Menée à partir de données de l'essai "the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial" portant sur 138 614 personnes, cette étude analyse l'association entre la trajectoire de l'indice de masse corporelle au cours de la vie et le risque de carcinome à cellules rénales

Lifetime Body Weight Trajectories and Risk of Renal Cell Cancer: A Large U.S. Prospective Cohort Study

Deng, Zhengyi ; Hajihosseini, Morteza ; Moore, Justin X. ; Khan, Saira ; Graff, Rebecca E. ; Bondy, Melissa L. ; Chung, Benjamin I. ; Langston, Marvin E.

Body mass index (BMI) is a known risk factor for renal cell cancer (RCC), but data are limited as to the effect of lifetime exposure to excess body weight.Using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 138,614, 527 incident RCCs), we identified several anthropometric measures to capture the lifetime BMI patterns: (i) BMI at specific ages; (ii) adulthood BMI trajectories; (iii) cumulative exposure to overweight/obesity denoted as weighted years of living [...]

Menée en Australie auprès de 11 679 hommes âgés d'au moins 65 ans, cette étude analyse l'association entre un faible niveau de pollution aux particules fines (PM2,5), au dioxyde d'azote ou au carbone noir et le risque de cancer du poumon ou de la vessie

Exposure to low-level ambient air pollution and the relationship with lung and bladder cancer in older men, in Perth, Western Australia

Lim, Elizabeth H. ; Franklin, Peter ; Trevenen, Michelle L. ; Nieuwenhuijsen, Mark ; Yeap, Bu B. ; Almeida, Osvaldo P. ; Hankey, Graeme J. ; Golledge, Jonathan ; Etherton-Beer, Christopher ; Flicker, Leon ; Robinson, Suzanne ; Heyworth, Jane

Background: Air pollution is a cause of lung cancer and is associated with bladder cancer. However, the relationship between air pollution and these cancers in regions of low pollution is unclear. We investigated associations between fine particulate matter (PM2.5), nitrogen dioxide, and black carbon (BC), and both these cancers in a low-pollution city. Methods: A cohort of 11,679 men ≥65 years old in Perth (Western Australia) were followed from 1996–1999 until 2018. Pollutant concentrations, [...]

Menée aux Etats-Unis auprès de 196 905 femmes, cette étude analyse l'association entre des estimations à 5 et 10 ans de l'exposition aux polluants atmosphériques (PM2,5) et le risque de cancer du sein (15 870 cas)

Ambient fine particulate matter and breast cancer incidence in a large prospective US cohort

White, Alexandra J ; Fisher, Jared A ; Sweeney, Marina R ; Freedman, Neal D ; Kaufman, Joel D ; Silverman, Debra T ; Jones, Rena R

Fine particulate matter (PM2.5) has been inconsistently associated with breast cancer incidence, however few studies have considered historic exposure when levels were higher.Outdoor residential PM2.5 concentrations were estimated using a nationwide spatiotemporal model for women in the NIH-AARP Diet and Health Study, a prospective cohort located in 6 states (California, Florida, Louisiana, New Jersey, North Carolina, and Pennsylvania) and 2 metropolitan areas (Atlanta, Georgia, and Detroit, [...]

Menée en Afrique du Sud auprès de 3 447 908 femmes infectées par le VIH, cette étude identifie les facteurs de risque de développer un cancer du sein ou un cancer gynécologique (7 612 cas)

Gynaecologic and breast cancers in women living with HIV in South Africa: A record linkage study

Dhokotera, Tafadzwa G. ; Muchengeti, Mazvita ; Davidović, Maša ; Rohner, Eliane ; Olago, Victor ; Egger, Matthias ; Bohlius, Julia

Breast and gynaecologic cancers account for approximately half of all cancers diagnosed amongst women in South Africa, many of whom also live with HIV. We aimed to determine the incidence of and risk factors for developing breast and gynaecologic cancers in women living with HIV (WLHIV) in South Africa. This is a longitudinal analysis of the South African HIV Cancer Match study including women aged ≥15 years with two or more HIV-related laboratory tests. We used Cox proportional hazard models [...]

Menée à partir de données 2000-2018 des registres américains des cancers portant sur 445 523 patientes ayant survécu à un cancer du sein, cette étude analyse le risque de second cancer primitif lié au traitement par radiothérapie ainsi que la survie associée

Association of radiotherapy for stage I–III breast cancer survivors and second primary malignant cancers: a population-based study

Shi, Jin ; Liu, Jian ; Tian, Guo ; Li, Daojuan ; Liang, Di ; Wang, Jun ; He, Yutong

Purpose: With life span extending, breast cancer survivors may face the possibility of developing second primary cancers (SPCs). The objective of this research is to investigate the risk factors, risk attribute to radiotherapy and the survivalship for SPCs. Methods: A total of 445 523 breast cancer patients were enrolled from Surveillance, Epidemiology, and End Results database in 2000–2018. The risk factors for SPCs development were confirmed by competing risk model, and then were integrated [...]

Menée à partir de données de la "UK Biobank" portant sur 348 872 personnes (durée moyenne de suivi : 9 ans), cette étude analyse l'association entre la concentration sérique en urée et le risque de cancer colorectal (3 408 cas)

Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study

Gao, Peipei ; Mei, Zhendong ; Liu, Zhenqiu ; Zhu, Dongliang ; Yuan, Huangbo ; Zhao, Renjia ; Xu, Kelin ; Zhang, Tiejun ; Jiang, Yanfeng ; Suo, Chen ; Chen, Xingdong

Dysregulation of the urea cycle (UC) has been detected in colorectal cancer (CRC). However, the impact of the UC's end product, urea, on CRC development remains unclear. We investigated the association between serum urea and CRC risk based on the data of 348 872 participants cancer-free at recruitment from the UK Biobank. Multivariable Cox proportional hazards models were fitted to conduct risk estimates. Stratification analyses based on sex, diet pattern, metabolic factors (including body mass [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'association entre le taux sanguin d'acide urique et le risque de cancer colorectal

Serum uric acid and the risk of colorectal cancer: a meta-analysis

Liao, Wenqiang ; Wang, Yuxiang ; Zhang, Wenpeng

Background: A meta-analysis was performed in this study to evaluate the association between serum uric acid and the risk of colorectal cancer (CRC). Methods: Relevant observational studies observing the relationship between uric acid and the incidence of CRC were obtained by the search of electronic databases, including Medline, Embase, Cochrane Library and Web of Science. A randomized-effects model was selected to pool the data by incorporating the influence of potential heterogeneity. [...]

Menée auprès de 364 témoins et 182 patients atteints d'une tumeur germinale du testicule, cette étude analyse l'association entre les niveaux sériques des hormones sexuelles et le risque de développer la maladie

Prediagnostic Hormone Levels and Risk of Testicular Germ Cell Tumors: A Nested Case–Control Study in the Janus Serum Bank

Wu, Zeni ; Trabert, Britton ; Guillemette, Chantal ; Caron, Patrick ; Bradwin, Gary ; Graubard, Barry I. ; Weiderpass, Elisabete ; Ursin, Giske ; Langseth, Hilde ; McGlynn, Katherine A.

It has been hypothesized that poorly functioning Leydig and/or Sertoli cells of the testes, indicated by higher levels of serum gonadotropins and lower levels of androgens, are related to the development of testicular germ cell tumors (TGCT). To investigate this hypothesis, we conducted a nested case–control study within the Janus Serum Bank cohort.Men who developed TGCT (n = 182) were matched to men who did not (n = 364). Sex steroid hormones were measured using LC/MS. Sex hormone binding [...]

Menée à partir des données de 13 études asiatiques portant au total sur 332 625 femmes (âge moyen : 54,3 ans ; durée moyenne de suivi : 16,5 ans), cette étude analyse l'association entre des facteurs reproductifs (nombre d'accouchements, âge aux premières règles, âge à la ménopause,..) et le risque de cancer de l'endomètre (1 005 cas)

Reproductive Factors and Endometrial Cancer Risk Among Women

Katagiri, Ryoko ; Iwasaki, Motoki ; Abe, Sarah Krull ; Islam, Md. Rashedul ; Rahman, Md. Shafiur ; Saito, Eiko ; Merritt, Melissa A. ; Choi, Ji-Yeob ; Shin, Aesun ; Sawada, Norie ; Tamakoshi, Akiko ; Koh, Woon-Puay ; Sakata, Ritsu ; Tsuji, Ichiro ; Kim, Jeongseon ; Nagata, Chisato ; Park, Sue K. ; Kweon, Sun-Seog ; Shu, Xiao-Ou ; Gao, Yu-Tang ; Tsugane, Shoichiro ; Kimura, Takashi ; Yuan, Jian-Min ; Kanemura, Seiki ; Lu, Yukai ; Sugawara, Yumi ; Wada, Keiko ; Shin, Min-Ho ; Ahsan, Habibul ; Boffetta, Paolo ; Chia, Kee Seng ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee

Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries.To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk.This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium. Participants were Asian women. Data analysis [...]

Menée au Japon à partir de données portant sur 55 882 femmes âgées de 40 à 69 ans (durée moyenne de suivi : 20,2 ans), cette étude analyse l'association entre des facteurs reproductifs et le risque de cancer de la vessie (145 cas) ou des voies urinaires supérieures (49 cas)

Reproductive Factors in the Risk of Bladder Cancer and Upper Urinary Tract Cancer: The Japan Public Health Center-Based Prospective Study

Minami, Tetsuji ; Inoue, Manami ; Yamaji, Taiki ; Iwasaki, Motoki ; Tsugane, Shoichiro ; Sawada, Norie

Reproductive factors are hypothesized to play a role in the incidence of bladder cancer and upper urinary tract cancer (UUTC, together, urothelial cancer). However, evidence regarding these associations is limited, particularly in Asian populations.We analyzed data from 55,882 females ages 40 to 69 years, and performed Cox proportional hazards regression analyses with three types of adjustment, namely age; reproductive factor of interest and covariates in addition to age (conventional model); [...]