Menée à partir de données de la "UK Biobank" portant sur 1 563 patients atteints d'un mélanome et sur 193 296 témoins, cette étude sur le génome entier identifie 7 loci jouant un rôle dans l'association entre une consommation d'agrumes et le risque de développer la maladie

Citrus-Gene Interaction and Melanoma Risk in the UK Biobank

Han, Jiali ; Li, Xin ; Li, Ming ; Champion, Victoria L. ; Song, Yiqing ; Marley, Andrew R.

High citrus consumption may increase melanoma risk; however, little is known about the biological mechanisms of this association, or whether it is modified by genetic variants. We conducted a genome-wide analysis of gene-citrus consumption interactions on melanoma risk among 1,563 melanoma cases and 193,296 controls from the UK Biobank. Both the 2-degrees-of-freedom (df) joint test of genetic main effect and gene-environment (G-E) interaction and the standard 1-df G-E interaction test were [...]

A partir d'une revue systématique de la littérature (21 études, 29 866 patients), cette méta-analyse évalue l'association entre le potentiel inflammatoire de l'alimentation, déterminé à l'aide d'un système de score, et le risque de cancer du sein

Dietary inflammatory index and breast cancer risk: an updated meta-analysis of observational studies

Hayati, Zahra ; Jafarabadi, Mohammad Asghari ; Pirouzpanah, Saeed

This updated meta-analysis sought to determine whether the pro-inflammatory potential of diet is a risk factor for breast cancer (BrCa) development, for the first time focusing on the effects of design heterogeneity. The search was performed using Scopus, PubMed, and Embase databases. Data were extracted from twenty-one eligible studies, including eleven cohorts (336,085 participants/20,033 incidence cases), and ten case-control studies (9,833 cases/12,752controls). The random-effect was used [...]

Menée auprès de 122 patients atteints d'un cancer du pancréas et 354 témoins, cette étude analyse l'association entre le microbiome buccal et le risque de développer la maladie dans la population afro-américaine

The oral microbiome in relation to pancreatic cancer risk in African Americans

Petrick, Jessica L. ; Wilkinson, Jeremy E. ; Michaud, Dominique S. ; Cai, Qiuyin ; Gerlovin, Hanna ; Signorello, Lisa B. ; Wolpin, Brian M. ; Ruiz-Narváez, Edward A. ; Long, Jirong ; Yang, Yaohua ; Johnson, W. Evan ; Shu, Xiao-Ou ; Huttenhower, Curtis ; Palmer, Julie R.

Background: African Americans have the highest pancreatic cancer incidence of any racial/ethnic group in the United States. The oral microbiome was associated with pancreatic cancer risk in a recent study, but no such studies have been conducted in African Americans. Poor oral health, which can be a cause or effect of microbial populations, was associated with an increased risk of pancreatic cancer in a single study of African Americans. Methods: We prospectively investigated the oral [...]