subi une coloscopie de dépistage (âge médian : 60 ans ; 11 103 patients de moins de 50 ans), cette étude analyse la prévalence d'adénomes et de lésions précurseurs ainsi que l'incidence de cancer colorectal par catégorie d'âge (âge supérieur ou inférieur à 50 ans)

Colorectal Cancer and Precursor Lesion Prevalence in Adults Younger Than 50 Years Without Symptoms

Penz, Daniela ; Waldmann, Elisabeth ; Hackl, Monika ; Jiricka, Lena ; Rockenbauer, Lisa-Maria ; Gessl, Irina ; Zessner-Spitzenberg, Jasmin ; Ferlitsch, Arnulf ; Trauner, Michael ; Ferlitsch, Monika

Importance : Incidence of colorectal cancer (CRC) is increasing among younger adults. However, data on precursor lesions in patients who are asymptomatic, especially those aged younger than 50 years, are lacking. Objective : To analyze the prevalence and number needed to screen (NNS) for adenomas, advanced adenomas, and serrated lesions, as well as the incidence of CRC in patients older than age 20 years. Design, Setting, and Participants : This cohort study was conducted among 296 170 patients [...]

Menée en Norvège à partir de données portant sur 9 954 patientes atteintes d'un cancer du sein invasif diagnostiqué entre 1996 et 2011 (âge : 50-69 ans), cette étude de cohorte analyse, selon le mode de détection (dépistage organisé ou hors programme de dépistage), le profil histopathologique des cancers ayant entraîné ou non un décès (dans les 10 ans suivant le diagnostic)

Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study

Tsuruda, Kaitlyn M. ; Hoff, Solveig Roth ; Akslen, Lars A. ; Hofvind, Solveig

Background: Many breast cancer survivors experience anxiety related to dying from their disease even if it is detected at an early stage. We aimed to increase knowledge about fatal and non-fatal breast cancer by describing how histopathological tumour profiles and detection modes were associated with 10-year breast cancer-specific survival. Methods: This cohort study included data from women targeted by BreastScreen Norway (aged 50–69) and diagnosed with invasive breast cancer during 1996–2011. [...]

Menée aux Etats-Unis à partir de données portant sur un total de 198 patientes atteintes d'un cancer du sein, cette étude de cohorte rétrospective analyse, selon la présence d'une infection par le VIH (66 cas), le délai d'accès aux traitements et l'intensité des doses de chimiothérapies néoadjuvantes et adjuvantes reçues

Time to Cancer Treatment and Chemotherapy Relative Dose Intensity for Patients With Breast Cancer Living With HIV

O’Neil, Daniel S. ; Martei, Yehoda M. ; Crew, Katherine D. ; Castillo, Brenda S. ; Costa, Philippos ; Lim, Tristan ; Michel, Alissa ; Rubin, Elizabeth ; Goel, Neha ; Hurley, Judith ; Lopes, Gilberto ; Antoni, Michael H.

Importance : Patients with breast cancer and comorbid HIV experience higher mortality than other patients with breast cancer. Objective : To compare time to cancer treatment initiation and relative dose intensity (RDI) of neoadjuvant and adjuvant chemotherapy among patients with breast cancer with vs without HIV. Design, Setting, and Participants : A retrospective, matched cohort study enrolled women who received a diagnosis of breast cancer from January 1, 2000, through December 31, 2018. The [...]

Menée aux Etats-Unis à partir de données portant sur 1 230 patientes atteintes d'un cancer épithélial de l'ovaire, cette étude analyse la survie en fonction de l'origine ethnique

Epithelial ovarian cancer survival by race and ethnicity in an equal-access healthcare population

Arter, Zhaohui L. ; Desmond, Daniel ; Berenberg, Jeffrey L. ; Killeen, Jeffrey L. ; Bunch, Kristen ; Merritt, Melissa A.

Background: Previous studies in the general population observed that compared with non-Hispanic White women, Pacific Islander and Black women have higher age-adjusted mortality rates from epithelial ovarian cancer (EOC), while Asian American patients have lower mortality. We investigated whether race and ethnicity is associated with differences in EOC survival in a United States Military population where patients have equal access to healthcare. Methods: This retrospective study included women [...]

A partir d'une revue systématique de la littérature (37 essais randomisés), cette méta-analyse compare l'intérêt, pour réduire la détresse psychique et améliorer la qualité de vie des patients atteints d'un cancer de stade avancé, des thérapies cognitives et comportementales et d'interventions basées sur le concept de la pleine conscience

Cognitive-behavioral and mindfulness-based interventions for distress in patients with advanced cancer: A meta-analysis

Krueger, Ellen ; Secinti, Ekin ; Stewart, Jesse C. ; Rand, Kevin L. ; Mosher, Catherine E.

Objective: Various psychosocial interventions have been developed to reduce distress and improve quality of life (QoL) in patients with advanced cancer, many of which are traditional cognitive-behavioral interventions (CBIs) or mindfulness-based interventions (MBIs). The aims of this meta-analysis were to determine and compare the overall effects of traditional CBIs and MBIs on distress and QoL in this population and to explore potential moderators of intervention efficacy. Methods: A [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité de deux stratégies thérapeutiques de deuxième ligne pour prendre en charge les patients atteints d'un lymphome diffus à grandes cellules B, l'une utilisant une immunothérapie à base de lymphocytes CAR-T et l'autre utilisant une chimio-immunothérapie de sauvetage et une greffe autologue de cellules souches en consolidation

Second-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma: A Cost-Effectiveness Analysis

J. Ferdinandus ; H. Müller ; C. Damaschin ; et al.

Background: First-line treatment of diffuse large B-cell lymphoma (DLBCL) achieves durable remission in approximately 60% of patients. In relapsed or refractory disease, only about 20% achieve durable remission with salvage chemoimmunotherapy and consolidative autologous stem cell transplantation (ASCT). The ZUMA-7 (axicabtagene ciloleucel [axi-cel]) and TRANSFORM (lisocabtagene maraleucel [liso-cel]) trials demonstrated superior event-free survival (and, in ZUMA-7, overall survival) in [...]