Menée à l'aide de données de la cohorte européenne EPIC portant sur 450 112 participants (durée médiane de suivi : 15 ans), cette étude analyse l'association entre les niveaux sanguins d'acides gras spécifiques (saturés, mono-insaturés, trans) et le risque de cancer colorectal (6 162 cas)

Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the EPIC cohort

Aglago, Elom K. ; Murphy, Neil ; Huybrechts, Inge ; Nicolas, Genevieve ; Casagrande, Corinne ; Fedirko, Veronika ; Weiderpass, Elisabete ; Rothwell, Joseph A. ; Dahm, Christina C. ; Olsen, Anja ; Tjønneland, Anne ; Kaaks, Rudolf ; Katzke, Verena ; Schulze, Matthias B. ; Masala, Giovanna ; Agnoli, Claudia ; Panico, Salvatore ; Tumino, Rosario ; Sacerdote, Carlotta ; Bueno-de-Mesquita, Bas H. ; Derksen, Jeroen W. G. ; Skeie, Guri ; Gram, Inger Torhild ; Brustad, Magritt ; Jakszyn, Paula ; Sánchez, María-José ; Amiano, Pilar ; Huerta, José María ; Ericson, Ulrika ; Wennberg, Maria ; Perez-Cornago, Aurora ; Heath, Alicia K. ; Jenab, Mazda ; Chajès, Veronique ; Gunter, Marc J.

Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450,112 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (23 études), cette méta-analyse évalue l'association entre un emploi sédentaire et le risque de cancer du côlon ou du rectum

Association of sedentary work with colon and rectal cancer: systematic review and meta-analysis

Lee, JaeYong ; Lee, Jongin ; Ahn, Joonho ; Lee, Dong-wook ; Kim, Hyoung-Ryoul ; Kang, Mo-Yeol

Objectives: There has been no research on sedentary behaviour in the occupational domain that occupies a large portion of the daily life. Methods: We conducted a meta-analysis to investigate the association between sedentary work and colorectal cancer. We searched PubMed, Embase and Cochrane databases up to 12 August 2020 for peer-reviewed journal articles that assessed the association between sedentary work and colon or rectal cancer. Pooled estimates of ORs were obtained using random effects [...]

Menée aux Etats-Unis à l'aide d'une enquête et d'échantillons d'urines collectés auprès de 139 patients atteints d'un cancer de l'endomètre et 139 témoins, cette étude analyse l'association entre les concentrations de métabolites du BPA, de triclosan, de parabens ou de phtalates et le risque de développer la maladie

BPA, Parabens, and Phthalates in Relation to Endometrial Cancer Risk: A Case-Control Study Nested in the Multiethnic Cohort

Danja Sarink ; Adrian A. Franke ; Kami K. White ; Anna H. Wu ; Iona Cheng ; Brandon Quon ; Loic Le Marchand ; Lynne R. Wilkens ; Herbert Yu ; Melissa A. Merritt

Bisphenol A (BPA), phthalates, parabens, and triclosan are endocrine disrupting chemicals (EDCs); that is, they are exogenous substances that alter functions of the endocrine system and may cause adverse health effects. BPA and phthalates are plasticizers, whereas parabens and triclosan are antimicrobial chemicals or preservatives (Giulivo et al. 2016). Nuclear estrogen and progesterone receptors are EDC targets and BPA, selected phthalates, and parabens can bind to the estrogen receptor (ER) [...]

Menée auprès de 1 370 personnes ayant réalisé un examen de dépistage par coloscopie entre 2016 et 2020 (âge moyen : 60,7 ans ; 57 % de femmes), cette étude analyse l'association entre des facteurs de risque métaboliques autodéclarés (diabète, hypertension, hyperlipidémie, surpoids / obésité) et l'apparition de polypes dentelés seuls ou associés à des polypes adénomateux

Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps

Santiago, Celina N ; Rifkin, Samara ; Drewes, Julia ; Mullin, Gerard ; Spence, Emma ; Hylind, Linda M ; Gills, Joell J ; Kafonek, David ; Cromwell, David M ; LaLuna, Louis ; Giardello, Francis ; Sears, Cynthia L

Studies have found a positive association between metabolic risk factors, such as obesity and diabetes, and adenomatous polyps (APs). However, fewer studies have assessed the association between sessile serrated polyps (SSPs) or synchronous diagnosis of APs and SSPs (synch polyps). Study participants (N=1,370; ages 40-85) undergoing screening colonoscopy were enrolled between August 2016 and February 2020. Self-reported metabolic risk factors, including diabetes, hypertension, hyperlipidemia, [...]

Menée par questionnaire auprès de 1 313 témoins et de 587 patients atteints d'un adénome colorectal, cette étude analyse l'association entre le potentiel inflammatoire de l'alimentation, évalué à l'aide d'un système de score, et le risque de développer la maladie, puis identifie les facteurs modifiant cette association (origine ethnique, indice de masse corporelle, statut tabagique, utilisation d'anti-inflammatoires non stéroïdiens)

Dietary inflammatory index and risk of colorectal adenoma: effect measure modification by race, nonsteroidal anti-inflammatory drugs, cigarette smoking and body mass index?

Yuan, Fangcheng ; Deng, Lin ; Sun, Xiangqing ; Chen, Zhengyi ; Shivappa, Nitin ; Sheth, Ashutosh K. ; Cooper, Gregory S. ; Hebert, James R. ; Li, Li

Purpose: To investigate if the association between dietary inflammatory potential and colorectal adenoma (CRA) is modified by race and factors known to modulate inflammation. Methods: We examined effect measure modification of race, nonsteroidal anti-inflammatory drugs (NSAIDs), cigarette smoking and body mass index (BMI) on the diet-CRA association by employing energy-adjusted dietary inflammatory index (E-DII™) to characterize dietary inflammatory potential among 587 cases and 1,313 controls [...]

Menée à partir de données 2012-2018 portant sur 2 188 patientes afro-américaines atteintes d'un cancer du sein (âge : 25-75 ans), cette étude analyse l'association entre des facteurs reproductifs et la distribution des sous-types de cancer du sein (ER, PR et HER2)

A pooled case-only analysis of reproductive risk factors and breast cancer subtype among black women in the Southeastern United States

Sanderson, Maureen ; Pal, Tuya ; Beeghly-Fadiel, Alicia ; Fadden, Mary Kay ; Dujon, Steffie-Ann ; Clinton, Chrystina ; Jimenez, Cecilia ; Davis, Jennifer ; Fortune, Mieke ; Thompson, Jasmine ; Benson, Kiera ; Conley, Nicholas ; Reid, Sonya ; Tezak, Ann ; Shu, Xiao-Ou ; Zheng, Wei ; Blot, William J. ; Lipworth, Loren

Background: We investigated the association between reproductive risk factors and breast cancer subtype in Black women. Based on the previous literature, we hypothesized that the relative prevalence of specific breast cancer subtypes might differ according to reproductive factors. Methods: We conducted a pooled analysis of 2,188 (591 premenopausal, 1,597 postmenopausal) Black women with a primary diagnosis of breast cancer from four studies in the southeastern US. Breast cancers were classified [...]