Menée aux Etats-Unis auprès de 425 patients ayant survécu à un cancer (âge moyen : 60,9 ans), cette étude analyse, en fonction de l'âge, la présence et la sévérité d'une neuropathie périphérique induite par la chimiothérapie

Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors

Wong, Melisa L. ; Cooper, Bruce A. ; Paul, Steven M. ; Abrams, Gary ; Topp, Kimberly ; Kober, Kord M. ; Chesney, Margaret A. ; Mazor, Melissa ; Schumacher, Mark A. ; Conley, Yvette P. ; Levine, Jon D. ; Miaskowski, Christine

Purpose : While older adults with cancer are more likely to develop chemotherapy-induced peripheral neuropathy (CIPN), the study aimed to determine if patient-reported and objective measures of CIPN differ by age among cancer survivors. Methods : Cancer survivors with persistent CIPN after completion of platinum and/or taxane chemotherapy completed CIPN questionnaires (severity, interference with activities, sensory, and motor symptoms) and objective testing (light touch, vibration, pain, cold [...]

Mené au Danemark sur 143 patients atteints d'un lymphome, cet essai randomisé évalue l'intérêt, du point de vue de la réduction de l'anxiété et de l'amélioration de la qualité de vie, d'une intervention à base des musiques préférées du patient, pré-enregistrées ou jouées en direct pendant 30 minutes, au moment de la chimiothérapie

Effects of live music during chemotherapy in lymphoma patients: a randomized, controlled, multi-center trial

Bro, Margrethe Langer ; Johansen, Christoffer ; Vuust, Peter ; Enggaard, Lisbeth ; Himmelstrup, Bodil ; Mourits-Andersen, Torben ; Brown, Peter ; d’Amore, Francesco ; Andersen, Elisabeth Anne Wreford ; Abildgaard, Niels ; Gram, Jeppe

Purpose : Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients. Methods : A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving [...]

Menée aux Pays-Bas à partir de données portant sur 1 860 patientes atteintes d'un cancer du sein de stade précoce après la ménopause et incluses dans un essai de phase III évaluant l'efficacité d'un traitement adjuvant par anastrozole, cette étude analyse leur santé osseuse en lien avec l'hormonothérapie (durée de suivi : 3 et 6 ans)

Assessment and Management of Bone Health in Women with Early Breast Cancer Receiving Endocrine Treatment in the DATA Study

van Hellemond, Irene E.G. ; Smorenburg, Carolien H. ; Peer, Petronella G.M. ; Swinkels, Astrid C.P. ; Seynaeve, Caroline M. ; van der Sangen, Maurice J.C. ; Kroep, Judith R. ; de Graaf, Hiltje ; Honkoop, Aafke H. ; Erdkamp, Frans L.G. ; van den Berkmortel, Franchette W.P.J. ; de Boer, Maaike ; de Roos, Wïlfred K. ; Linn, Sabine C. ; Imholz, Alexander L.T. ; Tjan-Heijnen, Vivianne C.G. ; on behalf of the Dutch Breast Cancer Research Group

The phase III DATA study investigates the efficacy of adjuvant anastrozole (6 versus 3 year) in postmenopausal women with breast cancer previously treated with 2-3 years of tamoxifen. This planned side-study assessed patterns of care regarding detection and treatment of osteopenia/osteoporosis, and trends in bone mineral density (BMD) during and after therapy. We registered all BMD measurements and bisphosphonate-use. Time to osteopenia/osteoporosis was analysed by Kaplan Meier methodology. For [...]

Cette étude présente une projection pour l'année 2019 de l'incidence des cancers, de la survie et de la mortalité spécifique chez les personnes afro-américaines

Cancer statistics for African Americans, 2019

DeSantis, Carol E. ; Miller, Kimberly D. ; Goding Sauer, Ann ; Jemal, Ahmedin ; Siegel, Rebecca L.

In the United States, African American/black individuals bear a disproportionate share of the cancer burden, having the highest death rate and the lowest survival rate of any racial or ethnic group for most cancers. To monitor progress in reducing these inequalities, every 3 years, the American Cancer Society provides the estimated number of new cancer cases and deaths for blacks in the United States and the most recent data on cancer incidence, mortality, survival, screening, and risk factors [...]

Menée en Suède à partir de données portant sur des patients ayant survécu à un cancer diagnostiqué entre 1958 et 2015, cette étude analyse les facteurs associés à une hospitalisation de leurs enfants nés entre 1997 et 2015

Hospitalization rate in offspring of cancer survivors: a national cohort study

Ji, Jianguang ; Huang, Wuqing ; Sundquist, Jan ; Sundquist, Kristina

Purpose : The number of childbirths among cancer survivors continues to increase, but it is still largely unknown whether the children of cancer survivors might experience adverse health outcomes during the process of growing up. Methods : We identified all individuals diagnosed with cancer between 1958 and 2015 from the Swedish Cancer Registry and linked them to the Swedish Medical Birth Register to identify their offspring born between 1997 and 2015. Up to 10 children, whose parents did not [...]

Menée en France entre 2009 et 2017 auprès de 44 751 personnes âgées d'au moins 45 ans, cette étude analyse l'association entre la consommation d'aliments ultratransformés et la mortalité toutes causes confondues

Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France

Schnabel, Laure ; Kesse-Guyot, Emmanuelle ; Allès, Benjamin ; Touvier, Mathilde ; Srour, Bernard ; Hercberg, Serge ; Buscail, Camille ; Julia, Chantal

Importance: Growing evidence indicates that higher intake of ultraprocessed foods is associated with higher incidence of noncommunicable diseases. However, to date, the association between ultraprocessed foods consumption and mortality risk has never been investigated. Objective: To assess the association between ultraprocessed foods consumption and all-cause mortality risk. Design, Setting, and Participants: This observational prospective cohort study selected adults, 45 years or older, from [...]

Menée aux Etats-Unis à partir de données portant sur 3 999 patientes atteintes d'un cancer de l'ovaire diagnostiqué entre 2002 et 2011, cette étude de cohorte rétrospective analyse les disparités ethniques dans l'adhésion aux recommandations relatives aux soins (notamment aux consultations auprès d'un oncologue gynécologue), dans la survie et dans la mortalité spécifique

Racial Disparities in the Receipt of Guideline Care and Cancer Deaths for Women with Ovarian Cancer

Cronin, Kathleen A. ; Howlader, Nadia ; Stevens, Jennifer L. ; Trimble, Edward L. ; Harlan, Linda C. ; Warren, Joan L.

Background: Black women with ovarian cancer experience worse survival than white women. Receipt of guideline care improves survival, yet care may vary by race. We assessed rates of guideline care and role of guideline treatment on survival disparities. Methods: This retrospective cohort analysis used the NCI's Patterns of Care data for women diagnosed with ovarian cancer, 2002 and 2011 (weighted n = 3,999), with follow-up through December 12, 2014. Logistic regression included patient [...]

Menée en Espagne auprès de 202 patientes atteintes d'un cancer du sein et de 243 patients atteints d'un cancer colorectal, cette étude analyse l'efficacité d'un questionnaire européen pour détecter la détresse psyschologique avant le début d'un traitement adjuvant

Emotional functioning to screen for psychological distress in breast and colorectal cancer patients prior to adjuvant treatment initiation

Calderon, Caterina ; Carmona-Bayonas, Alberto ; Jara, Carlos ; Beato, Carmen ; Mediano, Marilo ; Ramón y Cajal, Teresa ; Carmen Soriano, Mª ; Jiménez-Fonseca, Paula

Introduction : The objective was to analyze the usefulness of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC‐QLQ‐C30) EF subscale to detect emotional problems in patients with breast (BC) and colorectal cancer (CRC). Methods : A prospective, observational, cross‐sectional study was conducted. Participants completed the Brief Symptom Inventory (BSI) and EORTC‐QLQ‐C30. The following psychometric properties were calculated: accuracy, [...]

Mené sur 254 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt d'une psychothérapie comportementale dispensée en ligne pour alléger les symptômes de la ménopause (bouffées de chaleur, suées nocturnes), réduire la détresse psychologique et améliorer la qualité de vie (vie sexuelle, sommeil, etc.)

Efficacy of Internet-Based Cognitive Behavioral Therapy for Treatment-Induced Menopausal Symptoms in Breast Cancer Survivors: Results of a Randomized Controlled Trial

Vera Atema ; Marieke van Leeuwen ; Jacobien M. Kieffer ; Hester S.A. Oldenburg ; Marc van Beurden ; Miranda A. Gerritsma ; Marianne A. Kuenen ; Peter W. Plaisier ; Alexander M.F. Lopes Cardozo ; Yvonne E.A. van Riet ; Gijsbert Heuff ; Herman Rijna ; Suzan van der Meij ; Eva M. Noorda ; Gert-Jan Timmers ; Bart C. Vrouenraets ; Matthé Bollen ; Henk van der Veen ; Nina Bijker ; Myra S. Hunter ; Neil K. Aaronson

PURPOSE : We evaluated the effect of Internet-based cognitive behavioral therapy (iCBT), with or without therapist support, on the perceived impact of hot flushes and night sweats (HF/NS) and overall levels of menopausal symptoms (primary outcomes), sleep quality, HF/NS frequency, sexual functioning, psychological distress, and health-related quality of life in breast cancer survivors with treatment-induced menopausal symptoms. PATIENTS AND METHODS : We randomly assigned 254 breast cancer [...]

Menée en Italie à partir de données portant sur 326 patients décédés d'un cancer en 2014 et 2015, cette étude rétrospective analyse les facteurs associés à l'implication du patient et de la famille dans les discussions avec le médecin sur les soins palliatifs et la sédation palliative

Discussions about palliative sedation in hospice: Frequency, timing and factors associated with patient involvement

Ingravallo, Francesca ; de Nooijer, Kim ; Pucci, Valentina ; Casini, Cinzia ; Miccinesi, Guido ; Rietjens, Judith A. C. ; Morino, Piero

Objective : To investigate whether and when palliative sedation was discussed with hospice patients with cancer and/or with their families and factors associated with patient involvement in such discussions. Methods : Medical records of all patients with cancer who died in an Italian hospice in 2014–2015 (N = 326) were retrospectively reviewed. Multiple logistic regression was used to assess the association between patients’ characteristics and palliative sedation discussion with the patient [...]

Menée auprès de 122 dyades constituées d'un enfant atteint de cancer et âgé de plus de 7 ans au moment de la première consultation de soins palliatifs et de son aidant, cette étude évalue l'intérêt d'un questionnaire permettant à chacun (enfant comme aidant) de déclarer les symptômes, puis analyse ces différents symptômes

Systematic Symptom Reporting by Pediatric Palliative Care Patients with Cancer: A Preliminary Report

Madden Kevin ; Magno Charone Maira ; Mills Sarah ; Dibaj Seyedeh ; Williams Janet L. ; Liu Diane ; Bruera Eduardo

Background: Systematic symptom assessment is not a standard of care in children with cancer. Many well-known symptom assessment tools are lengthy or difficult to integrate into a daily pediatric palliative care practice. We created a series of brief and simple questions to be systematically given to children and their caregivers. Objective: The primary objective was to determine the percentage of eligible children and caregivers exposed to the questions that were able to complete the [...]

Menée au Japon à partir de données portant sur 46 patients atteints d'un sarcome musculo-squelettique de stade avancé, cette étude rétrospective analyse les symptômes physiques et les soins palliatifs reçus dans les deux dernières semaines de vie

Symptom Burden and End-of-Life Palliative Treatments during the Last Two Weeks of Life in Patients with Advanced Musculoskeletal Sarcoma

Kawashima Hiroyuki ; Ariizumi Takashi ; Yamagishi Tetsuro ; Ogose Akira ; Ikoma Miho ; Hotta Tetsuo ; Endo Naoto

Background: Musculoskeletal sarcomas (MSSs) are rare cancers and often aggressive tumors that originate from mesenchymal tissue. Patients with advanced MSS often report difficulties with symptom burden, which can reduce their health-related quality-of-life. Objective: The aim of this study was to describe the patterns of the physical symptoms of MSS patients in the palliative setting and to detail the palliative treatment used in the last two weeks of life. Design: Retrospective study using the [...]