Mené sur 23 puis 37 patients atteints d'une tumeur solide, cet essai de phase II évalue l'efficacité, du point de vue de la numération plaquettaire à 3 semaines, du romiplostime pour traiter une thrombocytopénie induite par la chimiothérapie

Romiplostim Treatment of Chemotherapy-Induced Thrombocytopenia

Gerald A. Soff ; Yimei Miao ; Gemma Bendheim ; Jeanette Batista ; Jodi V. Mones ; Rekha Parameswaran ; Cy R. Wilkins ; Sean M. Devlin ; Ghassan K. Abou-Alfa ; Andrea Cercek ; Nancy E. Kemeny ; Debra M. Sarasohn ; Simon Mantha

PURPOSE : Chemotherapy-induced thrombocytopenia (CIT) leads to delay or reduction in cancer treatment. There is no approved treatment. METHODS : We conducted a phase II randomized trial of romiplostim versus untreated observation in patients with solid tumors with CIT. Before enrollment, patients had platelets less than 100,000/  [...]

Mené aux Etats-Unis auprès de 51 patients ayant survécu à un cancer (âge moyen : 55 ans), cet essai évalue l'efficacité d'un programme pédagogique mené en deux étapes pour traiter l'insomnie

Developing efficient and effective behavioral treatment for insomnia in cancer survivors: Results of a stepped care trial

Zhou, Eric S. ; Michaud, Alexis L. ; Recklitis, Christopher J.

Background : Insomnia is common among cancer survivors. Although behavioral treatments for insomnia are effective, access is limited. Stepped care delivery models may provide insomnia treatment that is more efficient and accessible to cancer survivors. Methods : Fifty‐one survivors (mean age, 55 years) with elevated Insomnia Severity Index (ISI) scores (≥12) first participated in Sleep Training Education Program (STEP)‐1: a single, sleep education session. Those reporting elevated ISI scores 1 [...]

Menée aux Etats-Unis à partir de données portant sur 542 patients ayant survécu à un lymphome ou à une leucémie pédiatriques (âge moyen : 15,5 ans), cette étude transversale analyse l'association entre une faible densité minérale osseuse détectée dans le cadre d'un programme de surveillance et le risque de fracture

Severity of reduced bone mineral density and risk of fractures in long-term survivors of childhood leukemia and lymphoma undergoing guideline-recommended surveillance for bone health

Bloomhardt, Hadley M. ; Sint, Kyaw ; Ross, Wilhelmenia L. ; Rotatori, Jaime ; Ness, Kathryn ; Robinson, Cemre ; Carpenter, Thomas O. ; Chow, Eric J. ; Kadan-Lottick, Nina S.

Background : Survivors of childhood leukemia/lymphoma are at increased risk for reduced bone mineral density (BMD). The authors sought to determine the frequency of reduced BMD detected by off‐therapy surveillance, factors associated with reduced BMD, and the association of reduced BMD with fractures. Methods : This cross‐sectional study included childhood leukemia/lymphoma survivors attending 2 survivorship clinics who received guideline‐recommended BMD surveillance ≥2 years post‐therapy with [...]

Mené sur 44 patients atteints d'une leucémie myéloïde chronique (âge moyen : 55 ans, 48 % de femmes), cet essai randomisé évalue l'efficacité, du point de vue de la réduction de la fatigue liée aux thérapies ciblées et de l'amélioration de la qualité de vie, d'une intervention de psychothérapie comportementale dispensée sur internet

Internet-assisted cognitive behavioral intervention for targeted therapy–related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial

Jim, Heather S. L. ; Hyland, Kelly A. ; Nelson, Ashley M. ; Pinilla-Ibarz, Javier ; Sweet, Kendra ; Gielissen, Marieke ; Bulls, Hailey ; Hoogland, Aasha I. ; Jacobsen, Paul B. ; Knoop, Hans

Background : Fatigue is a common and disabling side effect of targeted therapies such as tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukemia (CML). The goal of the current study was to conduct a pilot randomized trial of the first cognitive behavioral intervention developed for fatigue due to targeted therapy. Methods : Patients with CML treated with a TKI who were reporting moderate to severe fatigue were recruited and randomized 2:1 to cognitive behavioral therapy for [...]

Menée aux Etats-Unis à partir de données portant sur 1 516 hommes ayant survécu à un cancer diagnostiqué pendant l'enfance (âge médian : 30,8 ans ; durée médiane après le diagnostic : 22 ans), cette étude rétrospective analyse les facteurs associés au risque d'anomalies de fonctionnement des cellules de Leydig et de troubles sexuels

Leydig Cell Function in Male Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

Wassim Chemaitilly ; Qi Liu ; Laura van Iersel ; Kirsten K. Ness ; Zhenghong Li ; Carmen L. Wilson ; Tara M. Brinkman ; James L. Klosky ; Nicole Barnes ; Karen L. Clark ; Rebecca M. Howell ; Susan A. Smith ; Matthew J. Krasin ; Monika L. Metzger ; Gregory T. Armstrong ; Michael W. Bishop ; Hanneke M. van Santen ; Ching-Hon Pui ; Deo Kumar Srivastava ; Yutaka Yasui ; Melissa M. Hudson ; Leslie L. Robison ; Daniel M. Green ; Charles A. Sklar

PURPOSE : Direct assessment of Leydig cell function in childhood cancer survivors has been limited. The objectives of this study were to describe the prevalence of and risk factors for Leydig cell failure (LCF), Leydig cell dysfunction (LCD), and associated adverse health outcomes. PATIENTS AND METHODS : In this retrospective study with cross-sectional health outcomes analysis, we evaluated 1,516 participants (median age, 30.8 years) at a median of 22.0 years after cancer diagnosis. LCF was [...]

Menée dans 195 pays sur la période 1990-2017, cette étude analyse l'évolution géographique de l'incidence de 29 types de cancers, les années de vies perdues, les années passées en situation de handicap, les années de vies ajustées sur l'incapacité et la mortalité

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study

Global Burden of Disease Cancer Collaboration

Importance Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving [...]

A partir d'une revue systématique de la littérature (14 études, 744 patientes), cette méta-analyse évalue les troubles de la fertilité et le taux de grossesses chez des patientes ayant survécu à une tumeur hématologique traitée par une greffe autologue ou allogénique de cellules souches hématopoïétiques

Reproductive outcomes following a stem cell transplant for a haematological malignancy in female cancer survivors: a systematic review and meta-analysis

Gerstl, Brigitte ; Sullivan, Elizabeth ; Koch, Jana ; Wand, Handan ; Ives, Angela ; Mitchell, Richard ; Hamad, Nada ; Anazodo, Antoinette

Purpose : The use of high-dose chemotherapy and radiotherapy combined with haematopoietic stem cell transplantation (HSCT) may negatively affect a woman’s reproductive potential. Reproductive outcomes such as infertility are a major concern for women who undergo treatment for a haematological cancer diagnosis. Objective : This systematic review and meta-analysis explores reproductive outcomes following a haematological cancer requiring HSCT. Methods : Electronic databases were searched to [...]

Menée à partir des données des registres américains des cancers, cette étude analyse l'évolution, depuis 1990, de l'incidence du cancer de la prostate chez les jeunes adultes âgés de 15 à 40 ans, de la survie et de la mortalité associées

Prostate cancer in young men: An emerging young adult and older adolescent challenge

Bleyer, Archie ; Spreafico, Filippo ; Barr, Ronald

Background : Recent observations suggest that prostate cancer is an increasing disease among older adolescents and young adults. Methods : Incidence, mortality, and survival data were obtained from the US National Cancer Institute Surveillance, Epidemiology, and End Results program and the Institute for Health Metrics and Evaluation Global Burden of Disease database. Results : Worldwide, the incidence of prostate cancer has increased in all groups between ages 15 and 40 years and increased [...]

Menée aux Etats-Unis à partir de données portant sur 1 800 708 femmes et 16 025 hommes atteints d'un cancer du sein diagnostiqué entre 2004 et 2014, cette étude de cohorte analyse les facteurs associés aux disparités dans la survie globale et dans la mortalité à 3 et 5 ans

Overall Mortality After Diagnosis of Breast Cancer in Men vs Women

Wang, Fei ; Shu, Xiang ; Meszoely, Ingrid ; Pal, Tuya ; Mayer, Ingrid A. ; Yu, Zhigang ; Zheng, Wei ; Bailey, Christina E. ; Shu, Xiao-Ou

Importance : Survival differences between male and female patients with breast cancer have been reported, but the underlying factors associated with the disparity have not been fully studied. This understanding is fundamental to developing strategies for cancer treatment and survivorship care. Objective :To compare mortality between male and female patients with breast cancer and quantitatively evaluate the factors associated with sex-based disparity in mortality. Design, Setting, and [...]

A partir d'une revue de la littérature, cette étude analyse l'intérêt de la médecine traditionnelle chinoise dans la prise en charge des patients atteints d'un cancer

Traditional Chinese Medicine in Oncotherapy: The Research Status

Tang, Huijuan ; Shu, Peng ; Liu, Shenlin ; Zhang, Xu ; Mattioli-Belmonte, Monica

In China, Traditional Chinese Medicine (TCM) plays a vital role in the comprehensive treatment of cancer. As an auxiliary and supplement of major treatment modalities for cancer such as surgery, chemotherapy, and radiotherapy, both clinical observations and biomolecular research have confirmed the therapeutic efficacy of TCM in cancer.