Menée en Chine à partir de données de deux cohortes portant sur 252 femmes et 427 hommes atteints d'un cancer primitif du foie (durées médianes de suivi : 17,1 et 11,2 ans), cette étude analyse l'association entre divers régimes alimentaires (à base de légumes, de fruits ou de viande) et le risque de développer la maladie, en fonction du sexe

Sex-specific impact of dietary patterns on liver cancer incidence: updated results from two population-based cohort studies in China

Shen, Qiu-Ming ; Tuo, Jia-Yi ; Li, Zhuo-Ying ; Fang, Jie ; Tan, Yu-Ting ; Zhang, Wei ; Li, Hong-Lan ; Xiang, Yong-Bing

Purpose: The associations between dietary patterns and liver cancer risk have received much attention, but evidence among the Chinese population is scarce. This study aims to update the results of two cohort studies and provide the sex-specific associations in the Chinese population. Methods: This study was based on two cohorts from the Shanghai Men’s Health Study (SMHS) and the Shanghai Women’s Health Study (SWHS). Diet information was collected by validated food frequency questionnaires. [...]

Menée à partir de données portant sur 92 000 adultes inclus dans la cohorte "French NutriNet-Santé" (durée moyenne de suivi : 6,7 ans ; environ 79 % de femmes), cette étude examine l'association entre la consommation de certains additifs alimentaires émulsifiants et le risque de cancer

Food additive emulsifiers and cancer risk: Results from the French prospective NutriNet-Santé cohort

Sellem, Laury ; Srour, Bernard ; Javaux, Guillaume ; Chazelas, Eloi ; Chassaing, Benoit ; Viennois, Emilie ; Debras, Charlotte ; Druesne-Pecollo, Nathalie ; Esseddik, Younes ; Szabo de Edelenyi, Fabien ; Arnault, Nathalie ; Agaësse, Cédric ; De Sa, Alexandre ; Lutchia, Rebecca ; Huybrechts, Inge ; Scalbert, Augustin ; Pierre, Fabrice ; Coumoul, Xavier ; Julia, Chantal ; Kesse-Guyot, Emmanuelle ; Allès, Benjamin ; Galan, Pilar ; Hercberg, Serge ; Deschasaux-Tanguy, Mélanie ; Touvier, Mathilde

Author summary Why was this study done? Emulsifiers are widely used food additives in industrially processed foods to improve texture and enhance shelf-life. Experimental in vivo/in vitro research as well as a pilot clinical trial on healthy individuals suggests deleterious effects of food additive emulsifier intake on the intestinal microbiota, metabolome, host inflammation, and susceptibility to carcinogenesis. To our knowledge, due to challenges to accurately estimate the exposure to food [...]

Menée à partir de données des registres américains des cancers portant sur 3 641 patients atteints d'un cancer colorectal, cette étude détermine les facteurs alimentaires impliqués dans la survenue précoce (1 087 cas diagnostiqués avant 50 ans) ou tardive de la maladie (2 254 cas diagnostiqués à 50 ans et plus)

Dietary Factors Differ Between Young-Onset and Older-Onset Colorectal Cancer Patients

Burnett-Hartman, Andrea N. ; Ton, Mimi ; He, Qianchuan ; Malen, Rachel C. ; Potter, John D. ; Reedy, Adriana M. ; Phipps, Amanda I. ; Newcomb, Polly A.

We aimed to evaluate differences in dietary factors between young-onset (diagnosed at ages <50) and older-onset colorectal cancer (CRC). CRC patients diagnosed from 1998 to 2018 reported to the Puget Sound Surveillance, Epidemiology, and End Results registry were recruited using mail and telephone. Consented patients completed questionnaires assessing demographics, medical history, and CRC risk factors, including dietary factors. We used multi-variable logistic regression to calculate adjusted [...]

A partir d'une revue systématique de la littérature (49 études), cette méta-analyse évalue l'association entre une exposition professionnelle à l'amiante et le risque de cancer de l'oesophage

Occupational asbestos exposure and risk of esophageal cancer: A systematic review and meta-analysis

Seyyedsalehi, Monireh Sadat ; Boffetta, Paolo

Esophageal cancer (EC), which includes squamous cell carcinoma (ESCC) and adenocarcinoma (EAC), is an important cancer with poor prognosis and high mortality rate. Several occupational exposures have been associated with EC. We aim to investigate the association between occupational asbestos exposure and EC risk, considering types of asbestos and histology of the disease. We included studies mentioned in the list of references in previous reviews and pooled analyses, and we conducted an [...]

Menée à partir de données de cohortes européennes portant au total sur 584 982 patients atteints d'un cancer de l'estomac ou des voies aérodigestives supérieures (durée de suivi : plus de 5 millions personnes-années), cette étude évalue l'association entre une exposition de longue durée à la pollution de l'air et l'incidence de ces deux types de cancer

Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project

Nagel, Gabriele ; Chen, Jie ; Jaensch, Andrea ; Skodda, Lea ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Hvidtfeldt, Ulla Arthur ; Katsouyanni, Klea ; Ketzel, Matthias ; Leander, Karin ; Magnusson, Patrik K. E. ; Pershagen, Göran ; Rizzuto, Debora ; Samoli, Evangelia ; Severi, Gianluca ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel C. H. ; Wolf, Kathrin ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole ; Weinmayr, Gudrun

Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5), nitrogen dioxide [...]

Menée aux Etats-Unis à partir de données portant sur 33 417 femmes (durée médiane de suivi : 9,8 ans), cette étude de cohorte analyse l'association entre une exposition à la pollution atmosphérique sur le lieu de résidence (particules fines et NO2) et le risque de cancer de l'utérus (319 cas)

Outdoor air pollution exposure and uterine cancer incidence in the sister study

Brown, Jordyn A ; Ish, Jennifer L ; Chang, Che-Jung ; Bookwalter, Deborah B ; O’Brien, Katie M ; Jones, Rena R ; Kaufman, Joel D ; Sandler, Dale P ; White, Alexandra J

Background: Outdoor air pollution is a ubiquitous exposure that includes endocrine-disrupting and carcinogenic compounds that may contribute to the risk of hormone-sensitive outcomes such as uterine cancer. However, there is limited evidence about the relationship between outdoor air pollution and uterine cancer incidence. Methods: We investigated the associations of residential exposure to particulate matter less than 2.5 µm in diameter (PM2.5) and nitrogen dioxide (NO2) with uterine cancer [...]

A partir d'une revue de la littérature (5 études), cette étude analyse l'association entre la qualité du sommeil et le risque de cancer en fonction de l'origine ethnique

Eyes Wide Open: Sleep as a Potential Contributor to Racial and Ethnic Disparities in Cancer

Barber, Lauren E. ; McCullough, Lauren E. ; Johnson, Dayna A.

U.S. racial and ethnic minoritized groups face disproportionate cancer burdens compared to White Americans. Investigating modifiable factors, such as sleep, that are socially patterned and inequitably distributed by race and ethnicity may advance understanding of cancer disparities and provide intervention opportunities. Emerging data suggest poor sleep health is associated with cancer. Yet, its contribution to racial and ethnic cancer disparities is understudied. In this narrative review, we [...]

Menée à partir de données portant sur 1 064 patients ayant bénéficié d'une greffe de rein (durée médiane de suivi : 73 mois), cette étude évalue l'association entre l'utilisation d'immunosuppresseurs contemporains (la prednisone, le mycophénolate et le tacrolimus) et le risque de cancer

Immunosuppression and cancer risk in kidney transplant recipients: A retrospective cohort study

Sapir-Pichhadze, Ruth ; Laprise, Claudie ; Beauchamp, Marie-Eve ; Kaouache, Mohammed ; Zhang, Xun ; Della Vecchia, Alexia ; Azoulay, Laurent ; Franco, Eduardo L. ; Abrahamowicz, Michal ; Nicolau, Belinda

We assessed whether contemporary immunosuppression agents were associated with cancer among kidney transplant recipients (KTR), and if this association varied by age and sex. We studied a retrospective province-wide cohort of primary KTR (1997–2016). Employing multivariable Cox models, we estimated associations of cumulative doses of prednisone, mycophenolate and tacrolimus administered over the past 10 years, lagged by 2 years, with the incidence of primary malignant neoplasms (PMN). We [...]

A partir d'une revue systématique de la littérature publiée entre 1976 et 2022 (181 études observationnelles), cette méta-analyse identifie les facteurs associés au risque de tumeur cérébrale pédiatrique

Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022

Onyije, Felix M. ; Dolatkhah, Roya ; Olsson, Ann ; Bouaoun, Liacine ; Deltour, Isabelle ; Erdmann, Friederike ; Bonaventure, Audrey ; Scheurer, Michael E. ; Clavel, Jacqueline ; Schüz, Joachim

Background: Childhood brain tumours (CBTs) are the leading cause of cancer death in children under the age of 20 years globally. Though the aetiology of CBT remains poorly understood, it is thought to be multifactorial. We aimed to synthesize potential risk factors for CBT to inform primary prevention. Methods: We conducted a systematic review and meta-analysis of epidemiological studies indexed in the PubMed, Web of Science, and Embase databases from the start of those resources through 27 [...]

Menée à partir de données d'études d'association sur le génome entier portant sur 29 266 patients atteints d'un cancer du poumon et sur 56 450 témoins, cette étude évalue l'association entre les niveaux circulants de protéine C-réactive et le risque de cancer du poumon par sous-type histologique

Genetic correlation and causal associations between circulating C-reactive protein levels and lung cancer risk

Shi, Jiajun ; Wen, Wanqing ; Long, Jirong ; Xue, Haoran ; Yang, Yaohua ; Tao, Ran ; Pan, Wei ; Shu, Xiao-Ou ; Cai, Qiuyin

Purpose: We aimed to characterize genetic correlations and causal associations between circulating C-reactive protein (CRP) levels and the risk of lung cancer (LC). Methods: Leveraging summary statistics from genome-wide association studies of circulating CRP levels among 575,531 individuals of European ancestry, and LC risk among 29,266 cases and 56,450 controls, we investigated genetic associations of circulating CRP levels with the risk of overall lung cancer and its histological subtypes, [...]

Menée à partir de données de deux cohortes suédoises, cette étude analyse le risque de cancer du sein chez 133 389 parentes au premier degré de femmes présentant des altérations constitutionnelles sur des gènes de prédisposition à la maladie (8 gènes impliqués)

Cancer risks among first-degree relatives of women with a genetic predisposition to breast cancer

Xiao, Qingyang ; Mao, Xinhe ; Ploner, Alexander ; Grassmann, Felix ; Rodriguez, Juan ; Eriksson, Mikael ; Hall, Per ; Czene, Kamila

Background: Associations between germline alterations in women and cancer risks among their relatives are largely unknown. Methods: We used women from two Swedish cohorts (KARMA and pKARMA), including 28,362 women with genotyping data and 13,226 with sequencing data. Using Swedish Multi-Generation Register, we linked these women to 133,389 first-degree relatives. Associations between protein-truncating variants (PTVs) in 8 risk genes and breast cancer polygenic risk score (PRS) in index women [...]

Menée aux Etats-Unis à partir de données 2003-2009 portant sur 50 884 femmes, cette étude de cohorte analyse l'association entre un fibrome (19 932 cas), une endométriose (3 970 cas) et le risque de cancer du sein en fonction du statut des récepteurs hormonaux

Association of Fibroids, Endometriosis, and Gynecologic Surgeries with Breast Cancer Incidence and Hormone Receptor Subtypes

Zeldin, Jordan ; Sandler, Dale P. ; Ogunsina, Kemi ; O'Brien, Katie M.

Background: Fibroids and endometriosis are sex hormone–mediated and exhibit cancer-like behavior. Breast cancer may be more common in women who have had these conditions, but the literature is conflicting and does not always address factors like hysterectomy/oophorectomy status, race/ethnicity, menopause, and hormone receptor subtypes. Methods: Data are from the Sister Study, a cohort of 50,884 U.S. women enrolled in 2003 to 2009 and followed through 2020. Cox proportional hazards models with [...]