Menée aux Etats-Unis auprès de 433 personnes atteintes d'une tumeur neuroendocrine de l'intestin grêle et de témoins, cette étude analyse l'association entre une exposition au tabac et/ou à l'alcool et le risque de développer la maladie

Associations of tobacco and alcohol use with risk of neuroendocrine tumors of the small intestine in Utah

Curtin, Karen ; Cannon-Albright, Lisa A. ; VanDerslice, James ; Yu, Zhe ; Herget, Kimberly A ; Thota, Ramya ; Neklason, Deborah W

Background : Incidence of small intestine neuroendocrine tumors (SINT) has been increasing in the United States over the past 40 years, with higher incidence in Utah than elsewhere. As information about how these tumors arise is limited, elucidating lifestyle factors associated with SINT in a statewide cohort could potentially identify those at risk to help mitigate their effects. Methods : Cases of SINT with a carcinoid histology (8240 or 8241) diagnosed in Utah in 1996-2014 with no prior [...]

Menée en Australie par questionnaire auprès de 1 254 patients atteints d'un cancer agressif de la prostate et de 818 témoins (âge : moins de 75 ans), cette étude analyse l'association entre le régime alimentaire, l'indice de masse corporelle et le risque de développer la maladie

Body size and dietary risk factors for aggressive prostate cancer: a case–control study

Pal, Mikaela ; Hodge, Allison M. ; Papa, Nathan ; MacInnis, Robert J. ; Bassett, Julie K. ; Bolton, Damien ; Davis, Ian D. ; Millar, Jeremy ; English, Dallas R. ; Hopper, John L. ; Severi, Gianluca ; Southey, Melissa C. ; Milne, Roger L. ; Giles, Graham G.

Purpose : Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive. Methods : A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2019 (10 études), cette méta-analyse évalue l'association entre un indicateur caractérisant une alimentation pro-inflammatoire et le risque de cancer de la prostate

Dietary inflammatory index and the risk of prostate cancer: a dose-response meta-analysis

Zhu, Yi ; Li, Qinchen ; Xu, Xin

Emerging epidemiological studies have assessed the potential relationship between the inflammatory potential of diet measured using the dietary inflammatory index (DII) and the risk of prostate cancer and found inconsistent results. The aim of this study was to systematically evaluate this issue using a meta-analysis approach. A comprehensive literature search of papers published through March 2019 was performed in the PubMed and EMBASE databases. The summary odds ratios (ORs) and 95% [...]

Menée en Argentine sur la période 2008-2016 par questionnaire auprès de 346 patientes atteintes d'un cancer du sein et de 566 témoins, cette étude analyse l'association entre l'obésité, la qualité de l'alimentation (mesurée par un système de score basé sur quinze composés alimentaires associés à une inflammation de bas grade) et le risque de développer la maladie

Diet Quality, Obesity and Breast Cancer Risk: An Epidemiologic Study in Córdoba, Argentina

Becaria Coquet, Julia ; Caballero, Victor Ramón ; Camisasso, María Cecilia ; González, María Florencia ; Niclis, Camila ; Román, María Dolores ; Muñoz, Sonia Edith ; Leone, Carla M. ; Procino, Filippo ; Osella, Alberto Rubén ; Aballay, Laura Rosana

Breast cancer (BC) is a multifactorial disease. Environmental factors, specifically, obesity and diet quality, have been linked with an increased risk of BC in women. This research was aimed at assessing the association of diet quality with BC risk, considering nutritional status, in Córdoba province (Argentina). A case-control study was conducted during the period 2008?2016 (346 cases/566 controls). A diet quality score was calculated for each woman based on fifteen dietary components related [...]

Menée en France par questionnaire auprès de 2 276 personnes atteintes d'un cancer du poumon et de 2 780 témoins, cette étude analyse l'association entre une exposition professionnelle aux poussières de bois et le risque de développer la maladie

Occupational exposure to wood dust and risk of lung cancer: the ICARE study

Matrat, Mireille ; Radoi, Loredana ; Févotte, Joëlle ; Guida, Florence ; Cenée, Sylvie ; Cyr, Diane ; Sanchez, Marie ; Menvielle, Gwenn ; Schmaus, Annie ; Marrer, Emilie ; Luce, Danièle ; Stücker, Isabelle

Objectives : In a previous analysis of data from a French population-based case–control study (the Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE) study), ‘having ever worked’ in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not for occupational factors. The present study aimed to investigate the relationship between lung cancer risk and wood dust exposure after adjusting for occupational exposures. [...]

Menée auprès de patientes incluses dans l'étude "Women’s Health Initiative Observational Study" (179 cas de cancer de l’ovaire et 396 témoins ; 230 cas de cancer de l’endomètre et 253 témoins), cette étude analyse l'association entre les niveaux d'œstrogènes circulants et le risque de cancer de l'ovaire ou de l'endomètre chez les femmes ménopausées sous traitement hormonal substitutif

Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women’s Health Initiative Observational Study

Trabert, Britton ; Coburn, Sally B. ; Falk, Roni T. ; Manson, JoAnn E. ; Brinton, Louise A. ; Gass, Margery L. ; Kuller, Lewis H. ; Rohan, Thomas E. ; Pfeiffer, Ruth M. ; Qi, Lihong ; Stefanick, Marcia L. ; Wentzensen, Nicolas ; Anderson, Garnet L. ; Xu, Xia

Purpose : Menopausal hormone therapy (MHT) use induces alterations in circulating estrogens/estrogen metabolites, which may contribute to the altered risk of reproductive tract cancers among current users. Thus, the current study assessed associations between circulating estrogens/estrogen metabolites and ovarian and endometrial cancer risk among MHT users. Methods : We conducted a nested case–control study among postmenopausal women using MHT at baseline in the Women’s Health Initiative [...]

Menée à partir des données d'un essai randomisé portant sur 2 963 personnes vaccinées par le BCG (âge médian à la vaccination : 8 ans ; durée de suivi : 60 ans), cette étude analyse l'association entre cette vaccination et le risque de cancer

Association of BCG Vaccination in Childhood With Subsequent Cancer Diagnoses: A 60-Year Follow-up of a Clinical Trial

Usher, Nicholas T. ; Chang, Suyoung ; Howard, Robin S. ; Martinez, Adriana ; Harrison, Lee H. ; Santosham, Mathuram ; Aronson, Naomi E.

The BCG vaccine is currently the only approved tuberculosis vaccine and is widely administered worldwide, usually during infancy. Previous studies found increased rates of lymphoma and leukemia in BCG-vaccinated populations.To determine whether BCG vaccination was associated with cancer rates in a secondary analysis of a BCG vaccine trial.Retrospective review (60-year follow-up) of a clinical trial in which participants were assigned to the vaccine group by systematic stratification by school [...]

Cette étude analyse l'association entre des composés chimiques dégagés par les bougies parfumées et le risque de cancer de la vessie

Scented Candles as an Unrecognized Factor that Increases the Risk of Bladder Cancer; Is There Enough Evidence to Raise a Red Flag?

Adamowicz, Jan ; Juszczak, Kajetan ; Poletajew, Slawomir ; van Breda, Shane Vontelin ; Pokrwczynska, Marta ; Drewa, Tomasz

The causes of bladder cancer are not yet fully uncovered, however the research has identified a number of factors that may increase the risk of developing this cancer. The chemical carcinogenesis of bladder cancer due to chronic exposure to aromatic hydrocarbons has been well-established. The identification of this correlation led to an improvement of safety measures in chemical industry and a gradual decrease of bladder cancer cases among workers. Nevertheless, in the majority of bladder [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2018 (37 études), cette méta-analyse évalue l'association entre l'indice de masse corporelle et le risque de cancer du foie

Excess Body Weight and the Risk of Liver Cancer: Systematic Review and a Meta-Analysis of Cohort Studies

Yang, Chao ; Lu, Yifei ; Xia, Hui ; Liu, Hechun ; Pan, Da ; Yang, Xian ; Sun, Guiju

Objective : To update and expand the previous meta-analysis including all prospective studies on the issue of the associations between overweight, obesity, and liver cancer risk. We also performed a meta-regression to investigate a potential nonlinear and/or linear association between body mass index (BMI) and liver cancer risk. Methods : Literature search was conducted in four libraries from the beginning of indexing for each database to 1st September, 2018. Results : The summary risk estimate [...]

Menée à partir des données de trois cohortes portant sur 600 témoins et sur 304 femmes atteintes d'un cancer épithélial de l'ovaire diagnostiqué entre 1996 et 2015 (âge : 53-80 ans), cette étude analyse l'association entre le niveau d'un biomarqueur urinaire des prostaglandines et le risque de développer la maladie

Urinary PGE-M Levels and Risk of Ovarian Cancer

Barnard, Mollie E. ; Beeghly-Fadiel, Alicia ; Milne, Ginger L. ; Akam, Eftitan Y. ; Chan, Andrew T. ; Eliassen, A. Heather ; Rosner, Bernard A. ; Shu, Xiao-Ou ; Terry, Kathryn L. ; Xiang, Yong-Bing ; Zheng, Wei ; Tworoger, Shelley S.

Background : Regular aspirin use may lower ovarian cancer risk by blocking the cyclooxygenase enzymes, resulting in lower expression of prostaglandins, including prostaglandin E2 (PGE2). We evaluated whether higher prediagnosis PGE-M (a urinary biomarker of PGE2) was associated with increased ovarian cancer risk in three prospective cohorts. Methods : We conducted a case–control study nested in the Nurses’ Health Study (NHS), NHSII, and Shanghai Women's Health Study. Our analyses included 304 [...]

Menée en Chine à l'aide de questionnaires et à l'aide d'échantillons d'urine collectés auprès de 275 patientes atteintes d'un cancer du poumon et de 289 témoins (âge médian : 61-62 ans ; durée médiane de suivi : 10,9 ans), cette étude analyse l'association entre des métabolites et le risque de cancer du poumon chez les femmes n'ayant jamais fumé

Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China

Seow, Wei Jie ; Shu, Xiao-Ou ; Nicholson, Jeremy K. ; Holmes, Elaine ; Walker, Douglas I. ; Hu, Wei ; Cai, Qiuyin ; Gao, Yu-Tang ; Xiang, Yong-Bing ; Moore, Steven C. ; Bassig, Bryan A. ; Wong, Jason Y. Y. ; Zhang, Jinming ; Ji, Bu-Tian ; Boulangé, Claire L. ; Kaluarachchi, Manuja ; Wijeyesekera, Anisha ; Zheng, Wei ; Elliott, Paul ; Rothman, Nathaniel ; Lan, Qing

Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood.To assess the association between metabolomics and lung cancer risk among never-smoking women.This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women’s Health Study recruited from December 28, 1996, to May 23, 2000. Validated food frequency [...]

A partir des données d'un registre du cancer familial du côlon portant sur 2 023 personnes porteuses d'une mutation d'un gène de réparation des mésappariements de l'ADN (syndrome de Lynch), cette étude analyse l'association entre un diabète de type 2, un taux de cholestérol ou de triglycérides élevé et le risque de cancer colorectal (802 cas ; âge médian au diagnostic : 42 ans)

Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome

Dashti, S. Ghazaleh ; Li, Wing Yan ; Buchanan, Daniel D. ; Clendenning, Mark ; Rosty, Christophe ; Winship, Ingrid M. ; Macrae, Finlay A. ; Giles, Graham G. ; Hardikar, Sheetal ; Hua, Xinwei ; Thibodeau, Stephen N. ; Figueiredo, Jane C. ; Casey, Graham ; Haile, Robert W. ; Gallinger, steven ; Le Marchand, Loic ; Newcomb, Polly A. ; Potter, John D. ; Lindor, Noralane M. ; Hopper, John L. ; Jenkins, Mark A. ; Win, Aung Ko

Background : Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal cancer. Methods : This study included 2023 (56.4% female) carriers with a mismatch repair gene mutation (737 in MLH1, 928 in MSH2, 230 in MSH6, 106 in PMS2, 22 in EPCAM) [...]

Menée aux Etats-Unis auprès de patientes atteintes d'un cancer du sein invasif (âge : 20-74 ans), cette étude identifie un schéma de classification des sous-types des cancers du sein basé sur des facteurs de risque génétiques

Evidence for Etiologic Subtypes of Breast Cancer in the Carolina Breast Cancer Study

Benefield, Halei C. ; Zabor, Emily C. ; Shan, Yue ; Allott, Emma H. ; Begg, Colin B. ; Troester, Melissa A.

Background : Distinctions in the etiology of triple-negative versus luminal breast cancer have become well established using immunohistochemical surrogates [notably estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)]. However, it is unclear whether established immunohistochemical subtypes are the sole or definitive means of etiologically subdividing breast cancers. Methods : We evaluated clinical biomarkers and tumor suppressor p53 with risk [...]