Mené sur 44 patients ayant survécu à un cancer, cet essai randomisé évalue l'intérêt d'une intervention de yoga pour soulager la douleur d'une neuropathie périphérique chronique induite par la chimiothérapie

Yoga for chronic chemotherapy-induced peripheral neuropathy pain: a pilot, randomized controlled trial

Knoerl, Robert ; Giobbie-Hurder, Anita ; Berfield, Juliana ; Berry, Donna ; Meyerhardt, Jeffrey A. ; Wright, Alexi A. ; Ligibel, Jennifer A.

Purpose : To determine the feasibility of implementing a yoga intervention for cancer survivors with chronic CIPN pain, as well as the impact of the intervention on patient-reported outcomes. Methods : Cancer survivors with chronic CIPN pain were recruited from the breast, gastrointestinal, and gynecological oncology centers at Dana-Farber Cancer Institute. Participants were randomized (2:1) to receive an 8-week yoga intervention or usual care. After 21/50 of participants were enrolled, the [...]

Menée aux Etats-Unis à partir de données 2010-2017 portant sur 21 335 patients atteints d'un cancer métastatique, cette étude rétrospective analyse les facteurs associés aux disparités dans les traitements reçus en fin de vie et dans la prise en charge lors de la dernière hospitalisation

Disparities in Care Management During Terminal Hospitalization Among Adults With Metastatic Cancer From 2010 to 2017

Deeb, Stephanie ; Chino, Fumiko L. ; Diamond, Lisa C. ; Tao, Anna ; Aragones, Abraham ; Shahrokni, Armin ; Yerramilli, Divya ; Gillespie, Erin F. ; Tsai, C. Jillian

Importance : Many patients with metastatic cancer receive high-cost, low-value care near the end of life. Identifying patients with a high likelihood of receiving low-value care is an important step to improve appropriate end-of-life care. Objective : To analyze patterns of care and interventions during terminal hospitalizations and examine whether care management is associated with sociodemographic status among adult patients with metastatic cancer at the end of life. Design, Setting, and [...]

Mené par enquête auprès d'oncologues dans 87 pays et régions, cette étude internationale transversale analyse l'accès des patients atteints d'un cancer aux médicament anticancéreux jugés essentiels

Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey

Fundytus, Adam ; Sengar, Manju ; Lombe, Dorothy ; Hopman, Wilma ; Jalink, Matthew ; Gyawali, Bishal ; Trapani, Dario ; Roitberg, Felipe ; de Vries, Elisabeth G. E. ; Moja, Lorenzo ; Ilbawi, Andre ; Sullivan, Richard ; Booth, Christopher M.

Background : The WHO Essential Medicines List (EML) identifies priority medicines that are most important to public health. Over time, the EML has included an increasing number of cancer medicines. We aimed to investigate whether the cancer medicines in the EML are aligned with the priority medicines of frontline oncologists worldwide, and the extent to which these medicines are accessible in routine clinical practice. Methods : This international, cross-sectional survey was developed by [...]

Cette étude présente une estimation de l'incidence des cancers et de la mortalité spécifique, chez la population hispanique vivant aux Etats-Unis pour l'année 2021

Cancer statistics for the US Hispanic/Latino population, 2021

Miller, Kimberly D. ; Ortiz, Ana P. ; Pinheiro, Paulo S. ; Bandi, Priti ; Minihan, Adair ; Fuchs, Hannah E. ; Martinez Tyson, Dinorah ; Tortolero-Luna, Guillermo ; Fedewa, Stacey A. ; Jemal, Ahmedin M. ; Siegel, Rebecca L.

The Hispanic/Latino population is the second largest racial/ethnic group in the continental United States and Hawaii, accounting for 18% (60.6 million) of the total population. An additional 3 million Hispanic Americans live in Puerto Rico. Every 3 years, the American Cancer Society reports on cancer occurrence, risk factors, and screening for Hispanic individuals in the United States using the most recent population-based data. An estimated 176,600 new cancer cases and 46,500 cancer deaths [...]

Cette étude passe en revue les effets sanitaires et économiques d'une résistance aux antibiotiques chez les patients atteints d'un cancer

Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward

Nanayakkara, Amila K. ; Boucher, Helen W. ; Fowler Jr, Vance G. ; Jezek, Amanda ; Outterson, Kevin ; Greenberg, David E.

Infection is the second leading cause of death in patients with cancer. Loss of efficacy in antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing success of cancer therapy. In this review, the authors focus on recent updates on the impact of antibiotic resistance in the cancer setting, particularly on the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and [...]

Menée aux Etats-Unis sur la période 1987-2014 à partir de données portant sur 221 962 personnes ayant reçu une greffe d'organe, cette étude analyse le risque de cancer et évalue les années de vies perdues liées à la maladie

Life-years lost due to cancer among solid organ transplant recipients in the United States, 1987 to 2014

Noone, Anne-Michelle ; Pfeiffer, Ruth M. ; Schaubel, Douglas E. ; Dorgan, Joanne F. ; Magder, Laurence S. ; Bromberg, Jonathan S. ; Lynch, Charles F. ; Morris, Cyllene R. ; Pawlish, Karen S. ; Engels, Eric A.

Background : Solid organ transplant recipients have an elevated risk of cancer. Quantifying the life-years lost (LYL) due to cancer provides a complementary view of the burden of cancer distinct from other metrics and may identify subgroups of transplant recipients who are most affected. Methods : Linked transplant and cancer registry data were used to identify incident cancers and deaths among solid organ transplant recipients in the United States (1987-2014). Data on LYL due to cancer within [...]

Menée aux Etats-Unis sur la période 2001-2017, cette étude analyse l'évolution de l'incidence du cancer colorectal chez les personnes âgées de 20 à 49 ans

Trends in the incidence of early-onset colorectal cancer in all 50 United States from 2001 through 2017

Shah, Rajesh R. ; Millien, Valentine O. ; da Costa Jr, Wilson L. ; Oluyomi, Abiodun O. ; Gould Suarez, Milena ; Thrift, Aaron P.

Background : The rate of change in the incidence of colorectal cancer (CRC) among persons younger than 50 years in the United States appears to vary by demographics, tumor location, and geography. This study analyzed data from all 50 states to examine recent changes in the incidence of CRC among persons younger than 50 years and to identify key subgroups with disproportionate risk. Methods :Annual incidence rates for CRC, colon cancer, and rectal cancer in persons aged 20 to 49 years were [...]

Menée aux Etats-Unis, cette étude analyse les coûts associés à l'utilisation de l'atézolizumab en traitement de deuxième ligne chez les patients atteints d'un carcinome urothélial et bénéficiant du système Medicare

Medicare Expenditures of Atezolizumab for a Withdrawn Accelerated Approved Indication

Ballreich, Jeromie ; Bennet, Charles ; Moore, Thomas J. ; Alexander, G. Caleb

The US Food and Drug Administration (FDA) grants accelerated approval for products that address serious or life-threatening illnesses that fill an unmet medical need; such products, which are initially approved using clinical surrogate end points, are then required to demonstrate clinical benefit through confirmatory trials. While the program has been praised as an important means to bring new products to market, the pathway has also been criticized as setting unacceptably low standards [...]