Mené sur 66 patients atteints d'un carcinome hépatocellulaire ou présentant des métastases hépatiques (âge médian : 65 ans), cet essai multicentrique de phase III évalue l'intérêt, du point de vue de la réduction de l'intensité de la douleur hépatique, de l'ajout d'une radiothérapie palliative aux "meilleurs soins de support"

Palliative radiotherapy versus best supportive care in patients with painful hepatic cancer (CCTG HE1): a multicentre, open-label, randomised, controlled, phase 3 study

Dawson, Laura A. ; Ringash, Jolie ; Fairchild, Alysa ; Stos, Paul ; Dennis, Kristopher ; Mahmud, Aamer ; Stuckless, Teri Lynn ; Vincent, Francois ; Roberge, David ; Follwell, Matthew ; Wong, Raimond K. W. ; Jonker, Derek J. ; Knox, Jennifer J. ; Zimmermann, Camilla ; Wong, Philip ; Barry, Aisling S. ; Gaudet, Marc ; Wong, Rebecca K. S. ; Purdie, Thomas G. ; Tu, Dongsheng ; O'Callaghan, Christopher J.

Background: Palliative treatment options for painful hepatic cancer can be restricted due to patients eventually becoming refractory to standard treatment. The aim of this study was to determine whether radiotherapy improves hepatic pain from cancer. Methods: In this open-label, randomised, controlled, phase 3 trial (CCTG HE1) done in nine cancer centres across Canada, we included patients aged 18 years or older with hepatocellular carcinoma or liver metastases, who were refractory to standard [...]

Mené sur 52 patients atteints d'un cancer, cet essai randomisé évalue l'efficacité, pour soulager leur fatigue pendant la chimiothérapie, d'exercices physiques combinés à des exercices de respiration (pratique de pranayama) et à une supplémentation en millet

The combined effect of physical exercise, pranayama, and diet on fatigue in adult cancer patients undergoing chemotherapy: a randomized controlled trial

Mehta, Suchitra Ajay ; Joshi, Anjali Mangesh ; Ramteke, Minori ; Tandiya, Poonam

Purpose: Cancer patients undergoing chemotherapy continue to experience significant fatigue, which affects their quality of life. The present study aims to evaluate the combined effect of comprehensive physical exercise, pranayama (regulated breathing practices of yoga), and dietary support intervention on fatigue in cancer patients undergoing chemotherapy. Methods: Non-advanced adult cancer patients undergoing chemotherapy (N = 52) were randomized into the intervention group (N = 26) or [...]

Menée auprès de 88 patients atteints d'un cancer de stade avancé et recevant des soins palliatifs, cette étude analyse l'effet, sur la douleur et leurs symptômes d'anxiété et de stress, d'une intervention combinant musique et aromathérapie

The effects of aromatherapy and music on pain, anxiety, and stress levels in palliative care patients

Akbaş Uysal, Duygu ; Şenuzun Aykar, Fisun ; Uyar, Meltem

Aim: Pain and anxiety levels in palliative care patients negatively impact their quality of life, highlighting the need for research on non-pharmacological methods. This study aimed to evaluate the effects of music and aromatherapy interventions on pain, anxiety, and stress levels in these patients. Material and Methods: The research was designed as a single-blind, four-group, randomized controlled trial. The sample consisted of 88 patients hospitalized in a palliative care center (receiving [...]

A partir d'une revue systématique de la littérature (37 études), cette méta-analyse évalue la prévalence de troubles du sommeil chez des patients atteints d'un cancer du poumon

Prevalence and risk factors of sleep disturbances among patients with lung cancer: systematic review and meta-analysis

Hu, Ying ; Xiao, Lily Dongxia ; Tang, Caiyun ; Cao, Wenhui ; Wang, Yao

Purpose: Patients with lung cancer endure the most sleep problems. Understanding the prevalence and risk factors of sleep disturbances in lung cancer populations is critical in reducing symptom burden and improving their quality of life. This systematic review aimed to determine the prevalence and risk factors of sleep disturbances in patients with lung cancer. Methods: Seven electronic databases were systematically screened for studies on the prevalence or risk factors of sleep disturbances in [...]

Menée à partir de données françaises, britanniques et américaines portant sur un total de 309 932 personnes travaillant dans une installation nucléaire, cette étude évalue l'association entre le niveau d'exposition aux rayonnements ionisants et la mortalité par leucémie, lymphome ou myélome multiple

Leukaemia, lymphoma, and multiple myeloma mortality after low-level exposure to ionising radiation in nuclear workers (INWORKS): updated findings from an international cohort study

Leuraud, Klervi ; Laurier, Dominique ; Gillies, Michael ; Haylock, Richard ; Kelly-Reif, Kaitlin ; Bertke, Stephen ; Daniels, Robert D. ; Thierry-Chef, Isabelle ; Moissonnier, Monika ; Kesminiene, Ausrele ; Schubauer-Berigan, Mary K. ; Richardson, David B.

Background: A major update to the International Nuclear Workers Study (INWORKS) was undertaken to strengthen understanding of associations between low-dose exposure to penetrating forms of ionising radiation and mortality. Here, we report on associations between radiation dose and mortality due to haematological malignancies. Methods: We assembled a cohort of 309 932 radiation-monitored workers (269 487 [87%] males and 40 445 [13%] females) employed for at least 1 year by a nuclear facility in [...]

Menée aux Etats-Unis à partir de données portant sur 291 899 adolescents ou jeunes adultes atteints d'un cancer (âge : 15-39 ans), cette étude de cohorte rétrospective analyse le stade de la maladie au diagnostic et la survie en fonction des origines ethniques

Racial Disparities in Cancer Stage at Diagnosis and Survival for Adolescents and Young Adults

Taparra, Kekoa ; Kekumano, Kaeo ; Benavente, Ryan ; Roberto, Luke ; Gimmen, Megan ; Shontell, Ryan ; Cakobau, Henrietta ; Deo, Neha ; Kinslow, Connor J. ; Betof Warner, Allison ; Deville, Curtiland ; Shing, Jaimie Z. ; Vo, Jacqueline B. ; Patel, Manali I. ; Pollom, Erqi

Importance : There are limited studies assessing stage at diagnosis and risk of death among all 5 federally defined races in the US among adolescent and young adult (AYA) patients with cancer. Objective : To identify racial disparities in stage at diagnosis and survival among AYA patients with cancer. Design, Setting, and Participants : This retrospective cohort study used data from a US national hospital-based oncology database on AYA patients, aged 15 to 39 years, with the 10 deadliest [...]

Menée au Royaume-Uni à partir de données 2014-2022 portant sur 77 149 patients atteints d'un cancer, cette étude analyse la prévalence et les types de comorbidités

Comorbidity in patients with cancer treated at The Christie

Abravan, Azadeh ; Faivre-Finn, Corinne ; Gomes, Fabio ; van Herk, Marcel ; Price, Gareth

Background: Comorbidities have been shown to impact the presentation and treatment of patients with cancers. This study investigates the prevalence and patterns of comorbidity in a pan-cancer cohort of patients treated at a large UK specialist cancer center over a 9-year period. Methods: A retrospective review of 77,149 patients from 01/01/2014 to 15/12/2022 was conducted using the Adult Comorbidity Evaluation 27 score (ACE-27) to assess the burden of comorbidities across 12 organ systems and [...]

Menée à partir de données 1980-2017 de 26 pays européens portant sur des hommes âgés de 35 à 84 ans, cette étude analyse l'évolution de l'incidence du cancer de la prostate et de la mortalité

Prostate cancer incidence and mortality in Europe and implications for screening activities: population based study

Vaccarella, Salvatore ; Li, Mengmeng ; Bray, Freddie ; Kvale, Rune ; Serraino, Diego ; Lorenzoni, Valentina ; Auvinen, Anssi ; Dal Maso, Luigino

Objective :To provide a baseline comparative assessment of the main epidemiological features of prostate cancer in European populations as background for the proposed EU screening initiatives. Design :Population based study. Setting :26 European countries, 19 in the EU, 1980-2017. National or subnational incidence data were extracted from population based cancer registries from the International Agency for Research on Cancer’s Global Cancer Observatory, and mortality data from the World Health [...]

Menée à partir de données portant sur des patients atteints d'un cancer du côlon de stade III, cette étude observationnelle évalue l'association entre le risque inflammatoire, la pratique d'une activité physique pendant et après la chimiothérapie postopératoire et la survie sans maladie

Inflammation, Physical Activity, and Disease-Free Survival in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance)

Brown, Justin C ; Ma, Chao ; Shi, Qian ; Couture, Felix ; Kuebler, Philip ; Kumar, Pankaj ; Tan, Benjamin ; Krishnamurthi, Smitha ; Chang, Victor ; Goldberg, Richard M ; O'Reilly, Eileen M ; Shields, Anthony F ; Meyerhardt, Jeffrey A

Background: Both inflammation and insufficient physical inactivity contribute to individual-level risk of disease recurrence and death in stage III colon cancer. The extent to which increased inflammatory risk can be offset by sufficient physical activity remains unknown. Methods: This cohort study was nested within the CALGB/SWOG 80702 (Alliance) randomized trial. Inflammatory burden was quantified by high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-  [...]

Menée à partir de données portant sur 1 284 patients atteints d'un cancer colorectal de stade métastatique (durée médiane de suivi : 6,1 ans), cette étude analyse l'association entre une alimentation d'origine végétale et la survie (survie globale et survie sans progression)

Plant-Based Diet and Survival Among Patients with Metastatic Colorectal Cancer

Cheng, En ; Ou, Fang-Shu ; Gatten, Clare ; Ma, Chao ; Venook, Alan P ; Lenz, Heinz-Josef ; O’Reilly, Eileen M ; Campbell, Peter T ; Kuang, Chaoyuan ; Caan, Bette J ; Blanke, Charles D ; Ng, Kimmie ; Meyerhardt, Jeffrey A

Background: Plant-based diet is associated with better survival among patients with non-metastatic colorectal cancer (CRC), but its association in metastatic CRC is unknown. Methods: Using an NCI-sponsored trial (CALGB/SWOG 80405), we included 1,284 patients who completed validated food frequency questionnaires at the initiation of metastatic CRC treatment. We calculated three indices: overall plant-based diet index (PDI), which emphasized consumption of all plant foods while reducing animal [...]

Menée au Canada à partir de données portant sur 5 078 patients atteints d'un cancer (12 localisations ; âge moyen : 56 ans), cette étude transversale identifie des facteurs associés à la présence et à la sévérité de symptômes cognitifs

Cognitive Symptoms Across Diverse Cancers

Mayo, Samantha J. ; Edelstein, Kim ; Atenafu, Eshetu G. ; Ajaj, Rand ; Li, Madeline ; Bernstein, Lori J.

Importance : Psychosocial health services for adults with cancer should include support for cognitive symptoms and symptom clusters. Objective : To characterize the frequency and severity of cognitive symptoms and to identify demographic and clinical risk factors associated with moderate to severe cognitive symptoms among outpatient adults with cancer seeking psychosocial support. Design, Setting, and Participants : This cross-sectional study analyzed data from routine patient-reported symptom [...]

Cette étude présente les recommandations de trois sociétés savantes internationales concernant les stratégies de préservation de la fertilité chez les patientes atteintes d'un cancer du col de l'utérus, de l'ovaire ou d'une tumeur de l'ovaire à la limite de la malignité

Fertility-sparing treatment and follow-up in patients with cervical cancer, ovarian cancer, and borderline ovarian tumours: guidelines from ESGO, ESHRE, and ESGE

Morice, Philippe ; Scambia, Giovanni ; Abu-Rustum, Nadeem R. ; Acien, Maribel ; Arena, Alessandro ; Brucker, Sara ; Cheong, Ying ; Collinet, Pierre ; Fanfani, Francesco ; Filippi, Francesca ; Eriksson, Ane Gerda Zahl ; Gouy, Sebastien ; Harter, Philipp ; Matias-Guiu, Xavier ; Pados, George ; Pakiz, Maja ; Querleu, Denis ; Rodolakis, Alexandros ; Rousset-Jablonski, Christine ; Stepanyan, Artem ; Testa, Antonia Carla ; Macklon, Kirsten Tryde ; Tsolakidis, Dimitrios ; De Vos, Michel ; Planchamp, François ; Grynberg, Michaël

The European Society of Gynaecological Oncology, the European Society of Human Reproduction and Embryology, and the European Society for Gynaecological Endoscopy jointly developed clinically relevant and evidence-based guidelines focusing on key aspects of fertility-sparing strategies and follow-up of patients with cervical cancers, ovarian cancers, and borderline ovarian tumours. The developmental process of these guidelines is based on a systematic literature review and critical appraisal [...]