Menée aux Etats-Unis à partir de données portant sur 1 158 patients atteints d'un cancer et ayant présenté un thromboembolisme veineux entre 2013 et 2015, cette étude analyse l'association entre la durée du traitement anticoagulant et le risque de récidive de la thromboembolie

Duration of anticoagulant therapy and VTE recurrence in patients with cancer

Khorana, Alok A. ; McCrae, Keith R. ; Milentijevic, Dejan ; Fortier, Jonathan ; Nelson, Winnie W. ; Laliberté, François ; Crivera, Concetta ; Lefebvre, Patrick ; Schein, Jeff

Purpose : Anticoagulant therapy for at least 3–6 months is currently recommended for treatment of venous thromboembolism (VTE) in patients with cancer, but the optimal duration of treatment is unknown. This study examines the association between the duration of anticoagulation treatment and VTE recurrence in cancer patients. Methods : The Humana claims database was used to identify newly diagnosed cancer patients who had their first VTE diagnosis between January 1, 2013, and May 31, 2015, and [...]

Menée en Italie par questionnaire auprès de 500 patients ayant survécu à un cancer, cette étude analyse l'impact, sur la qualité de vie, de facteurs sociodémographiques, cliniques et psychologiques

The impact of cancer: An Italian descriptive study involving 500 long-term cancer survivors

Muzzatti, Barbara ; Gipponi, Katiuscia ; Flaiban, Cristiana ; Cormio, Claudia ; Carnaghi, Carlo ; Tralongo, Paolo ; Caruso, Michele ; Cavina, Raffaele ; Tirelli, Umberto ; Annunziata, Maria Antonietta

Introduction : The well-being and quality of life (QoL) of long-term cancer survivors may be affected, both positively and negatively, by psychosocial factors related to the experience of being a cancer patient. We investigated whether, in long-term cancer survivors, the psychosocial impacts of cancer associate with socio-demographic–clinical variables; whether, within the positive and negative dimensions taken separately, some impacts are more intense than others; and whether these impacts [...]

A partir d'une revue systématique de la littérature (20 articles), cette étude évalue l'intérêt, du point de vue de la qualité de vie et des complications liées au cathéter, de l'alimentation parentérale à domicile chez les patients atteints d'un cancer

Is home parenteral nutrition safe for cancer patients? Positive effects and potential catheter-related complications: A systematic review

Ozcelik, Habibe ; Gozum, Sebahat ; Ozer, Zeynep

Purpose : Total Parenteral Nutrition began to be applied frequently in the houses of patients starting from the 1990s and is stated in literature as Home Parenteral Nutrition (HPN). The purpose of this review is to answer the question of whether or not HPN is safe for cancer patients. Methods : Searches were conducted in Cochrane, CINAHL, PubMed, Springer, Google Scholar, and the Web of Science databases. Results : The 1,949 articles were accessed in the total, and 20 articles have been [...]

Cette étude internationale présente les programmes d'activité physique destinés aux enfants atteints d'un cancer (10 pays, 46 programmes)

Physical activity programs for children diagnosed with cancer: an international environmental scan

Wurz, Amanda ; Daeggelmann, Julia ; Albinati, Natalia ; Kronlund, Liam ; Chamorro-Viña, Carolina ; Culos-Reed, S. Nicole

Background : Physical activity programs for children diagnosed with cancer may enhance health and quality of life. However, it is unknown where and in what capacity such programs are being offered internationally. Purpose : To identify physical activity programs for children diagnosed with cancer and summarize program characteristics. Methods : Five data sources were searched to identify physical activity programs offered to children diagnosed with cancer. Following confirmation of eligibility, [...]

Menée au Japon par questionnaire auprès de 2 044 patientes atteintes d'un cancer du sein et âgées de plus de 55 ans, cette étude analyse, selon la catégorie d'âge (56-69 ans et supérieur ou égal à 70 ans), la fréquence et la sévérité d'événements indésirables induits par deux types d'hormonothérapies (inhibiteurs de l'aromatase et modulateurs sélectifs des récepteurs aux œstrogènes)

Characteristics of adverse events of endocrine therapies among older patients with breast cancer

Honma, Naoko ; Makita, Masujiro ; Saji, Shigehira ; Mikami, Tetuo ; Ogata, Hideaki ; Horii, Rie ; Akiyama, Futoshi ; Iwase, Takuji ; Ohno, Shinji

Purpose : To clarify the profile of adverse events from endocrine therapies in older patients. Methods : We surveyed 15 subjective symptoms including hot flashes, sweating, knuckle stiffness, knee/shoulder joint pain, limb numbness, lethargy, forgetfulness, depressive state, irritated state, genital bleeding, leukorrhea increase, vaginal dryness, bone fracture, and weight gain by a questionnaire among 2044 patients over 55 years old (total number of answered sheets, 8875) and compared the [...]

Menée à partir des données d'une cohorte nordique incluant 2 582 patients âgés de 18 à 49 ans et atteints d'un lymphome hodgkinien diagnostiqué entre 2000 et 2013, cette étude analyse à 5 ans la survie globale, le risque de récidive et les restrictions en termes d'espérance de vie, en fonction des traitements systémiques utilisés en combinaison (durée médiane de suivi : 9 ans)

Relapse Risk and Loss of Lifetime After Modern Combined Modality Treatment of Young Patients With Hodgkin Lymphoma: A Nordic Lymphoma Epidemiology Group Study

Jorne Lionel Biccler ; Ingrid Glimelius ; Sandra Eloranta ; Knut B. Smeland ; Peter de Nully Brown ; Lasse Hjort Jakobsen ; Henrik Frederiksen ; Mats Jerkeman ; Alexander Fosså ; Therese M.L. Andersson ; Harald Holte ; Martin Bøgsted ; Tarec Christoffer El-Galaly ; Karin E. Smedby

PURPOSE : Estimates of short- and long-term survival for young patients with classic Hodgkin lymphoma (cHL) are of considerable interest. We investigated cHL prognosis in the era of contemporary treatment at different milestones during the follow-up. PATIENTS AND METHODS : On the basis of a Nordic cohort of 2,582 patients diagnosed at ages 18 to 49 years between 2000 and 2013, 5-year relapse risks and 5-year restricted losses in expectation of lifetime were estimated for all patients and for [...]

Menée à partir des données des registres américains des cancers, cette étude analyse l'évolution des traitements et l'utilisation de la surveillance active chez des patients atteints d'un cancer localisé de la prostate à faible risque de récidive et diagnostiqué entre 2010 et 2015

Use of Active Surveillance or Watchful Waiting for Low-Risk Prostate Cancer and Management Trends Across Risk Groups in the United States, 2010-2015

Mahal, Brandon A. ; Butler, Santino ; Franco, Idalid ; Spratt, Daniel E. ; Rebbeck, Timothy R. ; D’Amico, Anthony V. ; Nguyen, Paul L.

Historically, most patients with low-risk prostate cancer (clinical category T1c-T2a, prostate-specific antigen level <10 ng/mL, and Gleason 6 disease) were treated with radical prostatectomy, while radiotherapy-based treatment was the favored approach for high-risk localized prostate cancer.1 However, conservative management of low-risk prostate cancer with active surveillance or watchful waiting (AS/WW) offers an alternative to radical prostatectomy or radiotherapy,2 and national guidelines [...]

A partir de données portant sur 2 769 patientes chinoises atteintes d'un cancer du sein et menée à l'aide d'une technique de séquençage de nouvelle génération, cette étude analyse la prévalence de mutations constitutionnelles des gènes BRCA1/2 et PALB2, puis évalue leur association avec la survie

Prevalence and clinical outcomes of germline mutations in BRCA1/2 and PALB2 genes in 2769 unselected breast cancer patients in China

Deng, Mei ; Chen, Hui-Hui ; Zhu, Xuan ; Luo, Meng ; Zhang, Kun ; Xu, Chun-Jing ; Hu, Kai-Min ; Cheng, Pu ; Zhou, Jiao-Jiao ; Zheng, Shu ; Chen, Yi-Ding

To gain more information on the prevalence of germline mutations in BRCA1/2 and PALB2 genes in the Chinese population, and to explore the effects of the mutation status of these genes on clinical outcomes in patients with breast cancer, we performed a screening for BRCA1/2 and PALB2 mutations in a consecutive series of unselected breast cancer patients in the Chinese population. A total of 2769 cases were enrolled between June 1993 and September 2017. All of the exons and exon-intron boundaries [...]

Menée aux Etats-Unis à partir de données portant sur 1 311 patients ayant survécu à 5 ans ou plus à un médulloblastome diagnostiqué entre 1970 et 1999 (âge médian : 29 ans ; durée médiane depuis le diagnostic : 21 ans), cette étude analyse l'évolution à long terme des morbidités et de la mortalité toutes causes confondues en lien avec les traitements reçus

Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study

Ralph Salloum ; Yan Chen ; Yutaka Yasui ; Roger Packer ; Wendy Leisenring ; Elizabeth Wells ; Allison King ; Rebecca Howell ; Todd M. Gibson ; Kevin R. Krull ; Leslie L. Robison ; Kevin C. Oeffinger ; Maryam Fouladi ; Gregory T. Armstrong

PURPOSE : Treatment of medulloblastoma has evolved from surgery and radiotherapy to contemporary multimodal regimens. However, the impact on long-term health outcomes remains unknown. METHODS : Cumulative incidence of late mortality (5 or more years from diagnosis), subsequent neoplasms (SNs), and chronic health conditions were evaluated in the Childhood Cancer Survivor Study among 5-year survivors of medulloblastoma diagnosed between 1970 and 1999. Outcomes were evaluated by treatment [...]

A partir des données de trois registres américains des cancers, cette étude analyse l'évolution de l'incidence du carcinome épidermoïde de l'oropharynx et de la cavité buccale, dans la région du nord de la Nouvelle-Angleterre sur la période 2000-2013

Epidemiological trends of oropharyngeal and oral cavity squamous cell carcinomas in Northern New England, 2000–2013

Owosho, Adepitan A. ; Velez, Miguel ; Tyburski, Alexander ; Hofheins, John ; Wiley, Rashidah ; Stansbury, Tessie ; Gbadamosi, Semiu O. ; Ryder, Jon S.

Background : This study examines the epidemiological trends of oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC) in Northern New England. Methods : Data were obtained from the Maine, New Hampshire and Vermont cancer registries. The age-standardized incidence rates (ASIR), age-specific incidence rates, and annual percentage changes (APC) for OPSCC and OCSCC were calculated using Joinpoint regression. Results : The overall ASIR for OPSCC in Northern New [...]

Menée en France à partir de questionnaires auprès de 228 patients inclus dans la base clinico-biologique FREGAT et atteints d'un cancer de l'estomac ou de l'œsophage traité par chirurgie, cette étude analyse l'association entre l'intelligence émotionnelle, les symptômes de dépression et d'anxiété, et la qualité de vie

The role of trait emotional intelligence in quality of life, anxiety and depression symptoms after surgery for esophageal or gastric cancer: a French national database FREGAT

Baudry, A.-S. ; Anota, A. ; Mariette, C. ; Bonnetain, F. ; Renaud, F. ; Piessen, G. ; Christophe, V.

Objective : The main objective was to test the indirect effects of emotional competence (EC) after diagnosis (T1) on the health-related quality of life (HRQoL) after surgery (T2) of esogastric cancer patients via fewer anxiety and depression symptoms (T2). Methods : Data were collected from 30 French centers via the clinico-biological database FREGAT (French EsoGastric Tumors). Two hundred and twenty-eight participants completed a self-reported questionnaire at T1 and T2, assessing their EC [...]

Menée auprès de 110 patients atteints d'un cancer du poumon récemment diagnostiqué ou récidivant, cette étude analyse l'efficacité, pour prédire la survie à un an, d'un outil évaluant la détresse psychologique et utilisé en complément de 5 autres indicateurs

The Distress Thermometer as a Prognostic Tool for One-Year Survival among Patients with Lung Cancer

Geerse, O. P. ; Brandenbarg, D. ; Kerstjens, H. A. M. ; Berendsen, A. J. ; Duijts, S. F. A. ; Burger, H. ; Holtman, G. A. ; Hoekstra-Weebers, J. E. H. M. ; Hiltermann, T. J. N.

Introduction : The use of patient-reported outcome measures is increasingly advocated to support high-quality cancer care. We therefore investigated the added value of the Distress Thermometer (DT) when combined with known predictors to assess one-year survival in patients with lung cancer. Methods : All patients had newly diagnosed or recurrent lung cancer, started systemic treatment, and participated in the intervention arm of a previously published randomised controlled trial. A Cox [...]

A partir d'une revue de la littérature, cette étude analyse, dans un contexte palliatif, l'utilisation des traitements antimicrobiens, chez des patients atteints d'un cancer de stade avancé

Current opinion about antimicrobial therapy in palliative care: an update

Macedo, Filipa ; Bonito, Nuno

Purpose of review : The review englobes the latest studies published regarding the problem of antimicrobial usage with palliative intent. Recent findings : In the advanced stages of illness like cancer, dementia, or neurodegenerative diseases, important decisions have to be made concerning the global treatment plan. Infections are very common among this kind of patients as they typically have multiple comorbidities and are incapacitated. These infections, in a majority of the cases, will be [...]

Menée aux Etats-Unis à partir de l'analyse des prescriptions médicamenteuses pour traiter des patients atteints d'un cancer (prostate, rein, poumon, leucémie myéloïde chronique), cette étude analyse l'impact des relations des médecins avec l'industrie pharmaceutique (notamment la réception de paiements) sur les pratiques de prescription

Evaluating the Strength of the Association Between Industry Payments and Prescribing Practices in Oncology

Mitchell, Aaron P. ; Winn, Aaron N. ; Lund, Jennifer L. ; Dusetzina, Stacie B.

Financial relationships between physicians and the pharmaceutical industry are common, but factors that may determine whether such relationships result in physician practice changes are unknown.We evaluated physician use of orally administered cancer drugs for four cancers: prostate (abiraterone, enzalutamide), renal cell (axitinib, everolimus, pazopanib, sorafenib, sunitinib), lung (afatinib, erlotinib), and chronic myeloid leukemia (CML; dasatinib, imatinib, nilotinib). Separate physician [...]