Menée au Canada par enquête auprès de patients pédiatriques et de leurs aidants (64 participants), cette étude analyse les facteurs associés à une utilisation de cannabis thérapeutique pour soulager les symptômes liés à la maladie, pendant et après les traitements anticancéreux

Medical cannabis in pediatric oncology: a survey of patients and caregivers

Chapman, Stacy ; Protudjer, Jennifer ; Bourne, Cathy ; Kelly, Lauren E. ; Oberoi, Sapna ; Vanan, Magimairajan Issai

Background : There are minimal data regarding the safety and efficacy of cannabis used as an anti-cancer agent or for symptom management in pediatric oncology. We aimed to characterize the prevalence and factors associated with the use of cannabis for the treatment of cancer and management of cancer-related symptoms in children during or after cancer treatment. Methods : An anonymous 40 question paper survey was offered to patients/caregivers of children with cancer attending a pediatric [...]

Menée à partir de données de 3 essais randomisés incluant 250 patients ayant survécu à un cancer, cette étude analyse les mécanismes d'une psychothérapie comportementale impliqués dans la réduction de la sévérité d'une fatigue

Potential mechanisms of the fatigue-reducing effect of cognitive-behavioral therapy in cancer survivors: Three randomized controlled trials

Müller, Fabiola ; Wijayanto, Feri ; Abrahams, Harriët ; Gielissen, Marieke ; Prinsen, Hetty ; Braamse, Annemarie ; van Laarhoven, Hanneke W.M. ; Groot, Perry ; Heskes, Tom ; Knoop, Hans

Objective : Fatigue is a common symptom among cancer survivors that can be successfully treated with cognitive‐behavioral therapy (CBT). Insights into the working mechanisms of CBT are currently limited. The aim of this study was to investigate whether improvements in targeted cognitive‐behavioral variables and reduced depressive symptoms mediate the fatigue‐reducing effect of CBT. Methods : We pooled data from three randomized controlled trials that tested the efficacy of CBT to reduce severe [...]

Menée aux Etats-Unis à partir de données portant sur 1 355 patients ayant survécu à un cancer colorectal, cette étude analyse l'association entre les revenus du foyer et la qualité de vie, en fonction du statut socioéconomique du voisinage

Associations of household income with health-related quality of life following a colorectal cancer diagnosis varies with neighborhood socioeconomic status

Robinson, Jamaica RM ; Phipps, Amanda I. ; Barrington, Wendy E. ; Hurvitz, Philip M ; Sheppard, Lianne ; Malen, Rachel C ; Newcomb, Polly A

Background : Existing evidence indicates household income as a predictor of health-related quality of life (HRQoL) following a colorectal cancer (CRC) diagnosis. This association likely varies with neighborhood socioeconomic status (nSES), but evidence is limited. Methods : We included data from 1355 CRC survivors participating in the population-based Puget Sound Colorectal Cancer Cohort (PSCCC). Survivors reported current annual household income; we measured HRQoL via the Functional Assessment [...]

Menée à partir des données des registres américains des cancers sur la période 2000-2016, cette étude analyse les facteurs associés à l'incidence des cancers de faible pronostic de stade métastatique chez les adolescents et jeunes adultes (âge : 15-39 ans) et compare les incidences dans d'autres catégories d'âge (âges : 40-64 ans et 65-79 ans)

Poor-Prognosis Metastatic Cancers in Adolescents and Young Adults: Incidence Patterns, Trends, and Disparities

Bhutada, Jessica Sheth ; Hwang, Amie ; Liu, Lihua ; Deapen, Dennis ; Freyer, David R

Background : For adolescents and young adults (AYAs, age 15–39 years old) with cancer, metastatic disease at diagnosis is the strongest predictor of mortality, but its associations with age and sociodemographic factors are largely unexplored. Methods : Using Surveillance, Epidemiology, and End Results Program data from 2000–2016, we collected incident cases of poor-prognosis metastatic cancer (5-year survival < 50%) and compared the proportion, incidence, time trends, and incidence rate ratios [...]

Menée aux Etats-Unis à partir de données de registres (registres des cancers et registre des greffes) portant sur 10 524 326 patients ayant des antécédents de cancer (17 types de cancer), cette étude analyse l'association entre une greffe d'organe et la survie globale

Solid organ transplantation and survival among individuals with a history of cancer

Engels, Eric A. ; Haber, Gregory ; Hart, Allyson ; Lynch, Charles F. ; Li, Jie ; Pawlish, Karen S. ; Qiao, Baozhen ; Yu, Kelly J. ; Pfeiffer, Ruth M.

Background: The success of immunotherapy highlights a possible role for immunity in controlling cancer during remission for cancer patients in the general population. A prior cancer diagnosis is common among solid organ transplant candidates, and immunosuppressive medications administered to transplant recipients may increase recurrence risk. Methods: Using linked data from the United States solid organ transplant registry and 13 cancer registries, we compared overall and cancer-specific [...]

Menée aux Etats-Unis à partir de données 1999-2018 portant sur des adultes âgés de 25 à 64 ans, cette étude analyse l'évolution des disparités socioéconomiques dans la mortalité prématurée par cancer dans 3 028 comtés

Socioeconomic inequalities in premature cancer mortality among US counties during 1999 to 2018

Song, Suhang ; Duan, Yuqi ; Huang, Junjie ; Wong, Martin C. ; Chen, Hongda ; Trisolini, Michael G ; LaBresh, Kenneth A ; Smith, Sidney C ; Jin, Yinzi ; Zheng, Zhi-Jie

Background: This study investigated socioeconomic inequalities in premature cancer mortality by cancer types, and evaluated the associations between socioeconomic status (SES) and premature cancer mortality by cancer types. Methods: Using multiple databases, cancer mortality was linked to SES and other county characteristics. The outcome measure was cancer mortality among adults aged 25-64 years in 3,028 US counties, from 1999 to 2018. Socioeconomic inequalities in mortality were calculated as [...]

Menée en Chine sur la période 2008-2012 à partir des données de 36 registres régionaux des cancers, cette étude transversale analyse les disparités entre les zones urbaines et rurales dans l'incidence des cancers

Urban–rural disparity in cancer incidence in China, 2008–2012: a cross-sectional analysis of data from 36 cancer registers

Yuan, Shuai ; Xie, Shao-Hua

Objective : The substantial differences in socioeconomic and lifestyle exposures between urban and rural areas in China may lead to urban–rural disparity in cancer risk. This study aimed to assess the urban–rural disparity in cancer incidence in China. Methods : Using data from 36 regional cancer registries in China in 2008–2012, we compared the age-standardised incidence rates of cancer by sex and anatomic site between rural and urban areas. We calculated the rate difference and rate ratio [...]

Menée à partir de données portant sur 210 patients ayant survécu 5 ans ou plus à une leucémie lymphoïde aiguë pédiatrique traitée par chimiothérapie, cette étude analyse l'association entre une obésité et le risque de déficiences neurocognitives

Association between obesity and neurocognitive function in survivors of childhood acute lymphoblastic leukemia treated only with chemotherapy

Iijima, Mayuko ; Liu, Wei ; Panetta, John C. ; Hudson, Melissa M. ; Pui, Ching-Hon ; Srivastava, Deo Kumar ; Krull, Kevin R. ; Inaba, Hiroto

BACKGROUND : Neurocognitive impairment and obesity are common adverse sequelae in survivors of childhood acute lymphoblastic leukemia (ALL); however, the association has not been investigated. METHODS : Neurocognitive function was evaluated once in survivors of ALL who were at least 8 years old and 5 years from their diagnosis. In a cross‐sectional analysis, the associations with the body mass index (BMI) category and Z score were examined. A longitudinal analysis used the overweight/obesity [...]

Menée à partir des données 1990-2019 de "the Global Burden of Disease (GBD) Study" portant sur les cas de cancer du pancréas dans 28 pays d'Europe, cette étude analyse l'incidence, la mortalité globale, la mortalité attribuable à plusieurs facteurs de risque connus (tabagisme, glycémie à jeun élevée et indice de masse corporelle élevé) et les années de vies perdues ajustées sur l'incapacité puis réalise une projection de ces indicateurs jusqu'en 2039

Burden of pancreatic cancer along with attributable risk factors in Europe between 1990 and 2019, and projections until 2039

Yu, Jingru ; Yang, Xiaorong ; He, Wei ; Ye, Weimin

Projecting the burden of pancreatic cancer over time provides essential information to effectively plan measures for its management and prevention. Here, we obtained data from the Global Burden of Disease (GBD) Study between 1990 and 2019, to model how pancreatic cancer will affect the 27 countries of the European Union (EU) plus the United Kingdom (the pre‐Brexit EU‐28) until 2039 by conducting the Bayesian age‐period‐cohort analysis. The number of new pancreatic cancer cases in the EU‐28 was [...]

Menée en Pologne sur la période 2009-2018, cette étude rétrospective analyse l'évolution des stratégies thérapeutiques chez les patients atteints d'un cancer du larynx (22 957 cas de cancer)

Review of recent treatment trends of laryngeal cancer in Poland: a population-based study

Rzepakowska, Anna ; Żurek, Michał ; Niemczyk, Kazimierz

Objectives :To investigate the utilisation of different treatment modalities for patients with laryngeal cancer (LC) during last decade in Poland. Setting : Retrospective population-based study. Participants : Patients with LC treated between January 2009 and December 2018. Primary and secondary outcome measures : The contemporary utilisation of treatment modalities of LC: surgery with intent of radical resection (total or partial laryngectomy), radiotherapy (RT) and chemoradiotherapy (CRT). [...]

Menée en Allemagne à partir de données portant sur 2 141 patients atteints d'un cancer, cette étude analyse l'association entre des troubles psychiques et la présence de pensées suicidaires

Thoughts of death and suicidality among patients with cancer: Examining subtypes and their association with mental disorders

Vehling, Sigrun ; Mehnert-Theuerkauf, Anja ; Glaesmer, Heide ; Bokemeyer, Carsten ; Oechsle, Karin ; Härter, Martin ; Koch, Uwe

Objective : Cancer is associated with an increased risk for completed suicide. We explored subtypes of thoughts of death, death wishes, suicidal ideation and behavior and their association with mental disorders and demographic and disease‐related characteristics. Methods : We studied 2,141 cancer patients with the standardized Composite International Diagnostic Interview‐Oncology (CIDI‐O). Assessment included 4‐weeks‐prevalences of thoughts of death, wish to die, suicidal ideation, suicide [...]

Mené sur 139 enfants atteints d'une tumeur cérébrale ayant été traitée, cet essai prospectif longitudinal analyse les facteurs associés au risque de déficiences neurocognitives en lien avec les traitements anticancéreux (durée médiane de suivi : 816 jours)

Predictors of Cognitive Performance Among Infants Treated for Brain Tumors: Findings From a Multisite, Prospective, Longitudinal Trial

Jeanelle S. Ali ; Jason M. Ashford ; Michelle A. Swain ; Lana L. Harder ; Bonnie L. Carlson-Green ; Jonathan M. Miller ; Joanna Wallace ; Ryan J. Kaner ; Catherine A. Billups ; Arzu Onar-Thomas ; Thomas E. Merchant ; Amar Gajjar ; Heather M. Conklin

PURPOSE : Infants treated for CNS malignancies experience a significantly poorer response to treatment and are particularly at risk for neuropsychological deficits. The literature is limited and inconsistent regarding cognitive outcomes among this group. We investigated predictors of cognitive outcomes in children treated for brain tumors during infancy as part of a large, prospective, multisite, longitudinal trial. PATIENTS AND METHODS : One hundred thirty-nine infants with a newly diagnosed [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité d'un traitement de première ligne combinant nivolumab et ipilimumab chez des patients atteints d'un cancer du poumon non à petites cellules de stade avancé

Cost-effectiveness of Nivolumab-Ipilimumab Combination Therapy for the Treatment of Advanced Non–Small Cell Lung Cancer

Courtney, P. Travis ; Yip, Anthony T. ; Cherry, Daniel R. ; Salans, Mia A. ; Kumar, Abhishek ; Murphy, James D.

Importance : Treatment with nivolumab-ipilimumab combination therapy was found to improve overall survival compared with chemotherapy among patients with advanced non–small cell lung cancer (NSCLC) in the CheckMate 227 clinical trial. However, these drugs are substantially more expensive than chemotherapy and, given the high incidence of advanced NSCLC, the incorporation of dual immune checkpoint inhibitors into the standard of care could have substantial economic consequences. Objective : To [...]

Menée en Australie par enquête, cette étude transversale analyse la proportion et les caractéristiques des patients atteints d'un cancer et présentant de faibles capacités à trouver et à comprendre l'information médicale sur le cancer

Identification of low health and cancer literacy in oncology patients: a cross-sectional survey

Hyatt, Amelia ; Drosdowsky, Allison ; Koproski, Trista ; Milne, Donna ; Rametta, Meri ; McDonald, Geri ; McKenzie, Tanya ; Blaschke, Sarah-May

Objective : Health literacy is a significant public health concern, particularly given the increased complexity of chronic disease health management and health system navigation, and documented associations between low health literacy and poor health outcomes. This study therefore aimed to identify the proportion and characteristics of outpatients visiting a specialist cancer hospital who report low health literacy and/or low cancer health literacy. Method : This study used a cross-sectional [...]

Menée aux Etats-Unis auprès d'enfants atteints d'un cancer de stade avancé et de leurs parents, cette étude prospective longitudinale analyse les différentes stratégies de communication entre l'oncologue et les familles au sujet du pronostic

Prognostic Communication Between Oncologists and Parents of Children With Advanced Cancer

Kaye, Erica C. ; Stall, Melanie ; Woods, Cameka ; Velrajan, Srilakshmi ; Gattas, Melanie ; Lemmon, Monica ; Baker, Justin N. ; Mack, Jennifer W.

BACKGROUND AND OBJECTIVES: Parents of children with cancer perceive deficits in quality of prognostic communication. How oncologists disclose information about disease progression and incurability and how prognostic communication impacts parental understanding of prognosis are poorly understood. In this study, we aimed to (1) characterize communication strategies used by pediatric oncologists to share prognostic information across a child’s advancing illness course and (2) explore relationships [...]

A partir d'une revue systématique de la littérature publiée entre 2006 et 2019, cette étude analyse la qualité des outils d'aide à la décision présentant les options thérapeutiques et dédiés aux patients atteints d'un cancer colorectal de stade I à III (18 outils analysés)

Communication in decision aids for stage I–III colorectal cancer patients: a systematic review

Hommes, Saar ; Vromans, Ruben ; Clouth, Felix ; Verbeek, Xander ; de Hingh, Ignace ; Krahmer, Emiel

Objectives :To assess the communicative quality of colorectal cancer patient decision aids (DAs) about treatment options, the current systematic review was conducted. Design :Systematic review. Data sources : DAs (published between 2006 and 2019) were identified through academic literature (MEDLINE, Embase, CINAHL, Cochrane Library and PsycINFO) and online sources. Eligibility criteria: DAs were only included if they supported the decision-making process of patients with colon, rectal or [...]

Menée aux Etats-Unis à partir de données portant sur 510 238 patients hospitalisés pour une tumeur cérébrale, cette étude analyse l'évolution, sur la période 2007-2016, de l'utilisation des soins palliatifs

Trends in inpatient palliative care use for primary brain malignancies

Kubendran, Sindhu ; Schockett, Erica ; Jackson, Erin ; Huynh-Le, Minh Phuong ; Roberti, Fabio ; Rao, Yuan James ; Ojong-Ntui, Martin ; Goyal, Sharad

Introduction : Primary brain malignancies (PBMs) pose significant morbidity and poor prognosis. Despite NCCN recommendations that palliative care should be integrated into general oncologic care plans, it has been historically underused in patients with PBM. We sought to examine trends and factors associated with inpatient palliative care use in patients with PBM. Methods : Data from the 2007–2016 National (Nationwide) Inpatient Sample was analyzed for descriptive statistics and trends. [...]

Menée aux Etats-Unis auprès de 97 parents d'un enfant atteint d'une leucémie, cette étude prospective transversale analyse les facteurs associés à leurs perceptions et à leur accord concernant l'inclusion de leur enfant dans un essai clinique

Assessment of Factors Associated With Parental Perceptions of Voluntary Decisions About Child Participation in Leukemia Clinical Trials

Aristizabal, Paula ; Ma, Arissa K. ; Kumar, Nikhil V. ; Perdomo, Bianca P. ; Thornburg, Courtney D. ; Martínez, María Elena ; Nodora, Jesse

Importance : Obtaining voluntary informed consent prior to enrollment in clinical trials is a fundamental ethical requirement. Objective : To assess whether health literacy, contextual factors, or sociodemographic characteristics are associated with perception of voluntariness among parents who had consented for their child’s participation in a leukemia therapeutic clinical trial. Design, Setting, and Participants : This cross-sectional study prospectively enrolled 97 parents of children [...]