Menée dans un contexte de vie réelle en France, Allemagne, Italie, Espagne et Royaume-Uni, cette étude analyse les pratiques des médecins concernant la prévention des nausées et vomissements induits par la chimiothérapie et l'adhésion aux recommandations d'utilisation d'antiémétiques pour les patients atteints d'un cancer

Practice patterns for prevention of chemotherapy-induced nausea and vomiting and antiemetic guideline adherence based on real-world prescribing data

Aapro, Matti ; Scotté, Florian ; Escobar, Yolanda ; Celio, Luigi ; Berman, Richard ; Franceschetti, Alessandra ; Bell, Danielle ; Jordan, Karin

Background : Guideline‐recommended antiemetic prophylaxis improves nausea and vomiting control in most patients undergoing chemotherapy. Multinational Association of Supportive Care in Cancer/European Society for Medical Oncology (MASCC/ESMO) antiemetic guidelines recommend prophylaxis with a neurokinin‐1 receptor antagonist (NK1RA), a 5‐hydroxytryptamine‐3 (5‐HT3)RA, and dexamethasone for patients receiving highly emetogenic chemotherapy (HEC), including anthracycline‐cyclophosphamide (AC)– [...]

A partir d'une revue systématique de la littérature (13 articles), cette étude analyse les caractéristiques et l'efficacité des interventions d'auto-prise en charge chez des patients âgés atteints d'un cancer

Systematic review of self-management interventions for older adults with cancer

Haase, Kristen R. ; Sattar, Schroder ; Hall, Steven ; McLean, Bianca ; Wills, Aria ; Gray, Mikaela ; Kenis, Cindy ; Donison, Valentina ; Howell, Doris ; Puts, Martine

Aim : The purpose of this systematic review was to determine the effectiveness of self‐management interventions for older adults with cancer and to determine the effective components of said interventions. Methods : We conducted a systematic review of self‐management interventions for older adults (65+) with cancer guided by the Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA) statement. We conducted an exhaustive search of the following databases: Ageline, AMED, [...]

Menée aux Etats-Unis dans un contexte de vie réelle auprès de 85 patients atteints d'un lymphome non hodgkinien ou d'une leucémie lymphoïde chronique, cette étude rétrospective analyse l'efficacité, du point de vue de l'incidence d'une neutropénie fébrile ou d'une neutropénie de grade 3 ou 4 induite par un traitement à base de bendamustine et de rituximab, de facteurs de stimulation des colonies de granulocytes (G-CSF) dispensés en traitement prophylactique primaire ou secondaire

Outcomes of primary and secondary prophylaxis of chemotherapy-induced and febrile neutropenia in bendamustine plus rituximab regimens in patients with lymphoma and chronic lymphocytic leukemia: real-world, single-center experience

Moore, Logan ; Bartels, Trace ; Persky, Daniel O. ; Abraham, Ivo ; Kumar, Abhijeet ; McBride, Ali

Objective : To examine the outcomes associated with granulocyte colony stimulating factors (G-CSFs) administered as primary versus secondary prophylaxis in setting of bendamustine plus rituximab (BR) regimens. Methods : Eighty-five patients who underwent treatment for non-Hodgkin’s lymphoma (NHL) or chronic lymphocytic leukemia (CLL) with BR at the University of Arizona Cancer Center from November 2013 to June 2019 were evaluated through retrospective chart review. Patients were stratified into [...]

Menée auprès de 40 patients atteints d'un cancer colorectal, cette étude de cohorte prospective analyse l'association entre une sarcopénie (25 cas) et la qualité de vie, mesurée 1 et 3 mois après un traitement chirurgical

The association between sarcopenia and quality of life in patients undergoing colorectal cancer surgery: an exploratory study

Besson, Alex ; Deftereos, Irene ; Gough, Karla ; Taylor, Danielle ; Shannon, Roland ; Yeung, Justin M.

Objective : To describe changes in health-related quality of life (QoL) from before colorectal cancer (CRC) surgery to 1 and 3-month post-surgery in patients diagnosed pre-operatively as sarcopenic or non-sarcopenic by computed tomography (CT) analysis. Methods : Secondary analysis of a prospective observational cohort study with one pre-operative and two post-operative assessments. Patient-reported outcome measures (PROMs) were collected at each timepoint using Functional Assessment of Cancer [...]

Menée en Australie par entretiens auprès de 33 aidants de patients atteints d'un sarcome, cette étude qualitative analyse leurs besoins en soins de support

The unmet needs of carers of patients diagnosed with sarcoma: a qualitative study

Weaver, Rhys ; O'Connor, Moira ; Halkett, Georgia ; Smith, Richard Carey

Objective : Sarcoma is a rare cancer that may result in reduced mobility, social isolation, poorer mental health, and ongoing medical issues for patients. Family carers play a crucial role in supporting patients throughout their sarcoma journey. Despite the aggressive and debilitating nature of the disease the unmet needs of these carers are yet to be explored. The aim of this study was to explore the unmet needs of carers of patients diagnosed with sarcoma. Methods : An exploratory qualitative [...]

Menée en Angleterre, cette étude analyse les disparités socio-démographiques dans le stade au diagnostic de 10 types de cancer (sein, vessie, côlon, endomètre, poumon, mélanome, prostate, rectum, rein et ovaire)

Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact

Barclay, M. E. ; Abel, G. A. ; Greenberg, David C. ; Rous, B. ; Lyratzopoulos, G.

Background : Stage at diagnosis strongly predicts cancer survival and understanding related inequalities could guide interventions. Methods : We analysed incident cases diagnosed with 10 solid tumours included in the UK government target of 75% of patients diagnosed in TNM stage I/II by 2028. We examined socio-demographic differences in diagnosis at stage III/IV vs. I/II. Multiple imputation was used for missing stage at diagnosis (9% of tumours). Results : Of the 202,001 cases, 57% were [...]

Menée à partir des données des registres américains des cancers portant sur 187 535 patientes atteintes d'un cancer du sein et sur 14 689 patientes atteintes d'un cancer de l'ovaire diagnostiqué entre 2013 et 2017, cette étude analyse l'évolution, sur la période 2012-2019, de l'utilisation de tests génétiques et de leurs résultats

Time Trends in Receipt of Germline Genetic Testing and Results for Women Diagnosed With Breast Cancer or Ovarian Cancer, 2012-2019

Allison W. Kurian ; Kevin C. Ward ; Paul Abrahamse ; Irina Bondarenko ; Ann S. Hamilton ; Dennis Deapen ; Monica Morrow ; Jonathan S. Berek ; Timothy P. Hofer ; Steven J. Katz

PURPOSE : Genetic testing is important for breast and ovarian cancer risk reduction and treatment, yet little is known about its evolving use. METHODS : SEER records of women of age ≥ 20 years diagnosed with breast or ovarian cancer from 2013 to 2017 in California or Georgia were linked to the results of clinical germline testing through 2019. We measured testing trends, rates of variants of uncertain significance (VUS), and pathogenic variants (PVs). RESULTS : One quarter (25.2%) of 187,535 [...]

Menée à partir des données GLOBOCAN dans 185 pays, cette étude présente une estimation de l'incidence de 36 cancers et de la mortalité pour l'année 2020

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Sung, Hyuna ; Ferlay, Jacques ; Siegel, Rebecca L. ; Laversanne, Mathieu ; Soerjomataram, Isabelle ; Jemal, Ahmedin ; Bray, Freddie

This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated [...]

Menée en Norvège par enquête auprès de 274 patients ayant survécu à un lymphome traité par une chimiothérapie à hautes doses et une greffe autologue de cellules souches (âge moyen lors de l'enquête : 52 ans), cette étude analyse leur situation professionnelle après les traitements anticancéreux

Post-treatment work patterns amongst survivors of lymphoma treated with high-dose chemotherapy with autologous stem-cell transplantation

Hernæs, Kjersti Helene ; Smeland, Knut B. ; Fagerli, Unn-Merete ; Kiserud, Cecilie E.

Background : This study describes post-treatment work patterns in lymphoma survivors treated with high-dose chemotherapy with autologous stem-cell transplantation (HDT-ASCT). It aims to identify determinants for labour force participation and exclusion after HDT-ASCT. Methods : All survivors treated with HDT-ASCT for lymphoma in Norway between 1995 and 2008, aged ≥18 years at HDT-ASCT and alive at survey in 2012–2013 were eligible. We divide survivors by current employment status (full-time, [...]

Menée en Chine à partir de données portant sur 253 patients atteints d'un cancer du pancréas, cette étude rétrospective analyse l'association entre la glycémie à jeun et la survie globale

Association between fasting blood glucose levels at admission and overall survival of patients with pancreatic cancer

Zhang, Mingming ; Hu, Xiaoru ; Kang, Ye ; Xu, Wanfeng ; Yang, Xianghong

Background : The associations between fasting blood glucose and staging and overall survival of patients with pancreatic cancer are still controversial. This study aimed to investigate the association between fasting blood glucose levels and overall survival (OS) of patients with pancreatic cancer and to evaluate the impact of differentiation and staging of pancreatic cancer. Methods : This was a retrospective study of patients with pathologically confirmed pancreatic cancer admitted to [...]

Menée à partir de données portant sur 22 827 hommes (âge : 40 à 70 ans ; durée médiane de suivi : 7,5 ans), cette étude analyse l'association entre le niveau d'activité cardiorespiratoire, mesuré en équivalent métabolique, et le fait de bénéficier d'un test de dépistage du cancer de la prostate par dosage du PSA, le risque de cancer de la prostate et le risque de décès après le diagnostic de la maladie

Fitness and prostate cancer screening, incidence, and mortality: Results from the Henry Ford Exercise Testing (FIT) Project

Reiter-Brennan, Cara ; Dzaye, Omar ; Al-Mallah, Mouaz H. ; Dardari, Zeina ; Brawner, Clinton A. ; Lamerato, Lois E. ; Keteyian, Steven J. ; Ehrman, Jonathan K. ; Blaha, Michael J. ; Visvanathan, Kala ; Marshall, Catherine H.

Background : The relation between cardiorespiratory fitness (CRF) and prostate cancer is not well established. The objective of this study was to determine whether CRF is associated with prostate cancer screening, incidence, or mortality. Methods : The Henry Ford Exercise Testing Project is a retrospective cohort study of men aged 40 to 70 years without cancer who underwent physician‐referred exercise stress testing from 1995 to 2009. CRF was quantified in metabolic equivalents of task (METs) [...]

Cette étude passe en revue les facteurs associés à l'évolution, sur la période 1998-2012, de l'utilisation d'une mastectomie prophylactique bilatérale chez les patientes atteintes d'un cancer du sein unilatéral

Bilateral Mastectomy in Women With Unilateral Breast Cancer: A Review

Lim, David W. ; Metcalfe, Kelly A. ; Narod, Steven A.

Importance : Rates of bilateral mastectomy continue to increase in average-risk women with unilateral in situ and invasive breast cancer. Contralateral prophylactic mastectomy rates increased from 5% to 12% of all operations for breast cancer in the US from 2004 to 2012. Among women having mastectomy, rates of contralateral prophylactic mastectomy have increased from less than 2% in 1998 to 30% in 2012. Observations : The increased use of breast magnetic resonance imaging and genetic testing [...]

Menée en Finlande à partir des données portant sur 5 308 femmes nées en 1966, cette étude analyse l'association entre une exposition à certains facteurs de risque biologiques ou socio-économiques au début de la vie et le risque de cancer du sein à l'âge adulte (120 cas)

Early-life risk factors for breast cancer - prospective follow-up in the Northern Finland Birth Cohort 1966

Tastula, Anniina ; Jukkola, Arja ; Alakokkare, Anni-Emilia ; Nordström, Tanja ; Eteläinen, Sanna ; Karihtala, Peeter ; Miettunen, Jouko

Background: While some risk factors for breast cancer have been confirmed, less is known about the role of early biological and social risk factors for breast cancer in adult life. Methods: In a prospective follow-up in the Northern Finland Birth Cohort 1966 consisting of 5308 women, 120 breast cancers were reported via national registers by the end of 2018. Early risk factors were examined with univariate and multivariate analyses using Cox regression analysis. The main results are reported [...]

A partir d'une revue de la littérature publiée entre 2004 et 2020 (55 études), cette étude analyse l'effet d'une démence sur la prise de décision thérapeutique, sur les traitements anticancéreux reçus et sur la mortalité, chez les patients âgés atteints d'un cancer

The Impact of Dementia on Cancer Treatment Decision-Making, Cancer Treatment, and Mortality: A Mixed Studies Review

Caba, Yaelin ; Dharmarajan, Kavita ; Gillezeau, Christina ; Ornstein, Katherine A ; Mazumdar, Madhu ; Alpert, Naomi ; Schwartz, Rebecca M ; Taioli, Emanuela ; Liu, Bian

Dementia and cancer occur commonly in older adults. Yet, little is known about the effect of dementia on cancer treatment and outcomes in patients diagnosed with cancer, and no guidelines exist. We performed a mixed studies review to assess the current knowledge and gaps on the impact of dementia on cancer treatment decision-making, cancer treatment, and mortality. A search in PubMed, Medline, and PsycINFO identified 55 studies on older adults with a dementia diagnosis before a cancer diagnosis [...]

Menée au Canada auprès de 111 patients ayant survécu à un cancer pédiatrique (âge lors de l'étude : 8-25 ans ; âge médian au diagnostic : 6,7 ans), cette étude analyse la présence de symptômes somatiques et leur association avec la peur de la récidive et la qualité de vie

Worry about somatic symptoms as a sign of cancer recurrence: prevalence and associations with fear of recurrence and quality of life in survivors of childhood cancer

Cunningham, Sarah J. ; Patton, Michaela ; Schulte, Fiona ; Richardson, Patricia A. ; Heathcote, Lauren C.

Objective : Somatic symptoms (e.g., pain, fatigue) are common after childhood cancer and are associated with greater fear of cancer recurrence and poorer health‐related quality of life (HRQoL). Qualitative studies indicate that survivors of childhood cancer (SCCs) worry about somatic symptoms as indicating cancer recurrence, which could in part explain associations between symptoms and poorer psychosocial outcomes. However, the prevalence, characteristics, and impact of symptom worry has not [...]

Menée au Canada auprès de 245 patients ayant survécu à un cancer, cette étude analyse l'efficacité d'une intervention dispensée par téléphone pour les aider à prendre en charge eux-mêmes leur dépression

CanDirect: Effectiveness of a Telephone-Supported Depression Self-Care Intervention for Cancer Survivors

Jane McCusker ; Jennifer M. Jones ; Madeline Li ; Rosana Faria ; Mark J. Yaffe ; Sylvie D. Lambert ; Antonio Ciampi ; Eric Belzile ; Manon de Raad

PURPOSE : Depression in post-treatment cancer survivors is common and can impair quality of life. CanDirect is a novel, telephone-delivered depression self-care intervention for cancer survivors. We conducted a randomized controlled superiority trial to compare CanDirect with usual care (UC) in this population. METHODS : Participants completing cancer treatment within the past 10 years who had mild-moderate depressive symptoms with or without major depression were recruited from clinical and [...]

Cette étude passe en revue les sources d'information en ligne à destination des patients atteints d'un carcinome épidermoïde cutané à haut risque de récidive ou de stade avancé et à destination de leurs familles

An online review of informational sources for advanced or high-risk cutaneous squamous cell carcinoma

Starkings, Rachel ; Shilling, Valerie ; Fallowfield, Lesley

Objective : Cutaneous squamous cell carcinoma (cSCC) is one of the most prevalent non-melanoma skin cancers worldwide. While usually treatable, patients with high-risk or advanced disease have few treatment options and limited resources available. This review assesses what online information resources are available to patients and their families about either high-risk or advanced cSCC. Methods : Searches were run, via Google, using 8 terms such as ‘advanced cutaneous squamous cell carcinoma [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2020 (29 études), cette étude analyse l'effet, sur les comportements, les fonctions cognitives et la santé psychologique des femmes, d'une information concernant la densité mammaire

The Impact of Breast Density Information or Notification on Women's Cognitive, Psychological, and Behavioral Outcomes: A Systematic Review

Nickel, Brooke ; Copp, Tessa ; Brennan, Meagan ; Farber, Rachel ; McCaffery, Kirsten ; Houssami, Nehmat

Background : Breast density (BD) is an independent risk factor for breast cancer and reduces the sensitivity of mammography. This systematic review aims to synthesize evidence from existing studies to understand the impact of BD information and/or notification on women's cognitive, psychological and behavioral outcomes. Methods : Studies were identified via relevant database searches up to March 2020. Two authors evaluated the eligibility of studies with verification from the study team, [...]

Menée en Autriche à partir de données portant sur 80 818 patients décédés d'un cancer entre 2012 et 2016, cette étude rétrospective analyse le type et le lieu des soins reçus en fin de vie (à domicile, en milieu hospitalier)

Cancer care near the end-of-life in Austria: A retrospective data analysis

Robausch, Martin ; Grössmann, Nicole ; Wild, Claudia

Objective : Since end‐of‐life care (EOL) is an internationally accepted indicator for the quality of oncological care we aimed to investigate the current EOL care situation for Austrian cancer patients especially concerning the place of death cancer treatment hospitalisation near death and palliative care. Methods : A retrospective data analysis was carried out based on Austrian routine inpatient data of the years 2012 to 2016. Data including the date of death of adult patients with a main [...]