Menée en 2023 par enquête auprès de 156 personnes atteintes du syndrome de Lynch et originaires de 13 pays (âge médian : 51 ans), cette étude analyse l'association entre le niveau d'adhésion à 9 recommandations concernant le mode de vie (alimentation, activité physique, poids, consommation d'alcool...) et le risque de cancer

Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey

Power, Robert F. ; Doherty, Damien E. ; Horgan, Roberta ; Fahey, Pat ; Gallagher, David J. ; Lowery, Maeve A. ; Cadoo, Karen A.

Background: Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention. In this study, we aimed to characterise modifiable risk factors in people with Lynch syndrome and compare this with international guidelines for cancer prevention. Methods: A cross-sectional study was carried out utilizing survey methodology. Following public and patient involvement, the survey was disseminated [...]

Menée à l'aide de données pangénomiques portant sur 92 264 témoins et 9 058 patients atteints d'une leucémie infantile, cette étude évalue l'effet de 2 900 polymorphismes à simple nucléotide sur l'association entre le métabolisme des folates et le risque de développer la maladie

Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium

Metayer, Catherine ; Spector, Logan G. ; Scheurer, Michael E. ; Jeon, Soyoung ; Scott, Rodney J. ; Takagi, Masatoshi ; Clavel, Jacqueline ; Manabe, Atsushi ; Ma, Xiaomei ; Hailu, Elleni M. ; Lupo, Philip J. ; Urayama, Kevin Y. ; Bonaventure, Audrey ; Kato, Motohiro ; Meirhaeghe, Aline ; Chiang, Charleston W K. ; Morimoto, Libby M. ; Wiemels, Joseph L.

Background: Prenatal folate supplementation has been consistently associated with a reduced risk of childhood lymphoblastic leukemia (ALL). Previous germline genetic studies examining the one carbon (folate) metabolism pathway were limited in sample size, scope, and population diversity, and led to inconclusive results. Methods: We evaluated whether ~2,900 single nucleotide polymorphisms (SNPs) within 46 candidate genes involved in the folate metabolism pathway influence the risk of childhood [...]

Menée à l'aide de données portant sur 117 452 femmes ménopausées (âge : 55-79 ans ; durée de suivi : 18 ans), cette étude analyse l'association entre l'utilisation d'anti-inflammatoires non stéroïdiens et le risque de cancer du pancréas (727 cas)

Use of non-steroidal anti-inflammatory drugs and pancreatic cancer risk in the Women’s Health Initiative

Brasky, Theodore M. ; Jager, Leah R. ; Newton, Alison M. ; Li, Xilin ; Loomans-Kropp, Holli A. ; Hays, John L. ; Margolis, Karen L. ; Luo, Juhua

Background: Pancreatic cancer is among the most fatal human cancers and the fourth leading cause of cancer death in the United States. Evidence suggests that chronic inflammation may play a role in pancreatic carcinogenesis, and its inhibition through non-steroidal anti-inflammatory drugs (NSAIDs) may reduce pancreatic cancer incidence. Methods: We examined associations of total and individual NSAIDs with pancreatic cancer risk among postmenopausal women participating in the Women’s Health [...]

Mené en Finlande sur 458 personnes souhaitant arrêter de fumer (56 % de femmes ; âge moyen : 51 ans), cet essai randomisé évalue l'efficacité des cigarettes électroniques dans le sevrage tabagique par rapport à la varénicline

Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial

Tuisku, Anna ; Rahkola, Mikko ; Nieminen, Pentti ; Toljamo, Tuula

Little is known about the relative effectiveness of nicotine-containing electronic cigarettes (ECs) compared with varenicline as smoking cessation aids.To determine the relative effectiveness of ECs in smoking cessation.This randomized placebo-controlled single-center trial was conducted in northern Finland. Participants aged 25 to 75 years who smoked daily and had volunteered to quit smoking were recruited from August 1, 2018, to February 20, 2020, via local media. The trial included 52 weeks [...]