A partir d'une revue systématique de la littérature publiée jusqu'en février 2024 (24 études), cette étude analyse l'association entre la combinaison de deux facteurs (consommation d'alcool, obésité) et le risque de cancer

Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis

Macdonald, Graeme A. ; Thomas, James A. ; Dalais, Christine ; Kendall, Bradley J. ; Thrift, Aaron P.

Background: Rates of alcohol consumption and obesity are increasing in many Western populations. For some cancer types, both heavy alcohol consumption and obesity are independently associated with increased risk. Whether combined exposure to both synergistically increases an individual's risk of cancer is unclear. We performed a systematic review to assess whether alcohol and obesity interact to confer higher risk for cancer than the additive sum of their effects. Methods: A systematic [...]

Menée à l'aide de données pangénomiques européennes portant sur 5 329 témoins et 4 805 patients atteints d'un cancer du pancréas, cette étude analyse l'effet de polymorphismes à simple nucléotide sur l'association entre une forte consommation d'alcool et le risque de développer la maladie

Genome-wide analysis to assess if heavy alcohol consumption modifies the association between SNPs and pancreatic cancer risk

Ni, Zhanmo ; Kundu, Prosenjit ; McKean, David F. ; Wheeler, William ; Albanes, Demetrius ; Andreotti, Gabriella ; Antwi, Samuel O. ; Arslan, Alan A. ; Bamlet, William R. ; Beane Freeman, Laura E. ; Berndt, Sonja I. ; Bracci, Paige M. ; Brennan, Paul ; Buring, Julie E. ; Chanock, Stephen J. ; Gallinger, steven ; Gaziano, J Michael ; Giles, Graham G. ; Giovannucci, Edward L. ; Goggins, Michael G. ; Goodman, Phyllis J. ; Haiman, Christopher A. ; Hassan, Manal M. ; Holly, Elizabeth A. ; Hung, Rayjean J. ; Katzke, Verena ; Kooperberg, Charles ; Kraft, Peter ; Le Marchand, Loic ; Li, Donghui ; McCullough, Marjorie L. ; Milne, Roger L. ; Moore, Steven C. ; Neale, Rachel E. ; Oberg, Ann L. ; Patel, Alpa V. ; Peters, Ulrike ; Rabe, Kari G. ; Risch, Harvey A. ; Shu, Xiao-Ou ; Smith Byrne, Karl ; Visvanathan, Kala ; Wactawski-Wende, Jean ; White, Emily ; Wolpin, Brian M. ; Yu, Herbert ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Zhong, Jun ; Amundadottir, Laufey T. ; Stolzenberg-Solomon, Rachael Z. ; Klein, Alison P.

Background: Pancreatic cancer is a leading cause of cancer-related death globally. Risk factors for pancreatic cancer include common genetic variants and potentially heavy alcohol consumption. We assessed if genetic variants modify the association between heavy alcohol consumption and pancreatic cancer risk. Methods: We conducted a genome-wide interaction analysis of single nucleotide polymorphisms (SNP) by heavy alcohol consumption (more than 3 drinks per day) for pancreatic cancer in European [...]

Menée à partir de données italiennes 1991-2006 portant sur 5 907 témoins et 4 045 patientes, cette étude analyse l'association entre la consommation d'aliments riches en fibres prébiotiques et le risque de cancer du sein, de l'endomètre ou de l'ovaire

Fiber-type prebiotics and gynecological and breast cancers risk: the PrebiotiCa study

Turati, Federica ; Esposito, Giovanna ; Concina, Federica ; Fiori, Federica ; Parpinel, Maria ; Parazzini, Fabio ; Crispo, Anna ; Negri, Eva ; Serraino, Diego ; La Vecchia, Carlo

Prebiotics may influence the risk of hormone-related female cancers by modulating the gut microbiota involved in estrogens metabolism. We evaluated the association of fiber-type prebiotic intake with breast, endometrial, and ovarian cancers. Data derived from a network of Italian hospital-based case-control studies (1991-2006), including 2560 cases of cancer of the breast (2588 controls), 454 of the endometrium (908 controls) and 1031 of the ovary (2411 controls). Inulin-type fructans (ITFs), [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2023, cette étude analyse l'association entre une maladie parodontale et le risque de cancer

The relationship between periodontal disease and cancer: Insights from a Systematic Literature Network Analysis

Villar, Alice ; Mendes, Bruna ; Viègas, Mirna ; de Aquino Alexandre, Ana Léa ; Paladini, Stefania ; Cossatis, João

This paper investigates the relationship between periodontal disease and various cancer types. It provides a comprehensive overview of the existing knowledge about the interaction between periodontal disease and carcinogenesis, explores the underlying biological mechanisms of this connection, and consider the impact of these findings on healthcare practices and future research directions. Utilizing Systematic Literature Network Analysis, which combines bibliometric analysis with Systematic [...]

Cette étude fait le point sur les associations entre le microbiote vaginal et les cancers gynécologiques

Vaginal microbiota and gynecological cancers: a complex and evolving relationship

Javadi, Kasra ; Ferdosi-Shahandashti, Elaheh ; Rajabnia, Mehdi ; Khaledi, Mansoor

The vagina hosts a community of microorganisms known as the vaginal microbiota. This community is relatively stable and straightforward, with Lactobacillus species being the most dominant members. The vaginal microbiota has various functions that are essential for maintaining human health and balance. For example, it can metabolise dietary nutrients, produce growth factors, communicate with other bacteria, modulate the immune system, and prevent the invasion of harmful pathogens. When the [...]

Menée en Ile-de-France à l'aide de données portant sur des échantillons tumoraux issus de 697 patients atteints d'un cancer oropharyngé, cette étude estime la part de ces cancers attribuable à une infection par un papillomavirus humain à haut risque

HPV-driven oropharyngeal cancer burden in Paris and its region (ILE DE FRANCE) from 1981 TO 2021

Mirghani, Haïtham ; Tendron, Alexandre ; Auperin, Anne ; Casiraghi, Odile ; Classe, Marion ; Badoual, Cecile ; Legoupil, Clémence ; Puech, Julien ; Veyer, David ; Dalstein, Veronique ; Pere, Helene ; Gorphe, Philippe

Background: France has the sixth highest incidence of oropharyngeal cancer (OPC) in Europe, but the epidemiological impact of high-risk HPV (HR-HPV) remains poorly documented. The objective of our study was to assess the proportion of OPCs caused by HR-HPV in Paris, and its suburbs, over the four past decades. This area accounts for almost one-fifth of the total population of France. Methods: OPCs diagnosed in 1981, 1986, 1991, 1996, 2001, 2006, 2011, 2016 and 2020/2021 in two of the main [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2024 (18 études), cette étude analyse l'association entre des caractéristiques génétiques, des interactions gène-traitement et le risque de second cancer chez des patients ayant survécu à un cancer pédiatrique

Genetic Risk of Second Malignant Neoplasm after Childhood Cancer Treatment: A Systematic Review

Ducos, Claire ; Aba, Naïla ; Rosselli, Filippo ; Fresneau, Brice ; Al Ahmad Nachar, Baraah ; Zidane, Monia ; de Vathaire, Florent ; Benhamou, Simone ; Haddy, Nadia

Second malignant neoplasm (SMN) is one of the most severe long-term risks for childhood cancer survivors (CCS), significantly impacting long-term patient survival. While radiotherapy and chemotherapy are known risk factors, the observed inter-individual variability suggests a genetic component contributing to the risk of SMN. This article aims to conduct a systematic review of genetic factors implicated in the SMN risk among CCS. Searches were performed in PubMed, Scopus, and Web of Sciences. [...]

Menée auprès de 139 958 participants à l'essai "the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial" (durée médiane de suivi : 16 ans), cette étude analyse l'association entre des antécédents familiaux de cancer et le risque de cancers primitifs multiples (6 170 cas)

A Linear Relationship between the Number of Cancers among First-degree Relatives and the Risk of Multiple Primary Cancers

He, Shisi ; Barry, Kathryn Hughes. ; Mitchell, Braxton D. ; Chen, Shuo ; Zhang, Yuji ; Beane Freeman, Laura E. ; Berndt, Sonja I.

With advances in the early detection and treatment of cancer, the incidence of multiple primary cancers (MPC), or second primary cancers, has risen over time. Characterization of etiologic risk factors, including family history of cancer, within the general population is critical for assessing MPC risk in patients. We examined the association between family history of cancer among first-degree relatives and MPC risk in a prospective study of 139,958 participants from the Prostate, Lung, [...]

Menée à l'aide d'une modélisation et de données multicentriques portant sur 213 familles dont plus d'un membre est porteur d'un variant du gène CDH1, cette étude analyse l'association entre ce variant et le risque de cancer de l'estomac ou du sein

Germline CDH1 Variants and Lifetime Cancer Risk

Ryan, Carrie E. ; Fasaye, Grace-Ann ; Gallanis, Amber F. ; Gamble, Lauren A. ; McClelland, Paul H. ; Duemler, Anna ; Samaranayake, Sarah G. ; Blakely, Andrew M. ; Drogan, Christine M. ; Kingham, Kerry ; Patel, Devanshi ; Rodgers-Fouche, Linda ; Siegel, Ava ; Kupfer, Sonia S. ; Ford, James M. ; Chung, Daniel C. ; Dowty, James G. ; Sampson, Joshua ; Davis, Jeremy L.

Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breast cancer. Previously, the lifetime risk of gastric cancer was estimated to be approximately 25% to 83% and for breast cancer it was estimated to be approximately 39% to 55% in individuals with loss of function CDH1 gene variants.To describe gastric and breast cancer risk [...]

A partir d'une revue systématique de la littérature (12 études), cette méta-analyse évalue l'association entre les polymorphismes rs13181 et rs1799793 du gène Xeroderma Pigmentosum groupe D (XPD) et le risque de cancer de la cavité buccale

The association between XPD rs13181 and rs1799793 polymorphism and oral cancer risk: evidence from a meta-analysis

Zeng, Wenli ; Xu, Wanting ; Long, Wu

Objective: Single nucleotide polymorphisms (SNPs) are common in genes and can lead to dysregulation of gene expression in tissues, which can affect carcinogenesis. Many studies reporting the association between xeroderma pigmentosum group D (XPD) polymorphisms of rs13181 and rs1799793 with oral cancer risk, but with conflicting and inconclusive results. Methods: We performed a comprehensive and systematic search through the PubMed, Elsevier, Web of science, and Embase databases, twelve studies [...]