Menée à partir de données chinoises portant sur 512 715 adultes (41 % d'hommes ; durée médiane de suivi : 10 ans), cette étude analyse l'association entre les habitudes de consommation d'alcool et le risque de cancer du foie (2 531 cas)

Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults

Im, Pek Kei ; Millwood, Iona Y. ; Kartsonaki, Christiana ; Guo, Yu ; Chen, Yiping ; Turnbull, Iain ; Yu, Canqing ; Du, Huaidong ; Pei, Pei ; Lv, Jun ; Walters, Robin G. ; Li, Liming ; Yang, Ling ; Chen, Zhengming ; on behalf of the China Kadoorie Biobank collaborative, group

Background: Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability, which differ appreciably between Chinese and Western populations. Methods: The prospective China Kadoorie Biobank included 512,715 adults (41% men) aged 30–79 years recruited from ten areas during 2004–2008, recording alcohol intake, drinking patterns, and other [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (9 études, 1 762 patients), cette méta-analyse évalue l'association entre une infection par le virus de l'hépatite B ou C et le risque de lymphome de Hodgkin

Is Hodgkin Lymphoma Associated with Hepatitis B and C Viruses? A Systematic Review and Meta-Analysis

Mullen, Callum JR ; Volesky, Karena D ; Greenwald, Zoë R ; El-Zein, Mariam ; Franco, Eduardo L

Background: Apart from the Epstein-Barr virus (EBV), the etiology of the hematological malignancy, Hodgkin lymphoma (HL) is not well defined. Hepatitis B and C viruses (HBV, HCV) are associated with some lymphoproliferative diseases with similarities to HL. Methods: We performed a systematic review and meta-analysis, by searching Embase, MEDLINE, and Web of Science databases on March 9, 2021, for studies reporting a measure of association for HBV and HL or HCV and HL. We calculated pooled [...]

Menée aux Etats-Unis auprès de 153 200 témoins et de 3 604 patients atteints d'un lymphome non hodgkinien diagnostiqué avant l'âge de 37 ans, cette étude analyse l'association entre le mode d'accouchement, des caractéristiques de naissance et le risque de développer la maladie

Mode of Delivery, Birth Characteristics and Early-Onset Non-Hodgkin Lymphoma in a Population-Based Case-Control Study

Dwyer, Kayla E ; Wang, Rong ; Cozen, Wendy ; Cartmel, Brenda ; Wiemels, Joseph L ; Morimoto, Libby M ; Metayer, Catherine ; Ma, Xiaomei

Background: The etiology of non-Hodgkin lymphoma (NHL) in children, adolescents, and young adults (AYA) is not well-understood. Methods: We evaluated potential associations between mode of delivery, birth characteristics and NHL risk in a population-based case-control study, which included 3,064 cases of NHL (490 with Burkitt lymphoma, 981 with diffuse large B-cell lymphoma [DLBCL], and 978 with T-cell NHL) diagnosed at the age of 0-37 years in California during 1988-2015 and 153,200 controls [...]

Menée aux Etats-Unis et au Canada à partir de données généalogiques de registres portant sur 130 familles (2 227 personnes ; âge médian : 58 ans ; 49 % de femmes), cette étude analyse, selon l'âge, la pénétrance du cancer du pancréas chez des personnes présentant un variant pathogène du gène ATM

Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene

Hsu, Fang-Chi ; Roberts, Nicholas J. ; Childs, Erica ; Porter, Nancy ; Rabe, Kari G. ; Borgida, Ayelet ; Ukaegbu, Chinedu ; Goggins, Michael G. ; Hruban, Ralph H. ; Zogopoulos, George ; Syngal, Sapna ; Gallinger, steven ; Petersen, Gloria M. ; Klein, Alison P.

Pathogenic germline variants in the ATM gene have been associated with pancreatic cancer risk. Although genetic testing identifies these variants in approximately 1% to 3% of unselected patients with pancreatic cancer, the lifetime risk of pancreatic cancer among individuals with pathogenic ATM variants has not been well estimated.To estimate age-specific penetrance of pancreatic cancer in individuals with a pathogenic variant in the ATM gene.This was a multicenter cohort study of pancreatic [...]

Menée notamment à l'aide de données de la cohorte européenne EPIC portant sur 502 témoins et 502 patients atteints d'un cancer du pancréas dignostiqué entre 1993 et 2008 (durée médiane de suivi : 8 ans ; âge moyen au diagnostic : 64 ans), cette étude analyse l'association entre le nombre de cellules immunitaires circulantes et le risque de développer la maladie

Are circulating immune cells a determinant of pancreatic cancer risk? A prospective study using epigenetic cell count measures

Katzke, Verena ; Le Cornet, Charlotte ; Mahfouz, Rayaan ; Brauer, Bianca ; Johnson, Theron ; Canzian, Federico ; Rebours, Vinciane ; Boutron-Ruault, Marie-Christine ; Severi, Gianluca ; Schulze, Matthias B. ; Olsen, Anja ; Tjoenneland, Anne ; Overvad, Kim ; Crous-Bou, Marta ; Molina-Montes, Esther ; Amiano, Pilar ; Huerta, José María ; Ardanaz, Eva ; Perez-Cornago, Aurora ; Masala, Giovanna ; Pala, Valeria ; Tumino, Rosario ; Sacerdote, Carlotta ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; Vermeulen, Roel ; Sund, Malin ; Franklin, Oskar ; Christakoudi, Sofia ; Dossus, Laure ; Weiderpass, Elisabete ; Olek, Sven ; Kaaks, Rudolf

Background: Evidence is accumulating that immune cells play a prominent role in pancreatic cancer aetiology but prospective investigations are missing. Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sub-lineages: total CD3+, CD8+, CD4+, and FOXP3+ regulatory T cells [...]

Menée en Corée auprès de 3 095 336 femmes ménopausées (âge : 40-79 ans), cette étude analyse l'association entre un syndrome métabolique, une obésité ou la combinaison des 2 et le risque de cancer du sein

Associations between obesity, metabolic health, and the risk of breast cancer in East Asian women

Park, Boyoung ; Kim, Soyeoun ; Kim, Hayoung ; Cha, Chihwan ; Chung, Min Sung

Background: This study examined the associations between metabolic syndrome(MetS), obesity, their combination as a metabolic obesity phenotype, and the risk of breast cancer in East Asian postmenopausal women. Methods: A total of 3,095,336 postmenopausal cancer-free women aged 40–79 years who underwent the National Health Insurance Service health examination between 2009 and 2010 were included. The incidence of invasive breast cancer was followed up until 2018. The presence of obesity (body [...]