Menée à l'aide de données 1968-2005 de registres danois portant sur 1 329 225 diades mère-fils, cette étude analyse l'association entre le tabagisme maternel (déterminé par la présence d'un cancer du poumon) et le risque de cancer du testicule pour le fils

Smoking and testicular cancer: A Danish nationwide cohort study

Hermansen, Maja ; Hjelmborg, Jacob ; Thinggaard, Mikael ; Znaor, Ariana ; Skakkebæk, Niels Erik ; Lindahl-Jacobsen, Rune

Background: Testicular cancer (TC) incidence has increased worldwide, but specific exposures of TC still need investigation. In this cohort study, we investigated the association between mothers' smoking and the risk of TC in their sons. TC was divided into the morphological subtype seminoma and non-seminomas. Because information about maternal smoking was not available in the study period maternal lung cancer diagnosis was used as a proxy for maternal smoking, making it possible for 51 years [...]

Menée en Allemagne à l'aide d'une projection et de données d'enquêtes, cette étude estime, pour 2024, 2030 et 2040, le nombre et la fraction de cancers attribuables à la sédentarié ainsi que les coûts associés

Burden of cancer attributable to sedentary behaviour in Germany: an epidemiological analysis of survey data

Schaber, Katharina ; Leitzmann, Michael ; Pukrop, Tobias ; Quentin, Wilm ; Stein, Michael J ; Jochem, Carmen

Objectives: Sedentary behaviour (SB) is associated with increased risks of breast, colorectal, endometrial, ovarian and rectal cancers. However, the number of cancer cases attributable to SB in Germany and the associated costs are unknown. Setting: Numbers and proportions (population-attributable fractions, PAF) of new cancer cases attributable to SB with published risk estimates for Germany for the years 2024, 2030 and 2040. Participants: Sex-specific and age-specific population projections, [...]

Menée à partir de données mondiales 1990-2019 de la base "Global Burden of Disease", cette étude estime la part des cancers attribuable à l'alimentation et la mortalité associée

The global burden of cancer attributable to dietary factors from 1990 to 2019

Xie, Jiping ; Zhao, Jing

Objective: To analyze the global cancer burden associated with dietary factors across 204 countries and regions from 1990 to 2019. Design: A population-based study Setting: Global Burden of Disease Study Participants: Using data from the 2019 global burden of disease, we calculated Population Attributable Fractions (PAFs), death and disability-adjusted life years (DALYs). A comparative risk assessment framework was employed, along with estimated annual percentage changes (EAPCs). Results: In [...]

Menée en Australie auprès d'une cohorte de 882 999 témoins et 176 601 patientes atteintes d'un cancer, cette étude analyse l'association entre l'utilisation d'un système contraceptif réversible à longue durée d'action (stérilet au lévonorgestrel, implant à l'étonogestrel ou acétate de dépot-médroxyprogestérone) et le risque de développer la maladie

Long-acting, progestin-based contraceptives and risk of breast, gynecological, and other cancers

Tuesley, Karen M ; Spilsbury, Katrina ; Pearson, Sallie-Anne ; Donovan, Peter ; Obermair, Andreas ; Coory, Michael D ; Ali, Sitwat ; Pandeya, Nirmala ; Stewart, Louise ; Jordan, Susan J ; Webb, Penelope M

Use of long-acting, reversible contraceptives has increased over the past 20 years, but an understanding of how they could influence cancer risk is limited.We conducted a nested case-control study among a national cohort of Australian women (n = 176 601 diagnosed with cancer between 2004 and 2013; 882 999 matched control individuals) to investigate the associations between the levonorgestrel intrauterine system, etonogestrel implants, depot-medroxyprogesterone acetate and cancer risk and [...]

Menée à partir de données néerlandaises portant sur 2 095 personnes transmasculines, cette étude analyse l'association entre un traitement à base de testostérone et le risque de cancer du col de l'utérus et de néoplasie intraépithéliale

Incidence of cervical intraepithelial neoplasia and cervical cancer in transmasculine and gender diverse individuals using testosterone: a retrospective, single-centre cohort study

Vestering, Asra ; van Vugt, Wouter L. J. ; Berner, Alison M. ; Snijders, Malou L. H. ; Heijer, Martin den ; Groenman, Freek A. ; Huirne, Judith A. F. ; Wiepjes, Chantal M. ; van Mello, Norah M.

Background: The number of transmasculine and gender diverse (TMGD) individuals who retain their uterus or postpone surgery while using testosterone is increasing. However, the influence of exogenous testosterone on the risk of cervical cancer remains unclear. This study aims to assess the risk of cervical cancer and intraepithelial neoplasia in TMGD individuals undergoing testosterone treatment. Methods: This retrospective, cohort study was conducted at the Amsterdam University Medical Centre [...]

Menée à partir de données néerlandaises portant sur 234 patients atteints d'achalasie (durée médiane de suivi : 13 ans), cette étude analyse l'association entre une infection oesophagienne à Candida et le risque de cancer de l'oesophage (24 cas)

Esophageal Candida Infection and Esophageal Cancer Risk in Patients With Achalasia

Guo, Xiaopei ; Lam, Suk Yee ; Janmaat, Vincent T. ; de Jonge, Pieter Jan F. ; Hansen, Bettina E. ; Leeuwenburgh, Ivonne ; Peppelenbosch, Maikel P. ; Spaander, Manon C. W. ; Fuhler, Gwenny M.

Patients with achalasia face a higher risk of developing esophageal cancer (EC), but the surveillance strategies for these patients remain controversial due to the long disease duration and the lack of identified risk factors.To investigate the prevalence of esophageal Candida infection among patients with achalasia and to assess the association of Candida infection with EC risk within this population.This retrospective cohort study included patients with achalasia diagnosed at or referred for [...]

Menée en Norvège à l'aide de données d'enquêtes de santé publique, cette étude estime, en fonction du sexe et pour la période 2016-2020, la part des cancers attribuable à 12 facteurs modifiables liés au mode vie

Cancers attributed to Modifiable Factors in Norway 2016-2020

Berstad, Paula ; Haugan, Kristin ; Knudsen, Markus D. ; Nygård, Mari ; Ghiasvand, Reza ; Robsahm, Trude Eid

Background: Targeting modifiable factors offers significant potential for primary cancer prevention. For public health strategies, it is essential to quantify the contribution from each factor on a national level. We estimated the contribution of 12 modifiable factors on cancer incidence in the Norwegian population. Methods: Nationally representative data (1990–2015) on the prevalence of tobacco smoking, over-exposure to ultraviolet radiation (UVR), alcohol consumption, physical inactivity, [...]

Menée à partir de données de la "UK Biobank" portant sur 458 543 personnes (äge médian : 57 ans ; 53 % de femmes), cette étude analyse la part des cancers colorectaux attribuable à un surpoids, qu'il soit évalué par l'indice de masse corporelle ou par le tour de taille et le rapport taille/hanches

Colorectal Cancer and Central Obesity

Safizadeh, Fatemeh ; Mandic, Marko ; Hoffmeister, Michael ; Brenner, Hermann

The proportion of colorectal cancer (CRC) cases attributable to excess weight, known as population attributable fraction (PAF), has been commonly based on measures of body mass index (BMI). Central obesity metrics, such as waist circumference (WC) and waist to hip ratio (WHR), are potentially better indicators of adiposity and have demonstrated stronger associations with CRC incidence.To examine PAFs of CRC cases that are attributable to high WC and WHR and compare them to those attributable to [...]

Menée à l'aide de données portant sur 33 939 Danoises participant à un programme de dépistage du cancer du sein et sur 833 patientes atteintes d'un cancer du sein après la ménopause, cette étude analyse l'influence de la densité mammaire sur l'association entre des facteurs anthropométriques de l'enfance, la puberté et le risque de développer la maladie

Associations of early life body size and pubertal timing with breast density and postmenopausal breast cancer risk: a mediation analysis

Pedersen, Dorthe C. ; Hameiri-Bowen, Dan ; Aarestrup, Julie ; Jensen, Britt W. ; Tjønneland, Anne ; Mellemkjær, Lene ; von Euler-Chelpin, My ; Vejborg, Ilse ; Andersen, Zorana J. ; Baker, Jennifer L.

Purpose: Whether breast density mediates associations between early life body size and pubertal timing with postmenopausal breast cancer is underexplored. Methods: We studied 33,939 Danish women attending the Capital Mammography Screening Program at ages 50-69 years. Early life anthropometry and pubertal timing information came from the Copenhagen School Health Records Register. Postmenopausal breast cancer information came from the Danish Breast Cancer Group database (n=833). Breast density [...]

Menée à partir de données de registres danois portant sur 990 850 femmes nées entre 1962 et 1996, cette étude analyse l'association entre un syndrome des ovaires polykystiques (SOPK) et le risque de cancer de la thyroïde (980 cas)

Polycystic ovary syndrome and risk of differentiated thyroid cancer: A nationwide, register-based cohort study based on Danish health data

Frandsen, Clarissa L. B. ; Sørensen, Sarah M. ; Maltesen, Thomas ; Munk, Christian ; Feldt-Rasmussen, Ulla ; Jensen, Allan ; Kjær, Susanne K.

Objectives: To evaluate the association between polycystic ovary syndrome (PCOS) and the risk of differentiated and papillary thyroid cancer. Methods: We included all individuals assigned female at birth and born during 1962–1996 in Denmark. Information on vital status, PCOS- and cancer diagnoses, and covariates were attained from various Danish nationwide registers. Personal identification numbers assigned to all individuals at birth are used throughout all registers and allows accurate [...]