Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Interruptions in bladder cancer care during the COVID-19 public health emergency

Gore, John L. ; Follmer, Kristin ; Reynolds, Jason ; Nash, Michael ; Anderson, Christopher B. ; Catto, James W. F. ; Chamie, Karim ; Daneshmand, Siamak ; Dickstein, Rian ; Garg, Tullika ; Gilbert, Scott M. ; Guzzo, Thomas J. ; Kamat, Ashish M. ; Kates, Max R. ; Lane, Brian R. ; Lotan, Yair ; Mansour, Ahmed M. ; Master, Viraj A. ; Montgomery, Jeffrey S. ; Morris, David S. ; Nepple, Kenneth G. ; O'Neil, Brock B. ; Patel, Sanjay ; Pohar, Kamal ; Porten, Sima P. ; Riggs, Stephen B. ; Sankin, Alexander ; Scarpato, Kristen R. ; Shore, Neal D. ; Steinberg, Gary D. ; Strope, Seth A. ; Taylor, Jennifer M. ; Comstock, Bryan A. ; Kessler, Larry G. ; Wolff, Erika M. ; Smith, Angela B.

Background: Academic and community urology centers participating in a pragmatic clinical trial in non-muscle-invasive bladder cancer completed monthly surveys assessing restrictions in aspects of bladder cancer care due to the COVID-19 Public Health Emergency. Our objective was to describe pandemic-related restrictions on bladder cancer care. Methods: We invited 32 sites participating in a multicenter pragmatic bladder cancer trial to complete monthly surveys distributed through REDCap [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

COVID-19 in cancer patients: The impact of vaccination on outcomes early in the pandemic

Khawaja, Fareed ; Angelidakis, Georgios ; Feldman, Adina ; Ravi, Vinod ; Woodman, Eric ; Bhatti, Micah ; Ariza-Heredia, Ella ; Elhajj, Peter ; Spallone, Amy ; Jiang, Ying ; Chemaly, Roy F.

Background: With the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the development of effective and safe vaccines was of utmost importance to protect vulnerable individuals, including cancer patients. Studies comparing the clinical outcomes of cancer patients with or without vaccination against coronavirus disease 2019 (COVID-19) have not demonstrated clear benefit. We aimed to determine the protective effects of COVID-19 vaccination by comparing [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Antibody responses to SARS-CoV-2 Omicron infection in patients with hematological malignancies: A multicenter, prospective cohort study

Li, Jun ; Liu, Yi ; Wei, Xia ; Liu, Zhanshu ; Yang, Zailiang ; Liu, Ling ; Zhou, Meiyu ; Xu, Guofa ; Chen, Lanting ; Ding, Yao ; Lei, Haike ; Yang, Zailin ; Chen, Shuang ; Zhang, Xiaomei ; Tang, Yifeng ; Fu, Huihui ; He, Sanxiu ; Guo, Bingling ; Liang, Xiping ; Zhang, Lingqian ; Zhang, Wenjun ; Wu, Jing ; Wang, Chaoyu ; Hu, Chongling ; Hu, Renzhi ; Luo, Xin ; Quan, Xi ; Zeng, Chensi ; Liang, Shunsi ; Liu, Tingting ; Lv, Jing ; Luo, Qin ; Qi, Qin ; Xu, Luxiang ; Xiong, Yan ; Liu, Jueyin ; Huang, Dehong ; Xiao, Chunyan ; Liu, Jun ; Yang, Tao ; Xiang, Ying ; Li, Qiying ; Nan, Yingyu ; Li, Jieping ; Zhang, Yong ; Wu, Yongzhong ; Liu, Yao

Little is known about antibody responses to natural Omicron infection and the risk factors for poor responders in patients with hematological malignancies (HM). We conducted a multicenter, prospective cohort study during the latest Omicron wave in Chongqing, China, aiming to compare the antibody responses, as assessed by IgG levels of anti-receptor binding domain of spike protein (anti-S-RBD), to Omicron infection in the HM cohort (HMC) with healthy control cohort (HCC), and solid cancer cohort [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Single-cell transcriptomics reveals pre-existing COVID-19 vulnerability factors in lung cancer patients

Liu, Wendao ; Li, Wenbo ; Zhao, Zhongming

COVID-19 and cancer are major health threats, and individuals may develop both simultaneously. Recent studies have indicated that cancer patients are particularly vulnerable to COVID-19, but the molecular mechanisms underlying the associations remain poorly understood. To address this knowledge gap, we collected single-cell RNA sequencing data from COVID-19, lung adenocarcinoma, small cell lung carcinoma patients and normal lungs to perform an integrated analysis. We characterized altered cell [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Psycho-oncologists’ experiences with video consultations during the Covid-19 pandemic and implications for the future—a multi-methods study

Schuster, Lara ; Führes, Hannah ; Wandke, Svenja ; Thomas, Mareike ; Scholl, Isabelle

Objective: During the Covid-19 pandemic, there has been a substantial uptake of telemental health interventions. Consequently, the objective of this study was to assess psycho-oncologists’ attitudes toward and experiences with video consultations (VC) since the beginning of the Covid-19 pandemic. Additionally, we sought to investigate psycho-oncologists’ perspectives on the benefits and drawbacks of VC and its' potential implementation beyond the pandemic. Methods: We used a multi-methods study [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Surviving the Storm: The Impact of COVID-19 on Cervical Cancer Screening in Low- and Middle-Income Countries

Vahabi, Mandana ; Shahil-Feroz, Anam ; Lofters, Aisha ; Wong, Josephine Pui-Hing ; Prakash, Vijayshree ; Pimple, Sharmila ; Anand, Kavita ; Mishra, Gauravi

According to the Center for Disease Control and Prevention’s National Breast and Cervical Cancer Early Detection Program, the cervical cancer screening rate dropped by 84% soon after the declaration of the COVID-19 pandemic. The challenges facing cervical cancer screening were largely attributed to the required in-person nature of the screening process and the measures implemented to control the spread of the virus. While the impact of the COVID-19 pandemic on cancer screening is [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway

Zhang, Xusheng ; Chen, Bendong ; Liu, Kejun ; Ma, Yongxin ; Liu, Yimin ; Zhou, Hongcai ; Wei, Peng

Objective: To investigate the effect of COVID-19 infection on pancreatic cancer. Methods: Based on the mRNA-Seq data of COVID-19 patients and pancreatic cancer (PC) patients in the GEO database, we used a support vector machine (SVM), LASSO-Cox regression analysis and random forest tree (RF) to screen the common signature genes of the two diseases and further investigate their effects and functional characteristics on PC, respectively. The above procedures were performed in R software. Results: [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Impact of SARS-CoV-2 infection on patients with hematological malignancies: a retrospective study

Zhao, Huihan ; He, Yu ; Li, Zhongqing ; Huang, Yanlu ; Ying, Yanping ; Huang, Zhaoquan

Objectives: This study aimed to evaluate the characteristics of patients with hematological malignancies (HM) and SARS-CoV-2 infection and analyze the risk factors of their severity and mortality. Methods: A retrospective study including inpatients diagnosed HM and SARS-CoV-2 infection between December 2022 and February 2023 were conducted. Demographic information, medical history, comorbidities, diagnosis, treatment related information and outcomes were extracted from electronic medical [...]

Menée en Angleterre, cette étude estime l'évolution de la mortalité par cancer sur la période 2002-2019

Mortality from leading cancers in districts of England from 2002 to 2019: a population-based, spatiotemporal study

Rashid, Theo ; Bennett, James E. ; Muller, David C. ; Cross, Amanda J. ; Pearson-Stuttard, Jonathan ; Asaria, Perviz ; Daby, Hima Iyathooray ; Fecht, Daniela ; Davies, Bethan ; Ezzati, Majid

Background: Cancers are the leading cause of death in England. We aimed to estimate trends in mortality from leading cancers from 2002 to 2019 for the 314 districts in England. Methods: We did a high-resolution spatiotemporal analysis of vital registration data from the UK Office for National Statistics using data on all deaths from the ten leading cancers in England from 2002 to 2019. We used a Bayesian hierarchical model to obtain robust estimates of age-specific and cause-specific death [...]

Menée en Angleterre, cette étude estime l'évolution de la mortalité par cancer sur la période 2002-2019

Utilising cancer registry data to monitor cancer burden

Seppä, Karri ; Pitkäniemi, Janne

Geographical equity in cancer burden can be assessed based on high-resolution data from population-based registries. In The Lancet Oncology, Theo Rashid and colleagues 1 combined vital registration data with novel statistical methodology to provide insight into small-area variation in cancer mortality in England, how it has changed from 2002 to 2019, and how it correlates with district-level poverty.

Menée aux Etats-Unis à partir de données portant sur 21 824 patients atteints d'un cancer invasif de l'anus diagnostiqué entre 2001 et 2019, cette étude de cohorte rétrospective analyse la survie en fonction du sexe et de la présence d'une infection par le VIH (2 662 cas)

Survival by sex and HIV status in patients with anal cancer in the USA between 2001 and 2019: a retrospective cohort study

Shing, Jaimie Z. ; Engels, Eric A. ; Austin, April A. ; Clarke, Megan A. ; Hayes, Jennifer H. ; Kreimer, Aimee R. ; Monterosso, Analise ; Horner, Marie-Josephe ; Pawlish, Karen S. ; Luo, Qianlai ; Zhang, Elizabeth R. ; Koestler, Aimee J. ; Pfeiffer, Ruth M. ; Shiels, Meredith S.

Background: The risk of anal cancer is increased among people with HIV, particularly men who have sex with men. Estimating survival by HIV status and sex and identifying groups at high risk is crucial for documenting prognostic differences between populations. We aimed to compare all-cause and anal cancer-specific survival in patients with anal cancer with and without HIV, stratified by sex, and to identify predictors of survival, stratified by HIV status. Methods: In this retrospective cohort [...]

Menée aux Etats-Unis à partir de données portant sur 21 824 patients atteints d'un cancer invasif de l'anus diagnostiqué entre 2001 et 2019, cette étude de cohorte rétrospective analyse la survie en fonction du sexe et de la présence d'une infection par le VIH (2 662 cas)

Expanding early detection of anal cancer to improve survival

Nowak, Rebecca G.

As the emergence of antiretroviral therapy (ART) has improved survival in people with HIV, the prevalence of age-related diseases, such as cancer, has increased. Specifically, the incidence of anal cancer has escalated in people with HIV with oncogenic HPV, 1 , 2 , 3 , 4 leading to a growing population of people with HIV diagnosed with anal cancer. Consequently, questions have arisen regarding whether controlling HIV with ART leads to an increased risk of overall or anal-cancer specific [...]

Menée aux Etats-Unis auprès de 223 parents d'un enfant atteint d'un cancer récemment diagnostiqué, cette étude transversale analyse l'association entre des déterminants sociaux de santé (statut marital, niveau d'éducation, emploi, statut socioéconomique, etc.), des facteurs socio-contextuels et leur consentement éclairé à l'inclusion de leur enfant dans un essai clinique

Social Determinants of Health and Informed Consent Comprehension for Pediatric Cancer Clinical Trials

Aristizabal, Paula ; Nataraj, Shilpa ; Ma, Arissa K. ; Kumar, Nikhil V. ; Perdomo, Bianca P. ; Martínez, María Elena ; Nodora, Jesse ; Liu, Lin ; Lee, Euyhyun ; Thornburg, Courtney D.

Importance : Ensuring valid informed consent (IC) prior to enrollment in clinical trials is a fundamental ethical right. Objective : To assess whether social determinants of health (SDOH) and related sociocontextual factors are associated with parental IC comprehension in therapeutic childhood cancer clinical trials. Design, Setting, and Participants : This cross-sectional study prospectively enrolled 223 parents of children with newly diagnosed cancer at Rady Children’s Hospital San Diego, a [...]

Menée aux Etats-Unis auprès de 223 parents d'un enfant atteint d'un cancer récemment diagnostiqué, cette étude transversale analyse l'association entre des déterminants sociaux de santé (statut marital, niveau d'éducation, emploi, statut socioéconomique, etc.), des facteurs socio-contextuels et leur consentement éclairé à l'inclusion de leur enfant dans un essai clinique

Opportunities to Advance Equity Through Informed Consent Discussions

Umaretiya, Puja J. ; Johnston, Emily E.

As pediatric oncologists, we often ask parents to do the unthinkable: grapple with a child’s new cancer diagnosis and participate in a clinical trial informed consent discussion within hours to days of each other. Informed consent is essential to our practice because access to clinical trials is the standard of care in pediatric oncology. These discussions are both emotionally charged and medically complex, adding challenges to effective communication. Nearly 2 decades ago, Kodish and [...]