Menée en France auprès de 100 témoins et 51 patients atteints d'un cancer des voies biliaires, cette étude analyse l'association entre une exposition alimentaire à l'aflatoxine et le risque de développer la maladie

Aflatoxin exposure is associated with an increased risk of gallbladder cancer

Yadav, Amit ; Gupta, Pankaj ; Gupta, Parikshaa ; Patil, Amol N. ; Das, Chandan K. ; Hooda, Harish ; Thakur, Deepa ; Sharma, Vishal ; Singh, Anupam K. ; Yadav, Thakur Deen ; Kaman, Lileswar ; Thakur, Jarnail Singh ; Sudini, Hari Kishan ; Srinivasan, Radhika ; Dutta, Usha

Gall bladder cancer (GBC) is common among the socioeconomically deprived populations of certain geographical regions. Aflatoxin is a genotoxic hepatocarcinogen, which is recognized to have a role in the pathogenesis of hepatocellular carcinoma. However, the role of aflatoxin in the pathogenesis of GBC is largely unknown. We determined serum AFB1-Lys albumin adduct (AAA) levels as a marker of aflatoxin exposure in the patients with GBC and compared to those without GBC. The relationship of AAA [...]

Menée en Chine auprès de 134 449 personnes, cette étude analyse l'association entre une exposition professionnelle au benzène et le risque de lymphome non hodgkinien

Occupational exposure to benzene and risk of non-Hodgkin lymphoma in an extended follow-up of two population-based prospective cohorts of Chinese men and women

Bassig, Bryan A. ; Shu, Xiao-Ou ; Friesen, Melissa C. ; Vermeulen, Roel ; Purdue, Mark P. ; Ji, Bu-Tian ; Yang, Gong ; Wong, Jason Y. Y. ; Appel, Nathan ; Hu, Wei ; Gao, Yu-Tang ; Zheng, Wei ; Rothman, Nathaniel ; Lan, Qing

The carcinogenicity of benzene was reevaluated by the International Agency for Research on Cancer in 2017, with the Working Group reaffirming positive yet inconclusive associations with non-Hodgkin lymphoma (NHL). To extend our previous observation of a significant exposure-response for cumulative occupational benzene exposure and NHL risk among Chinese women in a population-based cohort in Shanghai, we extended follow-up of this cohort and pooled the data with a similarly designed [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2024 (80 études), cette méta-analyse évalue l'association entre une exposition professionnelle au benzène et le risque de cancer du rein ou de la vessie

Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis

Seyyedsalehi, Monireh Sadat ; Bonetti, Mattia ; Shah, Darshi ; DeStefano, Vincent ; Boffetta, Paolo

Introduction: Benzene is recognized as leukemogenic. However, the association between it and solid cancers has been the subject of less investigation. We aim to conduct a systematic review and meta-analysis to evaluate the association between occupational exposure to benzene and the risk of urinary tract cancer, including kidney and bladder. Methods: We included 41 cohort and case–control studies listed in the most recent International Agency for Research on Cancer (IARC) Monograph on benzene [...]

Menée à l'aide de données hospitalières chinoises 2013-2021 portant sur 74 484 patients atteints d'un cancer de l'estomac, cette étude analyse l'association entre une exposition aux particules fines ambiantes PM1 et le risque de développer la maladie

Does ambient particulate matter 1 increase the risk of gastric cancer in the northwest of China?

Liu, Jie ; Gan, Ting ; Hu, Wenbiao ; Li, Yumin

Gastric cancer (GC) remains a significant health concern in Gansu province, China, with morbidity and mortality rates surpassing national averages. Despite the recognized health risks associated with ambient particulate matter with an aerodynamic diameter <1 μm (PM1), the relationship between PM1 exposure and GC incidence has not been extensively studied. Data on GC cases from 2013 to 2021 were gathered from 262 hospitals in Gansu, China. Concurrently, data on the normalized vegetation index [...]

A partir d'une revue systématique de la littérature (63 articles), cette étude analyse l'association entre une exposition aux champs électromagnétiques RF des téléphones portables et le risque de cancer

The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies – Part I: Most researched outcomes

Karipidis, Ken ; Baaken, Dan ; Loney, Tom ; Blettner, Maria ; Brzozek, Chris ; Elwood, Mark ; Narh, Clement ; Orsini, Nicola ; Röösli, Martin ; Paulo, Marilia Silva ; Lagorio, Susanna

Background: The objective of this review was to assess the quality and strength of the evidence provided by human observational studies for a causal association between exposure to radiofrequency electromagnetic fields (RF-EMF) and risk of the most investigated neoplastic diseases. Methods: Eligibility criteria: We included cohort and case-control studies of neoplasia risks in relation to three types of exposure to RF-EMF: near-field, head-localized, exposure from wireless phone use (SR-A); [...]

Menée à partir de données 2019 de l'"US Environmental Protection Agency", cette étude analyse le risque de cancer associé aux polluants atmosphériques de la circulation en fonction d'indicateurs socio-économiques et ethniques

Multidimensional structural racism and estimated cancer risk from traffic-related air pollution

White, Emily B. ; Ekenga, Christine C.

Background: Traffic-related air pollutants have been associated with a variety of adverse human health impacts, including cancers. In the United States, numerous studies have documented racial inequities in neighborhood exposures to traffic-related air pollution. Emerging evidence suggests that structural racism may influence neighborhood exposures to air pollutants. However, existing research has largely focused on residential racial segregation, one indicator of structural racism. This study [...]

Menée à partir de données de la "Mayo Clinic Biobank" portant sur 7 334 personnes (durée médiane de suivi : 3,2 ans), cette étude analyse l'association entre une lymphocytose monoclonale à cellules B et le risque de mélanome (131 cas)

Risk of Incident Melanoma Among Individuals With Low-Count Monoclonal B-Cell Lymphocytosis

Bryan A. Vallejo ; Ahmed Ansari ; Sameer A. Parikh ; Sara J. Achenbach ; Kari G. Rabe ; Aaron D. Norman ; Janet E. Olson ; Neil E. Kay ; Esteban Braggio ; Curtis A. Hanson ; Celine M. Vachon ; James R. Cerhan ; Cristian L. Baum ; Tait D. Shanafelt ; Susan L. Slager

PURPOSE: Chronic lymphocytic leukemia (CLL)-phenotype monoclonal B-cell lymphocytosis (MBL) is a premalignant condition that is roughly 500-fold more common than CLL. It is unknown whether the two-fold increased risk of developing melanoma associated with CLL extends to individuals with MBL. METHODS: Using the Mayo Clinic Biobank, we identified participants who were 40 years or older with no previous hematological malignancies, who resided in the 27 counties around Mayo Clinic, and who had [...]

Menée à partir de données 1990-2015 des registres américains des cancers, cette étude analyse l'association entre une radiothérapie pour un cancer du sein et le risque de second cancer primitif, en fonction du statut des récepteurs à oestrogènes

Association between radiotherapy and the risk of second primary malignancies in breast cancer patients with different estrogen receptor statuses

Zhao, Chengshan ; Yu, Yang ; Xiang, Pi’ao ; Liao, Jiahu ; Yu, Boyang ; Xing, Yifeng ; Yin, Guobing

Background: Breast cancer is the most common cancer among women. Second primary malignancies (SPMs) related to radiotherapy are significant complications. This study aims to investigate the correlation between radiotherapy and the occurrence of SPMs in breast cancer patients with different estrogen receptor statuses. Methods: We used data from the Surveillance, Epidemiology, and End Results (SEER) database, selecting estrogen receptor(+) and estrogen receptor(−) breast cancer patients from 1990 [...]

Menée à partir de données portant sur 30 569 témoins et 13 846 patientes atteintes d'un cancer de l'endomètre (âge : moins de 50 ans), cette étude identifie des facteurs de risque de la maladie en fonction de l'âge

Understanding risk factors for endometrial cancer in young women

Peeri, Noah Charles ; Bertrand, Kimberly A ; Na, Renhua ; De Vivo, Immaculata ; Setiawan, Veronica Wendy ; Seshan, Venkatraman E ; Alemany, Laia ; Chen, Yu ; Clarke, Megan A ; Clendenen, Tess ; Cook, Linda S ; Costas, Laura ; Dal Maso, Luigino ; Freudenheim, Jo L ; Friedenreich, Christine M ; Gierach, Gretchen L ; Goodman, Marc T ; La Vecchia, Carlo ; Levi, Fabio ; López-Querol, Marta ; Lu, Lingeng ; Moysich, Kirsten B ; Mutter, George ; Naduparambil, Jeffin ; Negri, Eva ; O'Connell, Kelli ; O'Mara, Tracy ; Palmer, Julie R ; Parazzini, Fabio ; Penney, Kathryn Lee ; Petruzella, Stacey ; Reynolds, Peggy ; Ricceri, Fulvio ; Risch, Harvey ; Rohan, Thomas E ; Sacerdote, Carlotta ; Sandin, Sven ; Shu, Xiao-Ou ; Stolzenberg-Solomon, Rachael Z ; Webb, Penelope M ; Wentzensen, Nicolas ; Wilkens, Lynne R ; Xu, Wanghong ; Yu, Herbert ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Guo, Xingyi ; Lipworth, Loren ; Du, Mengmeng

The American Cancer Society recommends physicians inform average risk women about endometrial cancer (EC) risk on reaching menopause, but new diagnoses are rising fastest in women <50 years. Educating these women about EC risks requires knowledge of risk factors. However, EC in young women is rare and challenging to study in single study populations.We included 13,846 incident EC patients (1,639 < 50 years) and 30,569 matched control individuals from the Epidemiology of Endometrial Cancer [...]

Menée à l'aide de données de la "UK Biobank" portant sur 66 308 personnes de moins de 50 ans, cette étude analyse l'association entre des facteurs génétiques et/ou liés au mode de vie et le risque de survenue précoce d'un cancer du sein

Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Zhang, Yin ; Lindström, Sara ; Kraft, Peter ; Liu, Yuxi

Early-onset cancer (diagnosed under age 50) generally manifests as an aggressive disease phenotype. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants remains unclear.We analyzed a prospective cohort of 66,308 participants who were under age 50 and free of cancer at baseline in the UK Biobank. Using Cox regression, we estimated Hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset total and breast cancer based on [...]

Menée au Canada à partir de données coloscopiques portant sur 1 831 adultes, cette étude analyse l'association entre l'indice de masse corporelle et le risque d'adénome à haut risque de transformation maligne

Body mass index and the prevalence of high-risk colorectal adenomas in a population undergoing screening colonoscopy in Alberta, Canada

Hutchinson, John M. ; Chow, Joshua ; Farah, Eliya ; Warkentin, Matthew T. ; Ruan, Yibing ; Hilsden, Robert J. ; Brenner, Darren R.

Purpose: There is limited evidence regarding body mass index (BMI) as an early marker of high-risk adenoma (HRA) at the time of screening colonoscopy. Because high-risk adenomas (HRA) can develop into colorectal cancer (CRC), BMI could serve as an important clinical predictor of future risk of CRC. Methods: We examined data from 1831 adults undergoing screening colonoscopy at the Forzani & MacPhail Colon Cancer Screening Center in Alberta, Canada. We fit multivariable logistic regression models [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2023, cette méta-analyse identifie des facteurs métaboliques associés au risque de cancer colorectal

Metabolic risk factors of colorectal cancer: Umbrella review

Molla, Meseret Derbew ; Symonds, Erin L. ; Winter, Jean M. ; Debie, Ayal ; Wassie, Molla M.

Background and aim: The association between metabolic factors and colorectal cancer (CRC) risk is inconclusive. This umbrella review aimed to summarise and describe the association using existing systematic reviews and/or meta-analyses. Method: Four databases (Medline, Scopus, Web of Science, and Cochrane Library) were searched for systematic reviews and/or meta-analyses of observational studies. Two independent authors extracted data on the summary estimated effect and heterogeneity of studies [...]

Menée à partir de données de la cohorte américaine "the Nurses' Health Study" portant sur 639 témoins et 328 patientes ménopausées atteintes d'un cancer du sein, cette étude analyse l'association entre les oestrogènes ou leurs métabolites et le risque de développer la maladie

Circulating Estrogen Metabolites and Risk of Breast Cancer among Postmenopausal Women in the Nurses’ Health Study

Brantley, Kristen D. ; Ziegler, Regina G. ; Craft, Neal E. ; Hankinson, Susan E. ; Eliassen, A Heather

Background: Estradiol and estrone are well-established risk factors for postmenopausal breast cancer (BC). Experimental evidence suggests that specific estrogen metabolites, produced via irreversible hydroxylation of estrone and estradiol at the 2- or 16-position may independently influence carcinogenesis. Methods: We performed a nested case-control study of BC (328 BC cases; 639 controls) among postmenopausal women within the Nurses’ Health Study (NHS)to examine the role of estrogens and [...]

Menée en Allemagne sur la période 2005-2021 auprès de 29 784 femmes, cette étude analyse l'association entre une mastite et le risque de cancer du sein

Is there an association between mastitis and breast cancer? a retrospective cohort study from Germany

Krishnan, Vedanth D. ; Kostev, Karel ; Kalder, Matthias

Purpose: The aim of the study was to explore the association between mastitis and subsequent breast cancer. Methods: This retrospective cohort study included women aged   [...]

Menéee auprès de 4,9 millions de femmes âgées d'au moins 40 ans et ayant réalisé une mammographie de dépistage dans le cadre du Programme national coréen de dépistage du cancer entre 2009 et 2014, cette étude analyse l'association entre la taille du sein, la densité mammographique et le risque de cancer du sein

A Large Cohort Study of Height and Mammographic Density in Relation to Breast Cancer Risk among Korean Women

Park, Ga Eun ; Kim, Sung Hun ; Han, Kyungdo

Background: Height and mammographic breast density are well-known risk factors for breast cancer. This study aims to investigate the association between height and mammographic density with breast cancer risk in a large population-based cohort of Korean women. Methods: This retrospective cohort study included 4,851,115 women aged 40 and older who underwent screening mammography through the Korean National Cancer Screening Program (KNCSP) between 2009 and 2014 and were followed up until 2016. [...]