Menée à partir de données portant sur 126 patients porteurs d'un variant constitutionnel du gène CDH1 et ayant subi une gastrectomie totale pour prévenir le développement d'un cancer gastrique diffus héréditaire (durée médiane de suivi : 24 mois) , cette étude analyse les séquelles physiques et psychologiques ainsi que la qualité de vie en lien avec le traitement chirurgical

Costs of Cancer Prevention: Physical and Psychosocial Sequelae of Risk-Reducing Total Gastrectomy

Amber F. Gallanis ; Lauren A. Gamble ; Sarah G. Samaranayake ; Rachael Lopez ; Amanda Rhodes ; Suraj Rajasimhan ; Grace-Ann Fasaye ; Olvan Juma ; Maureen Connolly ; Stacy Joyce ; Ann Berger ; Theo Heller ; Andrew M. Blakely ; Jonathan M. Hernandez ; Jeremy L. Davis

PURPOSE: Risk-reducing surgery for cancer prevention in solid tumors is a pressing clinical topic because of the increasing availability of germline genetic testing. We examined the short- and long-term outcomes of risk-reducing total gastrectomy (RRTG) and its lesser-known impacts on health-related quality of life (QOL) in individuals with hereditary diffuse gastric cancer syndrome. METHODS: Individuals who underwent RRTG as part of a single-institution natural history study of hereditary [...]

Menée aux Etats-Unis par enquête auprès de 28 942 patients atteints d'un cancer, cette étude identifie les facteurs associés à l'utilisation d'un portail informatique donnant accès au dossier médical et permettant de déclarer les symptômes pendant et après les traitements anticancéreux

Disparities in Electronic Health Record Portal Access and Use among Patients with Cancer

Griffin, Joan M ; Kroner, Barbara L ; Wong, Sandra L ; Preiss, Liliana ; Smith, Ashley Wilder ; Cheville, Andrea L ; Mitchell, Sandra A ; Lancki, Nicola ; Hassett, Michael J ; Schrag, Deborah ; Osarogiagbon, Raymond U ; Ridgeway, Jennifer L ; Cella, David ; Jensen, Roxanne E ; Flores, Ann Marie ; Austin, Jessica D ; Yanez, Betina ; the IMPACT Consortium

BACKGROUND: Electronic health record (EHR)-linked portals may improve healthcare quality for cancer patients. Barriers to portal access and use undermine interventions leveraging portals to reduce cancer care disparities. This study examined portal access and persistence of portal use and associations with patient- and structural-factors prior to the implementation of three portal-based interventions within the Improving the Management of symPtoms during And following Cancer Treatment (IMPACT) [...]

Cet article passe en revue les données évaluant l'intérêt du cannabis thérapeutique pour limiter les symptômes gastro-intestinaux des patients atteints d'un cancer de stade avancé

Supporting gut health with medicinal cannabis in people with advanced cancer: potential benefits and challenges

Wardill, Hannah R. ; Wooley, Luke T. ; Bellas, Olivia M. ; Cao, Katrina ; Cross, Courtney B. ; van Dyk, Madele ; Kichenadasse, Ganessan ; Bowen, Joanne M. ; Zannettino, Andrew C. W. ; Shakib, Sepehr ; Crawford, Gregory B. ; Boublik, Jaroslav ; Davis, Mellar M. ; Smid, Scott D. ; Price, Timothy J.

The side effects of cancer therapy continue to cause significant health and cost burden to the patient, their friends and family, and governments. A major barrier in the way in which these side effects are managed is the highly siloed mentality that results in a fragmented approach to symptom control. Increasingly, it is appreciated that many symptoms are manifestations of common underlying pathobiology, with changes in the gastrointestinal environment a key driver for many symptom sequelae. [...]

A partir d'une revue de la littérature, cette étude analyse l'association entre la composition corporelle et la survie des patients atteints d'un cancer

Body composition and cancer survival: a narrative review

Bradshaw, Patrick T.

Interest in understanding the relationship between body composition and cancer survival has remained strong for decades, with a number of recent systematic reviews on the topic. However, the current state of evidence is based on heterogeneous exposure definitions based on anthropometry, yielding inconsistent findings with regard to this association. Recently the field has taken an exciting direction with the application of radiological assessments to measure specific aspects of body [...]

Menée à partir de données des registres américains des cancers, cette étude analyse, par rapport aux enfants et aux adultes atteints d'un cancer, l'évolution de la survie relative à 5 ans des adolescents et jeunes adultes (15-39 ans)

Survival Trends Among Adolescents and Young Adults Diagnosed With Cancer in the United States: Comparisons With Children and Older Adults

Theresa H.M. Keegan ; Renata Abrahão ; Elysia M. Alvarez

PURPOSE: Although data from 1975 to 1997 revealed a gap in cancer survival improvement in adolescents and young adults (AYAs; 15-39 years) compared with children and older adults, more recent studies have reported improvements in AYA cancer survival overall. The current analysis provides an update of 5-year relative survival and cancer survival trends among AYAs compared with children and older adults. METHODS: We obtained data from the National Cancer Institute Surveillance, Epidemiology, and [...]

Menée à partir de données portant sur 1 929 adolescents et jeunes adultes décédés d'un cancer entre 2003 et 2019 (âge : 12-39 ans), cette étude analyse la qualité des soins de fin de vie (soins palliatifs, prise en charge des symptômes, soutien psychosocial, etc.)

Quality of End-of-Life Care Among Adolescents and Young Adults With Cancer

Jennifer W. Mack ; Colin Cernik ; Hajime Uno ; Cecile A. Laurent ; Lauren Fisher ; Lanfang Xu ; Julie Munneke ; Nancy Cannizzaro ; Mallory Casperson ; Corey M. Schwartz ; Joshua R. Lakin ; Robert M. Cooper ; Andrea Altschuler ; Lori Wiener ; Chun R. Chao ; Lawrence Kushi

Adolescents and young adults (AYAs) receive high rates of medically intensive measures at the end of life, but less is known about other measures of quality cancer care, such as use of palliative care and hospice, symptom management, and psychological support. We conducted a review of electronic health data and medical records for 1,929 AYAs age 12-39 years who died after receiving cancer care at one of three sites (Dana-Farber Cancer Institute, Kaiser Permanente Northern California, and Kaiser [...]

Menée à partir de données portant sur 743 enfants, adolescents et jeunes adultes atteints d'une leucémie lymphoblastique aiguë à cellules B et d'un syndrome de Down (âge : 1-30 ans), cette étude analyse la survie sans événement à 5 ans et la survie globale

Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group

Karen R. Rabin ; Meenakshi Devidas ; Zhiguo Chen ; Lingyun Ji ; John Kairalla ; Johann K. Hitzler ; Jun J. Yang ; Andrew J. Carroll ; Nyla A. Heerema ; Michael J. Borowitz ; Brent L. Wood ; Kathryn G. Roberts ; Charles G. Mullighan ; Richard C. Harvey ; I-Ming Chen ; Cheryl L. Willman ; Shalini C. Reshmi ; Julie M. Gastier-Foster ; Deepa Bhojwani ; Susan R. Rheingold ; Kelly W. Maloney ; Leonard A. Mattano ; Eric C. Larsen ; Reuven J. Schore ; Michael J. Burke ; Wanda L. Salzer ; Naomi J. Winick ; William L. Carroll ; Elizabeth A. Raetz ; Mignon L. Loh ; Stephen P. Hunger ; Anne L. Angiolillo

PURPOSE: Patients with Down syndrome (DS) and B-ALL experience increased rates of relapse, toxicity, and death. We report results for patients with DS B-ALL enrolled on Children's Oncology Group trials between 2003 and 2019. METHODS: We analyzed data for DS (n = 743) and non-DS (n = 20,067) patients age 1-30 years on four B-ALL standard-risk (SR) and high-risk trials. RESULTS: Patients with DS exhibited more frequent minimal residual disease (MRD) ≥0.01% at end induction (30.8% v 21.5%; P < [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2023 (26 articles), cette étude analyse l'incidence du cancer du poumon et la mortalité chez des individus ayant fumé pendant une durée supérieure ou égale à 20 ans et ayant arrêté de fumer depuis plus de 15 ans

Lung cancer diagnosis and mortality beyond 15 years since quit in individuals with a 20+ pack-year history: A systematic review

Kondo, Karli K. ; Rahman, Basmah ; Ayers, Chelsea K. ; Relevo, Rose ; Griffin, Jessica C. ; Halpern, Michael T.

Current US lung cancer screening recommendations limit eligibility to adults with a pack-year (PY) history of ≥20 years and the first 15 years since quit (YSQ). The authors conducted a systematic review to better understand lung cancer incidence, risk and mortality among otherwise eligible individuals in this population beyond 15 YSQ. The PubMed and Scopus databases were searched through February 14, 2023, and relevant articles were searched by hand. Included studies examined the relationship [...]

Cette étude estime le risque absolu de développer un cancer du poumon chez les individus ayant arrêté de fumer pendant plus de 15 ans

Absolute lung cancer risk increases among individuals with >15 quit-years: Analyses to inform the update of the American Cancer Society lung cancer screening guidelines

Landy, Rebecca ; Cheung, Li C. ; Young, Corey D. ; Chaturvedi, Anil K. ; Katki, Hormuzd A.

Background: This report quantifies counteracting effects of quit-years and concomitant aging on lung cancer risk, especially on exceeding 15 quit-years, when the US Preventive Services Task Force (USPSTF) recommends curtailing lung-cancer screening. Methods: Cox models were fitted to estimate absolute lung cancer risk among Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) and National Lung Screening Trial (NLST) participants who ever smoked. Absolute lung cancer risk and [...]

Cette étude passe en revue les données évaluant les disparités ethniques dans l'accès aux traitements systémiques chez les patients atteints d'un cancer de la prostate de stade métastatique

Disparities With Systemic Therapies for Black Men Having Advanced Prostate Cancer: Where Do We Stand?

Jun Gong ; Daniel M. Kim ; Amanda M. De Hoedt ; Neil Bhowmick ; Robert Figlin ; Hyung L. Kim ; Howard Sandler ; Dan Theodorescu ; Edwin Posadas ; Stephen J. Freedland

PURPOSE: Prostate cancer represents the most common cancer diagnosis in Black men and is the second leading cause of cancer death in this population. Multilevel disparities have been well-documented in Black men with prostate cancer and play a role in poorer survival outcomes when compared with White men with prostate cancer. In this review, we highlight the changing trend in disparities for systemic therapy outcomes in Black men diagnosed with metastatic prostate cancer. METHODS: We reviewed [...]

A partir d'une revue systématique de la littérature publiée entre 2005 et 2023 (11 essais randomisés, 2 249 patientes), cette étude analyse l'effet, sur la santé mentale de patientes ayant survécu à un cancer du sein, d'interventions de santé psychique dispensées via des applications mobiles

Systematic review on the effectiveness of mobile health applications on mental health of breast cancer survivors

Horn, Anna ; Jírů-Hillmann, Steffi ; Widmann, Jonas ; Montellano, Felipe A. ; Salmen, Jessica ; Pryss, Rüdiger ; Wöckel, Achim ; Heuschmann, Peter U.

Purpose: Breast cancer survivors are more likely to report psychological distress and unmet need for support compared to healthy controls. Psychological mobile health interventions might be used in follow-up care of breast cancer patients to improve their mental health. Methods: We searched MEDLINE, PsychINFO, Cochrane and PROSPERO for articles on controlled trials examining the effectiveness of psychological mobile health interventions compared to routine care regarding mental health outcomes [...]

Menée dans un contexte américain à partir de données portant sur 1 347 patients atteints d'un cancer, cette étude rétrospective analyse l'impact, sur le taux de rendez-vous manqués dans les 180 premiers jours du traitement, d'un programme d'aides financières non médicales

Economic Evaluation of a Nonmedical Financial Assistance Program on Missed Treatment Appointments Among Adults With Cancer

Caitlin B. Biddell ; Lisa P. Spees ; Justin G. Trogdon ; Erin E. Kent ; Donald L. Rosenstein ; Rebekah S.M. Angove ; Cindy D. Rogers ; Stephanie B. Wheeler

PURPOSE: We retrospectively evaluated the clinical and economic impact of a program providing nonmedical financial assistance on missed treatment appointments among patients receiving cancer treatment at a large, Southeastern public hospital system. MATERIALS AND METHODS: We used patient electronic health records, program records, and cancer registry data to examine the impact of the program on rates of missed (or no-show) radiation therapy and infusion chemotherapy/immunotherapy appointments [...]

Menée à partir de données portant sur 225 patients atteints d'un cancer du pancréas non résécable et présentant des saignements gastro-intestinaux, cette étude rétrospective analyse l'intérêt, du point de vue de l'hémostase et de la survie globale, d'une radiothérapie palliative

Palliative radiotherapy for tumor bleeding in patients with unresectable pancreatic cancer: a single-center retrospective study

Shibuki, Taro ; Sasaki, Mitsuhito ; Yamaguchi, Shota ; Inoue, Kanae ; Taira, Tomonao ; Satake, Tomoyuki ; Watanabe, Kazuo ; Imaoka, Hiroshi ; Mitsunaga, Shuichi ; Fujisawa, Takeshi ; Tomizawa, Kento ; Oyoshi, Hidekazu ; Nakamura, Masaki ; Hojo, Hidehiro ; Ikeda, Masafumi

Background: Patients with unresectable pancreatic cancer (PC) sometimes experience gastrointestinal bleeding (GIB) due to tumor invasion of the gastrointestinal tract (tumor bleeding); no standard treatment has been established yet for this complication. Palliative radiotherapy (PRT) could be promising, however, there are few reports of PRT for tumor bleeding in patients with unresectable PC. Therefore, we evaluated the outcomes of PRT for tumor bleeding in patients with unresectable PC. [...]