Menée à l'aide de données de l'Assurance maladie portant sur 76 162 personnes âgées d'au moins 60 ans et souffrant d'un diabète de type 2, cette étude analyse l'association entre une incapacité physique liée au diabète et le risque de cancer de l'estomac

The impact of physical disability on the risk of gastric cancer incidence in elderly patients with diabetes: a focus on regional disparity

Choi, Mingee ; Lee, Woo-Ri ; Han, Kyu-Tae ; Kim, Woorim

Purpose: Elderly patients with type 2 diabetes mellitus (T2DM) may have a higher risk of physical disability. This study investigated the incidence of gastric cancer according to physical disability status in elderly patients with T2DM. Methods: The National Health Insurance Service claims data were used. A total of 76,162 participants aged 60 years or above, diagnosed with T2DM, were included. The association between physical disability status and gastric cancer incidence was evaluated using [...]

Menée aux Etats-Unis à l'aide des données d'une enquête réalisée auprès de 1 610 adultes habitant en zone rurale et fumant quotidiennement, cette étude analyse la prévalence des tentatives de sevrage tabagique et identifie des facteurs favorisant ou entravant ces tentatives

Smoking Quit Attempts and Associated Factors Among Rural Adults Who Smoke Daily in the US

Bittencourt, Lorna ; Rubenstein, Dana ; Noonan, Devon ; McClernon, F Joseph ; Carroll, Dana Mowls

Rural American communities are heavily affected by tobacco-related health disparities. This study aims to evaluate the prevalence of quit attempts (QA) and factors that promote or impede QA among rural adults who smoke daily. Data from Wave 5 of the Population Assessment of Tobacco and Health study were analyzed. Multivariable logistic regression was used to identify factors associated with quit attempt. Backwards selection was used to identify variables included in the final model with [...]

Menée à partir de données de la "UK Biobank" portant sur 340 631 personnes (durée médiane de suivi : 13 ans), cette étude analyse l'association entre un score de risque polygénique, des facteurs liés au mode de vie et le risque de cancer du pancréas (1 129 cas) en fonction de l'âge

Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort study in the UK Biobank

Zeng, Liangtang ; Wu, Zhuo ; Yang, Jiabin ; Zhou, Yu ; Chen, Rufu

Background: Pancreatic cancer (PC) is influenced by both genetic and lifestyle factors. However, further research is still needed to comprehensively clarify the relationships among lifestyle, genetic factors, their combined effect on PC, and how these associations might be age-dependent. Methods: We included 340,631 participants from the UK Biobank. Three polygenic risk score (PRS) models for PC were applied, which were derived from the previous study and were categorized as low, intermediate, [...]

Menée à l'aide de données d'études portant sur 547 601 femmes non ménopausées (durée médiane de suivi : 11,5 ans), cette étude analyse l'association entre une activité physique de loisir et le risque de cancer du sein avant la ménopause (10 231 cas)

International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts

Iain R. Timmins ; Michael E. Jones ; Katie M. O'Brien ; Hans-Olov Adami ; Dagfinn Aune ; Laura Baglietto ; Kimberly A. Bertrand ; Kristen D. Brantley ; Yu Chen ; Jessica Clague DeHart ; Tess V. Clendenen ; Laure Dossus ; A. Heather Eliassen ; Olivia Fletcher ; Agnès Fournier ; Niclas Håkansson ; Susan E. Hankinson ; Richard S. Houlston ; Corinne E. Joshu ; Victoria A. Kirsh ; Cari M. Kitahara ; Woon-Puay Koh ; Martha S. Linet ; Hannah Lui Park ; Brigid M. Lynch ; Anne M. May ; Lene Mellemkjær ; Roger L. Milne ; Julie R. Palmer ; Fulvio Ricceri ; Thomas E. Rohan ; Kathryn J. Ruddy ; Maria-Jose Sánchez ; Xiao-Ou Shu ; Karl Smith-Byrne ; Karen Steindorf ; Malin Sund ; Celine M. Vachon ; Lars J. Vatten ; Kala Visvanathan ; Elisabete Weiderpass ; Walter C. Willett ; Alicja Wolk ; Jian-Min Yuan ; Wei Zheng ; Hazel B. Nichols ; Dale P. Sandler ; Anthony J. Swerdlow ; Minouk J. Schoemaker

PURPOSE: There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer. METHODS: We pooled individual-level data on self-reported leisure-time physical activity across 19 cohort studies comprising 547,601 premenopausal women, with 10,231 [...]

Menée aux Etats-Unis à partir de données de la plateforme "TriNetX" portant sur 7,4 millions de patients atteints de diabète de type 2 (durée de suivi : 15 ans), cette étude évalue l'effet, sur le risque de cancer colorectal, d'une utilisation d'analogues du GLP-1 par rapport aux autres traitements anti-diabétiques (insuline, metformine, inhibiteurs de l'alpha-glucosidase, inhibiteurs de la DPP-4, inhibiteurs de SGLT2, sulfonylurées et thiazolidinédiones)

GLP-1 Receptor Agonists and Colorectal Cancer Risk in Drug-Naive Patients With Type 2 Diabetes, With and Without Overweight/Obesity

Wang, Lindsey ; Wang, William ; Kaelber, David C. ; Xu, Rong ; Berger, Nathan A.

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are approved by the US Food and Drug Administration for treating type 2 diabetes (T2D). GLP-1RAs have pleiotropic effects on lowering plasma glucose, inducing weight loss, and modulating immune functions. Because overweight/obesity is a major risk factor for colorectal cancer (CRC), we hypothesize that GLP-1RAs are associated with a decreased risk for CRC in patients with T2D compared with non–GLP-1RA antidiabetics. We conducted a nationwide, [...]

Menée en Belgique en 2022 auprès de 822 clients (âge médian : 59 ans ; 69 % de femmes), cette étude analyse l'association entre des conseils sur les cancers de la peau et sur les types de peau dispensés en pharmacie et l'achat d'une protection solaire ou la susceptibilité de consulter un dermatologue

The role of community pharmacists in primary and secondary prevention of skin cancer: an evaluation of a Flemish skin cancer prevention campaign

Proesmans, Kristiaan ; Van Vaerenbergh, Frauke ; Lahousse, Lies

Background: Skin cancer is a leading form of cancer in Belgium. Prevention of skin cancer by community pharmacists can play a role in increasing awareness and promoting sun protection. However, which persons could be reached by community pharmacists for skin cancer awareness in Belgium and whether this increased awareness is associated with increased sun protection and early detection remains unclear. Methods: Demographics of approached persons in Flemish community pharmacies during the months [...]

Menée au Royaume-Uni sur la période 2019-2021 par entretiens auprès de 30 personnes, cette étude identifie les facteurs influençant l'arrêt du tabac et la motivation à arrêter de fumer après avoir refusé l'aide au sevrage tabagique proposée lors du dépistage du cancer du poumon

Barriers and facilitators to engaging in smoking cessation support among lung screening participants

Smith, Pamela ; Quinn-Scoggins, Harriet ; Murray, Rachael L ; McCutchan, Grace ; Nelson, Annmarie ; Moore, Graham ; Callister, Mat ; Tong, Hoang ; Brain, Kate

Embedded smoking cessation support within lung cancer screening is recommended in the UK; however, little is known about why individuals decline smoking cessation support in this setting. This study identified psychosocial factors that influence smoking cessation and quit motivation among those who declined support for quitting smoking alongside lung cancer screening.Qualitative interviews conducted between August 2019 - April 2021 with thirty adults with a smoking history, recruited from the [...]