Menée à l'aide de données de la "UK Biobank" portant sur 471 144 personnes (durée médiane de suivi : 10,9 ans), cette étude analyse l'association entre la fréquence d'ajout de sel aux aliments et le risque de cancer gastrique (640 cas)

Adding salt to food at table as an indicator of gastric cancer risk among adults: a prospective study

Kronsteiner-Gicevic, Selma ; Thompson, Alysha S. ; Gaggl, Martina ; Bell, William ; Cassidy, Aedín ; Kühn, Tilman

Background: While dietary salt intake has been linked with gastric cancer risk in Asian studies, findings from Western populations are sparse and limited to case—control studies. Our aim was to evaluate the frequency of adding salt to food at table in relation to gastric cancer risk among UK adults. Methods: We evaluated associations between the frequency of adding salt to food and the risk of gastric cancer in the UK Biobank (N = 471,144) using multivariable Cox regression. Frequency of adding [...]

Menée à partir de données de registres canadiens portant sur 2 531 témoins et 2 340 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre une exposition résidentielle aux hydrocarbures aromatiques polycycliques (HAP) ambiants et le risque de développer la maladie, en fonction du statut ménopausique

Ambient polycyclic aromatic hydrocarbon exposure and breast cancer risk in a population-based Canadian case–control study

Hinton, Patrick ; Villeneuve, Paul J. ; Galarneau, Elisabeth ; Larsen, Kristian ; Wen, Deyong ; Meng, Jun ; Savic-Jovcic, Verica ; Zhang, Junhua ; King, Will D.

Purpose: Polycyclic aromatic hydrocarbons (PAHs) represent a class of ubiquitous pollutants recognized as established human carcinogens and endocrine-disrupting chemicals. PAHs have seldom been modeled at the population-level in epidemiological studies. Fluoranthene is a prevalent PAH in urban settings and correlates with the occurrence of other PAHs. The purpose of this study was to evaluate associations between long-term residential exposure to ambient PAHs and breast cancer risk, both pre- [...]

Cat article fait le point sur les cancers associés à une infection persistante par le papillomavirus humain

Human malignancies associated with persistent HPV infection

McBride, Alison A

Human papillomavirus (HPV)-associated malignancies account for ~5% of human cancers worldwide. Thirteen, or more, HPV types are oncogenic, but infection with these viruses is common and usually cleared within 2 years. Only infections that become persistent are associated with the development of cancer, often occurring several decades later. These cancers mostly arise in 6 different anatomical regions: 5 are anogenital (anus, cervix, penis, vagina, and vulva) and the sixth is the oropharynx. [...]

Cet article passe en revue les facteurs génétiques associés au risque d'adénocarcinome canalaire du pancréas

Understanding familial risk of pancreatic ductal adenocarcinoma

Paranal, Raymond M. ; Wood, Laura D. ; Klein, Alison P. ; Roberts, Nicholas J.

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is the result of an accumulation of sequential genetic alterations. These genetic alterations can either be inherited, such as pathogenic germline variants that are associated with an increased risk of cancer, or acquired, such as somatic mutations that occur during the lifetime of an individual. Understanding the genetic basis of inherited risk of PDAC is essential to advancing patient care and outcomes through improved clinical [...]

Menée à partir de données portant sur 1 297 patientes ayant survécu à un cancer du sein diagnostiqué avant l'âge de 40 ans (durée médiane de suivi : 10 ans), cette étude analyse l'incidence d'un second cancer du sein puis identifie les facteurs de risque associés

Second Primary Breast Cancer in Young Breast Cancer Survivors

Brantley, Kristen D. ; Rosenberg, Shoshana M. ; Collins, Laura C. ; Ruddy, Kathryn J. ; Tamimi, Rulla M. ; Schapira, Lidia ; Borges, Virginia F. ; Warner, Ellen ; Come, Steven E. ; Zheng, Yue ; Kirkner, Gregory J. ; Snow, Craig ; Winer, Eric P. ; Partridge, Ann H.

Among women diagnosed with primary breast cancer (BC) at or younger than age 40 years, prior data suggest that their risk of a second primary BC (SPBC) is higher than that of women who are older when they develop a first primary BC. To estimate cumulative incidence and characterize risk factors of SPBC among young patients with BC. Participants were enrolled in the Young Women’s Breast Cancer Study, a prospective study of 1297 women aged 40 years or younger who were diagnosed with stage 0 to [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" portant sur 428 632 personnes (durée médiane de suivi : 13 ans), cette étude analyse l'association entre la méthylation de l'ADN liée à la pollution de l'air et le risque de cancer colorectal (5 767 cas) ainsi que la mortalité spécifique (533 décès)

Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study

Jiang, Fangyuan ; Zhao, Jianhui ; Sun, Jing ; Chen, Wenxi ; Zhao, Yuyuan ; Zhou, Siyun ; Yuan, Shuai ; Timofeeva, Maria ; Law, Philip J. ; Larsson, Susanna C. ; Chen, Dong ; Houlston, Richard S. ; Dunlop, Malcolm G. ; Theodoratou, Evropi ; Li, Xue

Background: This study investigates the associations between air pollution and colorectal cancer (CRC) risk and survival from an epigenomic perspective. Methods: Using a newly developed Air Pollutants Exposure Score (APES), we utilized a prospective cohort study (UK Biobank) to investigate the associations of individual and combined air pollution exposures with CRC incidence and survival, followed by an up-to-date systematic review with meta-analysis to verify the associations. In epigenetic [...]