Menée à partir de données 2008-2019 des registres américains des cancers et de données Medicare, cette étude analyse la qualité de vie des patients ayant survécu à un cancer

Do Contemporary Cancer Survivors Experience Better Quality of Life? Evaluating a Decade of SEER Medicare Health Outcomes Survey Data

Allaire, Benjamin T. ; Horvath, Marc L. ; Lines, Lisa M. ; Davidoff, Amy J. ; Smith, Ashley W. ; Jensen, Roxanne E.

Background: A cancer diagnosis may have deleterious effects on health-related quality of life (HRQOL) as adults age. This study examined differences in HRQOL between cancer and matched non-cancer Medicare beneficiaries over 65, within and across two time periods. Methods: We used novel matching methods on data from the Surveillance, Epidemiology and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) data resource. We matched SEER-MHOS respondents with cancer from a recent period [...]

A partir d'une revue systématique de la littérature publiée entre mai et novembre 2022 (27 études), cette étude analyse l'utilisation de cannabis par des patients atteints d'un cancer ou ayant survécu à la maladie

Cannabis use among cancer patients and survivors in the United States: a systematic review

Amin, Samia ; Chae, Si Woo ; Kawamoto, Crissy T ; Phillips, Kristina T ; Pokhrel, Pallav

Background: How cannabis products are being used by cancer patients and survivors in the U.S is poorly understood. This study reviewed observational data to understand the modes, patterns, reasons, discontinuation and adverse experiences of cannabis use. Methods: PubMed and PsycINFO database searches were conducted between May 2022 and November 2022. Of the 1,162 studies identified, 27 studies met the inclusion criteria. The inter-coder agreement was strong (0.81). Results: The majority of the [...]

Menée à partir de données portant sur 270 patients atteints d'un cancer traité en ambulatoire, cette étude de cohorte prospective analyse la fréquence des poussées de douleur et identifie les facteurs prédictifs

Trajectories and predictors of High-Occurrence pain flares in ambulatory cancer patients on opioids

Meghani, Salimah H ; Quinn, Ryan ; Robinson, Andrew ; Chittams, Jesse ; Vapiwala, Neha ; Naylor, Mary ; Cheatle, Martin ; Knafl, George J

Background: Pain flares have a substantive impact on the quality of life and well-being of patients with cancer. We identified longitudinal trajectories (clusters) of cancer pain flares in ambulatory patients and sociodemographic and clinical predictors of these trajectories. Methods: In a prospective cohort study using ecological momentary assessment (mEMA), we collected patient-reported daily pain flare ratings data over 5 months and identified predictors and correlates using validated [...]

Menée en Belgique à partir de données portant sur 328 patients atteints d'un cancer de stade avancé, cette étude prospective analyse la prévalence d'une malnutrition et d'une cachexie

Malnutrition prevalence in cancer patients in Belgium: The ONCOCARE study

Rasschaert, Marika ; Vandecandelaere, Pieter ; Marechal, Stéphanie ; D’hondt, Randal ; Vulsteke, Christof ; Mailleux, Marie ; De Roock, Wendy ; Van Erps, Joanna ; Himpe, Ulrike ; de Man, Marc ; Mertens, Geertrui ; Ysebaert, Dirk

Rationale: Unintentional weight loss and malnutrition are common among cancer patients. Malnutrition has been associated with impaired health-related quality of life, less well-tolerated chemotherapy regimens and shorter life duration. In Belgium there is a lack of epidemiological data on malnutrition in oncology patients at advanced stages of the disease. Methods: Malnutrition assessment data was collected through a prospective, observational study in 328 patients who started a neoadjuvant [...]

Mené sur 1 096 patients atteints d'un carcinome à cellules rénales de stade avancé traité par sunitinib en monothérapie ou par nivolumab et ipilimumab en combinaison (durée médiane de suivi : 25,2 mois), cet essai de phase III évalue l'association entre la qualité de vie mesurée à l'aide d'un score et la survie globale

The Relationship Between Health-Related Quality of Life and Overall Survival in Patients With Advanced Renal Cell Carcinoma in CheckMate 214

Cella, David ; Choueiri, Toni K ; Hamilton, Melissa ; Blum, Steven I ; Ivanescu, Cristina ; Karu, Karl ; Ejzykowicz, Flavia ; Motzer, Robert J

Background: In CheckMate 214 (median follow-up, 25.2 months), nivolumab plus ipilimumab yielded greater overall survival (OS) benefit than sunitinib in patients with intermediate-/poor-risk advanced renal cell carcinoma (aRCC). Health-related quality of life (HRQoL) assessed by the Functional Assessment of Cancer Therapy-Kidney Symptom Index-19 (FKSI-19) was also more favorable for the nivolumab plus ipilimumab group than the sunitinib group. We investigated whether HRQoL scores can predict OS [...]

Mené sur 153 patientes ménopausées atteintes d'un cancer du sein et recevant un traitement endocrinien (âge moyen : 62 ans), cet essai randomisé évalue l'intérêt d'exercices aérobiques d'intensité modérée pour améliorer leurs fonctions neurocognitives

Effects of aerobic exercise on neurocognitive function in postmenopausal women receiving endocrine therapy for breast cancer: The Exercise Program in Cancer and Cognition randomized controlled trial

Bender, Catherine M. ; Sereika, Susan M. ; Gentry, Amanda L. ; Cuglewski, Cheryl ; Duquette, Jennie ; Grove, George ; Cummings, Meredith ; Cho, Myeong-ga ; Brufsky, Adam M. ; McAuliffe, Priscilla ; Budway, Raye J. ; Diego, Emilia J. ; Evans, Steven ; Rosenzweig, Margaret Q. ; Marsland, Anna L. ; Conley, Yvette P. ; Erickson, Kirk

Objective: The Exercise Program in Cancer and Cognition Study was a randomized controlled trial designed to determine whether 6 months of moderate-intensity aerobic exercise improves neurocognitive function in women with breast cancer (BC) receiving endocrine therapy (ET). Methods: Postmenopausal women with hormone receptor+, early-stage BC, within two years post-primary therapy were randomized to the exercise intervention (six months, ≥150 min of moderate-intensity aerobic exercise/week) or [...]

Menée à partir de données portant sur des patients présentant des métastatases cérébrales, cette étude évalue la pertinence d'un système de score pour mesurer les changements dans leurs fonctions neurocognitives après une radiothérapie du cerveau

Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001

Cherng, Hua-Ren R ; Qu, Melody ; Zafari, Zafar ; Bentzen, Søren ; Armstrong, Terri S ; Gondi, Vinai ; Brown, Paul D ; Mehta, Minesh ; Mishra, Mark V

BACKGROUND: EuroQoL EQ-5D is a commonly used measure of health-related quality of life (HRQOL) in clinical trials given the use of its index score as a measure of health utilities. It is unclear whether EQ-5D is sensitive to changes in neurocognitive function and progression that occur following brain radiation. This study sought to evaluate the sensitivity of EQ-5D-5L in reflecting these changes. PATIENTS and METHODS: A secondary analysis of NRG Oncology CC001 was performed. Mean EQ-5D-5L [...]

Mené sur 279 patients ayant survécu à un cancer du système nerveux central, présentant des troubles cognitifs et professionnellement actifs, cet essai multicentrique randomisé évalue l'intérêt d'une intervention de réadaptation cognitive dispensée sur internet pour améliorer leurs fonctions physiques et leur qualité de vie

Internet-based cognitive rehabilitation for working cancer survivors: Results of a multicenter randomized controlled trial

Klaver, Kete M ; Duijts, Saskia F A ; Geusgens, Chantal A V ; Kieffer, Jacobien M ; van Rentergem, J Agelink ; Hendriks, Mathijs P ; Nuver, Janine ; Marsman, Hendrik A ; Poppema, Boelo J ; Oostergo, Tanja ; Doeksen, Annemiek ; Aarts, Maureen J B ; Ponds, Rudolf W H M ; van der Beek, Allard J ; Schagen, Sanne B

Cognitive problems contribute to decline in work performance. We evaluated (1) the effectiveness of basic self-management and extensive therapist-guided online cognitive rehabilitation on attainment of individually predetermined work-related goals among occupationally active cancer survivors, and (2) whether effectiveness of the programs differed for survivors with and without formal cognitive impairment.In a three-armed randomized controlled trial (NCT03900806), 279 non-central nervous system [...]

Cette étude présente les conseils d'un groupe d'experts en neuro-oncologie concernant l'utilisation d'anticoagulants par voie orale pour traiter une thromboembolie veineuse chez des patients atteints d'une tumeur cérébrale primitive ou métastatique

Practical guidance for direct oral anticoagulant use in the treatment of venous thromboembolism in primary and metastatic brain tumor patients

Ranjan, Surabhi ; Leung, Denise ; Ghiaseddin, Ashley P. ; Taylor, Jennie W. ; Lobbous, Mina ; Dhawan, Andrew ; Budhu, Joshua A. ; Coffee, Elizabeth ; Melnick, Kaitlyn ; Chowdhary, Sajeel A. ; Lu-Emerson, Christine ; Kurz, Sylvia C. ; Burke, Joy E. ; Lam, Keng ; Patel, Mallika P. ; Dunbar, Erin M. ; Mohile, Nimish A. ; Peters, Katherine B.

Management of venous thromboembolism (VTE) in patients with primary and metastatic brain tumors (BT) is challenging because of the risk of intracranial hemorrhage (ICH). There are no prospective clinical trials evaluating safety and efficacy of direct oral anticoagulants (DOACs), specifically in patients with BT, but they are widely used for VTE in this population. A group of neuro-oncology experts convened to provide practical clinical guidance for the off-label use of DOACs in treating VTE in [...]

Menée à partir de données de 61 registres européens des cancers, cette étude estime, en 2020, la prévalence des cancers par localisation et en fonction du sexe et de l'âge

Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): a population-based study

De Angelis, Roberta ; Demuru, Elena ; Baili, Paolo ; Troussard, Xavier ; Katalinic, Alexander ; Chirlaque López, María Dolores ; Innos, Kaire ; Santaquilani, Mariano ; Blum, Marcel ; Ventura, Leonardo ; Paapsi, Keiu ; Galasso, Rocco ; Guevara, Marcela ; Randi, Giorgia ; Bettio, Manola ; Botta, Laura ; Guzzinati, Stefano ; Dal Maso, Luigino ; Rossi, Silvia ; Hackl, Monika ; van Eycken, Elizabeth ; Van Damme, Nancy ; Valerianova, Zdravka ; Sekerija, Mario ; Scoutellas, Vasos ; Demetriou, Anna ; Dušek, Ladislav ; Krejici, Denisa ; Storm, Hans ; Mägi, Margit ; Pitkäniemi, Janne ; Velten, Michel ; Bouvier, Anne-Marie ; Jooste, Valérie ; Guizard, Anne-Valérie ; Launoy, Guy ; Dabakuyo Yonli, Sandrine ; Maynadie, Marc ; Woronoff, Anne-Sophie ; Nousbaum, Jean-Baptiste ; Coureau, Gaelle ; Monnereau, Alain ; Baldi, Isabelle ; Hammas, Karima ; Tretarre, Brigitte ; Colonna, Marc ; Plouvier, Sandrine ; D'Almeida, Tania ; Molinié, Florence ; Cowppli-Bony, Anne ; Bara, Simona ; Debreuve, Adeline ; Defossez, Gautier ; Lapôtre-Ledoux, Bénédicte ; Grosclaude, Pascale ; Daubisse-Marliac, Laetitia ; Luttmann, Sabine ; Stabenow, Roland ; Nennecke, Alice ; Kieschke, Joachim ; Zeissig, Sylke ; Holleczek, Bernd ; Birgisson, Helgi ; Murray, Deirdre ; Walsh, Paul M. ; Mazzoleni, Guido ; Vittadello, Fabio ; Cuccaro, Francesco ; Sampietro, Giuseppe ; Rosso, Stefano ; Gasparotti, Cinzia ; Maifredi, Giovanni ; Ferrante, Margherita ; Ragusa, Rosalia ; Sutera Sardo, Antonella ; Gambino, Maria Letizia ; Lanzoni, Monica ; Ballotari, Paola ; Giacomazzi, Erica ; Ferretti, Stefano ; Caldarella, Adele ; Manneschi, Gianfranco ; Gatta, Gemma ; Sant, Milena ; Berrino, Franco ; Trama, Annalisa ; Lillini, Roberto ; Bernasconi, Alice ; Bonfarnuzzo, Simone ; Vener, Claudia ; Didonè, Fabio ; Lasalvia, Paolo ; Buratti, Lucia ; Tagliabue, Giovanna ; Serraino, Diego ; Capocaccia, Riccardo ; Di Benedetto, Corrado ; Venanzi, Serenella ; Tallon, Marco ; Boni, Luca ; Iacovacci, Silvia ; Gennaro, Valerio ; Russo, Antonio Giampiero ; Gervasi, Federico ; Spagnoli, Gianbattista ; Cavalieri D'Oro, Luca ; Fusco, Mario ; Vitale, Maria Francesca ; Usala, Mario ; Mazzucco, Walter ; Michiara, Maria ; Chiranda, Giorgio ; Cascone, Giuseppe ; Giurdanella, Maria Concetta ; Mangone, Lucia ; Falcini, Fabio ; Cavallo, Rossella ; Piras, Daniela ; Madeddu, Anselmo ; Bella, Francesca ; Fanetti, Anna Clara ; Minerba, Sante ; Candela, Giuseppina ; Scuderi, Tiziana ; Rizzello, Roberto Vito ; Stracci, Fabrizio ; Rugge, Massimo ; Brustolin, Angelita ; Pildava, Santa ; Smailyte, Giedre ; Azzopardi, Miriam ; Johannesen, Tom Børge ; Didkowska, Joanna ; Wojciechowska, Urszula ; Bielska-Lasota, Magdalena ; Pais, Ana ; Bento, Maria José ; Calisto, Rita ; Lourenço, Antonio ; Safaei Diba, Chakameh ; Zadnik, Vesna ; Zagar, Tina ; Sánchez-Contador Escudero, Carmen ; Franch Sureda, Paula ; Lopez de Munain, Arantza ; De-La-Cruz, Marta ; Rojas, Marìa Dolores ; Aleman, Araceli ; Vizcaino, Ana ; Marcos-Gragera, Rafael ; Sanvisens, Arantza ; Sánchez, María José ; Sánchez-Gil, Antonia ; Ardanaz, Eva ; Galceran, Jaume ; Carulla, Marià ; Bergeron, Yvan ; Bouchardy, Christine ; Mohsen Mousavi, Seyed ; Went, Philip ; Bordoni, Andrea ; Visser, Otto ; Stevens, Sarah ; Broggio, John ; Bennett, Damien ; Gavin, Anna ; Morrison, David ; Huws, Dyfed Wyn

Background: Cancer survivors—people living with and beyond cancer—are a growing population with different health needs depending on prognosis and time since diagnosis. Despite being increasingly necessary, complete information on cancer prevalence is not systematically available in all European countries. We aimed to fill this gap by analysing population-based cancer registry data from the EUROCARE-6 study. Methods: In this population-based study, using incidence and follow-up data up to Jan 1, [...]

Menée au Canada par enquête auprès de 1 001 patients ayant survécu à un cancer (dont 656 cas de cancer du sein), cette étude transversale analyse leurs perceptions concernant les causes de leur maladie

What do cancer survivors believe caused their cancer? A secondary analysis of cross-sectional survey data

Galica, Jacqueline ; Saunders, Stephanie ; Pan, Ziwei ; Silva, Amina ; Ling, Hok Kan

Purpose : Given that risk reduction and healthy lifestyles can prevent 4 in 10 cancers, it is important to understand what survivors believe caused their cancer to inform educational initiatives. Methods: In this secondary analysis, we analyzed cancer survivor responses on the Causes Subscale of the Revised Illness Perception Questionnaire, which lists 18 possible causes of illness and a free text question. We used descriptive statistics to determine cancer survivors’ agreement with the listed [...]

Menée à partir des données 2000-2019 des registres américains des cancers portant sur 217 815 femmes atteintes d'un cancer du sein (âge : 20-49 ans), cette étude transversale analyse l'évolution de l'incidence de la maladie en fonction de l'origine ethnique, du statut des récepteurs hormonaux et du stade au diagnostic

Breast Cancer Incidence Among US Women Aged 20 to 49 Years by Race, Stage, and Hormone Receptor Status

Xu, Shuai ; Murtagh, Sara ; Han, Yunan ; Wan, Fei ; Toriola, Adetunji T.

Importance : Breast cancer in young women has a less favorable prognosis compared with older women. Yet, comprehensive data on recent trends and how period and cohort effects may affect these trends among young women are not well-known. Objective : To evaluate breast cancer incidence among young women in the US over a 20-year period by race and ethnicity, hormone receptor status (estrogen receptor [ER] and progesterone receptor [PR]), tumor stage, and age at diagnosis, as well as how period and [...]

Menée en Chine, cette étude présente les données d'incidence des tumeurs pédiatriques du système nerveux central et de la mortalité spécifique

A system review of central nervous system tumors on children in China: epidemiology and clinical characteristics

Yao, Bing ; Wang, Hongying ; Wu, Xiaomei ; Wang, Chenyu ; Tang, Tao ; An, Wenxiu ; Zhu, Bo

Background: Central nervous system (CNS) tumors are the most common solid tumors in children and the leading cause of cancer-related death in the latter. Currently, the incidence rate exceeds that of leukemia and ranks first in the incidence of malignant tumors in children. Methods: The epidemiological data on childhood CNS tumors were collected from the Chinese Cancer Registry Annual Report. The annual percent change (APC) of incidence and mortality-rate changes were estimated via Joinpoint [...]