Menée à l'aide de données portant sur 88 468 personnes atteintes de diabète (âge médian : 61,5 ans ; 53,3 % d'hommes ; durée médiane de suivi : 7,2 ans), cette étude analyse l'association entre le contrôle optimal de la glycémie et la réduction du risque d'adénome ou de cancer colorectal

Optimal glycaemic control and the reduced risk of colorectal adenoma and cancer in patients with diabetes: a population-based cohort study

Xianhua Mao ; Ka Shing Cheung ; Jing-Tong Tan ; Lung-Yi Mak ; Chi-Ho Lee ; Chi-Leung Chiang ; Ho Ming Cheng ; Rex Wan-Hin Hui ; Man Fung Yuen ; Wai Keung Leung ; Wai-Kay Seto

Objective: Whether varying degrees of glycaemic control impact colonic neoplasm risk in patients with diabetes mellitus (DM) remains uncertain. Design: Patients with newly diagnosed DM were retrieved from 2005 to 2013. Optimal glycaemic control at baseline was defined as mean haemoglobin A1c (HbA1c)<7%. Outcomes of interest included colorectal cancer (CRC) and colonic adenoma development. We used propensity score (PS) matching with competing risk models to estimate subdistribution HRs [...]

Menée à partir de données coréennes portant sur 2 480 témoins et 1 420 patients atteints d'un cancer colorectal, cette étude analyse l'effet du polymorphisme IL10 rs1800871 sur l'association entre un apport alimentaire en sélénium et le risque de développer la maladie

The interaction effect of dietary selenium intake and the IL10 rs1800871 polymorphism on the risk of colorectal cancer: a case–control study in Korea

Tran, Tao Thi ; Gunathilake, Madhawa ; Lee, Jeonghee ; Oh, Jae Hwan ; Chang, Hee Jin ; Sohn, Dae Kyung ; Shin, Aesun ; Kim, Jeongseon

The importance of Se in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of Se was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary Se. Our study aimed to explore whether Se potentially reduces CRC risk and whether the IL10 rs1800871 [...]

Menée à partir des données d'une enquête réalisée en 2019 aux Etats-Unis auprès de 15 863 personnes âgées de 27 à 45 ans, cette étude analyse leur statut vaccinal contre le papillomavirus humain (HPV) et identifie les facteurs associés à la vaccination après l'âge de 26 ans

Human papillomavirus vaccination uptake among 27-to-45-year-olds in the United States

Akpan, Idara N. ; Taskin, Tanjila ; Wheldon, Christopher W. ; Rossheim, Matthew E. ; Thompson, Erika L.

Objective: The human papillomavirus (HPV) vaccine prevents six types of cancer. Previously, this vaccine was only approved for 9–26-year-olds. However, in October 2018 the U.S. Food and Drug Administration approved the HPV vaccine for 27- to 45-year-olds (mid-adults). The current study aimed to assess HPV vaccination among a national sample of U.S adults aged 27–45 years. This study also assessed factors associated with HPV vaccine initiation after age 26. Methods: Data were analyzed using the [...]

Menée à l'aide de données taïwanaises 2000-2016 portant sur 3 168 820 témoins et 316 882 femmes ayant subi un traitement chirurgical pour une grossesse extra-utérine (durée de suivi : 17 ans), cette étude analyse l'association entre une salpingectomie et le risque de carcinome ovarien

Salpingectomy for ectopic pregnancy reduces ovarian cancer risk—a nation-wide study

Yen, Ju-Chuan ; Wu, Tzu-I ; Stone, Rebecca ; Wang, Tian-Li ; Visvanathan, Kala ; Chen, Li-Ying ; Hsu, Min-Huei ; Shih, Ie-Ming

Recent studies propose fallopian tubes as the tissue origin for many ovarian epithelial cancers. To further support this paradigm, we assessed whether salpingectomy for treating ectopic pregnancy had a protective effect using the Taiwan Longitudinal National-Health-Research Database. We identified 316,882 women with surgical treatment for ectopic pregnancy and 3,168,820 age- and index-date-matched controls from 2000-2016. In a nested cohort, 91.5% of cases underwent unilateral salpingectomy, [...]